白介素-17、白介素-33与支气管哮喘关系的研究进展
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摘要
为研究白介素-17及白介素-33与支气管哮喘的关系,本文将各学者的研究成果与本人的临床经验结合,对相关问题进行了总结。首先,本文分析了支气管哮喘及其病因,介绍了白细胞介素,阐述了白细胞介素的功能。其次,分析了白介素-17及白介素-33与支气管哮喘发病之间的关系,强调了通过调整白介素-17及白介素-33治疗支气管哮喘的重要性。最后从中西医两方面出发,观察了采用不同方法治疗支气管哮喘,对白介素-17及白介素-33指标的影响。最终证实了白介素-17及白介素-33在疾病诊断、病情评估中的应用价值。
In order to study the relationship between interleukin-17, interleukin-33 and bronchial asthma, this paper summarizes the related problems by combining the research results of various scholars with my own clinical experience.Firstly, this paper analyzes bronchial asthma and its etiology, introduces interleukin, and expounds the function of interleukin. Secondly, the relationship between interleukin-17 and interleukin-33 and asthma was analyzed, and the importance of adjusting interleukin-17 and interleukin-33 in the treatment of bronchial asthma were emphasized.Finally, from the two aspects of traditional Chinese and western medicine, the different methods of treating bronchial asthma were observed. The effects of interleukin-17 and interleukin-33 on bronchial asthma were studied. Finally, the value of interleukin-17 and interleukin-33 in the diagnosis and evaluation of disease was confirmed.
In order to study the relationship between interleukin-17, interleukin-33 and bronchial asthma, this paper summarizes the related problems by combining the research results of various scholars with my own clinical experience.Firstly, this paper analyzes bronchial asthma and its etiology, introduces interleukin, and expounds the function of interleukin. Secondly, the relationship between interleukin-17 and interleukin-33 and asthma was analyzed, and the importance of adjusting interleukin-17 and interleukin-33 in the treatment of bronchial asthma were emphasized.Finally, from the two aspects of traditional Chinese and western medicine, the different methods of treating bronchial asthma were observed. The effects of interleukin-17 and interleukin-33 on bronchial asthma were studied. Finally, the value of interleukin-17 and interleukin-33 in the diagnosis and evaluation of disease was confirmed.
引文
[1]孔霞.脂氧素A4受体激动剂及白介素-1β在Toll样受体2核因子-κB信号通路对哮喘小鼠气道炎症的调控作用[J].儿科药学杂志,2018,24(7):1-6.
[2]卢锋峰,岳文香,陈愉生.有气道重塑的支气管哮喘患者急性发作期血清白介素-13的表达及其基因多态性的意义[J].海峡药学,2017,29(12):99-102.
[3]张美,李敏,张季红.血清白介素-13、白介素-4水平及吸入过敏原在新疆维吾尔族哮喘儿童相关研究[J].新疆医科大学学报,2017,40(1):48-50,54.
[4]李黎,韩晓英,赵莹莹.血清白介素及黏附分子与支气管哮喘的关系分析[J].实用临床医药杂志,2017,21(1):188-189.
[5]许柏华.C反应蛋白、白介素-17、色素上皮衍生因子与哮喘患儿免疫球蛋白E的相关性分析[J].中国当代医药,2018,25(22):122-124.
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[9]安新业,任瑞,宋琼.哮喘儿童诱导痰IL-8、IL-17、白三烯B4检测及临床意义[J].滨州医学院学报,2018,41(1):34-35.
[10]甘兵,张洪浩,邓应美.支气管哮喘急性发作期诱导痰中白介素-17变化临床研究[J].中国实用内科杂志,2018,38(2):157-159.
[11]邵莉,曹兰芳,李晓丽.支气管哮喘合并肺炎支原体感染小鼠模型白介素9、白介素-17、γ干扰素的变化[J].内科理论与实践,2016,11(1):47-51.
[12]史兆雯,蔡朱莺,王昌惠.哮喘急性发作患者血清中IL-18、IL-33表达意义及其与肺功能的关系[J].同济大学学报(医学版),2017,38(6):58-62.
[13]张鑫,王炜,孙英.上皮源性细胞因子IL-33、IL-25和TSLP在哮喘发病机制中的作用[J].微生物学免疫学进展,2017,45(5):53-58.
[14]张子友.孟鲁司特片联合布地奈德雾化吸入治疗对儿童支气管哮喘呼吸道功能及血清IL-17水平的影响[J].湖南师范大学学报(医学版),2018,15(4):151.
[15]薛燕.孟鲁司特联合沙美特罗替卡松对哮喘患儿外周血白介素水平的影响[J].北方药学,2017,14(6):59.
[16]高晓平.孟鲁司特钠治疗支气管哮喘的效果及对气道上皮细胞白介素-25和α-平滑肌肌动蛋白的影响[J].临床医学研究与实践,2018,3(6):36-37.
[17]李吉梅,孙成英.多索茶碱注射液对急性支气管哮喘患者血清IL-18,IL-33及TNF-α水平的影响[J].现代生物医学进展,2017,17(21):4116-4119.
[18]卢晓君,孙雪皎.布地奈德/福莫特罗粉吸入治疗对支气管哮喘患者IL-33、IL-17水平及肺功能的影响[J].临床医学,2018,38(5):13-17.
[19]沈雪艳,陈三妹.新生期卡介苗和乙肝疫苗联合接种对哮喘小鼠IFN-γ、IL-4和IL-17A表达的影响[J].中国病理生理杂志,2018,34(3):515-520.
[20]王芳.加味射干麻黄汤治疗哮喘患儿的临床评价及对血清TGF-β1、NGF、白介素族及肺换气功能的影响[J].中药材,2017,40(8):1969-1971.
[2]卢锋峰,岳文香,陈愉生.有气道重塑的支气管哮喘患者急性发作期血清白介素-13的表达及其基因多态性的意义[J].海峡药学,2017,29(12):99-102.
[3]张美,李敏,张季红.血清白介素-13、白介素-4水平及吸入过敏原在新疆维吾尔族哮喘儿童相关研究[J].新疆医科大学学报,2017,40(1):48-50,54.
[4]李黎,韩晓英,赵莹莹.血清白介素及黏附分子与支气管哮喘的关系分析[J].实用临床医药杂志,2017,21(1):188-189.
[5]许柏华.C反应蛋白、白介素-17、色素上皮衍生因子与哮喘患儿免疫球蛋白E的相关性分析[J].中国当代医药,2018,25(22):122-124.
[6]吴彪.支气管哮喘合并感染性肺炎患儿对血小板指标、炎性因子水平及Th1/Th2比值的影响观察[J].中华医院感染学杂志,2016,26(24):5716-5719.
[7]曹华,屠强.支气管哮喘患者血清IL-4、IL-10、IL-17和IFN-γ水平测定及其临床意义[J].国际检验医学杂志,2018,39(12):1506-1508.
[8]李小明.支气管哮喘患者外周血CD4+T、CD8+T、Th17、IL-17表达水平与肺功能的相关性研究[J].河北医科大学学报,2018,39(5):504-507,513.
[9]安新业,任瑞,宋琼.哮喘儿童诱导痰IL-8、IL-17、白三烯B4检测及临床意义[J].滨州医学院学报,2018,41(1):34-35.
[10]甘兵,张洪浩,邓应美.支气管哮喘急性发作期诱导痰中白介素-17变化临床研究[J].中国实用内科杂志,2018,38(2):157-159.
[11]邵莉,曹兰芳,李晓丽.支气管哮喘合并肺炎支原体感染小鼠模型白介素9、白介素-17、γ干扰素的变化[J].内科理论与实践,2016,11(1):47-51.
[12]史兆雯,蔡朱莺,王昌惠.哮喘急性发作患者血清中IL-18、IL-33表达意义及其与肺功能的关系[J].同济大学学报(医学版),2017,38(6):58-62.
[13]张鑫,王炜,孙英.上皮源性细胞因子IL-33、IL-25和TSLP在哮喘发病机制中的作用[J].微生物学免疫学进展,2017,45(5):53-58.
[14]张子友.孟鲁司特片联合布地奈德雾化吸入治疗对儿童支气管哮喘呼吸道功能及血清IL-17水平的影响[J].湖南师范大学学报(医学版),2018,15(4):151.
[15]薛燕.孟鲁司特联合沙美特罗替卡松对哮喘患儿外周血白介素水平的影响[J].北方药学,2017,14(6):59.
[16]高晓平.孟鲁司特钠治疗支气管哮喘的效果及对气道上皮细胞白介素-25和α-平滑肌肌动蛋白的影响[J].临床医学研究与实践,2018,3(6):36-37.
[17]李吉梅,孙成英.多索茶碱注射液对急性支气管哮喘患者血清IL-18,IL-33及TNF-α水平的影响[J].现代生物医学进展,2017,17(21):4116-4119.
[18]卢晓君,孙雪皎.布地奈德/福莫特罗粉吸入治疗对支气管哮喘患者IL-33、IL-17水平及肺功能的影响[J].临床医学,2018,38(5):13-17.
[19]沈雪艳,陈三妹.新生期卡介苗和乙肝疫苗联合接种对哮喘小鼠IFN-γ、IL-4和IL-17A表达的影响[J].中国病理生理杂志,2018,34(3):515-520.
[20]王芳.加味射干麻黄汤治疗哮喘患儿的临床评价及对血清TGF-β1、NGF、白介素族及肺换气功能的影响[J].中药材,2017,40(8):1969-1971.