白附饮配合中药注射针剂治疗小儿类百日咳综合征疗效观察
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摘要
目的观察白附饮配合中药注射针剂治疗婴幼儿类百日咳综合征的临床疗效。方法选择2014年3月至2015年12月江西省中医院收治的类百日咳综合征痉咳期患儿60例为研究对象,随机分为观察组和对照组各30例。对照组给予环酯红霉素干混悬剂治疗,观察组给予白附饮联合喜炎平注射液和(或)喘可治注射液治疗。两组均治疗14d。观察治疗前后主症和中医证候积分及临床疗效、不良反应情况。结果两组治疗7、14d后主症及中医证候积分及总积分均显著低于治疗前,差异有统计学意义(P<0.01)。观察组治疗7、14d后主症及中医证候积分及总积分均低于对照组,差异有统计学意义(P<0.05)。观察组治疗7、14d后主症及中医证候有效率、临床总有效率均显著高于对照组,差异有统计学意义(P<0.05)。两组均未发生明显的不良反应。结论白附饮配合中药注射针剂的中医疗法治疗婴幼儿类百日咳综合征临床疗效可、安全性高、可行性好,值得在临床推广应用。
Objective To explore the clinical efficacy of Baifuyin combined with traditional Chinese medicine injection in the treatment of infants and young children with pertussis syndrome.Methods A total of 60 children with whooping cough syndrome were selected from March 2014 to December 2015.By random number table they were divided into observation group(30 cases)and control group(30 cases).The control group was treated with cyclamycin erythromycin dry suspension.The observation group was treated with Baifuyin combined with Xiyanping and/or Chuankezhi injection.Both groups were treated for 14 days.Observe the main symptoms and traditional Chinese medicine syndrome score before and after treatment as well as the clinical efficacy and adverse reactions.Results After treatment,the total scores,the scores of primary and TCM syndromes in the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).After 7 dand 14 dof treatment,the above-mentioned scores were lower in observation group than in control group;the effective rate and total effective rate of TCM syndrome were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).There was no obvious adverse reaction in the two groups.Conclusion The clinical curative effect of Baifuyin combined with traditional Chinese medicine injection is feasible and safe in the treatment of infants with whooping cough syndrome,which is worthy of clinical application.
Objective To explore the clinical efficacy of Baifuyin combined with traditional Chinese medicine injection in the treatment of infants and young children with pertussis syndrome.Methods A total of 60 children with whooping cough syndrome were selected from March 2014 to December 2015.By random number table they were divided into observation group(30 cases)and control group(30 cases).The control group was treated with cyclamycin erythromycin dry suspension.The observation group was treated with Baifuyin combined with Xiyanping and/or Chuankezhi injection.Both groups were treated for 14 days.Observe the main symptoms and traditional Chinese medicine syndrome score before and after treatment as well as the clinical efficacy and adverse reactions.Results After treatment,the total scores,the scores of primary and TCM syndromes in the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).After 7 dand 14 dof treatment,the above-mentioned scores were lower in observation group than in control group;the effective rate and total effective rate of TCM syndrome were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).There was no obvious adverse reaction in the two groups.Conclusion The clinical curative effect of Baifuyin combined with traditional Chinese medicine injection is feasible and safe in the treatment of infants with whooping cough syndrome,which is worthy of clinical application.
引文
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[2]郝磊,吴秋珍.毛细支气管炎引致百日咳综合征9例分析[J].中国中西医结合儿科学,2012,4(6):523-525.
[3]诸福棠,吴瑞萍,胡亚美.实用儿科学[M].4版.北京:人民卫生出版社,1991:883-884.
[4]江载芳,申昆玲,沈颖.诸福棠实用儿科学[M].8版.北京:人民卫生出版社,2015:1015-1018.
[5]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1995.
[6]陆权.儿童社区获得性肺炎管理指南(试行)(上)[J].中华儿科杂志,2007,45(2):83-90.
[7]郑筱萸.中医新药临床研究指导原则[M].北京:中国医药科技出版社,2002.
[8]曾世荣.活幼心书[M].天津:天津科学技术出版社,2000.
[9]陈其华.虫类药在小儿哮喘病中的运用[J].湖北中医杂志,2009,31(7):47-48.
[10]唐军.喜炎平注射液在儿科的应用进展[J].临床合理用药杂志,2012,5(21):162-163.
[11]万欢英,周敏,余莉,等.喘可治注射液治疗哮喘的疗效及其作用机制研究[J].中国新药与临床杂志,2005,24(3):210-212.
[12]陈弘群,余荣环,黄运平.喘可治注射液改善COPD患者免疫功能的观察[J].临床肺科杂志,2007,12(11):1162-1163.
[13]李洪皎,仝小林.基于四气五味药性理论的糖尿病治法新探[J].四川中医,2007,25(7):21-22.