100例青海地区慢性心力衰竭患者的中医辨证分型与BNP水平相关性的临床观察
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摘要
目的观察青海地区慢性心力衰竭患者的中医证型与BNP水平的相关性。方法对100例长期居住于青海地区的慢性心力衰竭住院患者进行中医四诊辨证分型,同时测定BNP水平,运用统计学方法分析心衰患者的中医证型与BNP的相关性。结果 100例心衰患者中气阴两虚证有29例,气虚血瘀证32例,阳虚水泛证22例,痰饮阻肺证17例;随着BNP水平的升高,各证型的顺序依次为气虚血瘀证、气阴两虚证、阳虚水泛证、痰饮阻肺证;四种证型BNP水平两两相比差别均具有统计学意义(P<0.001),100例心衰患者各中医证型间BNP水平具有显著性差异。结论 100例青海地区慢性心衰患者的中医证型与BNP水平具有相关性,BNP水平在一定程度上可以作为心衰患者中医分型的客观参考指标。
Objective To observe the correlation between TCM syndromes and BNP levels in patients with chronic heart failure in Qinghai. Methods 100 inpatients with chronic heart failure who lived in Qinghai area for a long time were classified according to the syndrome differentiation of four diagnostic methods of traditional Chinese medicine, meanwhile the level of BNP was measured, the correlation between TCM syndromes and BNP was analyzed by statistical method. Results Among the 100 patients with heart failure, 29 were Qi-Yin deficiency, 32 were Qi deficiency and blood stasis, 22 were Yang deficiency and water flooding, and 17 were phlegm-yin obstruction; With the increase of BNP level, the order of each syndrome type was Qi deficiency and blood stasis, Qi-Yin deficiency,Yang deficiency and water flooding, phlegm-yin obstruction, the difference of BNP level between the four syndrome types was statistically significant(P<0.001),there were significant differences in BNP levels among TCM syndromes.Conclusion The TCM syndromes of 100 patients with chronic heart failure in Qinghai area are correlated with the level of BNP, to some extent, the level of BNP can be used as an objective reference index for TCM classification of patients with chronic heart failure.
Objective To observe the correlation between TCM syndromes and BNP levels in patients with chronic heart failure in Qinghai. Methods 100 inpatients with chronic heart failure who lived in Qinghai area for a long time were classified according to the syndrome differentiation of four diagnostic methods of traditional Chinese medicine, meanwhile the level of BNP was measured, the correlation between TCM syndromes and BNP was analyzed by statistical method. Results Among the 100 patients with heart failure, 29 were Qi-Yin deficiency, 32 were Qi deficiency and blood stasis, 22 were Yang deficiency and water flooding, and 17 were phlegm-yin obstruction; With the increase of BNP level, the order of each syndrome type was Qi deficiency and blood stasis, Qi-Yin deficiency,Yang deficiency and water flooding, phlegm-yin obstruction, the difference of BNP level between the four syndrome types was statistically significant(P<0.001),there were significant differences in BNP levels among TCM syndromes.Conclusion The TCM syndromes of 100 patients with chronic heart failure in Qinghai area are correlated with the level of BNP, to some extent, the level of BNP can be used as an objective reference index for TCM classification of patients with chronic heart failure.
引文
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[2]黄峻.心力衰竭现代教程[M].北京:科学出版社,2016:1-14.
[3]倪伟.内科学[M].北京:中国中医药出版社,2012:78-89.
[4]Kenneth Dickstein,Alain Cohen-Solal,Gerasimos Filippatos,et al,ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008[J].European Heart Journal,2008(29):2388-2442.
[5]张伯礼,薛博瑜.中医内科学[M].北京:人民出版社,2002:73-94.
[6]杨欣,任斌辉,许林.脑利钠肽BNP的临床研究进展[J].现代生物医学进展,2013(4):775-777.
[7]尹学凤,袁春霞,许林.慢性心力衰竭中医证型与BNP、NYHA心功能分级的相关性研究[J].光明中医,2012(2):255-256..
[8]王立超,马晓佳,李聪,等.慢性心力衰竭患者GDF-15、BNP水平的变化及其与心脏功能的相关性[J].养生保健指南,2016(18):186-186.
[9]陈一蕊.慢性心力衰竭患者血浆脑钠肽水平与心功能相关性临床研究[J].中西医结合心血管病杂志(电子版),2016(16):138-139.
[10]马育鹏,王国泰,曹宝国.慢性心力衰竭患者脑钠肽水平与中医证候学关系研究[J].辽宁中医杂志,2016(3):539-540.