2008—2017年陕西省宝鸡市克山病病情监测结果分析
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摘要
目的为进一步了解宝鸡市克山病病情和相关危险因素状况,为克山病重点防控提供依据。方法 2008—2017年按照《陕西省克山病监测技术方案》要求,先后在宝鸡市6个县选择历史病情较重的克山病病区村作为克山病监测点,对监测点常驻人口进行临床查体、心电图描记、X线胸部摄片、超声等检查,并依据《克山病诊断标准》筛查克山病。2016年抽取3个县共6个克山病病区村作为克山病病区人群硒营养水平调查点,在调查点采集儿童和成人发样进行硒含量检测。结果 2008—2017年共对宝鸡市44个克山病病区村进行了克山病监测,检出克山病141例,总检出率0.78%,以潜在型克山病为主,未发现急型、亚急型克山病病例,学龄儿童及以下年龄段、育龄妇女中未检出克山病。共采集发样360人份,发硒均值0.36±0.17mg/kg,为硒水平中等,且儿童发硒水平显著高于成人(t=3.17,P<0.05)。结论宝鸡市低硒等健康危险因素得到弱化,有效遏制了急型、亚急型克山病的发生,克山病病情处于平稳下降趋势。
Objective To further understand the status of Keshan disease and related risk factors in Baoji City, and provide evidence for the key prevention and control of Keshan disease. Methods In 2008 to 2017, in accordance with the requirements of the "Shaanxi Keshan Disease Monitoring Technology Program", the villages in six counties of Baoji City with historically severe illnesses were selected as the monitoring sites for Keshan disease. Clinical examinations of the resident population of the monitoring sites were conducted, including electrocardiogram, chest X-ray, and ultrasound, etc. Keshan disease was screened according to the "Keshan disease diagnostic criteria". In 2016, a total of 6 villages in the Keshan disease area in 3 counties were selected as the investigation sites for selenium nutrition in the Keshan disease area, and samples were collected from children and adults for selenium content detection. Results From 2008 to 2017, a total of 141 cases of Keshan disease were detected in 44 villages in the Keshan disease area of Baoji City. The total detection rate was 0.78%. The majority of the cases were the potential type of Keshan disease, and no cases of acute or sub-acute Keshan disease were found. Keshan disease was not detected among school-age and preschool children and women of childbearing age. A total of 360 samples were collected, and the average selenium value was 0.36±0.17 mg/kg, which was a moderate level of selenium. The level of selenium in children was significantly higher than that in adults(t=3.17, P<0.05). Conclusion The health risk factors such as low selenium in Baoji City have been ameliorated, which has effectively helped to contain the occurrence of acute and sub-acute Keshan disease. Keshan disease is in a steady downward trend.
Objective To further understand the status of Keshan disease and related risk factors in Baoji City, and provide evidence for the key prevention and control of Keshan disease. Methods In 2008 to 2017, in accordance with the requirements of the "Shaanxi Keshan Disease Monitoring Technology Program", the villages in six counties of Baoji City with historically severe illnesses were selected as the monitoring sites for Keshan disease. Clinical examinations of the resident population of the monitoring sites were conducted, including electrocardiogram, chest X-ray, and ultrasound, etc. Keshan disease was screened according to the "Keshan disease diagnostic criteria". In 2016, a total of 6 villages in the Keshan disease area in 3 counties were selected as the investigation sites for selenium nutrition in the Keshan disease area, and samples were collected from children and adults for selenium content detection. Results From 2008 to 2017, a total of 141 cases of Keshan disease were detected in 44 villages in the Keshan disease area of Baoji City. The total detection rate was 0.78%. The majority of the cases were the potential type of Keshan disease, and no cases of acute or sub-acute Keshan disease were found. Keshan disease was not detected among school-age and preschool children and women of childbearing age. A total of 360 samples were collected, and the average selenium value was 0.36±0.17 mg/kg, which was a moderate level of selenium. The level of selenium in children was significantly higher than that in adults(t=3.17, P<0.05). Conclusion The health risk factors such as low selenium in Baoji City have been ameliorated, which has effectively helped to contain the occurrence of acute and sub-acute Keshan disease. Keshan disease is in a steady downward trend.
引文
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[4] 相有章,何淑兰,王秀红,等.克山病患者差异基因表达及细胞凋亡通路研究[J].中华地方病学杂志,2017,36(12):859-865.
[5] 王铜.克山病消除的评估挑战与机遇[J] 中华地方病学杂志,2015,34(6):391-392.
[6] 黄广勇,相有章.克山病与扩张型心肌病基因表达与非编码RNA调控对比研究进展[J]. 中华地方病学杂志,2018,37(7):595-598.
[7] 朱宏伟,高艳琴,刘梅. 2012—2017年陕西省宝鸡市大骨节病病情监测评价[J].公共卫生与预防医学,2018,29(2):61-64.
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[9] 王哲,侯杰,王铜,等.2014年全国克山病病区居民异常心电图指数分析[J]. 中华地方病学杂志,2016,35(8):572-576.
[10] 孙树秋.克山病病因研究:从假说争论到线索追查之转变[J]. 中国地方病学杂志,2012,31(3):241-244.
[11] 高艳芹,朱宏伟,邓峰,等.2007—2011年陕西省宝鸡市克山病监测结果分析[J].中国地方病学杂志,2013,32(4):427-430.
[12] 冶超,王铜,李世娥,等.黑龙江省尚志市元宝镇克山病病情及防控评估[J]. 中华地方病学杂志,2015,34(6):433-436.
[13] 陈思强,彭再生,何晓宏,等. 恩施州不同环境硒水平和人体硒营养状态[J]. 公共卫生与预防医学,2018,29(1):112-115.
[14] 李昂,孙理,曹景,等.于维汉—克山病防治与研究的领军人[J].中华地方病学杂志,2017,36(1):1-3.
[15] 王铜.将论文写入克山病防治的中国梦[J].中华地方病学杂志,2016,35(8):620-622.
[16] Nishi N,Horikawa C,Murayama N.Characteristics of food group intake by household income in the National Health and Nutrition Survey,Japan[J].Asia Pacific Journal of Clinical Nutrition,2017,26(1):156.
[17] Chatterjee N,Rana S,Espinosa-Diez C,et al.MicroRNAs in Cancer:challenges and opportunities in early detection,disease monitoring,and therapeutic agents[J].Curr Pathobiol Rep,2017,5(1):35-42.
[18] Staniute M,Vaskelyte J,Rumbinaite E,et al.Impact of left ventricular function on health-related quality of life in coronary artery disease patients[J].Medicina(Kaunas),2015,51(4):233-239.
[2] Busch A,Eken SM,Maegdefessel L.Prospective and therapeutic screening value of non-coding RNA as biomarkers in cardiovascular disease[J].Annals of translational medicine,2016,4(12):236.
[3] Beukhof CM, Medici M, Van den Beld AW, et al.Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men[J].Plo S One, 2016,11(4):152748.
[4] 相有章,何淑兰,王秀红,等.克山病患者差异基因表达及细胞凋亡通路研究[J].中华地方病学杂志,2017,36(12):859-865.
[5] 王铜.克山病消除的评估挑战与机遇[J] 中华地方病学杂志,2015,34(6):391-392.
[6] 黄广勇,相有章.克山病与扩张型心肌病基因表达与非编码RNA调控对比研究进展[J]. 中华地方病学杂志,2018,37(7):595-598.
[7] 朱宏伟,高艳琴,刘梅. 2012—2017年陕西省宝鸡市大骨节病病情监测评价[J].公共卫生与预防医学,2018,29(2):61-64.
[8] 陕西地方病防治60年编委会.陕西地方病防治60年[M].陕西:陕西科学技术出版社,2011:73-107.
[9] 王哲,侯杰,王铜,等.2014年全国克山病病区居民异常心电图指数分析[J]. 中华地方病学杂志,2016,35(8):572-576.
[10] 孙树秋.克山病病因研究:从假说争论到线索追查之转变[J]. 中国地方病学杂志,2012,31(3):241-244.
[11] 高艳芹,朱宏伟,邓峰,等.2007—2011年陕西省宝鸡市克山病监测结果分析[J].中国地方病学杂志,2013,32(4):427-430.
[12] 冶超,王铜,李世娥,等.黑龙江省尚志市元宝镇克山病病情及防控评估[J]. 中华地方病学杂志,2015,34(6):433-436.
[13] 陈思强,彭再生,何晓宏,等. 恩施州不同环境硒水平和人体硒营养状态[J]. 公共卫生与预防医学,2018,29(1):112-115.
[14] 李昂,孙理,曹景,等.于维汉—克山病防治与研究的领军人[J].中华地方病学杂志,2017,36(1):1-3.
[15] 王铜.将论文写入克山病防治的中国梦[J].中华地方病学杂志,2016,35(8):620-622.
[16] Nishi N,Horikawa C,Murayama N.Characteristics of food group intake by household income in the National Health and Nutrition Survey,Japan[J].Asia Pacific Journal of Clinical Nutrition,2017,26(1):156.
[17] Chatterjee N,Rana S,Espinosa-Diez C,et al.MicroRNAs in Cancer:challenges and opportunities in early detection,disease monitoring,and therapeutic agents[J].Curr Pathobiol Rep,2017,5(1):35-42.
[18] Staniute M,Vaskelyte J,Rumbinaite E,et al.Impact of left ventricular function on health-related quality of life in coronary artery disease patients[J].Medicina(Kaunas),2015,51(4):233-239.