Maspin在肿瘤发生发展中的作用
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摘要
Maspin基因是一种肿瘤抑制基因,编码丝氨酸蛋白酶抑制剂。研究发现Maspin可诱导凋亡、抑制肿瘤细胞的侵袭和转移、抑制新生血管的形成从而发挥肿瘤抑制作用。近年来发现Maspin还与宿主的免疫相关。文章主要对Maspin的结构分布、肿瘤抑制作用机制及免疫相关性进行综述。
Maspin gene is a tumor suppressor that encodes serine protease inhibitor. It was found that maspin could induce apoptosis,inhibit the invasion and metastasis of tumor cells,and suppress angiogenesis. In recent years,maspin has also been found to be associated with host immunity. The review is to summarize structure distribution,tumor inhibition mechanism and immunological correlation of maspin.
Maspin gene is a tumor suppressor that encodes serine protease inhibitor. It was found that maspin could induce apoptosis,inhibit the invasion and metastasis of tumor cells,and suppress angiogenesis. In recent years,maspin has also been found to be associated with host immunity. The review is to summarize structure distribution,tumor inhibition mechanism and immunological correlation of maspin.
引文
[1] Zou Z,Anisowicz A,Hendrix MJC,et al. Maspin,a Serpin with tumor-suppressing activity in human mammary epithelial cells[J].Science,1994,263:526-529.
[2] Dzinic SH,Kaplun A,Li X,et al.Identification of an intrinsic determinant critical for maspin subcellular localization and function[J].PLoS One,2013,8(11):e74502.
[3] Dzinic SH,Bernardo MM,Li X,et al.An Essential Role of in Embryogenesis and Tumor Suppression[J].Cancer Res,2017,77(4):886-896.
[4] Bernardo MM,Meng Y,Lockett J,et al.Maspin reprograms the gene expression profile of prostate carcinoma cells for differentiation[J]. Genes Cancer,2011,2(11):1009-1022.
[5] Zhang M,Hendrix MJC,Pemberton PA,et al.An Essential Role of Maspin in Embryogenesis and Tumor Suppression-Response[J]. Cancer Res,2017,77(18):5208-5210.
[6] Berardi R,Morgese F,Onofri A,et al.Role of maspin in cancer[J]. Clin Transl Med,2013,2(1):8.
[7] Bal N,Kocer NE,Ertorer ME,et al.Maspin,E-selectin,and Pselectin expressions in papillary thyroid carcinomas and their correlation with prognostic parameters[J]. Pathol Res Pract,2008,204(10):743-750.
[8] Zhu H,Mao Q,Liu W,et al.Maspin suppresses growth,proliferation and invasion in cutaneous squamous cell carcinoma cells[J]Oncol Rep,2017,37(5):2875-2882.
[9]陈静,周园,郑磊,等.慢病毒载体构建稳定的maspin表达敲减食管癌细胞株[J].医学研究生学报,2014,27(2):138-142.
[10] Goulet B,Kennette W,Ablack A,et al.Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis[J]Lab Invest,2011,91(8):1181-1187.
[11] Machowska M,Wachowicz K,Sopel M.Nuclear location of tumor suppressor protein maspin inhibits proliferation of breast cancer cells without affecting proliferation of normal epithelial cells[J].BMC Cancer,2014,14:142.
[12] Liu Z,Shi Y,Meng W,et al. Expression and localization of maspin in cervical cancer and its role in tumor progression and lymphangiogenesis[J]. Arch Gynecol Obstet,2014,289(2):373-382.
[13] Ohno T,Kubouchi Y,Wakahara M,et al.Clinical Significance of Subcellular Localization of Maspin in Patients with Pathological Stage IA Lung Adenocarcinoma[J]. Anticancer Res,2018,38(5):3001-3007.
[14] Martinoli C,Gandini S,Luise C,et al.Maspin expression and melanoma progression:a matter of sub-cellular localization[J].Mod Pathol,2014,27(3):412-419.
[15] Liu J,Yin S,Reddy N,et al.Bax mediates the apoptosis-sensitizing effect of Maspin[J]. Cancer Res,2004,64(5):1703-1711.
[16] Zhang W,Shi HY.Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins[J].BMC Cancer,2005,5:50.
[17] Ben Shachar B,Feldstein O,Hacohen D.The tumor suppressor Maspin mediates E2F1-induced sensitivity of cancer cells to chemotherapy[J]. Mol Cancer Res,2010,8(3):363-372.
[18] Gan Y,Chen Q.Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling[J]. Oncol Lett,2017,14(4):4977-4982.
[19] Jiang N,Meng Y,Zhang S,et al.Maspin sensitizes breast carcinoma cells to induced apoptosis[J].Oncogene,2002,21(26):4089-4098.
[20] Chen J,Wang L,Tang Y,et al.Maspin enhances cisplatin chemosensitivity in bladder cancer T24 and 5637 cells and correlates with prognosis of muscle-invasive bladder cancer patients receiving cisplatin based neoadjuvant chemotherapy[J]. J Exp Clin Cancer Res,2016,35:2.
[21] Sheng S,Carey J,Seftor EA,et al.Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells[J]. Proc Natl Acad Sci USA,1996,93(21):11669-11674.
[22] Ravenhill L,Wagstaff L,Edwards DR,et al.G-helix of Maspin mediates effects on cell migration and adhesion[J]. J Biol Chem,2010,285(47):36285-36292.
[23] McGowen R,Biliran H,Sager R.The surface of prostate carcinoma DU145 cells mediates the inhibition of urokinase-type plasminogen activator by Maspin[J].Cancer Res,2000,60(17):4771-4778.
[24] Abraham S,Zhang W,Greenberg N.Maspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells[J]. J Urol,2003,169(3):1157-1161.
[25] Odero-Marah VA,Khalkhali-Ellis Z,Chunthapong J,et al.Maspin regulates different signaling pathways for motility and adhesion in aggressive breast cancer cells[J]. Cancer Biol Ther,2003,2(4):398-403.
[26] Cai Z,Zhou Y,Lei T,et al.Mammary serine protease inhibitor inhibits epithelial growth factor-induced epithelial-mesenchymal transition of esophageal carcinoma cells[J].Cancer,2009,115(1):36-48.
[27] Zhang M,Volpert O,Shi YH. Maspin is an angiogenesis inhibitor[J]. Nat Med,2000,6(2):196-199.
[28] Li Z,Shi HY.Targeted expression of Maspin in tumor vasculatures induces endothelial cell apoptosis[J].Oncogene,2005,24(12):2008-2019
[29] Cho JH,Kim HS,Park CS,et al.Maspin expression in early oral tongue cancer and its relation to expression of mutant-type p53and vascular endothelial growth factor(VEGF)[J]. Oral Oncol,2007,43(3):272-277.
[30] Zou Z,Gao C,Nagaich AK,et al.p53 regulates the expression of the tumor suppressor gene maspin[J]. J Biol Chem,2000,275(9):6051-6054.
[31] Bolat F,Gumurdulu D,Erkanli S,et al.Maspin overexpression correlates with increased expression of vascular endothelial growth factors A,C,and D in human ovarian carcinoma[J].Pathol Res Pract,2008,204(6):379-387.
[32] Qin L.Maspin regulates endothelial cell adhesion and migration through an integrin signaling pathway[J]. J Biol Chem,2010,285(42):32360-32369.
[33] Dzinic SH,Chen K,Thakur A,et al. Maspin expression in prostate tumor elicits host anti-tumor immunity[J]. Oncotarget,2014,5(22):11225-11236.
[34] Wang Y,Sun L,Song Z,et al.Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling[J]. Mol Immunol,2017,82:94-103.
[35] Yang Q,Roehrl MH.Proteomic profiling of antibody-inducing immunogens in tumor tissue identifies PSMA1,LAP3,ANXA3,and maspin as colon cancer markers[J].Oncotarget,2018,9(3):3996-4019.
[2] Dzinic SH,Kaplun A,Li X,et al.Identification of an intrinsic determinant critical for maspin subcellular localization and function[J].PLoS One,2013,8(11):e74502.
[3] Dzinic SH,Bernardo MM,Li X,et al.An Essential Role of in Embryogenesis and Tumor Suppression[J].Cancer Res,2017,77(4):886-896.
[4] Bernardo MM,Meng Y,Lockett J,et al.Maspin reprograms the gene expression profile of prostate carcinoma cells for differentiation[J]. Genes Cancer,2011,2(11):1009-1022.
[5] Zhang M,Hendrix MJC,Pemberton PA,et al.An Essential Role of Maspin in Embryogenesis and Tumor Suppression-Response[J]. Cancer Res,2017,77(18):5208-5210.
[6] Berardi R,Morgese F,Onofri A,et al.Role of maspin in cancer[J]. Clin Transl Med,2013,2(1):8.
[7] Bal N,Kocer NE,Ertorer ME,et al.Maspin,E-selectin,and Pselectin expressions in papillary thyroid carcinomas and their correlation with prognostic parameters[J]. Pathol Res Pract,2008,204(10):743-750.
[8] Zhu H,Mao Q,Liu W,et al.Maspin suppresses growth,proliferation and invasion in cutaneous squamous cell carcinoma cells[J]Oncol Rep,2017,37(5):2875-2882.
[9]陈静,周园,郑磊,等.慢病毒载体构建稳定的maspin表达敲减食管癌细胞株[J].医学研究生学报,2014,27(2):138-142.
[10] Goulet B,Kennette W,Ablack A,et al.Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis[J]Lab Invest,2011,91(8):1181-1187.
[11] Machowska M,Wachowicz K,Sopel M.Nuclear location of tumor suppressor protein maspin inhibits proliferation of breast cancer cells without affecting proliferation of normal epithelial cells[J].BMC Cancer,2014,14:142.
[12] Liu Z,Shi Y,Meng W,et al. Expression and localization of maspin in cervical cancer and its role in tumor progression and lymphangiogenesis[J]. Arch Gynecol Obstet,2014,289(2):373-382.
[13] Ohno T,Kubouchi Y,Wakahara M,et al.Clinical Significance of Subcellular Localization of Maspin in Patients with Pathological Stage IA Lung Adenocarcinoma[J]. Anticancer Res,2018,38(5):3001-3007.
[14] Martinoli C,Gandini S,Luise C,et al.Maspin expression and melanoma progression:a matter of sub-cellular localization[J].Mod Pathol,2014,27(3):412-419.
[15] Liu J,Yin S,Reddy N,et al.Bax mediates the apoptosis-sensitizing effect of Maspin[J]. Cancer Res,2004,64(5):1703-1711.
[16] Zhang W,Shi HY.Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins[J].BMC Cancer,2005,5:50.
[17] Ben Shachar B,Feldstein O,Hacohen D.The tumor suppressor Maspin mediates E2F1-induced sensitivity of cancer cells to chemotherapy[J]. Mol Cancer Res,2010,8(3):363-372.
[18] Gan Y,Chen Q.Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling[J]. Oncol Lett,2017,14(4):4977-4982.
[19] Jiang N,Meng Y,Zhang S,et al.Maspin sensitizes breast carcinoma cells to induced apoptosis[J].Oncogene,2002,21(26):4089-4098.
[20] Chen J,Wang L,Tang Y,et al.Maspin enhances cisplatin chemosensitivity in bladder cancer T24 and 5637 cells and correlates with prognosis of muscle-invasive bladder cancer patients receiving cisplatin based neoadjuvant chemotherapy[J]. J Exp Clin Cancer Res,2016,35:2.
[21] Sheng S,Carey J,Seftor EA,et al.Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells[J]. Proc Natl Acad Sci USA,1996,93(21):11669-11674.
[22] Ravenhill L,Wagstaff L,Edwards DR,et al.G-helix of Maspin mediates effects on cell migration and adhesion[J]. J Biol Chem,2010,285(47):36285-36292.
[23] McGowen R,Biliran H,Sager R.The surface of prostate carcinoma DU145 cells mediates the inhibition of urokinase-type plasminogen activator by Maspin[J].Cancer Res,2000,60(17):4771-4778.
[24] Abraham S,Zhang W,Greenberg N.Maspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells[J]. J Urol,2003,169(3):1157-1161.
[25] Odero-Marah VA,Khalkhali-Ellis Z,Chunthapong J,et al.Maspin regulates different signaling pathways for motility and adhesion in aggressive breast cancer cells[J]. Cancer Biol Ther,2003,2(4):398-403.
[26] Cai Z,Zhou Y,Lei T,et al.Mammary serine protease inhibitor inhibits epithelial growth factor-induced epithelial-mesenchymal transition of esophageal carcinoma cells[J].Cancer,2009,115(1):36-48.
[27] Zhang M,Volpert O,Shi YH. Maspin is an angiogenesis inhibitor[J]. Nat Med,2000,6(2):196-199.
[28] Li Z,Shi HY.Targeted expression of Maspin in tumor vasculatures induces endothelial cell apoptosis[J].Oncogene,2005,24(12):2008-2019
[29] Cho JH,Kim HS,Park CS,et al.Maspin expression in early oral tongue cancer and its relation to expression of mutant-type p53and vascular endothelial growth factor(VEGF)[J]. Oral Oncol,2007,43(3):272-277.
[30] Zou Z,Gao C,Nagaich AK,et al.p53 regulates the expression of the tumor suppressor gene maspin[J]. J Biol Chem,2000,275(9):6051-6054.
[31] Bolat F,Gumurdulu D,Erkanli S,et al.Maspin overexpression correlates with increased expression of vascular endothelial growth factors A,C,and D in human ovarian carcinoma[J].Pathol Res Pract,2008,204(6):379-387.
[32] Qin L.Maspin regulates endothelial cell adhesion and migration through an integrin signaling pathway[J]. J Biol Chem,2010,285(42):32360-32369.
[33] Dzinic SH,Chen K,Thakur A,et al. Maspin expression in prostate tumor elicits host anti-tumor immunity[J]. Oncotarget,2014,5(22):11225-11236.
[34] Wang Y,Sun L,Song Z,et al.Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling[J]. Mol Immunol,2017,82:94-103.
[35] Yang Q,Roehrl MH.Proteomic profiling of antibody-inducing immunogens in tumor tissue identifies PSMA1,LAP3,ANXA3,and maspin as colon cancer markers[J].Oncotarget,2018,9(3):3996-4019.