2005-2017年浙江省百日咳流行病学分析
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摘要
目的了解2005-2017年浙江省百日咳流行病学特征。方法通过中国传染病信息管理系统收集2005-2017年浙江省百日咳报告病例,进行描述性流行病学分析。结果 2005-2017年浙江省共报告百日咳1 475例,年均发病率为0.21/10万。3-8月份发病占73.15%。散居儿童病例占93.90%。外来就诊病例占23.01%。0岁、1-4岁、5-9岁、≥10岁组发病率(/10万)分别为16.53、0.82、0.14、0.03;其中2005-2009年分别为10.38、0.58、0.16、0.002,2010-2014年分别为14.81、0.30、0.04、0.00,2015-2017年分别为30.83、2.22、0.29、0.01。结论浙江省百日咳发病率呈上升趋势,发病水平可能被低估。需完善百日咳尤其是散居和流动儿童监测工作,提高实验室诊断能力。
Objective To determine epidemiological characteristics of pertussis in Zhejiang province during 2005-2017.Methods We used the Chinese Infectious Disease Information System to collect pertussis reports during 2005-2017 in Zhejiang for a descriptive epidemiological analysis. Results A total of 1 475 pertussis cases were reported during2005-2017, yielding an annual average incidence of 0.21 per 100 000 population; 73.15% of cases occurred from March to August, and 93.90% of cases were scattered-living children; 23.01% of cases were non-local. Incidences for 0, 1-4,5-9, and ≥10 year olds were 16.53, 0.82, 0.14, and 0.03 per 100 000, respectively, with 10.38, 0.58, 0.16, and 0.002 per100 000 in 2005-2009, 14.81, 0.30, 0.04, and 0.00 per 100 000 in 2010-2014, and 30.83, 2.22, 0.29, and 0.01 per 100 000 in 2015-2017. Conclusions The incidence of pertussis appeared to increase in Zhejiang, although incidences may be underestimates. We should improve pertussis surveillance, especially for scattered-living and migrant children, and strengthen laboratory diagnosis.
Objective To determine epidemiological characteristics of pertussis in Zhejiang province during 2005-2017.Methods We used the Chinese Infectious Disease Information System to collect pertussis reports during 2005-2017 in Zhejiang for a descriptive epidemiological analysis. Results A total of 1 475 pertussis cases were reported during2005-2017, yielding an annual average incidence of 0.21 per 100 000 population; 73.15% of cases occurred from March to August, and 93.90% of cases were scattered-living children; 23.01% of cases were non-local. Incidences for 0, 1-4,5-9, and ≥10 year olds were 16.53, 0.82, 0.14, and 0.03 per 100 000, respectively, with 10.38, 0.58, 0.16, and 0.002 per100 000 in 2005-2009, 14.81, 0.30, 0.04, and 0.00 per 100 000 in 2010-2014, and 30.83, 2.22, 0.29, and 0.01 per 100 000 in 2015-2017. Conclusions The incidence of pertussis appeared to increase in Zhejiang, although incidences may be underestimates. We should improve pertussis surveillance, especially for scattered-living and migrant children, and strengthen laboratory diagnosis.
引文
[1]DE MELKER HE,SCHELLEKENS JF,NEPPELENBROEKSE,et a l.Reeme rgence ofpe r tussis in the h ighly vaccinated population ofthe Netherlands:observations on surveillance data[J].Emerging Infectious Diseases(print),2000,6(4):348-357.
[2]MORAGA-LLOP FA,CAMPINS-MARTI M.Per tussis vaccine,reemergence ofthe disease and new vaccination strategies[J].Enfermedades Infecciosas Y Microbiologia Clinica,2015,33(3):190-196.
[3]符剑,王跃芳,徐宝祥,等.浙江省1954~2004年百日咳流行病学分析[J].中国计划免疫,2005,11(4):279-281.FU Jian,WANG Yuefang,XU Baoxiang,et al.Analysis on pertussis epidemiology in Zhejiang province in 1954-2004[J].Chinese Journal ofVaccines and Immunization,2005,11(4):279-281.
[4]中华人民共和国卫生部.WS274-2007百日咳诊断标准[S].2007.Ministry ofHealth,PRC.WS274-2007 Diagnostic criteria for pertussis[S].2007.
[5]朱岁松.圆形分布角均数可信区间的计算[J].数理医药学杂志,2008,21(4):398-399.ZHU Suisong.Calculat ion ofconfidence interval ofangula r mean in ci rcula r dist r ibut ion[J].Journal ofMathematical Medicine,2008,21(4):398-399.
[6]朱岁松.圆形分布角均数的显著性检验[J].数理医药学杂志,2009,22(1):53-55.ZHU Suisong.Significance test ofangular mean in circular distribution[J].Journal ofMathematical Medicine,2009,22(1):53-55.
[7]朱岁松.圆形分布时间与日期资料的角度转换[J].数理医药学杂志,2009,22(2):193-194.ZHU Suisong.Angular conversion between time in circular distribution and date data[J].Journal ofMathematical Medicine,2009,22(2):193-194.
[8]汪海波,罗会明,温宁,等.我国2006~2010年百日咳流行病学分析[J].中国疫苗和免疫,2012,18(3):207-210.WANG Ha i bo,LUO H u imi n g,WEN Ning,et al. during 2006-2010[J].Chinese Journal ofVaccines and Immunization,2012,18(3):207-210.
[9]邓青,张迟,王晓南,等.2005-2015年湖北省百日咳流行病学特征分析[J].中国儿童保健杂志,2016,24(12):1315-1318.DENG Qing,ZHANG Chi,WANG Xiaonan,et al.Analysis ofthe epidemiological characteristics ofpertussis in Hubei province in 2005-2015[J].Chinses Journal ofChild Health Care,2016,24(12):1315-1318.
[10]蒋凤,穆秋玥,张大勇,等.2004-2013年贵州省百日咳报告病例的流行病学特征分析[J].现代预防医学,2015,42(11):1927-1930.J IANG Feng,MU Qiu yue,ZHANG Dayong,et a l.Epidemiological character ist ic ofper tussis repor ted cases from 2004 to 2013,Guizhou province[J].Modern Preventive Medicine,2015,42(11):1927-1930.
[11]刘家洁,李银乔,方刚,等.2005-2014年四川省百日咳流行病学特征分析[J].预防医学情报杂志,2016,32(7):738-741.LIU Jiajie,LI Yinqiao,FANG Gang,et al.Epidemiological analysis ofpertussis in Sichuan,2005 to 2014[J].Journal ofPreventive Medicine Information,2016,32(7):738-741.
[12]于燕.2000~2004年河南省百日咳流行病学特征分析[J].疾病监测,2006,21(6):307-308.YU Yan.Analysis on the epidemiological characteristics ofpertussis in He'nan province from 2000 to 2004[J].Disease Surveillance,2006,21(6):307-308.
[13]CHERRY JD.The epidemiology ofpertussis and pertussis immunization in the United Kingdom and the United States:a comparat ive study[J].Cur rent Problems in Pediatrics,1984,14(2):1-78.
[14]GURIS D,STREBEL PM,BARDENHEIER B,et al.Changing epidemiology ofpertussis in the United States:increasing repor ted incidence among adolescents and adults,1990-1996[J].Clinical Infectious Diseases:an official publication ofthe Infectious Diseases Society ofAmerica,1999,28(6):1230-1237.
[15]STREBEL P,NORDIN J,EDWARDS K,et al.Populationbased incidence ofper tussis among adolescents and adults,Minnesota,1995-1996[J].The Journal ofInfectious Diseases,2001,183(9):1353-1359.
[16]张颖,黄海涛,刘勇,等.天津市社区人群百日咳发病监测及传播特征研究[J].中国疫苗和免疫,2011,17(3):209-211+257.ZHANG Ying,HUANG Haitao,LIU Yong,et al.Incidence surveillance ofpertussis based on community and analysis ofits transmitted features in Tianjin[J].Chinese Journal ofVaccines and Immunization,2011,17(3):209-211+257.
[17]宋凯军,刘铁诚,张先慧,等.山东省济南市医疗机构百日咳诊断能力调查[J].中国疫苗和免疫,2016,22(5):533-536+510.SONG Kai jun,LIU Tiecheng,ZHANG Xianhui,et al.Investigation ofthe ability to diagnose pertussis in Jinan city hospitals,Shandong province[J].Chinese Journal ofVaccines and Immunization,2016,22(5):533-536+510.
[18]黄海涛,李永成,高志刚,等.天津市2010-2015年百日咳病例临床症状与误诊的特征分析[J].疾病监测,2016,31(9):791-795.HUANG Haitao,LI Yongcheng,GAO Zhigang,et al.Characteristics ofclinical symptoms and misdiagnosis pertussis between 2010 and 2015 in Tianjin[J].Disease Surveillance,2016,31(9):791-795.
[19]ANTAI D.Migration and child immunization in Nigeria:individual-and community-level contexts[J].BMC Public Health,2010,10(1):1-12.
[20]SUN M,MA R,ZENG Y,et al.Immunization status and risk factors ofmigrant children in densely populated areas ofBeijing,China[J].Vaccine,2010,28(5):1264-1274.
[21]高志刚,黄海涛,刘勇,等.天津市百日咳发病反弹及流行病学特征改变的影响因素分析[J].中国疫苗和免疫,2011,17(3):212-215.GAO Zhiga ng,HUANG Ha i t ao,LIU Yong,e t a l.Analysis on influence factors about resurgence and changing epidemiological characteristic ofpertussis in Tianjin municipal[J].Chinese Journal ofVaccines and Immunization,2011,17(3):212-215.
[22]WOOD N,MCINTYRE P.Pertussis:review o fepidemiology,diagnosis,management and prevention[J].Paediatric Respiratory Reviews,2008,9(3):201-211.
[23]BOLOTIN S,HARVILL ET,CROWCROFT NS.What to do about pertussis vaccines?Linking what we know about pertussis vaccine effectiveness,immunology and disease transmission to create a better vaccine[J].Pathogens and Disease,2015,73(8):ftv057.
[24]SMITS K,POTTIER G,SMET J,et al.Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination[J].Vaccine,2013,32(1):111-118.
[25]MCGIRR A,FISMAN DN.Duration ofpertussis immunity after DTaP immunization:a meta-analysis[J].Pediatrics,2015,135(2):331-343.
[2]MORAGA-LLOP FA,CAMPINS-MARTI M.Per tussis vaccine,reemergence ofthe disease and new vaccination strategies[J].Enfermedades Infecciosas Y Microbiologia Clinica,2015,33(3):190-196.
[3]符剑,王跃芳,徐宝祥,等.浙江省1954~2004年百日咳流行病学分析[J].中国计划免疫,2005,11(4):279-281.FU Jian,WANG Yuefang,XU Baoxiang,et al.Analysis on pertussis epidemiology in Zhejiang province in 1954-2004[J].Chinese Journal ofVaccines and Immunization,2005,11(4):279-281.
[4]中华人民共和国卫生部.WS274-2007百日咳诊断标准[S].2007.Ministry ofHealth,PRC.WS274-2007 Diagnostic criteria for pertussis[S].2007.
[5]朱岁松.圆形分布角均数可信区间的计算[J].数理医药学杂志,2008,21(4):398-399.ZHU Suisong.Calculat ion ofconfidence interval ofangula r mean in ci rcula r dist r ibut ion[J].Journal ofMathematical Medicine,2008,21(4):398-399.
[6]朱岁松.圆形分布角均数的显著性检验[J].数理医药学杂志,2009,22(1):53-55.ZHU Suisong.Significance test ofangular mean in circular distribution[J].Journal ofMathematical Medicine,2009,22(1):53-55.
[7]朱岁松.圆形分布时间与日期资料的角度转换[J].数理医药学杂志,2009,22(2):193-194.ZHU Suisong.Angular conversion between time in circular distribution and date data[J].Journal ofMathematical Medicine,2009,22(2):193-194.
[8]汪海波,罗会明,温宁,等.我国2006~2010年百日咳流行病学分析[J].中国疫苗和免疫,2012,18(3):207-210.WANG Ha i bo,LUO H u imi n g,WEN Ning,et al. during 2006-2010[J].Chinese Journal ofVaccines and Immunization,2012,18(3):207-210.
[9]邓青,张迟,王晓南,等.2005-2015年湖北省百日咳流行病学特征分析[J].中国儿童保健杂志,2016,24(12):1315-1318.DENG Qing,ZHANG Chi,WANG Xiaonan,et al.Analysis ofthe epidemiological characteristics ofpertussis in Hubei province in 2005-2015[J].Chinses Journal ofChild Health Care,2016,24(12):1315-1318.
[10]蒋凤,穆秋玥,张大勇,等.2004-2013年贵州省百日咳报告病例的流行病学特征分析[J].现代预防医学,2015,42(11):1927-1930.J IANG Feng,MU Qiu yue,ZHANG Dayong,et a l.Epidemiological character ist ic ofper tussis repor ted cases from 2004 to 2013,Guizhou province[J].Modern Preventive Medicine,2015,42(11):1927-1930.
[11]刘家洁,李银乔,方刚,等.2005-2014年四川省百日咳流行病学特征分析[J].预防医学情报杂志,2016,32(7):738-741.LIU Jiajie,LI Yinqiao,FANG Gang,et al.Epidemiological analysis ofpertussis in Sichuan,2005 to 2014[J].Journal ofPreventive Medicine Information,2016,32(7):738-741.
[12]于燕.2000~2004年河南省百日咳流行病学特征分析[J].疾病监测,2006,21(6):307-308.YU Yan.Analysis on the epidemiological characteristics ofpertussis in He'nan province from 2000 to 2004[J].Disease Surveillance,2006,21(6):307-308.
[13]CHERRY JD.The epidemiology ofpertussis and pertussis immunization in the United Kingdom and the United States:a comparat ive study[J].Cur rent Problems in Pediatrics,1984,14(2):1-78.
[14]GURIS D,STREBEL PM,BARDENHEIER B,et al.Changing epidemiology ofpertussis in the United States:increasing repor ted incidence among adolescents and adults,1990-1996[J].Clinical Infectious Diseases:an official publication ofthe Infectious Diseases Society ofAmerica,1999,28(6):1230-1237.
[15]STREBEL P,NORDIN J,EDWARDS K,et al.Populationbased incidence ofper tussis among adolescents and adults,Minnesota,1995-1996[J].The Journal ofInfectious Diseases,2001,183(9):1353-1359.
[16]张颖,黄海涛,刘勇,等.天津市社区人群百日咳发病监测及传播特征研究[J].中国疫苗和免疫,2011,17(3):209-211+257.ZHANG Ying,HUANG Haitao,LIU Yong,et al.Incidence surveillance ofpertussis based on community and analysis ofits transmitted features in Tianjin[J].Chinese Journal ofVaccines and Immunization,2011,17(3):209-211+257.
[17]宋凯军,刘铁诚,张先慧,等.山东省济南市医疗机构百日咳诊断能力调查[J].中国疫苗和免疫,2016,22(5):533-536+510.SONG Kai jun,LIU Tiecheng,ZHANG Xianhui,et al.Investigation ofthe ability to diagnose pertussis in Jinan city hospitals,Shandong province[J].Chinese Journal ofVaccines and Immunization,2016,22(5):533-536+510.
[18]黄海涛,李永成,高志刚,等.天津市2010-2015年百日咳病例临床症状与误诊的特征分析[J].疾病监测,2016,31(9):791-795.HUANG Haitao,LI Yongcheng,GAO Zhigang,et al.Characteristics ofclinical symptoms and misdiagnosis pertussis between 2010 and 2015 in Tianjin[J].Disease Surveillance,2016,31(9):791-795.
[19]ANTAI D.Migration and child immunization in Nigeria:individual-and community-level contexts[J].BMC Public Health,2010,10(1):1-12.
[20]SUN M,MA R,ZENG Y,et al.Immunization status and risk factors ofmigrant children in densely populated areas ofBeijing,China[J].Vaccine,2010,28(5):1264-1274.
[21]高志刚,黄海涛,刘勇,等.天津市百日咳发病反弹及流行病学特征改变的影响因素分析[J].中国疫苗和免疫,2011,17(3):212-215.GAO Zhiga ng,HUANG Ha i t ao,LIU Yong,e t a l.Analysis on influence factors about resurgence and changing epidemiological characteristic ofpertussis in Tianjin municipal[J].Chinese Journal ofVaccines and Immunization,2011,17(3):212-215.
[22]WOOD N,MCINTYRE P.Pertussis:review o fepidemiology,diagnosis,management and prevention[J].Paediatric Respiratory Reviews,2008,9(3):201-211.
[23]BOLOTIN S,HARVILL ET,CROWCROFT NS.What to do about pertussis vaccines?Linking what we know about pertussis vaccine effectiveness,immunology and disease transmission to create a better vaccine[J].Pathogens and Disease,2015,73(8):ftv057.
[24]SMITS K,POTTIER G,SMET J,et al.Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination[J].Vaccine,2013,32(1):111-118.
[25]MCGIRR A,FISMAN DN.Duration ofpertussis immunity after DTaP immunization:a meta-analysis[J].Pediatrics,2015,135(2):331-343.