百乐眠胶囊联合艾司西酞普兰片治疗失眠伴抑郁焦虑的临床效果
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摘要
目的探讨百乐眠胶囊联合艾司西酞普兰片治疗失眠伴抑郁焦虑的临床效果。方法选取2016年2月～2018年4月河北大学附属医院收治的失眠伴抑郁焦虑患者143例。根据随机数字表法分为对照组(n=71)和研究组(n=72),对照组给予艾司西酞普兰片治疗,研究组则在对照组基础上联合百乐眠胶囊治疗。比较两组患者治疗2个月后临床效果,比较两组患者治疗前、治疗2个月后汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)、血清神经肽Y(NPY)、P物质(SP),记录两组患者治疗期间不良反应发生情况。结果研究组患者治疗后总有效率显著高于对照组(P <0.05)。两组患者治疗2个月后HAMA、HAMD及PSQI均较治疗前降低,且研究组低于对照组(P <0.05)。两组患者治疗2个月后血清NPY水平较治疗前升高,且研究组高于对照组(P <0.05),SP水平较治疗前降低,且研究组低于对照组(P <0.05)。研究组治疗期间不良反应总发生率低于对照组(P <0.05)。结论百乐眠胶囊联合艾司西酞普兰片治疗失眠伴抑郁焦虑,效果确切,可有效改善患者临床症状,改善患者血清NPY、SP水平,且能有效降低不良反应发生率。
Objective To investigate the clinical effect of Bailemian Capsules combined with Escitalopram Tablets in the treatment of insomnia with depression and anxiety. Methods From February 2016 to April 2018, 143 cases of insomnia patients with depression and anxiety admitted to the Affiliated Hospital of Hebei University were selected. According to the random number table method, they were divided into the control group(n = 71) and the research group(n = 72). The control group was treated with Escitalopram Tablets, while the research group was treated with Bailemian Capsules on the basis of the control group. The clinical effects of the two groups were compared after 2 months of treatment, compared two groups of patients Hamilton anxiety scale(HAMA) and Hamilton depression scale(HAMD), Pittsburgh sleep quality index(PSQI), serum neuropeptide Y(NPY) and substance P(SP) were compared before and after 2 months treatment, adverse reactions during treatment were recorded in both groups. Results The total effective rate of the study group was significantly higher than that of the control group(P < 0.05). HAMA, HAMD and PSQI of the two groups were decreased after 2 months of treatment compared with those before treatment, and the study group was lower than the control group(P < 0.05). After 2 months of treatment, the serum NPY level in the two groups was higher than that before treatment, and the level of SP in the study group was lower than that in the control group(P < 0.05). The total incidence of adverse reactions during treatment in the study group was lower than that in the control group(P <0.05). Conclusion Bailemian Capsules combined with Escitalopram Tablets for the treatment of insomnia with depression and anxiety has an accurate effect, which can effectively improve the clinical symptoms of patients, improve the serum NPY and SP levels of patients, and effectively reduce the incidence of adverse reactions.
Objective To investigate the clinical effect of Bailemian Capsules combined with Escitalopram Tablets in the treatment of insomnia with depression and anxiety. Methods From February 2016 to April 2018, 143 cases of insomnia patients with depression and anxiety admitted to the Affiliated Hospital of Hebei University were selected. According to the random number table method, they were divided into the control group(n = 71) and the research group(n = 72). The control group was treated with Escitalopram Tablets, while the research group was treated with Bailemian Capsules on the basis of the control group. The clinical effects of the two groups were compared after 2 months of treatment, compared two groups of patients Hamilton anxiety scale(HAMA) and Hamilton depression scale(HAMD), Pittsburgh sleep quality index(PSQI), serum neuropeptide Y(NPY) and substance P(SP) were compared before and after 2 months treatment, adverse reactions during treatment were recorded in both groups. Results The total effective rate of the study group was significantly higher than that of the control group(P < 0.05). HAMA, HAMD and PSQI of the two groups were decreased after 2 months of treatment compared with those before treatment, and the study group was lower than the control group(P < 0.05). After 2 months of treatment, the serum NPY level in the two groups was higher than that before treatment, and the level of SP in the study group was lower than that in the control group(P < 0.05). The total incidence of adverse reactions during treatment in the study group was lower than that in the control group(P <0.05). Conclusion Bailemian Capsules combined with Escitalopram Tablets for the treatment of insomnia with depression and anxiety has an accurate effect, which can effectively improve the clinical symptoms of patients, improve the serum NPY and SP levels of patients, and effectively reduce the incidence of adverse reactions.
引文
[1]Ypsilanti A,Lazuras L,Robson A,et al. Anxiety and depression mediate the relationship between self-disgust and insomnia disorder[J]. Sleep Health,2018,4(4):349-351.
[2]陆红宇,宋鲁平,李泓钰,等.心率变异性生物反馈干预不同类型失眠障碍的比较[J].中国康复理论与实践,2017,23(6):720-724.
[3]Kim JI,Park H,Kim JH. Alcohol use disorders and insomnia mediate the association between PTSD symptoms andsuicidal ideation in Korean firefighters[J]. Depress Anxiety,2018,35(11):1095-1103.
[4]吴伟,林传行,陈书丽,等.慢性失眠伴焦虑抑郁患者血清炎症相关标志物研究进展[J].医学与哲学,2017,38(10):18-21.
[5]Sheladia S,Patel B. Determination of Escitalopram Oxalate and L-Methylfolate in Tablet by Spectrophotometric and Reverse Phase High-Performance Liquid Chromatographic Methods[J]. J Chromatogr Sci,2017,55(5):550-555.
[6]卞勇,唐向东.百乐眠胶囊对失眠症小鼠的治疗机制[J].中华医学杂志,2014,94(46):3671-3674.
[7]国家中医药管理局.中医病证诊断疗效标准[J].南京大学出版社,1994,24(5):51-52
[8]Thompson E. Hamilton Rating Scale for Anxiety(HAMA)[J]. Occup Med(Lond),2015,65(7):601.
[9]Zimmerman M,Martinez JH,Young D,et al. Severity classification on the Hamilton Depression Rating Scale[J]. J Affect Disord,2013,150(2):384-388.
[10]路桃影,李艳,夏萍,等.匹兹堡睡眠质量指数的信度及效度分析[J].重庆医学,2014,43(3):260-263.
[11]郑筱萸.中药新药临床研究指导原则(试行)[M].中国医药科技出版社,2002,124-155.
[12]Gebara MA,Siripong N,DiNapoli EA,et al. Effect of insomnia treatments on depression:A systematic review and meta-analysis[J]. Depress Anxiety,2018,35(8):717-731.
[13]田鸿芳,王雷,周清辰,等.针灸治疗失眠症伴抑郁焦虑的临床研究评价[J].中医杂志,2016,57(22):1929-1933.
[14]宋春华,付嘉明,钟欢,等.基于调郁解虑治则针刺治疗失眠伴焦虑抑郁倾向的临床疗效观察[J].针灸临床杂志,2016,32(4):22-23.
[15]Li YI,Starr LR,Wray-Lake L. Insomnia mediates the longitudinal relationship between anxiety and depressive symptoms in a nationally representative sample of adolescents[J]. Depress Anxiety,2018,35(6):583-591.
[16]Knorr U,Koefoed P,Soendergaard MH,et al. No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals:a randomised trial[J]. Acta Neuropsychiatr,2016,28(2):101-109.
[17]张东,于逢春,罗斌,等.百乐眠胶囊治疗失眠症85例[J].南京中医药大学学报,2015,31(5):488-490.
[18]黄庆玲,高东,乐发国,等.百乐眠胶囊联合自助认知行为疗法对慢性失眠症的疗效[J].中华医学杂志,2016,96(36):2893-2897.
[19]韩美芹,张荻,陈智慧,等.百乐眠胶囊联合心理辅导治疗大学生失眠症疗效分析[J].世界中西医结合杂志,2017,12(12):1711-1714.
[20]孙亚平,张建春,王彩娟,等.疏肝解郁法对肝郁型围绝经期失眠女性血清IL-6、NPY及负性情绪的影响[J].世界中医药,2018,13(2):340-343,347.
[2]陆红宇,宋鲁平,李泓钰,等.心率变异性生物反馈干预不同类型失眠障碍的比较[J].中国康复理论与实践,2017,23(6):720-724.
[3]Kim JI,Park H,Kim JH. Alcohol use disorders and insomnia mediate the association between PTSD symptoms andsuicidal ideation in Korean firefighters[J]. Depress Anxiety,2018,35(11):1095-1103.
[4]吴伟,林传行,陈书丽,等.慢性失眠伴焦虑抑郁患者血清炎症相关标志物研究进展[J].医学与哲学,2017,38(10):18-21.
[5]Sheladia S,Patel B. Determination of Escitalopram Oxalate and L-Methylfolate in Tablet by Spectrophotometric and Reverse Phase High-Performance Liquid Chromatographic Methods[J]. J Chromatogr Sci,2017,55(5):550-555.
[6]卞勇,唐向东.百乐眠胶囊对失眠症小鼠的治疗机制[J].中华医学杂志,2014,94(46):3671-3674.
[7]国家中医药管理局.中医病证诊断疗效标准[J].南京大学出版社,1994,24(5):51-52
[8]Thompson E. Hamilton Rating Scale for Anxiety(HAMA)[J]. Occup Med(Lond),2015,65(7):601.
[9]Zimmerman M,Martinez JH,Young D,et al. Severity classification on the Hamilton Depression Rating Scale[J]. J Affect Disord,2013,150(2):384-388.
[10]路桃影,李艳,夏萍,等.匹兹堡睡眠质量指数的信度及效度分析[J].重庆医学,2014,43(3):260-263.
[11]郑筱萸.中药新药临床研究指导原则(试行)[M].中国医药科技出版社,2002,124-155.
[12]Gebara MA,Siripong N,DiNapoli EA,et al. Effect of insomnia treatments on depression:A systematic review and meta-analysis[J]. Depress Anxiety,2018,35(8):717-731.
[13]田鸿芳,王雷,周清辰,等.针灸治疗失眠症伴抑郁焦虑的临床研究评价[J].中医杂志,2016,57(22):1929-1933.
[14]宋春华,付嘉明,钟欢,等.基于调郁解虑治则针刺治疗失眠伴焦虑抑郁倾向的临床疗效观察[J].针灸临床杂志,2016,32(4):22-23.
[15]Li YI,Starr LR,Wray-Lake L. Insomnia mediates the longitudinal relationship between anxiety and depressive symptoms in a nationally representative sample of adolescents[J]. Depress Anxiety,2018,35(6):583-591.
[16]Knorr U,Koefoed P,Soendergaard MH,et al. No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals:a randomised trial[J]. Acta Neuropsychiatr,2016,28(2):101-109.
[17]张东,于逢春,罗斌,等.百乐眠胶囊治疗失眠症85例[J].南京中医药大学学报,2015,31(5):488-490.
[18]黄庆玲,高东,乐发国,等.百乐眠胶囊联合自助认知行为疗法对慢性失眠症的疗效[J].中华医学杂志,2016,96(36):2893-2897.
[19]韩美芹,张荻,陈智慧,等.百乐眠胶囊联合心理辅导治疗大学生失眠症疗效分析[J].世界中西医结合杂志,2017,12(12):1711-1714.
[20]孙亚平,张建春,王彩娟,等.疏肝解郁法对肝郁型围绝经期失眠女性血清IL-6、NPY及负性情绪的影响[J].世界中医药,2018,13(2):340-343,347.