钩芍降压方治疗老年慢性肾脏病合并高血压疗效观察
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摘要
目的观察钩芍降压方对慢性肾脏病并老年高血压病患者的影响。方法将124名老年慢性肾脏病并高血压病患者随机分为治疗组和对照组,两组均给予硝苯地平控释片治疗,治疗组加用钩芍降压方;动态血压监测仪记录治疗前后血压数值及变异性的变化,同时比较肾小球滤过率(GFR)。结果治疗后两组患者血压均有下降,治疗组较对照组下降明显,差异具有统计学意义(P<0.05);两组患者治疗结束后24小时血压变异率均有所下降,治疗组较对照组下降明显,差异具有统计学意义(P<0.05);治疗后两组GFR均有提高,治疗组较对照组提高,差异无统计学意义(P>0.05)。结论钩芍降压方对慢性肾脏病并老年高血压病患者的血压、血压变异性均有积极影响。
Objective To observe the effects of Goushao Jiangya prescription on chronic kidney disease combined with hypertension in aged patients. Methods 124 aged patients of chronic kidney disease combined with hypertension were divided into two groups randomly. Both groups were given nifedipine controlled release tablets, Goushao Jiangya prescription was added in treatment group. Blood pressure was detected with ambulatory blood pressure monitor before and after treatment in both groups. Glomerular filtration rate(GFR) was also detected in both groups. Results Blood pressure in both groups decreased after treatment. And the blood pressure in treatment group decreased significantly compared with that in control group, the difference was statistically significant(P<0.05). The blood pressure variety ratio was decreased in both groups 24 h after treatment, and the blood pressure variety ratio in treatment group decreased more significantly than that in control group, and the difference was statistically significant(P<0.05). After treatment, GFR was improved in both groups, and the GFR was higher in treatment group than that in control group, but the difference was not significant(P>0.05). Conclusion Goudhao Jianyya prescription shows positive effects on blood pressure, blood pressure variety ratio in aged patients of chronic kidney disease with hypertension.
Objective To observe the effects of Goushao Jiangya prescription on chronic kidney disease combined with hypertension in aged patients. Methods 124 aged patients of chronic kidney disease combined with hypertension were divided into two groups randomly. Both groups were given nifedipine controlled release tablets, Goushao Jiangya prescription was added in treatment group. Blood pressure was detected with ambulatory blood pressure monitor before and after treatment in both groups. Glomerular filtration rate(GFR) was also detected in both groups. Results Blood pressure in both groups decreased after treatment. And the blood pressure in treatment group decreased significantly compared with that in control group, the difference was statistically significant(P<0.05). The blood pressure variety ratio was decreased in both groups 24 h after treatment, and the blood pressure variety ratio in treatment group decreased more significantly than that in control group, and the difference was statistically significant(P<0.05). After treatment, GFR was improved in both groups, and the GFR was higher in treatment group than that in control group, but the difference was not significant(P>0.05). Conclusion Goudhao Jianyya prescription shows positive effects on blood pressure, blood pressure variety ratio in aged patients of chronic kidney disease with hypertension.
引文
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[12]杨黎明,谭元生.复方钩藤降压片治疗阴虚阳亢、瘀血阻络证高血压病的效果[J].中国医药导报,2017,14(1):78-81.
[13]项学贵,丁碧云.天麻钩藤饮联合钙离子拮抗剂治疗高血压病的有效性及安全性的Meta分析[J].中国中医急症,2015,24(12):2153-2156.
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[15]陈李萨,李萍萍,刘健.原发性高血压合并慢性肾脏病的危险因素分析[J].肾脏病与透析肾移植杂志,2013,22(3):213-218.
[2]官颖,官捷.不同证型老年高血压病患者心率变异性研究[J].中华中医药学刊,2009,27(5):1115-1117.
[3]FOUNDATION N K.K/DOQI clinical practice guidelines for chronic kidney disease:evaluation,classification,and stratification[J].Am J Kidney Dis,2002,39(2 Suppl 1):S1-66.
[4]刘力生.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-743.
[5]韩学杰.高血压病中医诊疗方案(初稿)[J].中华中医药杂志,2008,23(7):611-613.
[6]闫睿.高血压与慢性肾脏病不良预后相关[J].中国循证心血管医学杂志,2012,4(5):464.
[7]蒋阳,胡耀琪,唐娟.慢性肾脏病患者的高血压患病情况调查[J].浙江预防医学,2015,27(7):703-705.
[8]艾小叶,刘健,李素华.慢性肾脏病患者合并高血压的影响因素研究[J].中国全科医学,2015,18(19):2282-2285.
[9]朱旻霞,倪兆慧,张伟明,等.慢性肾脏病住院患者合并高血压的临床研究[J].上海交通大学学报(医学版),2015,35(12):1819-1823.
[10]侯丕华,陈改玲,谷万里,等.老年高血压病中医证型分布规律及相关因素分析[J].中国中西医结合杂志,2014,34(5):536-540.
[11]周静威,高雪,李侠.慢性肾脏病1~2期血压昼夜节律变化的中医病因病机探讨[J].中国中西医结合肾病杂志,2016,17(9):799-802.
[12]杨黎明,谭元生.复方钩藤降压片治疗阴虚阳亢、瘀血阻络证高血压病的效果[J].中国医药导报,2017,14(1):78-81.
[13]项学贵,丁碧云.天麻钩藤饮联合钙离子拮抗剂治疗高血压病的有效性及安全性的Meta分析[J].中国中医急症,2015,24(12):2153-2156.
[14]刘星,马文,陆瑶,等.动态血压监测在评价慢性肾脏病合并高血压患者血压达标中的价值[J].中国动脉硬化杂志,2014,22(1):32-36.
[15]陈李萨,李萍萍,刘健.原发性高血压合并慢性肾脏病的危险因素分析[J].肾脏病与透析肾移植杂志,2013,22(3):213-218.