自拟滋补肝肾组方联合替勃龙对更年期综合征女性激素水平、脂代谢及免疫应答的影响
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摘要
目的:研究自拟滋补肝肾组方联合替勃龙对更年期综合征女性激素水平、脂代谢及免疫应答的影响。方法:选择本院收治的更年期综合征患者作为研究对象,随机分为接受自拟滋补肝肾组方联合替勃龙治疗的联合组以及接受替勃龙单药治疗的对照组。治疗前及治疗后3个月,检测血清中性激素、脂代谢及免疫细胞因子的含量。结果:治疗后3个月,两组血清中E2、HDL-C、Omentin-1、VaspinC、IL-4、IL-10的含量较治疗前显著升高,LH、FSH、TC、TG、LDL-C、Rsistin、IFN-γ、IL-2的含量较治疗前显著降低且两组间E2、LH、FSH的含量无显著性差异,联合组血清中TC、TG、LDL-C、Rsistin、IFN-γ、IL-2的含量显著低于对照组,HDL-C、Omentin-1、VaspinC、IL-4、IL-10的含量显著高于对照组。结论:自拟滋补肝肾组方联合替勃龙治疗对更年期综合征患者性激素的调节作用与替勃龙单药治疗相当且改善脂代谢及免疫应答的效应较替勃龙单药治疗更为显著。
Objective:To study the effect of self prescription for nourishing liver and kidney combined with tibolone on hormone levels,lipid metabolism and immune response in women with menopausal syndrome.Methods:Patients with menopausal syndrome who were treated in Hebei Weichang County Hospital were selected as the research subjects,and randomly divided into to the combined group who received self prescription for nourishing liver and kidney combined with tibolone therapy,and the control group who were given tibolone monotherapy.The serum levels of sex hormones,lipid metabolism and immune cytokines were detected before treatment and 3 months after treatment.Results:Three months after treatment,serum E2,HDL-C,Omentin-1,VaspinC,IL-4 and IL-10 levels of both groups of patients were significantly higher than those before treatment,while LH,FSH,TC,TG,LDL-C,Rsistin,IFN-γand IL-2 levels were significantly lower than those before treatment,E2,LH and FSH levels were not significantly different between the two groups,serum TC,TG,LDL-C,Rsistin,IFN-γand IL-2 levels of combined group were significantly lower than those of control group,while HDL-C,Omentin-1,VaspinC,IL-4 and IL-10 levels were significantly higher than those of control group.Conclusion:Self prescription for nourishing liver and kidney combined with tibolone is equivalent to tibolone monotherapy in regulating the sex hormones,and more significant than tibolone monotherapy in improving the lipid metabolism and immune response in patients with menopausal syndrome.
Objective:To study the effect of self prescription for nourishing liver and kidney combined with tibolone on hormone levels,lipid metabolism and immune response in women with menopausal syndrome.Methods:Patients with menopausal syndrome who were treated in Hebei Weichang County Hospital were selected as the research subjects,and randomly divided into to the combined group who received self prescription for nourishing liver and kidney combined with tibolone therapy,and the control group who were given tibolone monotherapy.The serum levels of sex hormones,lipid metabolism and immune cytokines were detected before treatment and 3 months after treatment.Results:Three months after treatment,serum E2,HDL-C,Omentin-1,VaspinC,IL-4 and IL-10 levels of both groups of patients were significantly higher than those before treatment,while LH,FSH,TC,TG,LDL-C,Rsistin,IFN-γand IL-2 levels were significantly lower than those before treatment,E2,LH and FSH levels were not significantly different between the two groups,serum TC,TG,LDL-C,Rsistin,IFN-γand IL-2 levels of combined group were significantly lower than those of control group,while HDL-C,Omentin-1,VaspinC,IL-4 and IL-10 levels were significantly higher than those of control group.Conclusion:Self prescription for nourishing liver and kidney combined with tibolone is equivalent to tibolone monotherapy in regulating the sex hormones,and more significant than tibolone monotherapy in improving the lipid metabolism and immune response in patients with menopausal syndrome.
引文
1 Li RX,Ma M,Xiao XR,et al.Perimenopausal syndrome and mood disorders in perimenopause:prevalence,severity,relationships,and risk factors[J].Medicine(Baltimore),2016,95 (32):e4466.
2 Gurka MJ,Vishnu A,Santen RJ,et al.Progression of Metabolic Syndrome Severity During the Menopausal Transition[J].J Am Heart Assoc,2016,5(8):e003609.
3 Kou MJ,Ding XF,Chen JX,et al.Traditional chinese medicine combined with hormone therapy to treat premature ovarian failure:a meta-analysis of randomized controlled trials[J].Afr J Tradit Complement Altern Med,2016,13(5):160-169.
4 Gao L,Zhang L,Qi H,et al.Middle-aged Female Depression in Perimenopausal Period and Square Dance Intervention[J].PsychiatrDanub,2016,28(4):372-378.
5 Martin VT,Pavlovic J,Fanning KM,et al.Perimenopause and Menopause Are Associated With High Frequency Headache in Women With Migraine:Results of the American Migraine Prevalence and Prevention Study[J].Headache,2016,56(2):292-305.
6 Sun Y,Li W,Yin L,et al.Diagnostic accuracy of treadmill exercise tests among Chinese women with coronary artery diseases:A systematic review and meta-analysis[J].Int J Cardiol,2017,15(227):894-900.
7 Terauchi M,Hirose A,Akiyoshi M,et al.Prevalence and predictors of storage lower urinary tract symptoms in perimenopausal and postmenopausal women attending a menopause clinic[J].Menopause,2015,22(10):1084-1090.
8 Gregorio-Arenas E,Ruiz-Cabello P,Camiletti-Moirón D,et al.The associations between physical fitness and cardiometabolic risk and body-size phenotypes in perimenopausal women[J].Maturitas,2016,92:162-167.
9 Indhavivadhana S,Rattanasrithong P.The relationship between bone mineral density and metabolic syndrome in peri-and postmenopausal Thai women[J].Arch GynecolObstet,2015,292(5):1127-1133.
10 Georgiou GP,Provatopoulou X,Kalogera E,et al.Serum resistin is inversely related to breast cancer risk in premenopausal women[J].Breast,2016,29:163-169.
11 Menzel J,Di Giuseppe R,Biemann R,et al.Association between omentin-1,adiponectin and bone health under consideration of osteoprotegerin as possible mediator[J].J Endocrinol Invest,2016,39(11):1347-1355.
12 Erdogan S,Sezer S,Baser E,et al.Evaluating vaspin and adiponectin in postmenopausal women with endometrial cancer[J].EndocrRelat Cancer,2013,20(5):669-675.
13 'S widerska M,Mostowska A,Grzegorzewska AE.T helper cell-related cytokine gene polymorphisms and vitamin D pathway gene polymorphisms as predictors of survival probability in patients on renal replacement therapy[J].Pol Arch Med Wewn,2015,125(7-8):511-520.
14 Madhumitha H,Mohan V,Deepa M,et al.Increased Th1and suppressed Th2serum cytokine levels in subjects with diabetic coronary artery disease[J].CardiovascDiabetol,2014,3(13):1.
15 Taleb-Belkadi O,Chaib H,Zemour L,et al.Lipid profile,inflammation,and oxidative status in peri-and postmenopausal women[J].GynecolEndocrinol,2016,32(12):982-985.
16 Khalili H.Risk of Inflammatory Bowel Disease with Oral Contraceptives and Menopausal Hormone Therapy:Current Evidence and Future Directions[J].Drug Saf,2016,39(3):193-197.
2 Gurka MJ,Vishnu A,Santen RJ,et al.Progression of Metabolic Syndrome Severity During the Menopausal Transition[J].J Am Heart Assoc,2016,5(8):e003609.
3 Kou MJ,Ding XF,Chen JX,et al.Traditional chinese medicine combined with hormone therapy to treat premature ovarian failure:a meta-analysis of randomized controlled trials[J].Afr J Tradit Complement Altern Med,2016,13(5):160-169.
4 Gao L,Zhang L,Qi H,et al.Middle-aged Female Depression in Perimenopausal Period and Square Dance Intervention[J].PsychiatrDanub,2016,28(4):372-378.
5 Martin VT,Pavlovic J,Fanning KM,et al.Perimenopause and Menopause Are Associated With High Frequency Headache in Women With Migraine:Results of the American Migraine Prevalence and Prevention Study[J].Headache,2016,56(2):292-305.
6 Sun Y,Li W,Yin L,et al.Diagnostic accuracy of treadmill exercise tests among Chinese women with coronary artery diseases:A systematic review and meta-analysis[J].Int J Cardiol,2017,15(227):894-900.
7 Terauchi M,Hirose A,Akiyoshi M,et al.Prevalence and predictors of storage lower urinary tract symptoms in perimenopausal and postmenopausal women attending a menopause clinic[J].Menopause,2015,22(10):1084-1090.
8 Gregorio-Arenas E,Ruiz-Cabello P,Camiletti-Moirón D,et al.The associations between physical fitness and cardiometabolic risk and body-size phenotypes in perimenopausal women[J].Maturitas,2016,92:162-167.
9 Indhavivadhana S,Rattanasrithong P.The relationship between bone mineral density and metabolic syndrome in peri-and postmenopausal Thai women[J].Arch GynecolObstet,2015,292(5):1127-1133.
10 Georgiou GP,Provatopoulou X,Kalogera E,et al.Serum resistin is inversely related to breast cancer risk in premenopausal women[J].Breast,2016,29:163-169.
11 Menzel J,Di Giuseppe R,Biemann R,et al.Association between omentin-1,adiponectin and bone health under consideration of osteoprotegerin as possible mediator[J].J Endocrinol Invest,2016,39(11):1347-1355.
12 Erdogan S,Sezer S,Baser E,et al.Evaluating vaspin and adiponectin in postmenopausal women with endometrial cancer[J].EndocrRelat Cancer,2013,20(5):669-675.
13 'S widerska M,Mostowska A,Grzegorzewska AE.T helper cell-related cytokine gene polymorphisms and vitamin D pathway gene polymorphisms as predictors of survival probability in patients on renal replacement therapy[J].Pol Arch Med Wewn,2015,125(7-8):511-520.
14 Madhumitha H,Mohan V,Deepa M,et al.Increased Th1and suppressed Th2serum cytokine levels in subjects with diabetic coronary artery disease[J].CardiovascDiabetol,2014,3(13):1.
15 Taleb-Belkadi O,Chaib H,Zemour L,et al.Lipid profile,inflammation,and oxidative status in peri-and postmenopausal women[J].GynecolEndocrinol,2016,32(12):982-985.
16 Khalili H.Risk of Inflammatory Bowel Disease with Oral Contraceptives and Menopausal Hormone Therapy:Current Evidence and Future Directions[J].Drug Saf,2016,39(3):193-197.