自拟滋补肝肾组方对更年期综合征患者性激素水平、血脂水平及子宫内膜厚度的影响
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摘要
目的探讨自拟滋补肝肾组方对更年期综合征患者性激素水平、血脂水平及子宫内膜厚度的影响,观察其治疗效果。方法采用回顾性研究方法选取2014年7月至2016年9月收治的84例更年期综合征患者进行研究,根据治疗方法将其分为观察组和对照组,每组各42例。其中对照组患者采用常规治疗方法,观察组患者采用自拟滋补肝肾组方治疗方法,评价并比较两组患者的治疗效果,同时检测并比较两组患者治疗3个月时效果、不良反应、治疗前后性激素水平、血脂水平、子宫内膜厚度变化及Kupperman评分变化情况。结果 (1)观察组患者治疗总有效率明显高于对照组(P<0.05)。(2)治疗后两组患者的血清FSH均明显低于治疗前,血清E2则明显高于治疗前,且观察组治疗后血清FSH明显低于对照组,E2明显高于对照组(P<0.05)。(3)治疗后两组患者TG、TC、LDL-C明显低于治疗前,HDLC明显高于治疗前,且观察组治疗后TG、TC和LDL-C明显低于对照组,HDL-C明显高于对照组(P<0.05)。(4)两组患者治疗前后子宫内膜厚度比较差异无统计学意义(P>0.05)。(5)两组患者不良反应比较发生率差异无统计学意义(P>0.05)。结论自拟滋补肝肾组方治疗更年期综合征效果显著,能明显改善患者的临床症状,纠正患者的血脂代谢紊乱和各项性激素指标,同时不良反应轻微,安全性高,值得临床推广应用。
Objective To explore the effect of self-made prescription for nourishing liver and kidney on levels of sex hormones,blood lipids and endometrial thickness in patients with climacteric syndrome,and to observe the therapeutic effect and mechanism of its action. Methods Eighty-four patients with climacteric syndrome were selected as objects for this study in this hospital during July 2014 to September 2016. They were randomly divided into observation group and control group,each group with 42 cases. Patients in control group were treated with conventional therapy,patients in observation group were treated with self-made prescription for nourishing liver and kidney,the therapeutic effects of these two groups were evaluated and compared,and the levels of sex hormones,blood lipids and endometrial thickness were measured and compared between these two groups of patients before and after treatment. Results(1)The total efficacy of observation group was significantly higher than that of control group( P < 0. 05).(2)After treatment,the serum level of FSH in patients of these two groups were significantly lower than those before treatment,the serum level of E2 was significantly higher than that before treatment,and the serum level of FSH in observation group was significantly lower than that of control group,and level of E2 was significantly higher than that of control group( P < 0. 05).(3)After treatment,serum levels of TG,TC and LDL-C in patients of these two groups were significantly lower than those before treatment,level of HDL-C was significantly higher than that before treatment,and levels of TG,TC and LDL-C in observation group were significantly lower than those of control group,level of HDL-C was significantly higher than that of control group( P < 0. 05).(4)There was no significant difference in endometrial thickness between patients in these two groups before and after treatment( P > 0. 05).(5)There was no significant difference in incidence of adverse reactions between these two groups( P > 0. 05). Conclusion The self-made prescription for nourishing liver and kidney in treatment of patients with climacteric syndrome has significant efficacy,it can significantly improve the clinical symptoms of patients,correct the condition of lipid metabolic disorder and the index of sex hormone,and it has mild adverse reaction with high safety,hence it is worthy to be applied in clinical practice.
Objective To explore the effect of self-made prescription for nourishing liver and kidney on levels of sex hormones,blood lipids and endometrial thickness in patients with climacteric syndrome,and to observe the therapeutic effect and mechanism of its action. Methods Eighty-four patients with climacteric syndrome were selected as objects for this study in this hospital during July 2014 to September 2016. They were randomly divided into observation group and control group,each group with 42 cases. Patients in control group were treated with conventional therapy,patients in observation group were treated with self-made prescription for nourishing liver and kidney,the therapeutic effects of these two groups were evaluated and compared,and the levels of sex hormones,blood lipids and endometrial thickness were measured and compared between these two groups of patients before and after treatment. Results(1)The total efficacy of observation group was significantly higher than that of control group( P < 0. 05).(2)After treatment,the serum level of FSH in patients of these two groups were significantly lower than those before treatment,the serum level of E2 was significantly higher than that before treatment,and the serum level of FSH in observation group was significantly lower than that of control group,and level of E2 was significantly higher than that of control group( P < 0. 05).(3)After treatment,serum levels of TG,TC and LDL-C in patients of these two groups were significantly lower than those before treatment,level of HDL-C was significantly higher than that before treatment,and levels of TG,TC and LDL-C in observation group were significantly lower than those of control group,level of HDL-C was significantly higher than that of control group( P < 0. 05).(4)There was no significant difference in endometrial thickness between patients in these two groups before and after treatment( P > 0. 05).(5)There was no significant difference in incidence of adverse reactions between these two groups( P > 0. 05). Conclusion The self-made prescription for nourishing liver and kidney in treatment of patients with climacteric syndrome has significant efficacy,it can significantly improve the clinical symptoms of patients,correct the condition of lipid metabolic disorder and the index of sex hormone,and it has mild adverse reaction with high safety,hence it is worthy to be applied in clinical practice.
引文
[1]王晓凡,张海芹.女性更年期综合征现状及影响因素分析[J].护理学报,2014,21(6):70-72.
[2]李琦,周佩云,李浩,等.更年期综合征中医肾虚证患者实验室指标判别分析[J].中国中西医结合杂志,2013,33(8):1064-1068.
[3]殷冬梅,刘真,阮祥燕,等.激素治疗对更年期综合征患者生存质量的影响[J].首都医科大学学报,2013,34(3):428-431.
[4]吴少祯,吴敏.常见疾病的诊断与疗效判定(标准)[M].中国中医药出版社,1999:454-458.
[5]刘敏如,欧阳惠卿.实用中医妇科学[M].2版.上海:上海科学技术出版社,2010:63.
[6]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:66.
[7]刘雅,张欣文,王燕,等.Kupperman评价辅助化疗对乳腺癌患者更年期综合征的影响[J].中国妇幼健康研究,2015,26(6):1283-1285.
[8]杨春英,刘炼,朱震云.穴位埋线对围绝经期综合征患者Kupperman评分的影响[J].河北中医,2016,38(1):105-107.
[9]Kaunitz AM,Manson JE.Management of Menopausal Symptoms[J].Obstet Gynecol,2015,126(4):859-876.
[10]马锦霞,刘存芬.卵巢衰退过程中雌激素依赖性妇科疾病发生情况研究[J].昆明医科大学学报,2012,33(5):110-112.
[11]Lee AW,Ness RB,Roman LD,et al.Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk[J].Obstet Gynecol,2016,127(5):828-836.
[12]何文彬.雌激素与女性冠心病患者血脂及冠脉病变程度相关性研究[D].天津:天津医科大学,2013.
[13]Galesloot TE,Holewijn S,Kiemeney LA,et al.Serum hepcidin is associated with presence of plaque in postmenopausal women of a general population[J].Arterioscler Thromb Vasc Biol,2014,34(2):446-456.
[14]Schr9der K,Wegscheider K,Wenger NK,et al.Resting electrocardiogram predicts mortality in postmenopausal women with coronary heart disease or with risk factors for coronary heart disease[J].Eur J Prev Cardiol,2014,21(6):749-757.
[15]刘明波,刘韫宁,王文,等.2004-2011年中国人群心血管病死亡的性别差异分析[J].中国慢性病预防与控制,2014,22(3):267-269.
[16]孙雪艳,傅萍,李芳,等.中医药治疗围绝经期综合征的实验研究进展[J].中华中医药学刊,2010,28(9):1930-1932.
[17]刘雁峰,肖承悰,王铁枫,等.更年期综合征中医用药特点、症状及证型分布的现代文献分析[J].北京中药大学学报,2008,31(2):125-130.
[18]刘燕萍,李绍轩.滋肾涵肝法治疗围绝经期综合征疗效观察[J].临床和实验医学杂志,2009,8(10):117,230.
[19]王桂英,冯绍明,田力铭.补肾疏肝汤治疗围绝经期综合征56例临床观察[J].河北中医,2015,37(5):676-678.
[2]李琦,周佩云,李浩,等.更年期综合征中医肾虚证患者实验室指标判别分析[J].中国中西医结合杂志,2013,33(8):1064-1068.
[3]殷冬梅,刘真,阮祥燕,等.激素治疗对更年期综合征患者生存质量的影响[J].首都医科大学学报,2013,34(3):428-431.
[4]吴少祯,吴敏.常见疾病的诊断与疗效判定(标准)[M].中国中医药出版社,1999:454-458.
[5]刘敏如,欧阳惠卿.实用中医妇科学[M].2版.上海:上海科学技术出版社,2010:63.
[6]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:66.
[7]刘雅,张欣文,王燕,等.Kupperman评价辅助化疗对乳腺癌患者更年期综合征的影响[J].中国妇幼健康研究,2015,26(6):1283-1285.
[8]杨春英,刘炼,朱震云.穴位埋线对围绝经期综合征患者Kupperman评分的影响[J].河北中医,2016,38(1):105-107.
[9]Kaunitz AM,Manson JE.Management of Menopausal Symptoms[J].Obstet Gynecol,2015,126(4):859-876.
[10]马锦霞,刘存芬.卵巢衰退过程中雌激素依赖性妇科疾病发生情况研究[J].昆明医科大学学报,2012,33(5):110-112.
[11]Lee AW,Ness RB,Roman LD,et al.Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk[J].Obstet Gynecol,2016,127(5):828-836.
[12]何文彬.雌激素与女性冠心病患者血脂及冠脉病变程度相关性研究[D].天津:天津医科大学,2013.
[13]Galesloot TE,Holewijn S,Kiemeney LA,et al.Serum hepcidin is associated with presence of plaque in postmenopausal women of a general population[J].Arterioscler Thromb Vasc Biol,2014,34(2):446-456.
[14]Schr9der K,Wegscheider K,Wenger NK,et al.Resting electrocardiogram predicts mortality in postmenopausal women with coronary heart disease or with risk factors for coronary heart disease[J].Eur J Prev Cardiol,2014,21(6):749-757.
[15]刘明波,刘韫宁,王文,等.2004-2011年中国人群心血管病死亡的性别差异分析[J].中国慢性病预防与控制,2014,22(3):267-269.
[16]孙雪艳,傅萍,李芳,等.中医药治疗围绝经期综合征的实验研究进展[J].中华中医药学刊,2010,28(9):1930-1932.
[17]刘雁峰,肖承悰,王铁枫,等.更年期综合征中医用药特点、症状及证型分布的现代文献分析[J].北京中药大学学报,2008,31(2):125-130.
[18]刘燕萍,李绍轩.滋肾涵肝法治疗围绝经期综合征疗效观察[J].临床和实验医学杂志,2009,8(10):117,230.
[19]王桂英,冯绍明,田力铭.补肾疏肝汤治疗围绝经期综合征56例临床观察[J].河北中医,2015,37(5):676-678.