儿童传染性单核细胞增多症的临床特征
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摘要
目的探讨儿童传染性单核细胞增多症(IM)的临床特征。方法收集160例IM的临床症状、体征、实验室检查和并发症,进行回顾性分析。结果 160例患儿中,男85例,女75例,中位年龄7岁。发热、咽峡炎、颈淋巴结肿大是IM患儿的主要临床表现,肝脾肿大、鼻塞、眼睑浮肿也是重要体征。常见的并发症有肝损害、心肌受损、肺炎、血小板减少和中性粒细胞减少。结论不同年龄段儿童IM临床症状、体征、实验室检查及并发症存在差异,应予以重视,应用更昔洛韦治疗疗效确切。
Objective To investigate the clinical characteristics of children with infectious mononuclear cell histiocytosis(IM).Methods The clinical symptoms,signs,laboratory tests,and complications of 160 cases of IM were analyzed retrospectively.Results The results of 160 patients were 85 cases of male and 75 cases of female;median age was 7 years old.Fever,angina,cervical lymph nodes is the main clinical manifestations of IM patients,hepatosplenomegaly,nasal congestion,eyelid edema is an important sign.Common complications are liver damage,heart damage,reduced pneumonia,thrombocytopenia,and neutropenia.Conclusion Children of different ages had different IM clinical symptoms,signs,laboratory tests,complications,attention should be paid to the treatment efficacy of Ganciclovir.
Objective To investigate the clinical characteristics of children with infectious mononuclear cell histiocytosis(IM).Methods The clinical symptoms,signs,laboratory tests,and complications of 160 cases of IM were analyzed retrospectively.Results The results of 160 patients were 85 cases of male and 75 cases of female;median age was 7 years old.Fever,angina,cervical lymph nodes is the main clinical manifestations of IM patients,hepatosplenomegaly,nasal congestion,eyelid edema is an important sign.Common complications are liver damage,heart damage,reduced pneumonia,thrombocytopenia,and neutropenia.Conclusion Children of different ages had different IM clinical symptoms,signs,laboratory tests,complications,attention should be paid to the treatment efficacy of Ganciclovir.
引文
[1]胡亚美,江载芳.实用儿科学[M].北京:人民卫生出版社,2002:821.
[2]朱易平,高举,杜惠容,等.196例传染性单核细胞增多症的并发症和实验室检查[J].实用临床儿科杂志,2003,18(11):902.
[3]Kanegane H,Kanegane C,Yachie A,et al.Infectious mononucle-osis as a disease of early childhood in Japan caused by primaryEpstein-Barr virus infection[J].Acta Paediatr Jpn,1997,39(2):166-171.
[4]Kasahara Y,YachieA.Cell type specific infection of Epstein-Barr virus(EBV)in EBV-associated hemophagocytosis and chro-nic active EBV infection[J].Crit Rev Oncol Hematol,2002,44(3):283-294.
[5]赵方,彭华,曾宾,等.不同年龄儿童传染性单核细胞增多症临床分析[J].中华全科医学,2008,6(11):1133-1134.
[6]Chan KH,Tam JS,Peiris JS,et al.Epstein-Barr virus(EBV)infection in infancy[J].J Clin Virol,2001,21(1):57-62.
[7]石风英,丁学勤,刘辉,等.165例小儿传染性单核细胞增多症临床分析[J].中国小儿血液与肿瘤杂志,2007,12(4):180-182.
[8]Cohen J I.Ep stein-Barr virus infection[J].N Engl J M ed,2006,343(7):481-492.
[9]Papesch M,W atkins R.Ep stein-Barr virus infectious mono-nucleosis[J].C lin O tolaryngol A llied Sci,2004,26(1):3.
[10]Chan CW,Chiang AK,Chan RH,et al.Ep stein-Barr virus-associated infectious mononucleosis in Chinese children[J].Pedia tr Infect D is J,2003,22(11):974-978.
[11]Tsai MH,H su CY,Yen MH,et al.Epstein-Barr virus-asso-ciated infec2tious mononucleosis and risk factor analysis forcomp lications in hospita2lized children[J].J M icrobiol Immunol Infect,2005,38(4):255-261.
[12]岑丹阳,陈纯,薛红漫.儿童传染性单核细胞增多症238例临床分析[J].中国热带医学,2008:8(4):594-596.
[13]朴金花,孙景辉,杨思睿,等.儿童传染性单核细胞增多症临床特点与发病年龄的关系(附142例分析)[J].中国小儿血液,2005,10(2):71-74.
[14]王晓莉,于洁,徐西华.传染性单核细胞增多症及其相关疾病临床特点分析[J].中国实用儿科杂志,2006,21(9):696-698.
[15]张爱民,贺湘玲.182例小儿传染性单核细胞增多症的血液学表现[J].中国小儿血液,2005,10(1):12-13.
[2]朱易平,高举,杜惠容,等.196例传染性单核细胞增多症的并发症和实验室检查[J].实用临床儿科杂志,2003,18(11):902.
[3]Kanegane H,Kanegane C,Yachie A,et al.Infectious mononucle-osis as a disease of early childhood in Japan caused by primaryEpstein-Barr virus infection[J].Acta Paediatr Jpn,1997,39(2):166-171.
[4]Kasahara Y,YachieA.Cell type specific infection of Epstein-Barr virus(EBV)in EBV-associated hemophagocytosis and chro-nic active EBV infection[J].Crit Rev Oncol Hematol,2002,44(3):283-294.
[5]赵方,彭华,曾宾,等.不同年龄儿童传染性单核细胞增多症临床分析[J].中华全科医学,2008,6(11):1133-1134.
[6]Chan KH,Tam JS,Peiris JS,et al.Epstein-Barr virus(EBV)infection in infancy[J].J Clin Virol,2001,21(1):57-62.
[7]石风英,丁学勤,刘辉,等.165例小儿传染性单核细胞增多症临床分析[J].中国小儿血液与肿瘤杂志,2007,12(4):180-182.
[8]Cohen J I.Ep stein-Barr virus infection[J].N Engl J M ed,2006,343(7):481-492.
[9]Papesch M,W atkins R.Ep stein-Barr virus infectious mono-nucleosis[J].C lin O tolaryngol A llied Sci,2004,26(1):3.
[10]Chan CW,Chiang AK,Chan RH,et al.Ep stein-Barr virus-associated infectious mononucleosis in Chinese children[J].Pedia tr Infect D is J,2003,22(11):974-978.
[11]Tsai MH,H su CY,Yen MH,et al.Epstein-Barr virus-asso-ciated infec2tious mononucleosis and risk factor analysis forcomp lications in hospita2lized children[J].J M icrobiol Immunol Infect,2005,38(4):255-261.
[12]岑丹阳,陈纯,薛红漫.儿童传染性单核细胞增多症238例临床分析[J].中国热带医学,2008:8(4):594-596.
[13]朴金花,孙景辉,杨思睿,等.儿童传染性单核细胞增多症临床特点与发病年龄的关系(附142例分析)[J].中国小儿血液,2005,10(2):71-74.
[14]王晓莉,于洁,徐西华.传染性单核细胞增多症及其相关疾病临床特点分析[J].中国实用儿科杂志,2006,21(9):696-698.
[15]张爱民,贺湘玲.182例小儿传染性单核细胞增多症的血液学表现[J].中国小儿血液,2005,10(1):12-13.