系统性红斑狼疮伴血小板减少机制的研究进展
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摘要
系统性红斑狼疮是一种累及多系统、多脏器的自身免疫性疾病。血小板减少是系统性红斑狼疮常见临床表现之一,也是其预后不良的一个独立危险因素。
systemic lupus erythematosus(SLE) is an autoimmune disease involving multiple systems and organs. Thrombocytopenia is a common clinical symptom of systemic lupus erythematosus, also an independent risk factor for unfavourable prognosis.
systemic lupus erythematosus(SLE) is an autoimmune disease involving multiple systems and organs. Thrombocytopenia is a common clinical symptom of systemic lupus erythematosus, also an independent risk factor for unfavourable prognosis.
引文
[1]臧银善,鲍春德,张巍.系统性红斑狼疮伴血小板减少症近远期疗效观察及相关因素研究[J].中华风湿病学杂志,2003,7(2):86-89.
[2]杨拓,黄慈波,赖蓓等.抗血小板生成素抗体与系统性红斑狼疮伴血小板减少的相关性探讨[J].中华临床医师杂志(电子版),2012,06(16):4918-4920.
[3]刘青松,袁国华,唐中.网织血小板对系统性红斑狼疮的诊断和疗效判断价值[J].西安交通大学学报(医学版),2012,33(6):748-751.
[4]郑朝晖,于若寒,高冠民等.重组人血小板生成素治疗系统性红斑狼疮血小板减少的有效性和安全性研究[J].第三军医大学学报,2014,36(5):507-509.
[5]罗雄燕,武丽君,吴凤霞.巨核细胞增殖与分化障碍在系统性红斑狼疮伴发血小板减少中的作用[J].中华临床医师杂志(电子版),2010,4(2):150-153.
[6]罗雄燕,武丽君,陈龙.间接免疫荧光检测系统性红斑狼疮患者血清抗巨核细胞抗体[J].中国实验血液学杂志,2011,19(3):734-737.
[7]He R,Reid DM,Jones CE,et a1.Spectrum of Ig classes,specifieities,and titers of ser-um antiglycoproteins in chronic idiopathic thrombocytopenic purpura[J],Blood,1994,83(4):1024-1032.
[8]Kuwana M,Kaburaki J,Ikeda Y.Autoreactive T cells to platelet GP1Ib-Ⅲa in immune thrombocytopenic purpura.Role in production of anti-platelet autoantibody[J].J1998,102(7):1393-1402.
[9]Tripath AK,Mishra S,Kummar A,etal.Megakaryocyte morphology and its impact in predicting response to steroid in immune thrombocytopenia[J].Platelets,2014,25(7).
[10]欧大明,罗慧臣,颜家运.系统性红斑狼疮伴血小板减少疗效分析[J].现代诊断与治疗,2014,25(13):3000-3001.
[11]穆静,高忠恩,刘锐.系统性红斑狼疮伴重症血小板减少1例[J].广东医学,2013,34(7):1046.
[12]袁慧.JAK/STAT信号通路相关基因在系统性红斑狼疮发病中的作用研究[D].安徽医科大学,2010.
[13]Fridman JS,Sehede PA,Collins R,et a1.Selective inhibition of JAKl and JAK2 is eficacious in rodent models of arthritis:preclinical characterization of INCB028050.J Immunol,2010,184:5298-53 07.
[14]Lu LD,Stump KL,Wallace NH,eta1.Depletion of autoreaetive plasma cells and treatment of lupus nephritis inmice using CEP-33779,a novel,orally active,selective inhibitor of JAK2.Immunology,2011,187:3840-3853.
[15]Schett G,Firbas U,Fureder W,et a1.Decreaed serum erythropoietin and its rel–ation to anti-erythropoietin antibodies in anaemia of SLE.Rheumatology,2001,4 0:424-431.
[16]吴晓丹,罗雄燕,陈龙.抗血小板生成素抗体与系统性红斑狼疮伴血小板减少的相关性研究[J].中华风湿病学杂志,2012,16(11):745-748.
[17]闫金玉,赵晓民,侯伟等.系统性红斑狼疮伴骨髓纤维化2例[J].中国实用内科杂志,2003,23(3):159-159.
[18]Fureder W,Firbas U,Nichol JL,eta1.Serum thrombopoietin Levels and anti–thrombopoietin antibodies in systemic lupus erythematosus.Lupus,2002.11:221-2 26.
[19]Emmons RV,Reid DM,Cohen RL,et a1.Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction.Blood,1996,87:4068-4O71.
[20]Ziakas PD,Routsias JG,Giannouli S,et a1.Suspects in the tale of lupus-asso-ci ated thrombocytopenia.Clin Exp Immunol,2006,145:71-80.
[21]杨拓,黄慈波,赖蓓.抗c-mpl抗体在系统性红斑狼疮并发血小板减少中的作用[J].北京大学学报(医学版),2012,44(2):221-224.
[22]Deng MY,Zhang GS,Zhang Y,et a1.Analysis of clinical and laboratory characteristic in 42 patients with thrombotic throm-bocytopenic purpura from a single center in China[J].Tra-nsfus Apher Sci,2013,49(3):47-452.
[23]Letchumanan P,Ng HJ,Lee LH,eta1.A comparison of throm—boric thromb ocytopenic purpura in an inception cohort of patients with and without systemic lupus erythematosus[J].Rheumatology(Oxford),2009,48(4):399.403.
[24]朱晓浚,刘次伟.系统性红斑狼疮患者血小板减少与血小板相关抗体和抗心磷脂抗体的相关性研究[J].临床皮肤科杂志,2007,36(4):224-225.
[25]方荣成,青玉凤,周京国.系统性红斑狼疮伴血液系统损害的临床研究[J].中华临床医师杂志(电子版),2010,04(9):1574-1579.
[26]Kam T,Alexander M,drug-inducced immune thrombocytopenia[J].JPharm Pract,2014,27(5):430-439.
[2]杨拓,黄慈波,赖蓓等.抗血小板生成素抗体与系统性红斑狼疮伴血小板减少的相关性探讨[J].中华临床医师杂志(电子版),2012,06(16):4918-4920.
[3]刘青松,袁国华,唐中.网织血小板对系统性红斑狼疮的诊断和疗效判断价值[J].西安交通大学学报(医学版),2012,33(6):748-751.
[4]郑朝晖,于若寒,高冠民等.重组人血小板生成素治疗系统性红斑狼疮血小板减少的有效性和安全性研究[J].第三军医大学学报,2014,36(5):507-509.
[5]罗雄燕,武丽君,吴凤霞.巨核细胞增殖与分化障碍在系统性红斑狼疮伴发血小板减少中的作用[J].中华临床医师杂志(电子版),2010,4(2):150-153.
[6]罗雄燕,武丽君,陈龙.间接免疫荧光检测系统性红斑狼疮患者血清抗巨核细胞抗体[J].中国实验血液学杂志,2011,19(3):734-737.
[7]He R,Reid DM,Jones CE,et a1.Spectrum of Ig classes,specifieities,and titers of ser-um antiglycoproteins in chronic idiopathic thrombocytopenic purpura[J],Blood,1994,83(4):1024-1032.
[8]Kuwana M,Kaburaki J,Ikeda Y.Autoreactive T cells to platelet GP1Ib-Ⅲa in immune thrombocytopenic purpura.Role in production of anti-platelet autoantibody[J].J1998,102(7):1393-1402.
[9]Tripath AK,Mishra S,Kummar A,etal.Megakaryocyte morphology and its impact in predicting response to steroid in immune thrombocytopenia[J].Platelets,2014,25(7).
[10]欧大明,罗慧臣,颜家运.系统性红斑狼疮伴血小板减少疗效分析[J].现代诊断与治疗,2014,25(13):3000-3001.
[11]穆静,高忠恩,刘锐.系统性红斑狼疮伴重症血小板减少1例[J].广东医学,2013,34(7):1046.
[12]袁慧.JAK/STAT信号通路相关基因在系统性红斑狼疮发病中的作用研究[D].安徽医科大学,2010.
[13]Fridman JS,Sehede PA,Collins R,et a1.Selective inhibition of JAKl and JAK2 is eficacious in rodent models of arthritis:preclinical characterization of INCB028050.J Immunol,2010,184:5298-53 07.
[14]Lu LD,Stump KL,Wallace NH,eta1.Depletion of autoreaetive plasma cells and treatment of lupus nephritis inmice using CEP-33779,a novel,orally active,selective inhibitor of JAK2.Immunology,2011,187:3840-3853.
[15]Schett G,Firbas U,Fureder W,et a1.Decreaed serum erythropoietin and its rel–ation to anti-erythropoietin antibodies in anaemia of SLE.Rheumatology,2001,4 0:424-431.
[16]吴晓丹,罗雄燕,陈龙.抗血小板生成素抗体与系统性红斑狼疮伴血小板减少的相关性研究[J].中华风湿病学杂志,2012,16(11):745-748.
[17]闫金玉,赵晓民,侯伟等.系统性红斑狼疮伴骨髓纤维化2例[J].中国实用内科杂志,2003,23(3):159-159.
[18]Fureder W,Firbas U,Nichol JL,eta1.Serum thrombopoietin Levels and anti–thrombopoietin antibodies in systemic lupus erythematosus.Lupus,2002.11:221-2 26.
[19]Emmons RV,Reid DM,Cohen RL,et a1.Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction.Blood,1996,87:4068-4O71.
[20]Ziakas PD,Routsias JG,Giannouli S,et a1.Suspects in the tale of lupus-asso-ci ated thrombocytopenia.Clin Exp Immunol,2006,145:71-80.
[21]杨拓,黄慈波,赖蓓.抗c-mpl抗体在系统性红斑狼疮并发血小板减少中的作用[J].北京大学学报(医学版),2012,44(2):221-224.
[22]Deng MY,Zhang GS,Zhang Y,et a1.Analysis of clinical and laboratory characteristic in 42 patients with thrombotic throm-bocytopenic purpura from a single center in China[J].Tra-nsfus Apher Sci,2013,49(3):47-452.
[23]Letchumanan P,Ng HJ,Lee LH,eta1.A comparison of throm—boric thromb ocytopenic purpura in an inception cohort of patients with and without systemic lupus erythematosus[J].Rheumatology(Oxford),2009,48(4):399.403.
[24]朱晓浚,刘次伟.系统性红斑狼疮患者血小板减少与血小板相关抗体和抗心磷脂抗体的相关性研究[J].临床皮肤科杂志,2007,36(4):224-225.
[25]方荣成,青玉凤,周京国.系统性红斑狼疮伴血液系统损害的临床研究[J].中华临床医师杂志(电子版),2010,04(9):1574-1579.
[26]Kam T,Alexander M,drug-inducced immune thrombocytopenia[J].JPharm Pract,2014,27(5):430-439.