获得性对称性肢端角化病1例
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摘要
患者男,38岁。双手、足起褐色角化性斑片5年。皮损特点为双手及双足背部褐色角化性斑片,接触水后局部变白,冬季明显缓解。患者有鱼鳞病史。父母非近亲结婚,也均有鱼鳞病史。皮损组织病理示:表皮角化过度,棘层增生,真皮浅层血管周围淋巴细胞浸润。诊断:获得性对称性肢端角化病。
A 38-year-old male presented with brown hyperkeratotic patches distributed on dorsum of hands and feet for five years. The lesions became whitish with mild swelling after contact with water and the lesions improved or disappeared generally in winter. The patient had a history of ichthyosis. His parents were not consanguineous marriage,and both of them had history of ichthyosis. Histopathologic examination revealed epidermal hyperkeratosis,acanthosis,as well as superficial perivascular lymphohistiocytic infiltrate. The diagnosis was acquired symmetrical acrokeratoderma.
A 38-year-old male presented with brown hyperkeratotic patches distributed on dorsum of hands and feet for five years. The lesions became whitish with mild swelling after contact with water and the lesions improved or disappeared generally in winter. The patient had a history of ichthyosis. His parents were not consanguineous marriage,and both of them had history of ichthyosis. Histopathologic examination revealed epidermal hyperkeratosis,acanthosis,as well as superficial perivascular lymphohistiocytic infiltrate. The diagnosis was acquired symmetrical acrokeratoderma.
引文
[1]姜祎群,曾学思,薛燕宁,等.对称性肢端角化病——一种新命名的皮肤病[J].临床皮肤科杂志,2008,37(7):428-430.
[2]朱晓浚,李希清,杨容青,等.表现为色素性对称性肢端角化性皮损的一组患者临床分析[J].中华皮肤科杂志,2008,41(8):539-541.
[3]Fan YM,Li SF,Yang YP,et al.Is acquired symmetrical acrokeratoderma a new dermatosis two case reports and Chinese literature review[J].Int J Dermatol,2010,49(6):647-652.
[4]刘超,唐智慧,曾海燕,等.季节性获得性对称性色素性苔藓样肢端角化病31例临床分析[J].昆明医科大学学报,2013,(6):127-130.
[5]张志杨,郑晓晖.对称性肢端角化病九例分析[J].中华皮肤科杂志,2011,44(10):737-738.
[6]钱如发,饶小磊.对称性肢端角化病2例[J].临床皮肤科杂志,2012,41(11):679-680.
[2]朱晓浚,李希清,杨容青,等.表现为色素性对称性肢端角化性皮损的一组患者临床分析[J].中华皮肤科杂志,2008,41(8):539-541.
[3]Fan YM,Li SF,Yang YP,et al.Is acquired symmetrical acrokeratoderma a new dermatosis two case reports and Chinese literature review[J].Int J Dermatol,2010,49(6):647-652.
[4]刘超,唐智慧,曾海燕,等.季节性获得性对称性色素性苔藓样肢端角化病31例临床分析[J].昆明医科大学学报,2013,(6):127-130.
[5]张志杨,郑晓晖.对称性肢端角化病九例分析[J].中华皮肤科杂志,2011,44(10):737-738.
[6]钱如发,饶小磊.对称性肢端角化病2例[J].临床皮肤科杂志,2012,41(11):679-680.