摘要
目的:通过Meta分析的方法比较鼻内镜下翼管神经切断术与保守治疗中重度变应性鼻炎(AR)的临床疗效差异。方法:检索包括国内现已发表的相关临床对照研究。所检索的数据库包括Embase、Pubmed、Web of Science、Cochrane Library、中国知网、维普、万方等数据库。对检索的相文献进行阅读和筛选,并使用Review Manager 5.3软件分析纳入文献的相关数据。结果:纳入6篇病例对照研究。Meta分析结果显示,相较于保守治疗,采用鼻内镜下翼管神经切断术治疗中重度AR患者的RQLQ评分[95%CI(-0.98,-0.63),P<0.001]更低、并发症发生率[95%CI(0.17,0.67),P=0.002]更低、VAS评分[95%CI(-3.97,-3.65),P<0.001]更低、有效率[95%CI(1.18,50.52),P=0.03]更高,以上结果2组间差异均有统计学意义。结论:鼻内镜下翼管神经切断术治疗中重度AR疗效优于保守治疗。
Objective:To compare the clinical effects of vidian neurectomy with conservative management in the treatment for moderate-severe allergic rhinitis.Method:The studies using case controlled trials which were retrieved from Embase,Pubmed,Web of Science,Cochrane Library etc.The Cochrane risk assessment criteria were used to evaluate the quality of the articles that met the inclusion criteria.Manager 5.3 software was used to data analysis.Result:Six articles were included in meta-analysis.Meta-analysis showed that vidian neurectomy group got lower RQLQ scores[95%CI(-0.98,-0.63),P<0.001],less incidence of complications[95%CI(0.17,0.67),P=0.002],lower VAS score[95%CI(-3.97,-3.65),P<0.001]and higher clinically effective ratio[95%CI(1.18,50.52),P=0.03]than conservative treatment group.Conclusion:In summary,we believe that nasal endoscopic vidian neurectomy in the treatment of moderate-severe allergic rhinitis is superior to conservative treatment.
引文
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