河北省张家口地区高尿酸血症流行现状及影响因素分析
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摘要
目的探讨张家口地区高尿酸血症流行现状及其影响因素,为预防高尿酸血症提供科学依据。方法选取2016年5月~2017年5月在张家口市第一医院体检的17 273名体检者为研究对象,检测其血压、体质指数(BMI)、血糖(FBG)、血尿酸(UA)、甘油三酯(TG)和总胆固醇(CHOL);根据年龄分为6组,比较不同性别间尿酸水平及同一组不同性别间高尿酸血症患病率的差异;根据各指标判定标准,采用多因素logistic回归分析高尿酸血症与各个指标之间的关系。结果张家口地区体检人群高尿酸血症患病率为22.14%,其中男性患病率(28.39%)高于女性(12.87%),差异有统计学意义(χ~2=580.647,P<0.01)。男性尿酸水平随年龄增长而下降(H=435.347,P<0.01),而女性尿酸则升高(H=300.082,P<0.01)。多因素logistic回归分析结果显示男性、肥胖、高甘油三脂和高胆固醇为高尿酸血症的危险因素,而高血糖为保护因素。结论张家口地区高尿酸血症的患病率较高。应加强健康教育,一旦发现高尿酸应积极治疗;指导居民调整饮食结构,加强体育锻炼,有效预防高尿酸血症的发生。。
Objective Investigate the prevalence of hyperuricemia and its influencing factors in Zhangjiakou,to provide scientific basis for the prevention of hyperuricemia. Methods Select 17 273 people having physical examination from May 2016 to May 2017 in the first hospital of Zhangjiakou as the research objects. Test their blood pressure,body mass index( BMI),fasting blood glucose( FPG),blood uric acid( UA),triglyceride( TG) and total cholesterol( CHOL). Divide them into 6 groups according to their age; compare the differences of uric acid levels in different genders among the 6 groups and the prevalence rates of hyperuricemia between different genders in the same group. According to the criteria of each index,analyze the relationship between hyperuricemia and each index by multi-factor logistic regression. Results The prevalence rate of hyperuricemia in Zhangjiakou was 22. 14%; the rate of male( 28. 39%) was higher than women( 12. 87%),which of statistical significance( χ~2= 580. 647,P < 0. 01). Male uric acid levels decreased with age( H = 435. 347,P < 0. 01),while the levels increased in women( H = 300. 082,P < 0. 01). Logistic regression analysis showed that male,obesity,high TG and high CHOL were risk factors of hyperuricemia and high FBG was protective factors. Conclusion There is a higher prevalence of hyperuricemia in Zhangjiakou. Health education should be strengthened so that active treatment can be offered to patients with Hyperuricemia. Residents should be guided to adjust the diet and strengthen physical exercise to effectively prevent it.
Objective Investigate the prevalence of hyperuricemia and its influencing factors in Zhangjiakou,to provide scientific basis for the prevention of hyperuricemia. Methods Select 17 273 people having physical examination from May 2016 to May 2017 in the first hospital of Zhangjiakou as the research objects. Test their blood pressure,body mass index( BMI),fasting blood glucose( FPG),blood uric acid( UA),triglyceride( TG) and total cholesterol( CHOL). Divide them into 6 groups according to their age; compare the differences of uric acid levels in different genders among the 6 groups and the prevalence rates of hyperuricemia between different genders in the same group. According to the criteria of each index,analyze the relationship between hyperuricemia and each index by multi-factor logistic regression. Results The prevalence rate of hyperuricemia in Zhangjiakou was 22. 14%; the rate of male( 28. 39%) was higher than women( 12. 87%),which of statistical significance( χ~2= 580. 647,P < 0. 01). Male uric acid levels decreased with age( H = 435. 347,P < 0. 01),while the levels increased in women( H = 300. 082,P < 0. 01). Logistic regression analysis showed that male,obesity,high TG and high CHOL were risk factors of hyperuricemia and high FBG was protective factors. Conclusion There is a higher prevalence of hyperuricemia in Zhangjiakou. Health education should be strengthened so that active treatment can be offered to patients with Hyperuricemia. Residents should be guided to adjust the diet and strengthen physical exercise to effectively prevent it.
引文
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[17]卢雪婷,于祥远,秦林原,等.13675例体检者高尿酸血症的检出率及其与体重指数、血脂、血糖的相关性研究[J].现代预防医学,2015,42(4):713-716.
[18]张翠改,吴惠珍,吕超,等.体检人群中的高尿酸血症及危险因素分析[J].中国老年学,2013,33(16):4048-4049.
[19]刘志连,范文娟,王淑霞,等.成年体检人群中高尿酸血症患病率及相关危险因素调查研究[J].中国全科医学,2011,14(20):2284-2286.
[20]徐丽华,颜应琳,冀瑞俊,等.河北任丘老年人高尿酸血症患病率及相关因素分析[J].临床荟萃,2016,31(10):1088-1091.
[21]张磊,刘永建,焦丽亚,等.石家庄市40岁以上体检人群高尿酸血症患病率及危险因素分析[J].河北医科大学学报,2015,36(3):364-366.
[2]张亚玲.1645例体检人员高尿酸血症发生情况及其影响因素分析[J].中华实用诊断与治疗杂志,2016,30(9):933-934.
[3]闫婕,陶慧,蒙健军,等.广西省南宁地区一常规体检人群高尿酸血症患病率调查及与血脂相关性的研究[J].中华内分泌代谢杂志,2014,30(5):411-414.
[4]宋薇,刘精东,陈志雄,等.南昌地区40岁以上社区居民高尿酸血症和痛风的患病率调查及相关影响因素分析[J].中国全科医学,2014,17(2):181-184.
[5]王晔,高美芳,陆志刚,等.血尿酸水平与冠状动脉病变及代谢综合征的关系[J].中华内分泌代谢杂志,2011,27(1):24-27.
[6]郭艳芹.某高校教工高尿酸血症患病情况分析[J].中国学校卫生,2013,34(1):124-125.
[7]梁凯,曲勇,邓楠,等.无症状性高尿酸血症与代谢综合征及其组分相关性的研究[J].中国糖尿病杂志,2013,21(5):388-391.
[8]屈亚莉,孔丽华,田雨,等.中老年人血清尿酸水平与代谢综合征的关系[J].中华老年医学杂志,2013,32(8):897-901.
[9]朱武军,张富敏,陈芳.贵阳地区铁路职工血糖、血脂及尿酸水平调查分析[J].国际检验医学杂志,2016,34(1):96-97.
[10]杨延停.360例职工体检血脂、血糖、血尿酸、血常规结果分析[J].国际检验医学杂志,2016,37(9):1292-1293.
[11]赵醒艳.1446例在职处级干部健康体检结果分析[J].广西中医药大学学报,2016,19(3):50-52.
[12]胡坤,高楠楠,于海霞.成年人体重指数与血压、血脂、血糖、尿酸的相关性研究[J].中国医疗前沿,2012,7(1):91-92.
[13]刘秀雯.某高校职工体检血尿酸血糖血脂结果分析[J].中国校医,2016,30(4):254-256.
[14]赵晓钰.中海油职工高尿酸血症患病率及相关危因素分析[D].天津:天津医科大学,2015.
[15]王洪莎,郭蔚莹.高尿酸血症与高血糖、高血压及肥胖的关系[J].中国老年学,2016,36(22):5729-5732.
[16]李京,赵心童,胥欣,等.高尿酸血症与代谢综合征相关关系的研究[J].现代预防医学,2014,41(14):2671-2673.
[17]卢雪婷,于祥远,秦林原,等.13675例体检者高尿酸血症的检出率及其与体重指数、血脂、血糖的相关性研究[J].现代预防医学,2015,42(4):713-716.
[18]张翠改,吴惠珍,吕超,等.体检人群中的高尿酸血症及危险因素分析[J].中国老年学,2013,33(16):4048-4049.
[19]刘志连,范文娟,王淑霞,等.成年体检人群中高尿酸血症患病率及相关危险因素调查研究[J].中国全科医学,2011,14(20):2284-2286.
[20]徐丽华,颜应琳,冀瑞俊,等.河北任丘老年人高尿酸血症患病率及相关因素分析[J].临床荟萃,2016,31(10):1088-1091.
[21]张磊,刘永建,焦丽亚,等.石家庄市40岁以上体检人群高尿酸血症患病率及危险因素分析[J].河北医科大学学报,2015,36(3):364-366.