肌钙蛋白TnI定量检测相比单纯定性肌钙蛋白检测在诊断急性心肌梗死的应用
|
摘要
目的探讨心肌肌钙蛋白I(c Tn I)定量和定性检测在急性心肌梗死中的临床诊断价值,为临床急性心肌梗死的诊断和治疗提供参考依据。方法选取2017年1~6月我院出现胸闷胸痛患者28例作为对照组,入院后进行c Tn I定性检测,选取2017年7~11月我院出现胸闷胸痛患者28例作为研究组,入院后进行c Tn I定量检测,比较两组阳性率、敏感度和特异度。结果观察组阳性率为92.86%,高于对照组75.00%,差异有统计学意义(P<0.05);观察组敏感度和特异度分别为92.86%、96.43%,均高于对照组78.57%、82.14%,差异有统计学意义(P<0.05)。结论 c Tn I定量检测的敏感度及特异度均高于c Tn I定性检测,在急性心肌梗死筛查及诊断中具有良好的临床价值。
Objective To explore the clinical diagnostic value of quantitative and qualitative detection of cardiac troponin I(c Tn I) in acute myocardial infarction,and to provide reference for the diagnosis and treatment of clinical acute myocardial infarction. Methods Twenty-eight patients with chest distress chest pain in our hospital from January to June 2017 were selected as the control group,and c Tn I qualitative detection was performed after admission.Twenty-eight patients with chest distress and chest pain in our hospital from July to November 2017 were selected as the study group,and c Tn I was quantitatively detected after admission.The positive rate,sensitivity and specificity of the two groups were compared. Results The positive rate of the observation group was 92.86%,higher than that of the control group(75.00%),and the difference was statistically significant(P < 0.05).The sensitivity and specificity of the observation group were 92.86% and 96.43%,respectively,which were higher than those of the control group 78.57% and 82.14%,respectively,and the difference was statistically significant(P < 0.05). Conclusion The sensitivity and specificity of quantitative detection of c Tn I are higher than those of qualitative detection of c Tn I,which has good clinical value in screening and diagnosis of acute myocardial infarction.
Objective To explore the clinical diagnostic value of quantitative and qualitative detection of cardiac troponin I(c Tn I) in acute myocardial infarction,and to provide reference for the diagnosis and treatment of clinical acute myocardial infarction. Methods Twenty-eight patients with chest distress chest pain in our hospital from January to June 2017 were selected as the control group,and c Tn I qualitative detection was performed after admission.Twenty-eight patients with chest distress and chest pain in our hospital from July to November 2017 were selected as the study group,and c Tn I was quantitatively detected after admission.The positive rate,sensitivity and specificity of the two groups were compared. Results The positive rate of the observation group was 92.86%,higher than that of the control group(75.00%),and the difference was statistically significant(P < 0.05).The sensitivity and specificity of the observation group were 92.86% and 96.43%,respectively,which were higher than those of the control group 78.57% and 82.14%,respectively,and the difference was statistically significant(P < 0.05). Conclusion The sensitivity and specificity of quantitative detection of c Tn I are higher than those of qualitative detection of c Tn I,which has good clinical value in screening and diagnosis of acute myocardial infarction.
引文
[1]许茵,杨小娟,张根兴,等.肌钙蛋白及肌酸激酶同工酶检测在急性心肌梗死诊断中的临床意义[J].中国实验诊断学,2015,19(3):443-444.
[2]余苗苗,王奇志.急性心肌梗死患者血清BNP、Tn I、CK-MB水平及其临床意义[J].医学综述,2013,19(14):2640-2642.
[3]马丽,王铁军,李建军,等.C反应蛋白联合血清肌钙蛋白在急性心肌梗死早期诊断中的应用价值[J].陕西医学杂志,2014,43(4):440-441.
[4]余俊,朱武军,李红霞,等.急性心肌梗死早期血清和肽素、肌钙蛋白的变化及其临床意义[J].第三军医大学学报,2013,35(21):2382-2383.
[5]董念,李远,付建华,等.血清高敏肌钙蛋白T检测对急性心肌梗死的早期诊断效能评价[J].山东医药,2015,55(15):51-53.
[6]刘勇.高敏肌钙蛋白在急性心肌梗死患者临床诊断中的应用价值[J].职业与健康,2016,32(7):1003-1005.
[7]王家安,田玉峰,律洁,等.高敏心肌肌钙蛋白T检测在急性心肌梗死诊断中临床应用[J].标记免疫分析与临床,2015,22(3):177-180.
[8]张静瑜,张伟,夏昌宇,等.固相免疫层析定性法和化学发光定量法检测心肌肌钙蛋白I比较[J].临床检验杂志,2013,31(8):571-572.
[9]吴晓燕,张光宇,任江华,等.不同时间段检测肌钙蛋白对急性心肌梗死的诊断意义[J].中西医结合心脑血管病杂志,2014,12(7):812-813.
[10]杨硕,怀伟,刘桂花,等.高敏心肌肌钙蛋白T在急性心肌梗死早期诊断中的临床价值[J].中华检验医学杂志,2014,37(2):150-154.
[11]闫先侠,孙晓,牛爱军,等.高敏心肌肌钙蛋白T检测在急性心肌梗死诊断中临床应用[J].医学临床研究,2015,22(2):177-180.
[12]樊淑珍,赵国君.超敏肌钙蛋白T定量与急性冠状动脉综合征病人预后的相关性研究[J].内蒙古医科大学学报,2016,38(4):316-319.
[13]王冲.肌酸激酶同工酶联合肌红蛋白,肌钙蛋白对急性心肌梗死的快速诊断价值[J].中国卫生标准管理,2015,6(27):144-145.
[14]张美玲.急性心肌梗死患者肌钙蛋白与冠状动脉狭窄程度的关系[J].当代医学,2015,33(404):78-79.
[15]魏晓霞,肖传实,李虹,等.联合检测血浆和肽素与肌钙蛋白在急性心肌梗死诊断中的应用[J].临床医药实践,2013,22(4):243-245.
[2]余苗苗,王奇志.急性心肌梗死患者血清BNP、Tn I、CK-MB水平及其临床意义[J].医学综述,2013,19(14):2640-2642.
[3]马丽,王铁军,李建军,等.C反应蛋白联合血清肌钙蛋白在急性心肌梗死早期诊断中的应用价值[J].陕西医学杂志,2014,43(4):440-441.
[4]余俊,朱武军,李红霞,等.急性心肌梗死早期血清和肽素、肌钙蛋白的变化及其临床意义[J].第三军医大学学报,2013,35(21):2382-2383.
[5]董念,李远,付建华,等.血清高敏肌钙蛋白T检测对急性心肌梗死的早期诊断效能评价[J].山东医药,2015,55(15):51-53.
[6]刘勇.高敏肌钙蛋白在急性心肌梗死患者临床诊断中的应用价值[J].职业与健康,2016,32(7):1003-1005.
[7]王家安,田玉峰,律洁,等.高敏心肌肌钙蛋白T检测在急性心肌梗死诊断中临床应用[J].标记免疫分析与临床,2015,22(3):177-180.
[8]张静瑜,张伟,夏昌宇,等.固相免疫层析定性法和化学发光定量法检测心肌肌钙蛋白I比较[J].临床检验杂志,2013,31(8):571-572.
[9]吴晓燕,张光宇,任江华,等.不同时间段检测肌钙蛋白对急性心肌梗死的诊断意义[J].中西医结合心脑血管病杂志,2014,12(7):812-813.
[10]杨硕,怀伟,刘桂花,等.高敏心肌肌钙蛋白T在急性心肌梗死早期诊断中的临床价值[J].中华检验医学杂志,2014,37(2):150-154.
[11]闫先侠,孙晓,牛爱军,等.高敏心肌肌钙蛋白T检测在急性心肌梗死诊断中临床应用[J].医学临床研究,2015,22(2):177-180.
[12]樊淑珍,赵国君.超敏肌钙蛋白T定量与急性冠状动脉综合征病人预后的相关性研究[J].内蒙古医科大学学报,2016,38(4):316-319.
[13]王冲.肌酸激酶同工酶联合肌红蛋白,肌钙蛋白对急性心肌梗死的快速诊断价值[J].中国卫生标准管理,2015,6(27):144-145.
[14]张美玲.急性心肌梗死患者肌钙蛋白与冠状动脉狭窄程度的关系[J].当代医学,2015,33(404):78-79.
[15]魏晓霞,肖传实,李虹,等.联合检测血浆和肽素与肌钙蛋白在急性心肌梗死诊断中的应用[J].临床医药实践,2013,22(4):243-245.