光学生物传感器在致病菌检测中的研究进展
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摘要
作为快速检测生物分子的工具,生物传感器在食品、农作物及临床医学的致病菌检测与诊断领域具有巨大应用潜力,其中可视化光学生物传感器由于其高灵敏度、高精度和高选择性等特征而受到广泛关注。综述比色光学生物传感器、等离子体光学生物传感器、微流体光学生物传感器近年来的最新进展。讨论并总结各种光学生物传感器的特性与局限性。论述多元化集成光学生物传感器在今后食品安全检测与监管方面的应用前景。
Biosensor,as a tool for rapid detection of biomolecules,has shown its great potential of application in detection and diagnosis of pathogenic bacteria in food,crops,clinical medicine,and other fields. And visual optical biosensor has attracted much attention because of its advantages of quickness,sensitivity,accuracy and high selectivity. This paper mainly summarized the latest research progresses from three aspects of colorimetric optical biosensor,plasma optical biosensor and microfluid optical biosensor,discussed characteristics,application fields and main problems of various optical biosensors,and expounded the application prospects of diversified integrated optical biosensors in the field of detection and supervision on food safety in the future.
Biosensor,as a tool for rapid detection of biomolecules,has shown its great potential of application in detection and diagnosis of pathogenic bacteria in food,crops,clinical medicine,and other fields. And visual optical biosensor has attracted much attention because of its advantages of quickness,sensitivity,accuracy and high selectivity. This paper mainly summarized the latest research progresses from three aspects of colorimetric optical biosensor,plasma optical biosensor and microfluid optical biosensor,discussed characteristics,application fields and main problems of various optical biosensors,and expounded the application prospects of diversified integrated optical biosensors in the field of detection and supervision on food safety in the future.
引文
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[3]Luo X,Davis J J.ChemInform Abstract:Electrical Biosensors and the Label Free Detection of Protein Disease Biomarkers[J].Chemical Society Reviews,2013,42(13):5944-5962
[4]Ahmed A,Rushworth J V,Hirst N A,et al.Biosensors for whole-cell bacterial detection[J].Clin Microbiol Rev,2014,27(3):631-646
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[6]Harel E,Schroder L,Xu S.Novel detection schemes of nuclear magnetic resonance and magnetic resonance imaging:applications from analytical chemistry to molecular sensors[J].Annu Rev Anal Chem(Palo Alto Calif),2008,1(1):133-163
[7]Pires N M,Dong T,Hanke U,et al.Recent developments in optical detection technologies in lab-on-a-chip devices for biosensing applications[J].Sensors(Basel),2014,14(8):15458-15479
[8]Vasan A S,Mahadeo D M,Doraiswami R,et al.Point-of-care biosensor system[J].Frontiers in Bioscience,2013,s5(1):39-71
[9]P觟hlmann C,Dieser I,Sprinzl M.A lateral flow assay for identification of Escherichia coli by ribosomal RNA hybridisation[J].Analyst,2014,139(5):1063-71
[10]Hossain S M Z,Ozimok C,Sicard C,et al.Multiplexed paper test strip for quantitative bacterial detection[J].Analytical&Bioanalytical Chemistry,2012,403(6):1567-1576
[11]Shafiee H,Asghar W,Inci F.Paper and flexible substrates as materials for biosensing platforms to detect multiple biotargets[J].Scientific Reports,2015,5:8719
[12]Shu Q,Wang L,Ouyang H,et al.Multiplexed immunochromatographic test strip for time-resolved chemiluminescent detection of pesticide residues using a bifunctional antibody[J].Biosens Bioelectron,2017,87(9):8-14
[13]Ge S,Zhang L,Zhang Y,et al.Nanomaterials-modified cellulose paper as a platform for biosensing applications[J].Nanoscale,2017,9(13):4366-4382
[14]Martinez A W,Phillips S T,Wiley B J,et al.FLASH:A rapid method for prototyping paper-based microfluidic devices[J].Lab on a Chip,2008,8:2146-2150
[15]Xia Y,Si J,Li Z.Fabrication techniques for microfluidic paperbased analytical devices and their applications for biological testing:A review[J].Biosensors&Bioelectronics,2016,77(7):74-89
[16]Oliveira R A G D,Camargo F,Pesquero N C,et al.A simple method to produce 2D and 3D microfluidic paper-based analytical devices for clinical analysis[J].Analytica Chimica Acta,2017,957:40-46
[17]Roda A,Mirasoli M,Michelini E,et al.Progress in chemical luminescence-based biosensors:A critical review[J].Biosensors&Bioelectronics,2016,76:164-179
[18]Tram K,Kanda P,Salena B J,et al.Translating bacterial detection by DNAzymes into a litmus test[J].Angew Chem Int Ed Engl,2015,53:12799-12802
[19]Tokel O,Inci F,Demirci U.Advances in plasmonic technologies for point of care applications[J].Chem Rev,2014,114(11):5728-5752
[20]Torun O,Hakkl B I,Temür E,et al.Comparison of sensing strategies in SPR biosensor for rapid and sensitive enumeration of bacteria[J].Biosensors&Bioelectronics,2012,37(1):53-60
[21]Yoo S M,Kim D K,Lee S Y.Aptamer-functionalized localized surface plasmon resonance sensor for the multiplexed detection of different bacterial species[J].Talanta,2015,132:112-117
[22]Kim D K,Yoo S M,Park T J,et al.Plasmonic properties of the multispot copper-capped nanoparticle array chip and its application to optical biosensors for pathogen detection of multiplex DNAs[J].Analytical Chemistry,2011,83(16):6215-6222
[23]Kang T,Yoo S M,Yoon I,et al.Patterned multiplex pathogen DNAdetection by Au particle-on-wire SERS sensor[J].Nano Lett,2010,10(4):1189-1193
[24]Kearns H,Goodacre R,Jamieson L,et al.SERS Detection of Multiple Anti-microbial Resistant Pathogens using Nanosensors[J].Analytical Chemistry,2017,89(23):12666-12673
[25]Cate D M,Adkins J A,Mettakoonpitak J,et al.Recent developments in paper-based microfluidic devices[J].Anal Chem,2015,87(1):19-41
[26]Lee W,Kwon D,Choi W,et al.3D-Printed Microfluidic Device for the Detection of Pathogenic Bacteria Using Size-based Separation in Helical Channel with Trapezoid Cross-Section[J].Scientific Reports,2015,5(2):7717
[27]Ramalingam N,Rui Z,Liu H-B,et al.Real-time PCR-based microfluidic array chip for simultaneous detection of multiple waterborne pathogens[J].Sensors and Actuators B:Chemical,2010,145(1):543-552
[28]Connelly J T,Rolland J P,Whitesides G M.A"Paper Machine"for Molecular Diagnostics[J].Analytical Chemistry,2015,87(15):7595-7601
[29]Zhao X,Dong T,Yang Z,et al.Compatible immuno-NASBA LOCdevice for quantitative detection of waterborne pathogens:design and validation[J].Lab on A Chip,2012,12(3):602-612
[30]Foudeh A M,Daoud J T,Faucher S P,et al.Sub-femtomole detection of 16s rRNA from Legionella pneumophila using surface plasmon resonance imaging[J].Biosensors&Bioelectronics,2014,52(4):129-135
[31]Xu S,Zhang Y,Jia L,et al.Soft microfluidic assemblies of sensors,circuits,and radios for the skin[J].Science,2014,344:70-74
[32]Richarte A,Bruno J G.Aptamer-Quantum Dot Lateral Flow Test Strip Development for Rapid and Sensitive Detection of Pathogenic Escherichia coli via Intimin,O157-Specific LPS and Shiga Toxin 1Aptamers[J].Current Bionanotechnology,2015,1(2):80-86
[33]Li C Z,Vandenberg K,Prabhulkar S,et al.Paper based point-ofcare testing disc for multiplex whole cell bacteria analysis[J].Biosensors&Bioelectronics,2011,26(11):4342-4348
[34]Raich T,Powell S.Identification of bacterial and fungal pathogens from positive blood culture bottles:A microarray-based approach[M].New York:Springer,2015,1237:73-90
[35]Tissari P.Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform:an observational study[J].Lancet,2010,375:224-230
[36]Zhou H,Yang D,Ivleva N P,et al.SERS Detection of Bacteria in Water by in Situ Coating with Ag Nanoparticles[J].Analytical Chemistry,2014,86(3):1525-1533
[37]Wang Y,Knoll W,Dostalek J.Bacterial pathogen surface plasmon resonance biosensor advanced by long range surface plasmons and magnetic nanoparticle assays[J].Analytical Chemistry,2012,84(19):8345-8350
[38]Carey J R,Suslick K S,Hulkower K I,et al.Rapid identification of bacteria with a disposable colorimetric sensing array[J].Journal of the American Chemical Society,2011,133(19):7571-7576
[39]Fronczek C F,You D J,Yoon J Y.Single-pipetting microfluidic assay device for rapid detection of Salmonella from poultry package[J].Biosensors&Bioelectronics,2013,40(1):342-349
[40]Wan Y,Zheng L,Sun Y,et al.Multifunctional semiconducting polymer dots for imaging,detection,and photo-killing of bacteria[J].Journal of Materials Chemistry B,2014,2(30):4818-4825
[41]Zagorovsky K,Chan W C.A plasmonic DNAzyme strategy for pointof-care genetic detection of infectious pathogens[J].Angewandte Chemie,2013,125(11):3250-3253
[42]Song D,Yang R,Wang H,et al.A Label-free SERRS-based nanosensor for ultrasensitive detection of mercury ions in drinking water and wastewater effluent[J].Analytical Methods,2016,9(1):154-162
[43]Raj D R,Sudarsanakumar C.Surface plasmon resonance based fiber optic sensor for the detection of cysteine using diosmin capped silver nanoparticles[J].Sensors&Actuators A Physical,2017,253(4):1-8
[44]Khoshfetrat S M,Mehrgardi M A.Amplified detection of leukemia cancer cells using an aptamer-conjugated gold-coated magnetic nanoparticles on a nitrogen-doped graphene modified electrode[J].Bioelectrochemistry,2017,114:24-32
[45]Tawil N,Mouawad F,Lévesque S,et al.The differential detection of methicillin-resistant,methicillin-susceptible and borderline oxacillin-resistant Staphylococcus aureus by surface plasmon resonance[J].Biosensors&Bioelectronics,2013,49:334-340
[46]Tawil N,Sacher E,Mandeville R,et al.Surface plasmon resonance detection of E.coli and methicillin-resistant S.aureus using bacteriophages[J].Biosensors&Bioelectronics,2012,37(1):24-29
[47]Bruno J G.Application of DNA Aptamers and Quantum Dots to Lateral Flow Test Strips for Detection of Foodborne Pathogens with Improved Sensitivity versus Colloidal Gold[J].Pathogens,2014,3(2):341-55
[48]Joung H A,Oh Y K,Kim M G.An automatic enzyme immunoassay based on a chemiluminescent lateral flow immunosensor[J].Biosensors&Bioelectronics,2014,53:330-335
[49]Yang Y,Noviana E,Nguyen M P,et al.Paper-Based Microfluidic Devices:Emerging Themes and Applications[J].Anal Chem,2017,89(1):71-91
[50]Nusz G J,Curry A C,Marinakos S M,et al.Rational Selection of Gold Nanorod Geometry for Label-Free Plasmonic Biosensors[J].Acs Nano,2009,3(4):795-806
[51]Nikfarjam A,Rezayan A H,Mohammadkhani G,et al.Label-Free Detection of Digoxin Using Localized Surface Plasmon ResonanceBased Nanobiosensor[J].Plasmonics,2017,12(1):157-164
[52]Tokel O,Yildiz U H,Inci F,et al.Portable Microfluidic Integrated Plasmonic Platform for Pathogen Detection[J].Scientific Reports,2015,5(9):152
[53]Coskun A F,Cetin A E,Galarreta B C,et al.Lensfree optofluidic plasmonic sensor for real-time and label-free monitoring of molecular binding events over a wide field-of-view[J].Scientific Reports,2014,4(4):6789
[54]Kasera S,Herrmann L O,Barrio J D,et al.Quantitative multiplexing with nano-self-assemblies in SERS[J].Scientific Reports,2014,4(4):6785
[55]Hennigan S L,Driskell J D,Fergusonnoel N,et al.Detection and Differentiation of Avian Mycoplasmas by Surface-Enhanced Raman Spectroscopy Based on a Silver Nanorod Array[J].Applied&Environmental Microbiology,2012,78(6):1930-1935
[56]SM Y,T K,H K,et al.Combining a nanowire SERRS sensor and a target recycling reaction for ultrasensitive and multiplex identification of pathogenic fungi[J].Small(Weinheim an der Bergstrasse,Germany),2011,7(23):3371-3376
[57]Sivanesan A,Witkowska E,Adamkiewicz W,et al.Nanostructured silver-gold bimetallic SERS substrates for selective identification of bacteria in human blood[J].Analyst,2014,139(5):1037-1043
[58]Yi Z,Xu X,Kang X,et al.Fabrication of well-aligned ZnO@Ag nanorod arrays with effective charge transfer for surface-enhanced Raman scattering[J].Surface&Coatings Technology,2017,324:257-263
[2]Fournier P E,Drancourt M,Colson P,et al.Modern clinical microbiology:new challenges and solutions[J].Nature Reviews Microbiology,2013,11(8):574-585
[3]Luo X,Davis J J.ChemInform Abstract:Electrical Biosensors and the Label Free Detection of Protein Disease Biomarkers[J].Chemical Society Reviews,2013,42(13):5944-5962
[4]Ahmed A,Rushworth J V,Hirst N A,et al.Biosensors for whole-cell bacterial detection[J].Clin Microbiol Rev,2014,27(3):631-646
[5]Cheng C I,Chang Y P,Chu Y H.Biomolecular interactions and tools for their recognition:focus on the quartz crystal microbalance and its diverse surface chemistries and applications[J].Chemical Society Reviews,2012,41(5):1947-1971
[6]Harel E,Schroder L,Xu S.Novel detection schemes of nuclear magnetic resonance and magnetic resonance imaging:applications from analytical chemistry to molecular sensors[J].Annu Rev Anal Chem(Palo Alto Calif),2008,1(1):133-163
[7]Pires N M,Dong T,Hanke U,et al.Recent developments in optical detection technologies in lab-on-a-chip devices for biosensing applications[J].Sensors(Basel),2014,14(8):15458-15479
[8]Vasan A S,Mahadeo D M,Doraiswami R,et al.Point-of-care biosensor system[J].Frontiers in Bioscience,2013,s5(1):39-71
[9]P觟hlmann C,Dieser I,Sprinzl M.A lateral flow assay for identification of Escherichia coli by ribosomal RNA hybridisation[J].Analyst,2014,139(5):1063-71
[10]Hossain S M Z,Ozimok C,Sicard C,et al.Multiplexed paper test strip for quantitative bacterial detection[J].Analytical&Bioanalytical Chemistry,2012,403(6):1567-1576
[11]Shafiee H,Asghar W,Inci F.Paper and flexible substrates as materials for biosensing platforms to detect multiple biotargets[J].Scientific Reports,2015,5:8719
[12]Shu Q,Wang L,Ouyang H,et al.Multiplexed immunochromatographic test strip for time-resolved chemiluminescent detection of pesticide residues using a bifunctional antibody[J].Biosens Bioelectron,2017,87(9):8-14
[13]Ge S,Zhang L,Zhang Y,et al.Nanomaterials-modified cellulose paper as a platform for biosensing applications[J].Nanoscale,2017,9(13):4366-4382
[14]Martinez A W,Phillips S T,Wiley B J,et al.FLASH:A rapid method for prototyping paper-based microfluidic devices[J].Lab on a Chip,2008,8:2146-2150
[15]Xia Y,Si J,Li Z.Fabrication techniques for microfluidic paperbased analytical devices and their applications for biological testing:A review[J].Biosensors&Bioelectronics,2016,77(7):74-89
[16]Oliveira R A G D,Camargo F,Pesquero N C,et al.A simple method to produce 2D and 3D microfluidic paper-based analytical devices for clinical analysis[J].Analytica Chimica Acta,2017,957:40-46
[17]Roda A,Mirasoli M,Michelini E,et al.Progress in chemical luminescence-based biosensors:A critical review[J].Biosensors&Bioelectronics,2016,76:164-179
[18]Tram K,Kanda P,Salena B J,et al.Translating bacterial detection by DNAzymes into a litmus test[J].Angew Chem Int Ed Engl,2015,53:12799-12802
[19]Tokel O,Inci F,Demirci U.Advances in plasmonic technologies for point of care applications[J].Chem Rev,2014,114(11):5728-5752
[20]Torun O,Hakkl B I,Temür E,et al.Comparison of sensing strategies in SPR biosensor for rapid and sensitive enumeration of bacteria[J].Biosensors&Bioelectronics,2012,37(1):53-60
[21]Yoo S M,Kim D K,Lee S Y.Aptamer-functionalized localized surface plasmon resonance sensor for the multiplexed detection of different bacterial species[J].Talanta,2015,132:112-117
[22]Kim D K,Yoo S M,Park T J,et al.Plasmonic properties of the multispot copper-capped nanoparticle array chip and its application to optical biosensors for pathogen detection of multiplex DNAs[J].Analytical Chemistry,2011,83(16):6215-6222
[23]Kang T,Yoo S M,Yoon I,et al.Patterned multiplex pathogen DNAdetection by Au particle-on-wire SERS sensor[J].Nano Lett,2010,10(4):1189-1193
[24]Kearns H,Goodacre R,Jamieson L,et al.SERS Detection of Multiple Anti-microbial Resistant Pathogens using Nanosensors[J].Analytical Chemistry,2017,89(23):12666-12673
[25]Cate D M,Adkins J A,Mettakoonpitak J,et al.Recent developments in paper-based microfluidic devices[J].Anal Chem,2015,87(1):19-41
[26]Lee W,Kwon D,Choi W,et al.3D-Printed Microfluidic Device for the Detection of Pathogenic Bacteria Using Size-based Separation in Helical Channel with Trapezoid Cross-Section[J].Scientific Reports,2015,5(2):7717
[27]Ramalingam N,Rui Z,Liu H-B,et al.Real-time PCR-based microfluidic array chip for simultaneous detection of multiple waterborne pathogens[J].Sensors and Actuators B:Chemical,2010,145(1):543-552
[28]Connelly J T,Rolland J P,Whitesides G M.A"Paper Machine"for Molecular Diagnostics[J].Analytical Chemistry,2015,87(15):7595-7601
[29]Zhao X,Dong T,Yang Z,et al.Compatible immuno-NASBA LOCdevice for quantitative detection of waterborne pathogens:design and validation[J].Lab on A Chip,2012,12(3):602-612
[30]Foudeh A M,Daoud J T,Faucher S P,et al.Sub-femtomole detection of 16s rRNA from Legionella pneumophila using surface plasmon resonance imaging[J].Biosensors&Bioelectronics,2014,52(4):129-135
[31]Xu S,Zhang Y,Jia L,et al.Soft microfluidic assemblies of sensors,circuits,and radios for the skin[J].Science,2014,344:70-74
[32]Richarte A,Bruno J G.Aptamer-Quantum Dot Lateral Flow Test Strip Development for Rapid and Sensitive Detection of Pathogenic Escherichia coli via Intimin,O157-Specific LPS and Shiga Toxin 1Aptamers[J].Current Bionanotechnology,2015,1(2):80-86
[33]Li C Z,Vandenberg K,Prabhulkar S,et al.Paper based point-ofcare testing disc for multiplex whole cell bacteria analysis[J].Biosensors&Bioelectronics,2011,26(11):4342-4348
[34]Raich T,Powell S.Identification of bacterial and fungal pathogens from positive blood culture bottles:A microarray-based approach[M].New York:Springer,2015,1237:73-90
[35]Tissari P.Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform:an observational study[J].Lancet,2010,375:224-230
[36]Zhou H,Yang D,Ivleva N P,et al.SERS Detection of Bacteria in Water by in Situ Coating with Ag Nanoparticles[J].Analytical Chemistry,2014,86(3):1525-1533
[37]Wang Y,Knoll W,Dostalek J.Bacterial pathogen surface plasmon resonance biosensor advanced by long range surface plasmons and magnetic nanoparticle assays[J].Analytical Chemistry,2012,84(19):8345-8350
[38]Carey J R,Suslick K S,Hulkower K I,et al.Rapid identification of bacteria with a disposable colorimetric sensing array[J].Journal of the American Chemical Society,2011,133(19):7571-7576
[39]Fronczek C F,You D J,Yoon J Y.Single-pipetting microfluidic assay device for rapid detection of Salmonella from poultry package[J].Biosensors&Bioelectronics,2013,40(1):342-349
[40]Wan Y,Zheng L,Sun Y,et al.Multifunctional semiconducting polymer dots for imaging,detection,and photo-killing of bacteria[J].Journal of Materials Chemistry B,2014,2(30):4818-4825
[41]Zagorovsky K,Chan W C.A plasmonic DNAzyme strategy for pointof-care genetic detection of infectious pathogens[J].Angewandte Chemie,2013,125(11):3250-3253
[42]Song D,Yang R,Wang H,et al.A Label-free SERRS-based nanosensor for ultrasensitive detection of mercury ions in drinking water and wastewater effluent[J].Analytical Methods,2016,9(1):154-162
[43]Raj D R,Sudarsanakumar C.Surface plasmon resonance based fiber optic sensor for the detection of cysteine using diosmin capped silver nanoparticles[J].Sensors&Actuators A Physical,2017,253(4):1-8
[44]Khoshfetrat S M,Mehrgardi M A.Amplified detection of leukemia cancer cells using an aptamer-conjugated gold-coated magnetic nanoparticles on a nitrogen-doped graphene modified electrode[J].Bioelectrochemistry,2017,114:24-32
[45]Tawil N,Mouawad F,Lévesque S,et al.The differential detection of methicillin-resistant,methicillin-susceptible and borderline oxacillin-resistant Staphylococcus aureus by surface plasmon resonance[J].Biosensors&Bioelectronics,2013,49:334-340
[46]Tawil N,Sacher E,Mandeville R,et al.Surface plasmon resonance detection of E.coli and methicillin-resistant S.aureus using bacteriophages[J].Biosensors&Bioelectronics,2012,37(1):24-29
[47]Bruno J G.Application of DNA Aptamers and Quantum Dots to Lateral Flow Test Strips for Detection of Foodborne Pathogens with Improved Sensitivity versus Colloidal Gold[J].Pathogens,2014,3(2):341-55
[48]Joung H A,Oh Y K,Kim M G.An automatic enzyme immunoassay based on a chemiluminescent lateral flow immunosensor[J].Biosensors&Bioelectronics,2014,53:330-335
[49]Yang Y,Noviana E,Nguyen M P,et al.Paper-Based Microfluidic Devices:Emerging Themes and Applications[J].Anal Chem,2017,89(1):71-91
[50]Nusz G J,Curry A C,Marinakos S M,et al.Rational Selection of Gold Nanorod Geometry for Label-Free Plasmonic Biosensors[J].Acs Nano,2009,3(4):795-806
[51]Nikfarjam A,Rezayan A H,Mohammadkhani G,et al.Label-Free Detection of Digoxin Using Localized Surface Plasmon ResonanceBased Nanobiosensor[J].Plasmonics,2017,12(1):157-164
[52]Tokel O,Yildiz U H,Inci F,et al.Portable Microfluidic Integrated Plasmonic Platform for Pathogen Detection[J].Scientific Reports,2015,5(9):152
[53]Coskun A F,Cetin A E,Galarreta B C,et al.Lensfree optofluidic plasmonic sensor for real-time and label-free monitoring of molecular binding events over a wide field-of-view[J].Scientific Reports,2014,4(4):6789
[54]Kasera S,Herrmann L O,Barrio J D,et al.Quantitative multiplexing with nano-self-assemblies in SERS[J].Scientific Reports,2014,4(4):6785
[55]Hennigan S L,Driskell J D,Fergusonnoel N,et al.Detection and Differentiation of Avian Mycoplasmas by Surface-Enhanced Raman Spectroscopy Based on a Silver Nanorod Array[J].Applied&Environmental Microbiology,2012,78(6):1930-1935
[56]SM Y,T K,H K,et al.Combining a nanowire SERRS sensor and a target recycling reaction for ultrasensitive and multiplex identification of pathogenic fungi[J].Small(Weinheim an der Bergstrasse,Germany),2011,7(23):3371-3376
[57]Sivanesan A,Witkowska E,Adamkiewicz W,et al.Nanostructured silver-gold bimetallic SERS substrates for selective identification of bacteria in human blood[J].Analyst,2014,139(5):1037-1043
[58]Yi Z,Xu X,Kang X,et al.Fabrication of well-aligned ZnO@Ag nanorod arrays with effective charge transfer for surface-enhanced Raman scattering[J].Surface&Coatings Technology,2017,324:257-263