更眠安汤治疗肾阴虚型更年期失眠疗效观察
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摘要
目的:观察更眠安汤对肾阴虚型更年期失眠患者血清促卵泡激素(FSH)、泌乳素(PRL)、雌二醇(E2)表达的影响,并观察疗效。方法:选取在浦东新区东明社区卫生服务中心门诊接受治疗的肾阴虚型更年期失眠患者120例作为研究对象,按随机原则将其分为对照组与观察组,每组各60例;对照组给予乌灵胶囊治疗,观察组给予更安眠汤治疗,持续治疗3个疗程;采用放射免疫分析法(RIA)检测两组患者血清FSH、PRL、E2的表达水平;观察记录两组患者的睡眠质量及其临床疗效。结果:治疗后,观察组的临床总有效率为90. 00%,显著高于对照组的71. 67%(P<0. 01);治疗后,两组患者的入睡时间均显著短于治疗前(P<0. 01),其睡眠时间均显著长于治疗前(P<0. 01);治疗后,观察组的入睡时间显著短于对照组(P<0. 01),其睡眠时间均长于对照组(P<0. 01)。治疗后两组患者血清FSH表达水平均显著低于治疗前(P<0. 01),观察组血清FSH表达水平显著低于对照组(P<0. 01);治疗后两组患者血清E2表达水平均显著高于治疗前(P<0. 01),观察组血清E2表达水平显著高于对照组(P<0. 01);治疗前后两组血清PRL表达水平的差异无统计学意义(P>0. 05)。结论:更眠安汤针对肾阴虚型更年期失眠患者能有效下调其血清FSH的表达,上调E2的表达,并能改善患者睡眠质量,提高临床疗效。
Objective: To explore the influence on serum FSH,PRL and E2 expressions of using Gengmian' an Decoction in the treatment of menopausal insomnia of kidney Yin-deficiency type and observing its curative effect. Methods: 120 cases of patients with menopausal insomnia of kidney Yin-deficiency type treated in Dongming Community Health Service of Pudong New District were selected as the study objects,and were divided into controlled group and observation group randomly,60 cases in each group. The controlled group were given Wuling Capsule,and the observation group were given Gengmian' an Decoction,all treated for 3courses. Serum FSH,PRL and E2 expressions were detected by using radioimmunoassay(RIA) in the two groups,and sleep quality and clinical effect were observed and recorded in the two groups. Results: After treatment,the total effective rate of the observation group was 90. 00%,significantly higher than that 71. 67% of the controlled group(P< 0. 01).Fall asleep time of the two groups was significantly shorter than that before treatment(P<0. 01),which of the observation group was significantly shorter than that of the controlled group(P<0. 01). Sleeping time was significantly longer than that before treatment in the two groups(P<0. 01),and that of the observation group was significantly longer than that in the controlled group(P<0. 01). Serum FSH expression in the two groups was significantly lower than that before treatment(P<0. 01),and that in the observation group was significantly lower than that in the controlled group(P<0. 01). Serum E2 expression in the two groups was significantly higher than that before treatment(P<0. 01),and that in the observation group was significantly higher than that in the controlled group(P<0. 01). There was no significant difference in serum PRL level before and after treatment(P> 0. 05).Conclusion: Gengmian' an Decoction can effectively down-regulate serum FSH expression,and up regulate E2 expression for the treatment of menopausal insomnia of kidney Yin-deficiency type. It can improve clinical effect.
Objective: To explore the influence on serum FSH,PRL and E2 expressions of using Gengmian' an Decoction in the treatment of menopausal insomnia of kidney Yin-deficiency type and observing its curative effect. Methods: 120 cases of patients with menopausal insomnia of kidney Yin-deficiency type treated in Dongming Community Health Service of Pudong New District were selected as the study objects,and were divided into controlled group and observation group randomly,60 cases in each group. The controlled group were given Wuling Capsule,and the observation group were given Gengmian' an Decoction,all treated for 3courses. Serum FSH,PRL and E2 expressions were detected by using radioimmunoassay(RIA) in the two groups,and sleep quality and clinical effect were observed and recorded in the two groups. Results: After treatment,the total effective rate of the observation group was 90. 00%,significantly higher than that 71. 67% of the controlled group(P< 0. 01).Fall asleep time of the two groups was significantly shorter than that before treatment(P<0. 01),which of the observation group was significantly shorter than that of the controlled group(P<0. 01). Sleeping time was significantly longer than that before treatment in the two groups(P<0. 01),and that of the observation group was significantly longer than that in the controlled group(P<0. 01). Serum FSH expression in the two groups was significantly lower than that before treatment(P<0. 01),and that in the observation group was significantly lower than that in the controlled group(P<0. 01). Serum E2 expression in the two groups was significantly higher than that before treatment(P<0. 01),and that in the observation group was significantly higher than that in the controlled group(P<0. 01). There was no significant difference in serum PRL level before and after treatment(P> 0. 05).Conclusion: Gengmian' an Decoction can effectively down-regulate serum FSH expression,and up regulate E2 expression for the treatment of menopausal insomnia of kidney Yin-deficiency type. It can improve clinical effect.
引文
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[11]李淼,白正勇.经方辨治更年期失眠探析[J].实用中医内科杂志,2011,25(3):17~18
[12]郭丹丹,郑虎占.我院中医治疗更年期综合征的用药分析[J].中国医药导报,2015,12(3):130~133
[13]高泽芹.女性体内的主要性激素[J].生物学教学,2011,36(1):69
[14]刘金勇,王媁,张松英,等.低剂量重组人促卵泡刺激素(r FSH)递增方案诱导排卵的多中心前瞻性研究[J].生殖与避孕,2014,34(1):17~26
[15] Miller EH. Women and insomnia[J]. Clinical Cornerstone,2004,6(1):8~18
[16]张琼梅,于英,肖玲.女性更年期临床症状与血清雌激素和促卵泡刺激素水平的关系[J].宁夏医科大学学报,2015,37(8):956~958
[17] Rossouw JE,Anderson GL,Prentice RL,et al. Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women:Principal Results From the Women’ s Health Initiative Randomized Controlled Trial[J]. Revista Medica De Chile,2002,288(3):321~333
[2]刘剑钢,张培林.中西医结合治疗更年期综合征53例[J].河南中医,2006,26(10):69~70
[3]涂轶佳,朱燕芬,陈理,等.“更眠安汤”治疗肾阴虚型女性更年期失眠的临床疗效[J].上海医药,2014,35(22):36~38
[4]乐杰.妇产科学[M].第六版.北京:人民卫生出版社,2006:349~350
[5]中华医学会精神科分会.《CCMD-3中国精神障碍分类与诊断标准》[M].济南:山东科学技术出版社,2001:118~119
[6]中华人民共和国卫生部.中药新药临床研究指导原则[M].第三辑. 1997:17~18
[7]韦丽丽,娄必丹.从脏腑论治围绝经期综合征[J].中医药导报,2013,19(11):69~71
[8] Lindbloom EJ. Do the risks of estrogen plus progestin outweigh the benefits in healthy post-menopausal women?[J]. Journal of Family Practice,2002,51(10):245~249
[9]李艳华,危秀青,郑巧玲,等.妇女围绝经期综合征发生率及相关因素的调查[J].海峡预防医学杂志,2006,12(4):68~69
[10] Ebeigbe JA,Ebeigbe PN. Sex hormone levels and intraocular pressure in postmenopausal Nigerian women[J]. African journal of medicine and medical sciences,2013,42(4):317~323
[11]李淼,白正勇.经方辨治更年期失眠探析[J].实用中医内科杂志,2011,25(3):17~18
[12]郭丹丹,郑虎占.我院中医治疗更年期综合征的用药分析[J].中国医药导报,2015,12(3):130~133
[13]高泽芹.女性体内的主要性激素[J].生物学教学,2011,36(1):69
[14]刘金勇,王媁,张松英,等.低剂量重组人促卵泡刺激素(r FSH)递增方案诱导排卵的多中心前瞻性研究[J].生殖与避孕,2014,34(1):17~26
[15] Miller EH. Women and insomnia[J]. Clinical Cornerstone,2004,6(1):8~18
[16]张琼梅,于英,肖玲.女性更年期临床症状与血清雌激素和促卵泡刺激素水平的关系[J].宁夏医科大学学报,2015,37(8):956~958
[17] Rossouw JE,Anderson GL,Prentice RL,et al. Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women:Principal Results From the Women’ s Health Initiative Randomized Controlled Trial[J]. Revista Medica De Chile,2002,288(3):321~333