小剂量红霉素长期口服对支气管扩张的疗效评估
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摘要
目的探讨小剂量红霉素(erythromycin)长期规律口服对支气管扩张症(bronchiectasis)患者的病情改善作用。方法选取2016年7月～2017年12月我院收治的41例支气管扩张症患者作为研究对象,跟踪检测、记录所有患者的咳嗽频率、咳痰量,肺功能第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1占预计值百分比(FEV1%pred)、呼气流量峰值(PEF)的前后变化,对小剂量红霉素治疗支气管扩张症患者的疗效做出评价。结果治疗后,患者白昼和夜间的咳嗽症状积分低于治疗前,痰量少于治疗前,差异均有统计学意义(P<0.05);治疗后,患者FEV1、FVC、FEV1%pred、PEF各指标的水平高于治疗前,差异均有统计学意义(P<0.05);所有患者均无严重不良反应发生。结论长期小剂量红霉素规律口服对支气管扩张患者咳嗽、咳痰症状及肺功能指标均有不同程度的改善作用。
Objective To explore the effect of long-term regular oral administration of Erythromycin at low dosage on improving the condition of patients with bronchiectasis. Methods A total of 41 patients with bronchiectasis admitted to our hospital from July 2016 to December 2017 were selected as the study subjects, the cough frequency, sputum volume, FEV1, FVC, FEV1% pred and PEF of all patients were monitored and recorded, the treatment of bronchiectasis with low dose Erythromycin was studied, the curative effect of the patients was evaluated. Results After treatment, the scores of cough symptoms in day and night were lower than those before treatment, and the sputum volume was less than that before treatment, the differences were statistically significant(P<0.05). After treatment, the levels of FEV1, FVC, FEV1%pred and PEF were higher than those before treatment, the differences were statistically significant(P<0.05). No serious adverse reactions occurred in all patients. Conclusion Long-term low-dose Erythromycin regular oral administration can improve the cough, sputum symptoms and lung function of patients with bronchiectasis to varying degrees.
Objective To explore the effect of long-term regular oral administration of Erythromycin at low dosage on improving the condition of patients with bronchiectasis. Methods A total of 41 patients with bronchiectasis admitted to our hospital from July 2016 to December 2017 were selected as the study subjects, the cough frequency, sputum volume, FEV1, FVC, FEV1% pred and PEF of all patients were monitored and recorded, the treatment of bronchiectasis with low dose Erythromycin was studied, the curative effect of the patients was evaluated. Results After treatment, the scores of cough symptoms in day and night were lower than those before treatment, and the sputum volume was less than that before treatment, the differences were statistically significant(P<0.05). After treatment, the levels of FEV1, FVC, FEV1%pred and PEF were higher than those before treatment, the differences were statistically significant(P<0.05). No serious adverse reactions occurred in all patients. Conclusion Long-term low-dose Erythromycin regular oral administration can improve the cough, sputum symptoms and lung function of patients with bronchiectasis to varying degrees.
引文
[1]薛雨松,高永斌,王张莹.罗红霉素联合氨茶碱对支气管扩张的疗效[J].临床肺科杂志,2016,21(4):722-725.
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[10]李双雪.长期小剂量红霉素联合沙美特罗替卡松粉吸入剂治疗重症慢性阻塞性肺病合并支气管扩张的观察[J],中国药物与临床,2011,11(9):1093-1094.
[11]周微.分析探讨口服小剂量罗红霉素对支气管扩张长期治疗的临床效果[J].中国现代药物应用,2014,8(1):184-185.
[12]韩慧.口服小剂量罗红霉素对支气管扩张长期治疗的效果观察[J].北方药学,2016,13(5):13-14.
[13]李强,饶常红,汪明雪.长期小剂量口服阿奇霉素联合噻托溴铵对支气管扩张症的疗效研究[J].重庆医学,2014,43(30):4082-4085.
[14]王永仓,孙晓光,孙砚诚,等.脾氨肽联合小剂量罗红霉素对支气管扩张稳定期疗效观察[J].河北医学,2016,22(2):295-296.
[15]Mcneill S.Erythromycin to prevent exacerbations of bronchiectasis[J].Thorax,2014,69(2):660-667.
[16]武文娟,张国俊,胡俊祥,等.红霉素对支气管扩张症患者呼吸道细菌的影响[J].中国现代医学杂志,2017,27(17):119-124.
[2]吴昕.三种大环内酯类药物治疗支气管扩张症的疗效分析[J].临床肺科杂志,2017,22(5):904-907.
[3]朱献强.小剂量罗红霉素口服治疗支气管扩张的长期疗效[J].甘肃科技,2017,33(15):120-121.
[4]Rhee CK,Jung JY,Lee SW,et al.The Korean Cough Guideline:Recommendation and Summary Statement[J].Tuberc Respir Dis(Seoul),2016,79(1):14-21.
[5]中华医学会呼吸病学分会哮喘分组.咳嗽的诊断与治疗指南(2015)[J].中华结核和呼吸杂志,2016,39(5):323-354.
[6]金连顺,祝鸿发,宋苹,等.基于中医传承辅助系统对张忠德教授治疗支气管扩张症的用药规律分析[J].中国医药导报,2017,14(25):94-97,118.
[7]孟兆平.小剂量红霉素长疗程口服治疗支气管扩张症稳定期50例[J].中国药业,2015,12(24):232-234.
[8]杨凤霞.小剂量红霉素长期口服佐治支气管扩张症稳定期患者效果评估[J].临床医学研究与实践,2017,2(2):8-9.
[9]胡国荣.长期小剂量服用罗红霉素对支气管扩张症稳定期患者胸部CT影像学及临床症状改变的影响[J].重庆医学,2014,43(1):124-126.
[10]李双雪.长期小剂量红霉素联合沙美特罗替卡松粉吸入剂治疗重症慢性阻塞性肺病合并支气管扩张的观察[J],中国药物与临床,2011,11(9):1093-1094.
[11]周微.分析探讨口服小剂量罗红霉素对支气管扩张长期治疗的临床效果[J].中国现代药物应用,2014,8(1):184-185.
[12]韩慧.口服小剂量罗红霉素对支气管扩张长期治疗的效果观察[J].北方药学,2016,13(5):13-14.
[13]李强,饶常红,汪明雪.长期小剂量口服阿奇霉素联合噻托溴铵对支气管扩张症的疗效研究[J].重庆医学,2014,43(30):4082-4085.
[14]王永仓,孙晓光,孙砚诚,等.脾氨肽联合小剂量罗红霉素对支气管扩张稳定期疗效观察[J].河北医学,2016,22(2):295-296.
[15]Mcneill S.Erythromycin to prevent exacerbations of bronchiectasis[J].Thorax,2014,69(2):660-667.
[16]武文娟,张国俊,胡俊祥,等.红霉素对支气管扩张症患者呼吸道细菌的影响[J].中国现代医学杂志,2017,27(17):119-124.