低氧运动调节脂代谢的研究进展
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摘要
低氧运动能更好的增加机体的能量消耗,促进脂肪酸β氧化(fatty acidβ-oxidation,FAO),调节胆固醇代谢,提供了更优越的脂代谢应激,降低体脂调节脂代谢。本文通过综述低氧运动对脂代谢的影响,探讨低氧运动调节脂代谢的分子机制及生理学意义,展望脂代谢的研究前景,旨为解决全球性超重与肥胖问题提供新的思路。
Hypoxia exercise can increase the body's energy consumption, promote fatty acid β-oxidation(FAO), regulate cholesterol metabolism, provide superior lipid metabolism stress, and reduce body fat regulation of lipid metabolism. This paper reviewed the effects of hypoxic exercise on lipid metabolism, explored the molecular mechanism and physiological significance of hypoxic exercise regulating lipid metabolism, and prospected the research prospects of lipid metabolism, aiming at providing a new way to solve the global problem of overweight and obesity.
Hypoxia exercise can increase the body's energy consumption, promote fatty acid β-oxidation(FAO), regulate cholesterol metabolism, provide superior lipid metabolism stress, and reduce body fat regulation of lipid metabolism. This paper reviewed the effects of hypoxic exercise on lipid metabolism, explored the molecular mechanism and physiological significance of hypoxic exercise regulating lipid metabolism, and prospected the research prospects of lipid metabolism, aiming at providing a new way to solve the global problem of overweight and obesity.
引文
[1]朱磊,路瑛丽,冯连世,等.Microrna调节脂代谢的研究进展[J].中国体育科技,2016,52(3):61-68.
[2] Henderson G C,Fattor J A,Horning M A,etc.Lipolysis and fatty acidmetabolism in men and women during the postexercise recovery peri-od[J].Journal of Physiology,2007,584(3):963-981.
[3] Horscroft J,Murray A J.Skeletal muscle energy metabolism in envi-ronmental hypoxia:Climbing towards consensus[J]. Extreme Physi-ology&Medicine,2014,3(1):19.
[4] Edward M,Wendolyn G,Daniel B,et al.When energy balance ismaintained, exercise does not induce negative fat balance in leansedentary,obese sedentary,or lean endurance-trained individuals[J].Journal of Applied Physiology,2009,107(6):1847.
[5] Justin T,Kevin C,Daniel R M,et al.Acute high-intensity enduranceexercise is more effective than moderate-intensity exercise for atten-uation of postprandial triglyceride elevation[J]. Journal of AppliedPhysiology,2013,114(6):792-800.
[6] Liam K,Fabien A B.Acute normobaric hypoxia increases post-exer-cise lipid oxidation in healthy males[J].Frontiers in Physiology,2017,8(293):1-10.
[7]朱磊.低氧训练诱导mir-27/pparγ、mir-122/pparβ调控肥胖大鼠肝脏脂代谢机理的研究[D].上海体育学院,2016.
[8]朱磊,路瑛丽,冯连世.低氧训练诱导mir-27/pparγ调控肥胖大鼠肝脏脂肪酸代谢变化的研究[J].中国体育科技,2018(1):115-122.
[9] Qiang L,Juan Z.Lipid metabolism in alzheimer's disease[J].ScienceBulletin(English),2014(02):331-345.
[10] Zhao S,Jing W,Song X L,et al.Impact of dietary protein on lipidmetabolism-related gene expression in porcine adipose tissue[J].Nutrition&Metabolism,2010,7(1):6-6.
[11]张素娴,朱磊,冯连世,等.4周低氧运动对营养肥胖型大鼠骨骼肌自噬相关因子时序性变化的影响[J].中国运动医学杂志,2017,(12):1059-1065.
[12] Lu Y L,Jing W F,Lian S,et al.Effects of hypoxic exercise trainingon microrna expression and lipid metabolism in obese rat livers[J].Journal of Zhejiang University:b-volume English version,2014,15(9):820-829.
[13] Nikolaus N,Chytra R,Küpper T.Low intense physical exercise innormobaric hypoxia leads to more weight loss in obese people thanlow intense physical exercise in normobaric sham hypoxia[J].2008,12(2):129-134.
[14] Lippl F J,Neubauer S,Schipfer S,et al.Hypobaric hypoxia causesbody weight reduction in obese subjects[J]. Obesity,2012,18(4):675-681.
[15] Armellini F,Zamboni M,Robbi R,et al.The effects of high altitudetrekking on body composition and resting metabolic rate[J].Hor-mone&Metabolic Research,1997,29(09):458-461.
[16] Férézou J,Richalet J P,Coste T,et al.Changes in plasma lipids andlipoprotein cholesterol during a high altitude mountaineering expe-dition(4800m)[J].European Journal of Applied Physiology&Oc-cupational Physiology,1988,57(6):740-745.
[17] Galbès O,Goret L,Caillaud C,et al.Combined effects of hypoxia andendurance training on lipid metabolism in rat skeletal muscle[J].Acta Physiologica,2010,193(2):163-173.
[18] Keisho K,Kazushige G,Koji I,et al.Substrate utilization during ex-ercise and recovery at moderate altitude[J]. Metabolism Clinical&Experimental,2010,59(7):959-966.
[19] Wiesner S,Haufe S,Engeli S,et al.Influences of normobaric hypoxiatraining on physical fitness and metabolic risk markers in overweightto obese subjects[J].Obesity,2010,18(1):116.
[20] Chad W,Fabien A B.Post-metabolic response to passive normobarichypoxic exposure in sedendary overweight males:A pilot study[J].Nutrition&Metabolism,2012,9(1):103-103.
[21] Flatt J P.Carbohydrate-fat interactions and obesity examined by atwo-compartment computer model[J].Obesity,2012,12(12):2013-2022.
[22] Flatt J P.Misconceptions in body weight regulation:Implications forthe obesity pandemic[J]. Critical Reviews in Clinical LaboratorySciences,2012,49(4):150-165.
[23] Gregory H,Brando A.Determinants of resting lipid oxidation in re-sponse to a prior bout of endurance exercise[J]. Journal of AppliedPhysiology,2014,116(1):95-103.
[24]徐建方,路瑛丽,冯连世.低氧训练对肥胖大鼠脂肪组织miR-NA-27b/PPARγ脂代谢通路的影响[J].中国体育科技,2018,54(05):56-64.
[25]荆文,李传芬,冯连世,等.低氧训练通过HIF-1α-miR-122-5p-SREBP-1c调节肥胖大鼠肝脏脂代谢的机制研究[J].中国体育科技,2018,54(03):60-67.
[2] Henderson G C,Fattor J A,Horning M A,etc.Lipolysis and fatty acidmetabolism in men and women during the postexercise recovery peri-od[J].Journal of Physiology,2007,584(3):963-981.
[3] Horscroft J,Murray A J.Skeletal muscle energy metabolism in envi-ronmental hypoxia:Climbing towards consensus[J]. Extreme Physi-ology&Medicine,2014,3(1):19.
[4] Edward M,Wendolyn G,Daniel B,et al.When energy balance ismaintained, exercise does not induce negative fat balance in leansedentary,obese sedentary,or lean endurance-trained individuals[J].Journal of Applied Physiology,2009,107(6):1847.
[5] Justin T,Kevin C,Daniel R M,et al.Acute high-intensity enduranceexercise is more effective than moderate-intensity exercise for atten-uation of postprandial triglyceride elevation[J]. Journal of AppliedPhysiology,2013,114(6):792-800.
[6] Liam K,Fabien A B.Acute normobaric hypoxia increases post-exer-cise lipid oxidation in healthy males[J].Frontiers in Physiology,2017,8(293):1-10.
[7]朱磊.低氧训练诱导mir-27/pparγ、mir-122/pparβ调控肥胖大鼠肝脏脂代谢机理的研究[D].上海体育学院,2016.
[8]朱磊,路瑛丽,冯连世.低氧训练诱导mir-27/pparγ调控肥胖大鼠肝脏脂肪酸代谢变化的研究[J].中国体育科技,2018(1):115-122.
[9] Qiang L,Juan Z.Lipid metabolism in alzheimer's disease[J].ScienceBulletin(English),2014(02):331-345.
[10] Zhao S,Jing W,Song X L,et al.Impact of dietary protein on lipidmetabolism-related gene expression in porcine adipose tissue[J].Nutrition&Metabolism,2010,7(1):6-6.
[11]张素娴,朱磊,冯连世,等.4周低氧运动对营养肥胖型大鼠骨骼肌自噬相关因子时序性变化的影响[J].中国运动医学杂志,2017,(12):1059-1065.
[12] Lu Y L,Jing W F,Lian S,et al.Effects of hypoxic exercise trainingon microrna expression and lipid metabolism in obese rat livers[J].Journal of Zhejiang University:b-volume English version,2014,15(9):820-829.
[13] Nikolaus N,Chytra R,Küpper T.Low intense physical exercise innormobaric hypoxia leads to more weight loss in obese people thanlow intense physical exercise in normobaric sham hypoxia[J].2008,12(2):129-134.
[14] Lippl F J,Neubauer S,Schipfer S,et al.Hypobaric hypoxia causesbody weight reduction in obese subjects[J]. Obesity,2012,18(4):675-681.
[15] Armellini F,Zamboni M,Robbi R,et al.The effects of high altitudetrekking on body composition and resting metabolic rate[J].Hor-mone&Metabolic Research,1997,29(09):458-461.
[16] Férézou J,Richalet J P,Coste T,et al.Changes in plasma lipids andlipoprotein cholesterol during a high altitude mountaineering expe-dition(4800m)[J].European Journal of Applied Physiology&Oc-cupational Physiology,1988,57(6):740-745.
[17] Galbès O,Goret L,Caillaud C,et al.Combined effects of hypoxia andendurance training on lipid metabolism in rat skeletal muscle[J].Acta Physiologica,2010,193(2):163-173.
[18] Keisho K,Kazushige G,Koji I,et al.Substrate utilization during ex-ercise and recovery at moderate altitude[J]. Metabolism Clinical&Experimental,2010,59(7):959-966.
[19] Wiesner S,Haufe S,Engeli S,et al.Influences of normobaric hypoxiatraining on physical fitness and metabolic risk markers in overweightto obese subjects[J].Obesity,2010,18(1):116.
[20] Chad W,Fabien A B.Post-metabolic response to passive normobarichypoxic exposure in sedendary overweight males:A pilot study[J].Nutrition&Metabolism,2012,9(1):103-103.
[21] Flatt J P.Carbohydrate-fat interactions and obesity examined by atwo-compartment computer model[J].Obesity,2012,12(12):2013-2022.
[22] Flatt J P.Misconceptions in body weight regulation:Implications forthe obesity pandemic[J]. Critical Reviews in Clinical LaboratorySciences,2012,49(4):150-165.
[23] Gregory H,Brando A.Determinants of resting lipid oxidation in re-sponse to a prior bout of endurance exercise[J]. Journal of AppliedPhysiology,2014,116(1):95-103.
[24]徐建方,路瑛丽,冯连世.低氧训练对肥胖大鼠脂肪组织miR-NA-27b/PPARγ脂代谢通路的影响[J].中国体育科技,2018,54(05):56-64.
[25]荆文,李传芬,冯连世,等.低氧训练通过HIF-1α-miR-122-5p-SREBP-1c调节肥胖大鼠肝脏脂代谢的机制研究[J].中国体育科技,2018,54(03):60-67.