纸型便携式金纳米簇器件可视化检测汞离子
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摘要
合成了谷胱甘肽(GSH)包覆的荧光金纳米簇(AuNCs),基于Hg~(2+)-Au~+间的高亲合作用实现对汞离子(Hg~(2+))的高灵敏性、高选择性荧光检测,线性检测范围为4～200 nmol/L,检出限(LOD,S/N=3)为2.4 nmol/L。常见的金属离子(Ni~(2+), Mn~(2+), Co~(2+), Na~+, Ba~(2+), Cu~(2+), Zn~(2+), Mg~(2+), Cd~(2+), Ca~(2+), K~+, Fe~(3+), Al~(3+), Pb~(2+))和阴离子(F~-, C_2O■, Cl~-, H_2PO_4~-, NO_3~-, SO■, HCOO~-, I~-, C_5H_7O_5COO~-, CH_3COO~-, Br~-, CO■)对检测没有干扰。基于GSH-AuNCs构筑了两种纸型便携式AuNCs器件:半定量试纸和纸型横向流动检验(LFA)试剂盒,并成功用于可视化检测自来水样中Hg~(2+)。
Glutathione-stabilized gold nanoclusters(GSH-AuNCs) was synthesized for highly sensitive and selective detection of Hg~(2+) based on high-affinity metallophilic Hg~(2+)-Au~+ interactions. The linear detection range was 4-200 nmol/L,with a limit of detection(LOD, S/N=3) of 2.4 nmol/L(S/N=3). This sensing system had high selectivity towards Hg~(2+ )over some common cations(including Ni~(2+), Mn~(2+), Co~(2+), Na~+, Ba~(2+), Cu~(2+), Zn~(2+), Mg~(2+), Cd~(2+), Ca~(2+), K~+, Fe~(3+), Al~(3+) and Pb~(2+)) and anions(including F~-, C_2O■, Cl~-, H_2PO_4~-, NO_3~-, SO■, HCOO~-, I~-, C_5H_7O_5COO~-, CH_3COO~-, Br~- and CO■) did not interfere with the determination. Furthermore, paper-based portable AuNC devices, including test strip and lateral flow assay(LFA) devices, was constructed for visual detection of Hg~(2+) in tap water, which showed good potentials application procpect.
Glutathione-stabilized gold nanoclusters(GSH-AuNCs) was synthesized for highly sensitive and selective detection of Hg~(2+) based on high-affinity metallophilic Hg~(2+)-Au~+ interactions. The linear detection range was 4-200 nmol/L,with a limit of detection(LOD, S/N=3) of 2.4 nmol/L(S/N=3). This sensing system had high selectivity towards Hg~(2+ )over some common cations(including Ni~(2+), Mn~(2+), Co~(2+), Na~+, Ba~(2+), Cu~(2+), Zn~(2+), Mg~(2+), Cd~(2+), Ca~(2+), K~+, Fe~(3+), Al~(3+) and Pb~(2+)) and anions(including F~-, C_2O■, Cl~-, H_2PO_4~-, NO_3~-, SO■, HCOO~-, I~-, C_5H_7O_5COO~-, CH_3COO~-, Br~- and CO■) did not interfere with the determination. Furthermore, paper-based portable AuNC devices, including test strip and lateral flow assay(LFA) devices, was constructed for visual detection of Hg~(2+) in tap water, which showed good potentials application procpect.
引文
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2 Erxleben H, Ruzicka J. Anal. Chem., 2005, 77 (16): 5124-5128
3 Luis G, Rubio C, Revert C, Espinosa A, González-Weller D, Gutiérrez A J, Hardisson A. J. Food Compos. Anal., 2015, 39: 48-54
4 Shih T T, Hsu I H, Chen S N, Chen P H, Deng M J, Chen Y, Lin Y W, Sun Y C. Analyst, 2015, 140 (2): 600-608
5 Zhu Z Q, Su Y Y, Li J, Li D, Zhang J, Song S P, Zhao Y, Li G X, Fan C H. Anal. Chem., 2009, 81(18): 7660-7666
6 Sun Z Z, Zhang N, Si Y M, Li S, Wen J W, Zhu X B, Wang H. Chem. Commun., 2014, 50(65): 9196-9199
7 Niu C X, Liu Q L, Shang Z H, Zhao L, Ouyang J. Nanoscale, 2015, 7(18): 8457-8465
8 Shang L, Yang L X, Stockmar F, Popescu R, Trouillet V, Bruns M, Gerthsenb D, Nienhaus G U. Nanoscale, 2012, 4(14): 4155-4160
9 Li Y X, Chen Y T, Huang L, Ma L, Lin Q, Chen G N. Anal. Methods, 2015, 7(10): 4123-4129
10 Zhai Q F, Xing H H, Zhang X W, Li J, Wang E K. Anal. Chem., 2017, 89(14): 7788-7794
11 Mhetaer Tuerhong, XU Yang, YIN Xue-Bo. Chinese J. Anal. Chem., 2017, 45(1): 139-150木合塔尔·吐尔洪, 徐阳, 尹学博. 分析化学, 2017, 45(1): 139-150
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13 Yang X M, Yang L, Dou Y, Zhu S S. J. Mater. Chem. C, 2013, 1(41): 6748-6751
14 Xing H H, Zhang X W, Zhai Q F, Li J, Wang E K. Anal. Chem., 2017, 89(7): 3867-3872
15 Li L L, Liu H Y, Shen Y Y, Zhang J R, Zhu J J. Anal. Chem., 2011, 83(3): 661-665
16 Sun J, Yang F, Zhao D, Chen C X, Yang X R. ACS Appl. Mater. Interfaces, 2015, 7(12): 6860-6866
17 Shang L, Dong S J. Chem. Commun., 2008, 44(9): 1088-1090
18 GU Qiao-Rong, AI Jun-Jie, ZHANG Qian-Yun, DONG Ya-Nan, GAO Qiang. Chinese J. Anal. Chem., 2017, 45(9): 1278-1283谷巧荣, 艾俊杰, 张倩云, 董雅男, 高强. 分析化学, 2017, 45(9): 1278-1283
19 Chen L Y, Wang C W, Yuan Z Q, Chang H T. Anal. Chem. 2015, 87(1): 216-229
20 Shang L, Dong S J, Nienhausa G U. Nano Today, 2011, 6(4): 401-418
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24 Luo Z T, Yuan X, Yu Y, Zhang Q B, Leong D T, Lee J Y. Xie J P. J. Am. Chem. Soc., 2012, 134(40): 16662-16670
25 Pyo K, Thanthirige V D, Kwak K, Pandurangan P, Ramakrishna G, Lee D. J. Am. Chem. Soc., 2015, 137(25): 8244-8250
26 Zang J C, Li C A, Zhou K, Dong H S, Chen B, Wang F D, Zhao G H. Anal. Chem., 2016, 88(20): 10275-10283
27 Fang X E, Zhao Q Q, Cao H M, Liu J, Guan M, Kong J L. Analyst, 2015, 140(22): 7823-7826
28 Xu L Q, Neoh K G, Kang E T, Fu G D. J. Mater. Chem. A, 2013, 1(7): 2526-2532
29 Yang X, Wang J H, Su D Y, Xia Q D, Chai F, Wang C G, Qu F Y. Dalton Trans., 2014, 43(26): 10057-10063
30 Bian R X, Wu X T, Chai F, Li L, Zhang L Y, Wang T T, Wang C G, Su Z M. Sens. Actuators B, 2017, 241: 592-600
31 Negishi Y, Nobusada K, Tsukuda T. J. Am. Chem. Soc., 2005, 127(14): 5261-5270
32 EPA 816-F-02-013, National Primary Drinking Water Regulations, USA
33 GB/5749-2006, Standards for Drinking Water Quality. National Standards of the People's Republic of China 生活饮用水卫生标准. 中华人民共和国国家标准. GB/5749-2006
34 Huang L J, Zhu Q R, Zhu J, Luo L P, Pu S H, Zhang W T, Zhu W X, Sun J, Wang J L. Inorg. Chem., 2019, 58(2): 1638-1646
35 Gu S Y, Hsieh C T, Tsai Y Y, Gandomi Y A, Yeom S, Kihm K D, Fu C C, Juang R S. ACS Appl. Nano Mater., 2019, DOI: 10.1021/acsanm.8b02010
36 Yuan X, Yeow T J, Zhang Q B, Lee J Y, Xie J P. Nanoscale, 2012, 4(6): 1968-1971
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