畲族人群糖代谢异常对早期动脉粥样硬化的影响
摘要
目的通过臂踝脉搏波速度(baPWV)评估畲族人群糖代谢异常者的早期动脉粥样硬化(AS)情况及其影响因素。方法 4192例研究对象分为5组:正常糖代谢组(NGT)、空腹血糖受损组(IFG)、糖耐量异常组(IGT)、IFG+IGT组和糖尿病组(DM),比较各组一般临床资料:包括年龄、血压、体重指数(BMI),以及空腹血糖(FPG)、餐后2 h血糖(2hPG),血脂等生化指标,并以全自动动脉硬化检测仪测量baPWV。结果 1ba PWV在DM及糖调节受损(IGR)各组均显著高于正常血糖组,且DM组较各IGR组增加更为明显,而在IGR各组之间差异无统计学意义。2糖代谢异常者中baPWV与年龄、SBP、DBP、FPG、2hPG、TG、TC、LDL、HDL呈显著正相关,与BMI无相关性。结论畲族人群在糖尿病前期时早期AS已经开始。糖代谢异常导致的早期动脉病变是在血糖异常尤其是餐后血糖升高的基础上由血压、年龄、血脂等多种因素综合作用所致。
引文
[1]Cruickshank K,Riste L,Anderson SG,et al.Aortic pulsewave velocity and its relationship to mortality in diabetes and glucose intolerance:an integrated index of vascular function[J].Circulation,2002(106):2085-2090.
[2]ZJ Yang,J Liu,JP Ge,et al.Prevalence of cardiovascular disease risk factor in the Chinese population:the 2007–2008 China National Diabetes and Metabolic Disorders Study[J].Eur.Heart J,2011:7.
[3]Yamashina A,Tomiyama H,Arai T,et al.Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk[J].Hypertens Res,2003,26(8):615-622.
[4]Michele MD,Panico S,Celentano E,et al.Association of impaired glucose homeostasis with preclinical carotid atherosclerosis in women:Impact of the new American Diabetes Association criteria[J].Metabolism,2002(51):52-56.
[2]ZJ Yang,J Liu,JP Ge,et al.Prevalence of cardiovascular disease risk factor in the Chinese population:the 2007–2008 China National Diabetes and Metabolic Disorders Study[J].Eur.Heart J,2011:7.
[3]Yamashina A,Tomiyama H,Arai T,et al.Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk[J].Hypertens Res,2003,26(8):615-622.
[4]Michele MD,Panico S,Celentano E,et al.Association of impaired glucose homeostasis with preclinical carotid atherosclerosis in women:Impact of the new American Diabetes Association criteria[J].Metabolism,2002(51):52-56.