摘要
运用拼合原理,合成了2种桦木醛缩氨基硫脲配体以及它们的铜、银、镉、钯金属配合物,运用红外光谱、核磁共振氢谱、热重分析、飞行质谱和元素分析方法对其进行了结构表征,并测试了配体和配合物的抑菌活性和细胞毒性.结果表明:配合物Ag(L_1)_2NO_3·3H_2O对S.aureus 4220、S.mutans 3065和E.coli 1924有较好的抑制作用;配合物Ag(L_1)_2NO_3·3H_2O和Cu(L_1)_2Cl_2能够显著抑制Hela细胞的生存能力.
Using combination principle,two betulinal thiosemicarbazone ligands and their Cu(II),Ag(I),Cd(II)and Pd(II)metal complexes were synthesized,which were characterized by IR,~1H NMR,TGA,MALDI-TOF and elemental analysis.The ligands and their metal complexes were evaluated for their antimicrobial activity and cytotoxicity.The results showed that the complex Ag(L_1)_2NO_3·3H_2O has relatively good inhibitory effects on S.aureus 4220,S.mutans 3065 and E.coli 1924.Complexes Ag(L_1)_2NO_3·3H_2O and Cu(L_1)_2Cl_2 can significantly inhibit the viability of Hela cell.
引文
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