小儿豉翘清热颗粒辅助治疗小儿急性上呼吸道感染52例临床观察
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摘要
目的观察小儿豉翘清热颗粒联合头孢呋辛钠治疗小儿急性上呼吸道感染的疗效及对血清炎症因子的影响。方法选取我院儿内科收治的急性上呼吸道感染患儿104例,随机分为对照组和治疗组,各52例。对照组单纯予以头孢呋辛钠,治疗组在对照组治疗方法的基础上予小儿豉翘清热颗粒,治疗7 d后比较2组的临床疗效、治疗前后血清炎症因子的水平变化及不良反应发生情况。结果对照组总有效率为75.00%,治疗组为94.23%,2组比较,差异有统计学意义(P <0.05)。2组治疗前血清白细胞介素-2(IL-2)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平比较,差异均无统计学意义(P>0.05),具有可比性;治疗后2组IL-8、TNF-α水平均显著下降,IL-2水平明显升高,与同组治疗前比较,差异有统计学意义(P<0.01),且治疗组下降或升高更显著(P<0.05)。对照组总不良反应发生率为13.46%,治疗组为7.69%,2组比较,差异无统计学意义(P>0.05),且均经积极对症处理后缓解、消失。结论小儿豉翘清热颗粒联合头孢呋辛钠治疗小儿急性上呼吸道感染疗效显著,能有效改善机体炎症状态,且安全性较高,值得临床推广应用。
Objective To observe the efficacy of Xiao'er Chiqiao Qingre Keli( 小儿豉翘清热颗粒) combined with cefuroxime sodium in the treatment of children with acute upper respiratory tract infection and its effects on serum inflammatory factors.Methods A total of 104 children patients with acute upper respiratory tract infection admitted in the department of pediatric internal medicine of our hospital were randomly divided into control group and treatment group,with 52 cases in each. The control group was given cefuroxime sodium alone,the treatment group was given Xiao'er Chiqiao Qingre Keli on the basis of the control group.After 7 days of treatment,the clinical efficacy,the changes of the serum inflammatory factors before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the control group was 75.00%,that of the treatment group was 94. 23%,there was statistically significant difference between the two group( P <0.05).Before treatment,there was no statistically significant difference in serum levels IL-2,IL-8 and TNF-α between the two groups( P>0.05),and they were comparable; after treatment,the levels of IL-8 and TNF-α both decreased significantly,while the level of IL-2 increased significantly in the two groups,there was statistically significant difference compared with the same group before treatment( P<0.01),moreover,the decrease or increase of the treatment group was more significant( P < 0.05). The total incidence of adverse reactions of the control group was 13.46%,that of the treatment group was 7. 69%,there was no statistically significant difference between the two groups( P>0.05),and all of them were relieved and disappeared after positive symptomatic treatment.Conclusion It has significant effects to use Xiao'er Chiqiao Qingre Keli combined with cefuroxime sodium in the treatment of acute upper respiratory tract infection in children.It can effectively improve the inflammatory state of the body with good security,which is worthy of clinical promotion and application.
Objective To observe the efficacy of Xiao'er Chiqiao Qingre Keli( 小儿豉翘清热颗粒) combined with cefuroxime sodium in the treatment of children with acute upper respiratory tract infection and its effects on serum inflammatory factors.Methods A total of 104 children patients with acute upper respiratory tract infection admitted in the department of pediatric internal medicine of our hospital were randomly divided into control group and treatment group,with 52 cases in each. The control group was given cefuroxime sodium alone,the treatment group was given Xiao'er Chiqiao Qingre Keli on the basis of the control group.After 7 days of treatment,the clinical efficacy,the changes of the serum inflammatory factors before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the control group was 75.00%,that of the treatment group was 94. 23%,there was statistically significant difference between the two group( P <0.05).Before treatment,there was no statistically significant difference in serum levels IL-2,IL-8 and TNF-α between the two groups( P>0.05),and they were comparable; after treatment,the levels of IL-8 and TNF-α both decreased significantly,while the level of IL-2 increased significantly in the two groups,there was statistically significant difference compared with the same group before treatment( P<0.01),moreover,the decrease or increase of the treatment group was more significant( P < 0.05). The total incidence of adverse reactions of the control group was 13.46%,that of the treatment group was 7. 69%,there was no statistically significant difference between the two groups( P>0.05),and all of them were relieved and disappeared after positive symptomatic treatment.Conclusion It has significant effects to use Xiao'er Chiqiao Qingre Keli combined with cefuroxime sodium in the treatment of acute upper respiratory tract infection in children.It can effectively improve the inflammatory state of the body with good security,which is worthy of clinical promotion and application.
引文
[1]罗世惠,徐惠.小儿豉翘清热颗粒治疗小儿急性上呼吸道感染的疗效和安全性[J].现代中西医结合杂志,2014,23(29):3248-3249.
[2]杨爱英,杨俊红,肖雪娜,等.阿奇霉素与头孢呋辛治疗儿童呼吸道感染疗效比较[J].中国药师,2016,19(1):112-114.
[3]复旦大学上海医学院.实用内科学[M].12版.北京:人民卫生出版社,2005:245-247.
[4]中华人民共和国卫生部.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2012:354-355.
[5]张昆.喜炎平注射液联合小儿豉翘清热颗粒治疗儿童急性上呼吸道感染的临床观察[J].现代药物与临床,2015,30(9):1133-1136.
[6]左稳欣,张莉英.利巴韦林联合柴桂退热颗粒治疗上呼吸道感染患儿的疗效[J].实用临床医药杂志,2016,20(5):159-160.
[7]戴爱所.喜炎平对急性呼吸道感染患儿血清中TNF-α、IL-6及IL-18的影响[J].国际儿科学杂志,2017,44(5):46-47.
[2]杨爱英,杨俊红,肖雪娜,等.阿奇霉素与头孢呋辛治疗儿童呼吸道感染疗效比较[J].中国药师,2016,19(1):112-114.
[3]复旦大学上海医学院.实用内科学[M].12版.北京:人民卫生出版社,2005:245-247.
[4]中华人民共和国卫生部.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2012:354-355.
[5]张昆.喜炎平注射液联合小儿豉翘清热颗粒治疗儿童急性上呼吸道感染的临床观察[J].现代药物与临床,2015,30(9):1133-1136.
[6]左稳欣,张莉英.利巴韦林联合柴桂退热颗粒治疗上呼吸道感染患儿的疗效[J].实用临床医药杂志,2016,20(5):159-160.
[7]戴爱所.喜炎平对急性呼吸道感染患儿血清中TNF-α、IL-6及IL-18的影响[J].国际儿科学杂志,2017,44(5):46-47.