硫酸特布他林雾化联合噻托溴铵吸入治疗慢性阻塞性肺疾病46例疗效分析
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摘要
目的:分析慢性阻塞性肺疾病(COPD)联合硫酸特布他林与噻托溴铵粉剂治疗的临床疗效。方法:2015年1月至2017年5月,于我院收治的COPD患者中选取92例,对其行回顾性分析,按照不同治疗方式分为两组,对照组单独采用硫酸特布他林治疗,观察组在对照组基础上联合噻托溴铵粉剂治疗,对比两组临床疗效、治疗前后肺功能、炎症因子、血气分析指标变化情况。结果:观察组治疗后FEV1、FEV1/FVC、PEF均高于对照组,观察组治疗后IL-8、CRP、TNF-α、PCT均低于对照组,差异显著,P<0.05;观察组治疗总有效率为95.65%,明显高于对照组(78.26%),差异显著,P<0.05;观察组治疗后PaCO_2、PaO_2以及pH值等血气指标的改善度大于对照组,差异显著,P<0.05。结论:COPD联合硫酸特布他林与噻托溴铵粉剂治疗的临床疗效显著,值得推广。
Objective: To analyze the clinical efficacy of combined terbutaline sulfate and tiotropium bromide powder in the treatment of COPD(chronic obstructive pulmonary disease). Methods: From January 2015 to May 2017, 92 patients with COPD admitted to our hospital were retrospectively analyzed. They were divided into two groups according to different treatment methods. The control group was treated with terbutaline sulfate alone. The observation group was treated with tiotropium bromide powder on the basis of the control group. The clinical efficacy, changes of lung function, inflammatory factors and blood gas analysis indexes before and after treatment were compared. Results: The FEV1, FEV1/FVC and PEF in the observation group were higher than those in the control group. The IL-8, CRP, TNF-α and PCT in the observation group were lower than those in the control group, the difference was significant(P<0.05). The effective rate was 95.65%, which was significantly higher than that of the control group(78.26%)(P<0.05). The improvement of blood gas index such as PaCO2, PaO2 and pH value in the observation group was greater than that of the control group, the difference was significant(P<0.05). Conclusion: The clinical efficacy of combined terbutaline sulfate and tiotropium bromide powder in the treatment of COPD is significant and worthy of promotion.
Objective: To analyze the clinical efficacy of combined terbutaline sulfate and tiotropium bromide powder in the treatment of COPD(chronic obstructive pulmonary disease). Methods: From January 2015 to May 2017, 92 patients with COPD admitted to our hospital were retrospectively analyzed. They were divided into two groups according to different treatment methods. The control group was treated with terbutaline sulfate alone. The observation group was treated with tiotropium bromide powder on the basis of the control group. The clinical efficacy, changes of lung function, inflammatory factors and blood gas analysis indexes before and after treatment were compared. Results: The FEV1, FEV1/FVC and PEF in the observation group were higher than those in the control group. The IL-8, CRP, TNF-α and PCT in the observation group were lower than those in the control group, the difference was significant(P<0.05). The effective rate was 95.65%, which was significantly higher than that of the control group(78.26%)(P<0.05). The improvement of blood gas index such as PaCO2, PaO2 and pH value in the observation group was greater than that of the control group, the difference was significant(P<0.05). Conclusion: The clinical efficacy of combined terbutaline sulfate and tiotropium bromide powder in the treatment of COPD is significant and worthy of promotion.
引文
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[3]亓慧琴,张连莲,邢利平,等.慢性阻塞性肺疾病患者应用异丙托溴铵联合乙酰半胱氨酸治疗前后血清中TGF-β和MMP-9水平的变化及其临床意义[J].吉林大学学报:医学版, 2016, 42(4):777-782.
[4]侯艳,李继东,薛庆亮,等.布地奈德分别联合异丙托溴铵和沙丁胺醇两种吸入治疗方法对慢性阻塞性肺疾病的疗效及不良反应比较[J].临床军医杂志,2015, 43(2):123-125.
[5]许承斌,丁明霞,卢丹,等.复方异丙托溴铵联合布地奈德雾化吸入治疗慢性阻塞性肺疾病急性期的疗效观察[J].中国现代医学杂志, 2015, 25(20):92-95.
[6]郑玉兰,曾宪升.氨溴索联合异丙托溴铵治疗慢性阻塞性肺疾病急性加重期的疗效分析[J].中华老年医学杂志, 2014, 33(11):1210-1211.
[7]刘向龙,刘猛,于明克,等.补益肺肾汤加减联合异丙托溴铵治疗慢性阻塞性肺疾病稳定期效果观察[J].临床误诊误治, 2016, 29(8):76-80.