多囊卵巢综合征代谢异常特点及中医认识
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摘要
多囊卵巢综合征(PCOS)易出现代谢系统疾病,胰岛素抵抗(IR)和高雄激素血症(HA)为其两大基本特征,是代谢与生殖内分泌系统异常的妇科常见疾病,临床表现呈现多样化及复杂性,合并症和远期并发症繁多,易发生2型糖尿病、高脂血症(HLP)及心血管疾病等,远期威胁正逐渐显露且令人担忧。PCOS患者常以不孕就医,代谢并发症常因发展缓慢、早期临床症状不显而易被忽视,研究者们对PCOS研究最初也往往局限于排卵障碍、月经不调、不孕等方面,故着眼于探讨PCOS患者代谢出现的时期及其异常特点,进一步解读PCOS代谢对生殖的影响及其与中医病因病机、证候的联系。
Polycystic ovary syndrome is easy to occur diseases of metabolic system,with insulin resistance( IR) and hyperandrogenism( HA) as the two basic features. It is the common gynecologic disease with abnormal metabolism and reproductive endocrine system,its clinical manifestations showing the characteristics of diversification and complexity,of various complications and long-term complications,such as the type 2 diabetes mellitus,hyperlipidemia( HLP),and cardiovascular disease. Long-term threat is gradually revealed. PCOS patients often to seek medical advice for barrenness,while the metabolic complications were unnoticable due to the slow development and the early symptoms are not obvious,while the researchers initially often confined to the research on PCOS ovulation disorders,menstruation to be not moved,infertility and so forth. This paper focused on the metabolism emergence period on patients with polycystic ovary syndrome and their abnormal characteristics,further interpretation of the PCOS metabolic effects on reproductive and its links with the etiology,pathogenesis and syndrome of TCM.
Polycystic ovary syndrome is easy to occur diseases of metabolic system,with insulin resistance( IR) and hyperandrogenism( HA) as the two basic features. It is the common gynecologic disease with abnormal metabolism and reproductive endocrine system,its clinical manifestations showing the characteristics of diversification and complexity,of various complications and long-term complications,such as the type 2 diabetes mellitus,hyperlipidemia( HLP),and cardiovascular disease. Long-term threat is gradually revealed. PCOS patients often to seek medical advice for barrenness,while the metabolic complications were unnoticable due to the slow development and the early symptoms are not obvious,while the researchers initially often confined to the research on PCOS ovulation disorders,menstruation to be not moved,infertility and so forth. This paper focused on the metabolism emergence period on patients with polycystic ovary syndrome and their abnormal characteristics,further interpretation of the PCOS metabolic effects on reproductive and its links with the etiology,pathogenesis and syndrome of TCM.
引文
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[11]刘娟,梁瑞宁,范培.补肾活血法对多囊卵巢综合征并复发性流产患者早期自然流产影响的临床观察[J].中国妇幼保健,2013,28(7):1150-1151.
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[15]梁瑞宁,赵美兰,李佩双,等.滋肾清热化瘀利湿法治疗肾阴虚型多囊卵巢综合征临床观察[J].中国妇幼保健,2014,29(26):4215-4217.
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[2]FAUSER B C,TARLATZIS B C,REBAR R W,et al.Consensus on women's health aspects of polycystic ovary syndrome(PCOS):the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group[J].Fertil Steril,2012,97(1):28-38.
[3]孔小娇,许小凤.多囊卵巢综合征糖脂代谢紊乱的中西医研究[J].吉林中医药,2015,35(12):1238-1241.
[4]BARBER TM,WASS JA,MCCARTHY MI,et al.Changes in the expression of insulin signaling pathway molecules in endometria from polycystic ovary syndrome women with or without hyperinsulinemia[J].Mol Med,2010,16(3/4):129-136.
[5]杨兰英.多囊卵巢综合征患者的血脂代谢异常及与胰岛素抵抗关联[J].当代医学,2013,19(23):116-117.
[6]ROCHA MP,MARCONDES JA,BARCELLOS CR,et al.Dyslipidemia in women with polycystic ovary syndrome:incidence,pattern and predictors[J].Gynecol Endocinol,2011,27(10):814-819.
[7]杨屏日,胡旭君,赵正言.代谢综合征与多囊卵巢综合征的相关性研究进展[J].中国妇幼保健,2015,30(5):817-820.
[8]余玲玲,梁瑞宁,魏俊英.多囊卵巢综合征的中医证候研究[J].河南中医,2013,33(7):1171-1172.
[9]彭昌乐,侯丽辉.多囊卵巢综合征合并代谢综合征的中医证型特征研究[J].天津中医药,2015,32(5):264-267.
[10]王娜梅.隐丹参酮对多囊卵巢综合征大鼠糖脂代谢及性激素的影响[J].中国妇幼保健,2015,30(20):3090-3093.
[11]刘娟,梁瑞宁,范培.补肾活血法对多囊卵巢综合征并复发性流产患者早期自然流产影响的临床观察[J].中国妇幼保健,2013,28(7):1150-1151.
[12]张玉珍.中医妇科学[M].北京:中国中医药出版社,2009:29.
[13]李军,王必勤,谢伟,等.郭志强教授论妇人“阴常不足,阳非有余”[J].北京中医药大学学报:中医临床版,2009,16(4):22-23.
[14]吴小燕,梁瑞宁.浅析多囊卵巢综合征中医病因病机[J].江西中医药,2012,43(2):3-5.
[15]梁瑞宁,赵美兰,李佩双,等.滋肾清热化瘀利湿法治疗肾阴虚型多囊卵巢综合征临床观察[J].中国妇幼保健,2014,29(26):4215-4217.
[16]梁瑞宁,刘娟,卢君,等.多囊卵巢综合征伴胰岛素抵抗中医证候研究[J].国际中医中药杂志,2007,29(5):272-274,276.