牛碱性成纤维细胞生长因子眼用凝胶联合玻璃酸钠滴眼液对白内障术后眼表损伤的修复作用
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摘要
目的:探讨牛碱性成纤维细胞生长因子眼用凝胶(贝复舒)联合玻璃酸钠滴眼液对白内障术后眼表损伤的修复作用。方法:选取2015年1月-2017年1月在本院就诊的Ⅲ级以下晶体核硬度的老年性白内障行超声乳化白内障摘除术的患者80例(80眼)。按照随机抽签法将其分为对照组和研究组,各40例。对照组给予常规用药,研究组在对照组基础上加用贝复舒。比较两组泪膜破裂时间(BUT)、角膜荧光素染色(FL评分)、基础泪液分泌、眼部不适症状评分。结果:术前,两组BUT、FL评分、基础泪液分泌、眼部不适症状评分比较,差异均无统计学意义(P>0.05);术后1周、2周和1个月,研究组BUT水平均高于对照组,基础泪液分泌水平均低于对照组,FL及眼部不适症状评分均低于对照组,比较差异均有统计学意义(P<0.05)。结论:贝复舒联合玻璃酸钠滴眼液对白内障术后眼表损伤修复作用明显,值得推广应用。
Objective:To investigate the repair effect of Recombinant Bovine Basic Fibolast Growth Factor Eye-Gel combined with Sodium Hyaluronate Eye Drops on ocular surface injury after cataract surgery.Method:A total of 80 patients(80 eyes) with senile cataract with nucleus hardness below Ⅲ who underwent phacoemulsification from January 2015 to January 2017 in our hospital were selected.According to the random lottery method,they were divided into control group and study group,40 cases in each group.The control group was given routine medication,while study group was given Befloxacin on the basis of control group.The tear film rupture time(BUT),corneal fluorescein staining(FL score),basic tear secretion and eye discomfort score were compared between two groups.Result:Before surgery,the BUT,FL scores,basic tear secretion and eye discomfort score were compared between two groups,the differences were not statistically significant(P>0.05).After operation one week,two weeks and one month,the BUT level of study group were higher than those of control group,the basic tear secretion level were lower than those of control group,and the FL and eye discomfort scores were lower than those of control group,the differences were statistically significant(P<0.05).Conclusion:Recombinant Bovine Basic Fibolast Growth Factor Eye-Gel combined with Sodium Hyaluronate Eye Drops has obvious effect on repairing ocular surface injury after cataract surgery,which is worth popularizing and applying.
Objective:To investigate the repair effect of Recombinant Bovine Basic Fibolast Growth Factor Eye-Gel combined with Sodium Hyaluronate Eye Drops on ocular surface injury after cataract surgery.Method:A total of 80 patients(80 eyes) with senile cataract with nucleus hardness below Ⅲ who underwent phacoemulsification from January 2015 to January 2017 in our hospital were selected.According to the random lottery method,they were divided into control group and study group,40 cases in each group.The control group was given routine medication,while study group was given Befloxacin on the basis of control group.The tear film rupture time(BUT),corneal fluorescein staining(FL score),basic tear secretion and eye discomfort score were compared between two groups.Result:Before surgery,the BUT,FL scores,basic tear secretion and eye discomfort score were compared between two groups,the differences were not statistically significant(P>0.05).After operation one week,two weeks and one month,the BUT level of study group were higher than those of control group,the basic tear secretion level were lower than those of control group,and the FL and eye discomfort scores were lower than those of control group,the differences were statistically significant(P<0.05).Conclusion:Recombinant Bovine Basic Fibolast Growth Factor Eye-Gel combined with Sodium Hyaluronate Eye Drops has obvious effect on repairing ocular surface injury after cataract surgery,which is worth popularizing and applying.
引文
[1]方俊旭.小牛血去蛋白提取物眼用凝胶联合玻璃酸钠滴眼液治疗白内障超声乳化吸除术后并发干眼症的疗效观察[J].中国基层医药,2016,23(23):3609-3612.
[2]石韵洁,杜慧斌,肖旗彬.小牛血去蛋白提取物眼用凝胶和玻璃酸钠滴眼液对翼状胬肉术后眼表修复观察[J].中医眼耳鼻喉杂志,2017,7(3):144-145.
[3]王金铎,曹向荣,付学玲.普拉洛芬联合玻璃酸钠滴眼液对白内障超声乳化术后干眼的干预观察[J].中国实用眼科杂志,2016,34(1):24-26.
[4]张自音,姚勇,殷丽,等.0.3%玻璃酸钠滴眼液对白内障超声乳化联合人工晶体植入术后患者干眼的影响[J].河北医学,2017,23(11):1913-1916.
[5]银哲,银锐,李元彬.不含防腐剂的玻璃酸钠联合氟米龙滴眼液治疗白内障伴干眼的随机单盲对照研究[J].中华实验眼科杂志,2017,35(9):843-847.
[6]刘锦魁,唐健青.重组牛碱性成纤维细胞生长因子眼用凝胶在睑板腺异常相关干眼患者中的临床应用[J].海南医学,2017,28(4):658-659.
[7]宦会娟.小牛血去蛋白提取物眼用凝胶联合玻璃酸钠滴眼液治疗白内障术后干眼的效果观察[J].河南医学研究,2017,26(17):3121-3122.
[8]田莉,吴永红.玻璃酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对干眼症患者症状改善情况的影响研究[J].中国全科医学,2017,20(S2):164-165.
[9]范晓梅,刘丽丹.贝复舒眼用凝胶联合海露眼液治疗白内障超声乳化术后干眼[J].现代医药卫生,2017,33(5):741-742.
[10]张捷,成敏,韩玫,等.鼻内窥镜下鼻腔泪囊造孔术联合贝复舒凝胶及典必殊治疗慢性泪囊炎[J].中国保健营养,2016,26(31):4-5.
[11]郭颖卓,王华,何书喜.重组牛碱性成纤维细胞生长因子眼用凝胶在角膜塑形镜配戴的应用[J].湖南师范大学学报(医学版),2016,13(2):52-55.
[12]李建良,王蓉,杜红彦,等.舒眼方超声雾化治疗白内障超声乳化术后干眼30例临床观察[J].中国民间疗法,2016,24(4):84-85.
[13]杨树波,李珺,吴志鹏,等.红霉素眼膏联合贝复舒凝胶治疗鼻粘膜黎氏区鼻出血临床观察[J].世界最新医学信息文摘,2016,16(65):100-101.
[14]陈尔英,罗永香,黄国雄,等.贝复舒在全麻患者手术中眼睛保护的效果观察[J].医学理论与实践,2017,30(8):1180-1181.
[15]蔡树泓,张世华,林小勇.长期局部单用抗青光眼药物与联用贝复舒滴眼液在眼表损伤方面的对比研究[J].中国实用医药,2017,12(16):138-139.
[16]王涛.贝复舒滴眼液联合典必殊滴眼液治疗白内障超声乳化术后角膜水肿的临床效果观察[J].浙江创伤外科,2016,21(1):51-53.
[17]黎锦萍,周沛辉,陈硕,等.玻璃酸钠滴眼液与贝复舒滴眼液联合治疗干眼症效果[J].牡丹江医学院学报,2017,38(1):66-67.
[18]程维肖,杨志贤,李文洪.普拉洛芬联合贝复舒对麻疹性结膜炎的治疗分析[J].当代医学,2017,23(1):6-8.
[19]郑洪霞.贝复舒用于治疗角膜异物的时机观察[J].临床研究,2016,24(12):74-75.
[20]杨柯,张红敏.玻璃酸钠滴眼液与贝复舒滴眼液联合治疗干眼症效果观察[J].世界最新医学信息文摘,2018,18(35):29-30,35.
[2]石韵洁,杜慧斌,肖旗彬.小牛血去蛋白提取物眼用凝胶和玻璃酸钠滴眼液对翼状胬肉术后眼表修复观察[J].中医眼耳鼻喉杂志,2017,7(3):144-145.
[3]王金铎,曹向荣,付学玲.普拉洛芬联合玻璃酸钠滴眼液对白内障超声乳化术后干眼的干预观察[J].中国实用眼科杂志,2016,34(1):24-26.
[4]张自音,姚勇,殷丽,等.0.3%玻璃酸钠滴眼液对白内障超声乳化联合人工晶体植入术后患者干眼的影响[J].河北医学,2017,23(11):1913-1916.
[5]银哲,银锐,李元彬.不含防腐剂的玻璃酸钠联合氟米龙滴眼液治疗白内障伴干眼的随机单盲对照研究[J].中华实验眼科杂志,2017,35(9):843-847.
[6]刘锦魁,唐健青.重组牛碱性成纤维细胞生长因子眼用凝胶在睑板腺异常相关干眼患者中的临床应用[J].海南医学,2017,28(4):658-659.
[7]宦会娟.小牛血去蛋白提取物眼用凝胶联合玻璃酸钠滴眼液治疗白内障术后干眼的效果观察[J].河南医学研究,2017,26(17):3121-3122.
[8]田莉,吴永红.玻璃酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对干眼症患者症状改善情况的影响研究[J].中国全科医学,2017,20(S2):164-165.
[9]范晓梅,刘丽丹.贝复舒眼用凝胶联合海露眼液治疗白内障超声乳化术后干眼[J].现代医药卫生,2017,33(5):741-742.
[10]张捷,成敏,韩玫,等.鼻内窥镜下鼻腔泪囊造孔术联合贝复舒凝胶及典必殊治疗慢性泪囊炎[J].中国保健营养,2016,26(31):4-5.
[11]郭颖卓,王华,何书喜.重组牛碱性成纤维细胞生长因子眼用凝胶在角膜塑形镜配戴的应用[J].湖南师范大学学报(医学版),2016,13(2):52-55.
[12]李建良,王蓉,杜红彦,等.舒眼方超声雾化治疗白内障超声乳化术后干眼30例临床观察[J].中国民间疗法,2016,24(4):84-85.
[13]杨树波,李珺,吴志鹏,等.红霉素眼膏联合贝复舒凝胶治疗鼻粘膜黎氏区鼻出血临床观察[J].世界最新医学信息文摘,2016,16(65):100-101.
[14]陈尔英,罗永香,黄国雄,等.贝复舒在全麻患者手术中眼睛保护的效果观察[J].医学理论与实践,2017,30(8):1180-1181.
[15]蔡树泓,张世华,林小勇.长期局部单用抗青光眼药物与联用贝复舒滴眼液在眼表损伤方面的对比研究[J].中国实用医药,2017,12(16):138-139.
[16]王涛.贝复舒滴眼液联合典必殊滴眼液治疗白内障超声乳化术后角膜水肿的临床效果观察[J].浙江创伤外科,2016,21(1):51-53.
[17]黎锦萍,周沛辉,陈硕,等.玻璃酸钠滴眼液与贝复舒滴眼液联合治疗干眼症效果[J].牡丹江医学院学报,2017,38(1):66-67.
[18]程维肖,杨志贤,李文洪.普拉洛芬联合贝复舒对麻疹性结膜炎的治疗分析[J].当代医学,2017,23(1):6-8.
[19]郑洪霞.贝复舒用于治疗角膜异物的时机观察[J].临床研究,2016,24(12):74-75.
[20]杨柯,张红敏.玻璃酸钠滴眼液与贝复舒滴眼液联合治疗干眼症效果观察[J].世界最新医学信息文摘,2018,18(35):29-30,35.