氧氟沙星联合地塞米松治疗慢性化脓性中耳炎的疗效
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摘要
目的:探究氧氟沙星联合地塞米松治疗慢性化脓性中耳炎(CSOM)的疗效。方法:选取我院2017年1月至2017年12月收治的108例CSOM患者。随机分为观察组和对照组,每组54例。对照组选用盐酸左氧氟沙星注射液治疗,观察组选用盐酸左氧氟沙星注射液联合醋酸地塞米松片治疗,对比观察两组患者的总有效率、听力改善幅度、细菌清除率、不良反应发生率。结果:治疗后,观察组治疗有效率为90.74%,明显高于对照组的61.11%(P<0.01);观察组听力改善幅度、细菌清除率分别为(7.54±1.52)dB和89.20%,明显高于对照组患者的(4.32±1.24)dB和52.60%(P<0.01);观察组不良反应率为9.26%,较对照组12.96%降低,但差异无统计学意义(P>0.05)。结论:氧氟沙星联合地塞米松治疗CSOM患者,有显著的临床疗效,有助于患者听力的改善、提高细菌清除率,减少不良反应,具有积极的临床意义。
Objective:To investigate the efficacy of ofloxacin combined with dexamethasone in the treatment of chronic suppurative otitis media(CSOM).Methods:108 patients with CSOM treated in our hospital from January 2017 to December 2017 were selected and were randomly divided into the observation group and the control group,54 cases in each group. The control group were treated with levofloxacine hydrochloride injection while the observation group were treated with levofloxacine hydrochloride injection combined with dexamethasone acetate tablets. The total effective rate, hearing improvement range, bacterial clearance rate and adverse reaction rate were observed and compared between the two groups.Results:After treatment, the effective rate of the observation group was 90.74%, which was higher than that of the control group 61.11%(P<0.01). The improvement of hearing and the rate of bacterial clearance in the observation group were(7.54±1.52) dB and 89.20%, which were significantly higher than that in the control group(4.32±1.24), dB and 52.60%(P<0.01). The adverse reaction rate of the observation group was 9.26%, which was lower than 12.96% of the control group, but the difference was not statistically significant(P>0.05).Conclusion:Ofloxacin combined with dexamethasone in the treatment of patients with CSOM has significant clinical efficacy, which not only helps to improve the hearing of patients and reduce the bacterial clearance rate but also can adverse reaction and has positive clinical significance, which is worthy of promotion.
Objective:To investigate the efficacy of ofloxacin combined with dexamethasone in the treatment of chronic suppurative otitis media(CSOM).Methods:108 patients with CSOM treated in our hospital from January 2017 to December 2017 were selected and were randomly divided into the observation group and the control group,54 cases in each group. The control group were treated with levofloxacine hydrochloride injection while the observation group were treated with levofloxacine hydrochloride injection combined with dexamethasone acetate tablets. The total effective rate, hearing improvement range, bacterial clearance rate and adverse reaction rate were observed and compared between the two groups.Results:After treatment, the effective rate of the observation group was 90.74%, which was higher than that of the control group 61.11%(P<0.01). The improvement of hearing and the rate of bacterial clearance in the observation group were(7.54±1.52) dB and 89.20%, which were significantly higher than that in the control group(4.32±1.24), dB and 52.60%(P<0.01). The adverse reaction rate of the observation group was 9.26%, which was lower than 12.96% of the control group, but the difference was not statistically significant(P>0.05).Conclusion:Ofloxacin combined with dexamethasone in the treatment of patients with CSOM has significant clinical efficacy, which not only helps to improve the hearing of patients and reduce the bacterial clearance rate but also can adverse reaction and has positive clinical significance, which is worthy of promotion.
引文
1 袁丹,梅凌云.鼓膜成形术与药物保守治疗单纯慢性化脓性中耳炎临床疗效观察[J].河北医学,2016,22(3):444-447.
2 王艳芳,吕福成,杨隽,等.穴位按摩联合中西药辅助He-Ne激光照射在中耳炎乳突根治术的应用分析[J].山西医药杂志,2015,44(19):2300-2302.
3 杨红丽,安丽,冯蓉,等.慢性化脓性中耳炎鼓室成形术中钛听骨植入对患者修复后鼓膜形态及听力的影响[J].现代医学,2016,44(7):1005-1008.
4 汤咏梅,项勇刚.左氧氟沙星滴眼液联合地塞米松混合液在小儿泪道探通术中的应用[J].中国斜视与小儿眼科杂志,2016,24(4):43-45.
5 吴强.嗜麦芽窄食单胞菌的临床分布和耐药性分析[J].中国基层医药,2015,22(15):2356-2357.
6 张芳君,栾卫红,董雅萌,等.地氯雷他定联合地塞米松鼓室内注射对分泌性中耳炎患者咽鼓管功能的影响[J].现代生物医学进展,2015,15(33):6528-6530.
7 官文君,李朝军.慢性化脓性中耳炎细菌学研究进展[J].重庆医学,2015,44(6):842-844.
2 王艳芳,吕福成,杨隽,等.穴位按摩联合中西药辅助He-Ne激光照射在中耳炎乳突根治术的应用分析[J].山西医药杂志,2015,44(19):2300-2302.
3 杨红丽,安丽,冯蓉,等.慢性化脓性中耳炎鼓室成形术中钛听骨植入对患者修复后鼓膜形态及听力的影响[J].现代医学,2016,44(7):1005-1008.
4 汤咏梅,项勇刚.左氧氟沙星滴眼液联合地塞米松混合液在小儿泪道探通术中的应用[J].中国斜视与小儿眼科杂志,2016,24(4):43-45.
5 吴强.嗜麦芽窄食单胞菌的临床分布和耐药性分析[J].中国基层医药,2015,22(15):2356-2357.
6 张芳君,栾卫红,董雅萌,等.地氯雷他定联合地塞米松鼓室内注射对分泌性中耳炎患者咽鼓管功能的影响[J].现代生物医学进展,2015,15(33):6528-6530.
7 官文君,李朝军.慢性化脓性中耳炎细菌学研究进展[J].重庆医学,2015,44(6):842-844.