ILC细胞与自身炎症性疾病
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摘要
固有淋巴细胞(ILCs)是一群参与固有免疫的异质性淋巴细胞,多分布于黏膜屏障部位,接受局部微环境细胞因子的信号后,通过分泌细胞因子及其他介质,发挥早期的免疫监视和免疫调节作用。ILCs细胞多为组织驻留淋巴细胞,参与黏膜免疫的形成,在淋巴细胞的发育、组织损伤的修复及上皮屏障的维持方面发挥重要作用。但由于其数量或功能异常,将参与炎症、自身免疫性疾病、代谢性疾病、哮喘、过敏等多种疾病的发生发展。鉴于不同ILC亚群在免疫监视、组织修复、稳态维持和炎症应答中的重要作用,ILCs细胞有望成为免疫治疗或炎症相关疾病治疗的靶点。本文就ILC细胞亚群的表型、发育和功能特点、ILCs细胞在炎症、组织稳态和修复中的作用、与自身炎症性疾病发生发展的关系及相关治疗策略等新进展做一综述。
Innate lymphoid cells( ILCs) are a family of innate lymphocytes that mirror the phenotypes and functions of T cells. They usually localize at mucosal barriers and mediate early immunosurveillance and regulate immune responses through secreting cytokines. ILCs are mostly tissue-resident lymphocytes,and are involved in the development of lymphoid tissue,the tissue repair,the maintenance of tissue integrity. However,when their functions become uncontrolled,ILCs can enhance pathological states and induce inflammatory diseases such as asthma,atopic dermatitis,inflammatory bowel diseases,psoriasis and other autoimmune diseases. The importance of ILCs in immune response,homeostasis,and inflammation offers new strategies for immunotherapy. In this review,we summarize recent research progress on ILCs including their characteristics of phenotypes,development and function,their role in tissue homeostasis and inflammation,as well as the potential therapeutic strategies for targeting ILCs in inflammatory diseases.
Innate lymphoid cells( ILCs) are a family of innate lymphocytes that mirror the phenotypes and functions of T cells. They usually localize at mucosal barriers and mediate early immunosurveillance and regulate immune responses through secreting cytokines. ILCs are mostly tissue-resident lymphocytes,and are involved in the development of lymphoid tissue,the tissue repair,the maintenance of tissue integrity. However,when their functions become uncontrolled,ILCs can enhance pathological states and induce inflammatory diseases such as asthma,atopic dermatitis,inflammatory bowel diseases,psoriasis and other autoimmune diseases. The importance of ILCs in immune response,homeostasis,and inflammation offers new strategies for immunotherapy. In this review,we summarize recent research progress on ILCs including their characteristics of phenotypes,development and function,their role in tissue homeostasis and inflammation,as well as the potential therapeutic strategies for targeting ILCs in inflammatory diseases.
引文
[1]Eberl G,Colonna M,Di Santo JP,et al.Innate lymphoid cells.Innate lymphoid cells:a new paradigm in immunology[J].Science,2015,348(6237):aaa6566.
[2]Artis D,Spits H.The biology of innate lymphoid cells[J].Nature,2015,517(7534):293-301.
[3]Gronke K,Kofoed-Nielsen M,Diefenbach A.Innate lymphoid cells,precursors and plasticity[J].Immunol Lett,2016,179:9-18.
[4]Lim AI,Verrier T,Vosshenrich CA,et al.Development option and functional plasticity of innate lymphoid cells[J].Curr Opin Immunol,2017,44:61-68.
[5]Kim CH,Hashimoto-Hill S,Kim M.Migration and tissue tropism of innate lymphoid cells[J].Trends Immunol,2016,37(1):68-79.
[6]Ebbo M,Crinier A,Vély F,et al.Innate lymphoid cells:major players in inflammatory diseases[J].Nat Rev Immunol,2017,17(11):665-678.
[7]Mc Kenzie ANJ,Spits H,Eberl G.Innate lymphoid cells in inflammation and immunity[J].Immunity,2014,41(3):366-374.
[8]Vivier E,Artis D,Colonna M,et al.Innate lymphoid cells:10 years on[J].Cell,2018,174(5):1054-1066.
[9]Diefenbach A,Colonna M,Koyasu S.Development,differentiation,and diversity of innate lymphoid cells[J].Immunity,2014,41(3):354-365.
[10]Zhou Y,Xu X,Tian Z,et al.'Multi-Omics'analyses of the development and function of natural killer cells[J].Front Immunol,2017,8:1095.
[11]Weizman OE,Adams NM,Schuster IS,et al.ILC1 confer early host protection at initial sites of viral infection[J].Cell,2017,171(4):795-808.
[12]Freud AG,Keller KA,Scoville SD,et al.NKp80 defines a critical step during human natural killer cell development[J].Cell Rep,2016,16(2):379-391.
[13]Daussy C,Faure F,Mayol K,et al.T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow[J].J Exp Med,2014,211(3):563-577.
[14]Huang Y,Mao K,Germain RN.Thinking differently about ILCsNot just tissue resident and not just the same as CD4+T-cell effectors[J].Immunol Rev,2018,286(1):160-171.
[15]Monticelli LA,Osborne LC,Noti M,et al.IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions[J].Proc Natl Acad Sci USA,2015,112(34):10762-10767.
[16]Hernandez PP,Mahlakoiv T,Yang I,et al.Interferon-l and interleukin 22 act synergistically for the induction of interferonstimulated genes and control of rotavirus infection[J].Nat Immunol,2015,16(7):698-707.
[17]von Burg N,Chappaz S,Baerenwaldt A,et al.Activated group 3innate lymphoid cells promote T-cell-mediated immune responses[J].Proc Natl Acad Sci U S A,2014,111(35):12835-12840.
[18]van de Pavert SA,Mebius RE.New insights into the development of lymphoid tissues[J].Nat Rev Immunol,2010,10(9):664-674.
[19]Wang S,Xia P,Chen Y,et al.Regulatory innate lymphoid cells control innate intestinal inflammation[J].Cell,2017,171(1):201-216.
[20]Seehus CR,Kadavallore A,Torre B,et al.Alternative activation generates IL-10 producing type 2 innate lymphoid cells[J].Nat Commun,2017,8(1):1900.
[21]Branzk N,Gronke K,Diefenbach A.Innate lymphoid cells,mediators of tissue homeostasis,adaptation and disease tolerance[J].Immunol Rev,2018,286(1):86-101.
[22]Zaiss DM,Gause WC,Osborne LC,et al.Emerging functions of amphiregulin in orchestrating immunity,inflammation,and tissue repair[J].Immunity,2015,42(2):216-226.
[23]Monticelli LA,Sonnenberg GF,Abt MC,et al.Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus[J].Nat Immunol,2011,12(11):1045-1054.
[24]Turner JE,Morrison PJ,Wilhelm C,et al.IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation[J].J Exp Med,2013,210(13):2951-2965.
[25]Rak GD,Osborne LC,Siracusa MC,et al.IL-33-Dependent group2 innate lymphoid cells promote cutaneous wound healing[J].JInvest Dermatol,2016,136(2):487-496.
[26]Lindemans CA,Calafiore M,Mertelsmann AM,et al.Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration[J].Nature,2015,528(7583):560-564.
[27]Aparicio-Domingo P,Romera-Hernandez M,Karrich JJ,et al.Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage[J].J Exp Med,2015,212(11):1783-1791.
[28]Xiong T,Turner JE.Innate lymphoid cells in autoimmunity and chronic inflammatory diseases[J].Semin Immunopathol,2018,40(4):393-406.
[29]Sonnenberg GF,Monticelli LA,Alenghat T,et al.Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria[J].Science,2012,336(6086):1321-1325.
[30]Cording S,Medvedovic J,Aychek T,et al.Innate lymphoid cells in defense,immunopathology and immunotherapy[J].Nat Immunol,2016,17(7):755-757.
[31]Stehle C,Hernández DC,Romagnani C.Innate lymphoid cells in lung infection and immunity[J].Immunol Rev,2018,286(1):102-119.
[32]Sugita K,Steer CA,Martinez-Gonzalez I,et al.Type 2 innate lymphoid cells discrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients[J].JAllergy Clin Immunol,2018,141(1):300-310.
[33]Chang JE,Doherty TA,Baum R,et al.Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis[J].J Allergy Clin Immunol,2014,133(3):899-901.
[34]Barnig C,Cernadas M,Dutile S,et al.Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma[J].Sci Transl Med,2013,5(174):174ra26.
[35]Oliphant CJ,Hwang YY,Walker JA,et al.MHC II mediated dialog between group 2 innate lymphoid cells and CD4+T cells potentiates type 2 immunity and promotes parasitic helminth expulsion[J].Immunity,2014,41(2):283-295.
[36]Halim TY,Steer CA,MathL,et al.Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell mediated allergic lung inflammation[J].Immunity,2014,40(3):425-435.
[37]Halim TY,Hwang YY,Scanlon ST,et al.Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2cell responses[J].Nat Immunol,2016,17(1):57-64.
[38]Li D,Guabiraba R,Besnard AG,et al.IL-33 promotes ST2dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice[J].J Allergy Clin Immunol,2014,134(6):1422-1432.
[39]Kim HY,Lee HJ,Chang YJ,et al.Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity[J].Nat Med,2014,20(1):54-61.
[40]Cheng H,Jin C,Wu J,et al.Guards at the gate:physiological and pathological roles of tissue-resident innate lymphoid cells in the lung[J].Protein Cell,2017,8(12):878-895.
[41]Peng H,Tian Z.Diversity of tissue-resident NK cells[J].Semin Immunol,2017,31:3-10.
[42]Peng H,Tian Z.Re-examining the origin and function of liverresident NK cells[J].Trends Immunol,2015,36(5):293-299.
[43]Tang L,Peng H,Zhou J,et al.Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s[J].J Autoimmun,2016,67:29-35.
[44]Liu M,Zhang C.The Role of innate lymphoid cells in immunemediated liver diseases[J].Front Immunol,2017,8:695.
[45]Toens C,Berger C,Trippler M,et al.KIR2DL3(+)NKG2A(-)natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugs[J].JHepatol,2014,61(3):475-481.
[46]Mc Hedlidze T,Waldner M,Zopf S,et al.Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis[J].Immunity,2013,39(2):357-371.
[47]Neumann K,Karimi K,Meiners J,et al.A proinflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis[J].J Immunol,2017,198(1):128-137.
[48]Volarevic V,Mitrovic M,Milovanovic M,et al.Protective role of IL-33/ST2 axis in Con A-induced hepatitis[J].J Hepatol,2012,56(1):26-33.
[49]Liang Y,Jie Z,Hou L,et al.IL-33 induces nuocytes and modulates liver injury in viral hepatitis[J].J Immunol,2013,190(11):5666-5675.
[50]Pan H,Hong F,Radaeva S,et al.Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-,carbon tetrachloride-,and Fas ligand-induced injury via activation of STAT3[J].Cell Mol Immunol,2004,1(1):43-49.
[51]Zhao J,Zhang Z,Luan Y,et al.Pathological functions of interleukin-22 in chronic liver inflammation and fbrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment[J].Hepatology,2014,59(4):1331-1342.
[52]Li Z,Hodgkinson T,Gothard EJ,et al.Epidermal Notch1 recruits RORγ+group 3 innate lymphoid cells to orchestrate normal skin repair[J].Nat Commun,2016,7:11394.
[53]Rak GD,Osborne LC,Siracusa MC,et al.IL-33 Dependent group2 innate lymphoid cells promote cutaneous wound healing[J].JInvest Dermatol,2016,136(2):487-496.
[54]Salimi M,Barlow JL,Saunders SP,et al.A role for IL 25 and IL33 driven type 2 innate lymphoid cells in atopic dermatitis[J].JExp Med,2013,210(13):2939-2950.
[55]Salimi M,Xue L,Jolin H,et al.Group 2 innate lymphoid cells express functional NKp30 receptor inducing type 2 cytokine production[J].J Immunol,2016,196(1):45-54.
[56]Pantelyushin S,Haak S,Ingold B,et al.Rorγt+innate lymphocytes andγδT cells initiate psoriasiform plaque formation in mice[J].J Clin Invest,2012,122:2252-2256.
[57]Peng H,Tian Z.Natural killer cell memory:progress and implications[J].Front Immunol,2017,8:1143.
[58]Wang X,Peng H,Cong J,et al.Memory formation and long-term maintenance of IL-7Rα+ILC1s via a lymph node-liver axis[J].Nat Commun,2018,9(1):4854.
[59]Pantelyushin S,Haak S,Ingold B,et al.Rorγt+innate lymphocytes andγδT cells initiate psoriasiform plaque formation in mice[J].J Clin Invest,2012,122(6):2252-2256.
[2]Artis D,Spits H.The biology of innate lymphoid cells[J].Nature,2015,517(7534):293-301.
[3]Gronke K,Kofoed-Nielsen M,Diefenbach A.Innate lymphoid cells,precursors and plasticity[J].Immunol Lett,2016,179:9-18.
[4]Lim AI,Verrier T,Vosshenrich CA,et al.Development option and functional plasticity of innate lymphoid cells[J].Curr Opin Immunol,2017,44:61-68.
[5]Kim CH,Hashimoto-Hill S,Kim M.Migration and tissue tropism of innate lymphoid cells[J].Trends Immunol,2016,37(1):68-79.
[6]Ebbo M,Crinier A,Vély F,et al.Innate lymphoid cells:major players in inflammatory diseases[J].Nat Rev Immunol,2017,17(11):665-678.
[7]Mc Kenzie ANJ,Spits H,Eberl G.Innate lymphoid cells in inflammation and immunity[J].Immunity,2014,41(3):366-374.
[8]Vivier E,Artis D,Colonna M,et al.Innate lymphoid cells:10 years on[J].Cell,2018,174(5):1054-1066.
[9]Diefenbach A,Colonna M,Koyasu S.Development,differentiation,and diversity of innate lymphoid cells[J].Immunity,2014,41(3):354-365.
[10]Zhou Y,Xu X,Tian Z,et al.'Multi-Omics'analyses of the development and function of natural killer cells[J].Front Immunol,2017,8:1095.
[11]Weizman OE,Adams NM,Schuster IS,et al.ILC1 confer early host protection at initial sites of viral infection[J].Cell,2017,171(4):795-808.
[12]Freud AG,Keller KA,Scoville SD,et al.NKp80 defines a critical step during human natural killer cell development[J].Cell Rep,2016,16(2):379-391.
[13]Daussy C,Faure F,Mayol K,et al.T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow[J].J Exp Med,2014,211(3):563-577.
[14]Huang Y,Mao K,Germain RN.Thinking differently about ILCsNot just tissue resident and not just the same as CD4+T-cell effectors[J].Immunol Rev,2018,286(1):160-171.
[15]Monticelli LA,Osborne LC,Noti M,et al.IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions[J].Proc Natl Acad Sci USA,2015,112(34):10762-10767.
[16]Hernandez PP,Mahlakoiv T,Yang I,et al.Interferon-l and interleukin 22 act synergistically for the induction of interferonstimulated genes and control of rotavirus infection[J].Nat Immunol,2015,16(7):698-707.
[17]von Burg N,Chappaz S,Baerenwaldt A,et al.Activated group 3innate lymphoid cells promote T-cell-mediated immune responses[J].Proc Natl Acad Sci U S A,2014,111(35):12835-12840.
[18]van de Pavert SA,Mebius RE.New insights into the development of lymphoid tissues[J].Nat Rev Immunol,2010,10(9):664-674.
[19]Wang S,Xia P,Chen Y,et al.Regulatory innate lymphoid cells control innate intestinal inflammation[J].Cell,2017,171(1):201-216.
[20]Seehus CR,Kadavallore A,Torre B,et al.Alternative activation generates IL-10 producing type 2 innate lymphoid cells[J].Nat Commun,2017,8(1):1900.
[21]Branzk N,Gronke K,Diefenbach A.Innate lymphoid cells,mediators of tissue homeostasis,adaptation and disease tolerance[J].Immunol Rev,2018,286(1):86-101.
[22]Zaiss DM,Gause WC,Osborne LC,et al.Emerging functions of amphiregulin in orchestrating immunity,inflammation,and tissue repair[J].Immunity,2015,42(2):216-226.
[23]Monticelli LA,Sonnenberg GF,Abt MC,et al.Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus[J].Nat Immunol,2011,12(11):1045-1054.
[24]Turner JE,Morrison PJ,Wilhelm C,et al.IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation[J].J Exp Med,2013,210(13):2951-2965.
[25]Rak GD,Osborne LC,Siracusa MC,et al.IL-33-Dependent group2 innate lymphoid cells promote cutaneous wound healing[J].JInvest Dermatol,2016,136(2):487-496.
[26]Lindemans CA,Calafiore M,Mertelsmann AM,et al.Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration[J].Nature,2015,528(7583):560-564.
[27]Aparicio-Domingo P,Romera-Hernandez M,Karrich JJ,et al.Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage[J].J Exp Med,2015,212(11):1783-1791.
[28]Xiong T,Turner JE.Innate lymphoid cells in autoimmunity and chronic inflammatory diseases[J].Semin Immunopathol,2018,40(4):393-406.
[29]Sonnenberg GF,Monticelli LA,Alenghat T,et al.Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria[J].Science,2012,336(6086):1321-1325.
[30]Cording S,Medvedovic J,Aychek T,et al.Innate lymphoid cells in defense,immunopathology and immunotherapy[J].Nat Immunol,2016,17(7):755-757.
[31]Stehle C,Hernández DC,Romagnani C.Innate lymphoid cells in lung infection and immunity[J].Immunol Rev,2018,286(1):102-119.
[32]Sugita K,Steer CA,Martinez-Gonzalez I,et al.Type 2 innate lymphoid cells discrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients[J].JAllergy Clin Immunol,2018,141(1):300-310.
[33]Chang JE,Doherty TA,Baum R,et al.Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis[J].J Allergy Clin Immunol,2014,133(3):899-901.
[34]Barnig C,Cernadas M,Dutile S,et al.Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma[J].Sci Transl Med,2013,5(174):174ra26.
[35]Oliphant CJ,Hwang YY,Walker JA,et al.MHC II mediated dialog between group 2 innate lymphoid cells and CD4+T cells potentiates type 2 immunity and promotes parasitic helminth expulsion[J].Immunity,2014,41(2):283-295.
[36]Halim TY,Steer CA,MathL,et al.Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell mediated allergic lung inflammation[J].Immunity,2014,40(3):425-435.
[37]Halim TY,Hwang YY,Scanlon ST,et al.Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2cell responses[J].Nat Immunol,2016,17(1):57-64.
[38]Li D,Guabiraba R,Besnard AG,et al.IL-33 promotes ST2dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice[J].J Allergy Clin Immunol,2014,134(6):1422-1432.
[39]Kim HY,Lee HJ,Chang YJ,et al.Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity[J].Nat Med,2014,20(1):54-61.
[40]Cheng H,Jin C,Wu J,et al.Guards at the gate:physiological and pathological roles of tissue-resident innate lymphoid cells in the lung[J].Protein Cell,2017,8(12):878-895.
[41]Peng H,Tian Z.Diversity of tissue-resident NK cells[J].Semin Immunol,2017,31:3-10.
[42]Peng H,Tian Z.Re-examining the origin and function of liverresident NK cells[J].Trends Immunol,2015,36(5):293-299.
[43]Tang L,Peng H,Zhou J,et al.Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s[J].J Autoimmun,2016,67:29-35.
[44]Liu M,Zhang C.The Role of innate lymphoid cells in immunemediated liver diseases[J].Front Immunol,2017,8:695.
[45]Toens C,Berger C,Trippler M,et al.KIR2DL3(+)NKG2A(-)natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugs[J].JHepatol,2014,61(3):475-481.
[46]Mc Hedlidze T,Waldner M,Zopf S,et al.Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis[J].Immunity,2013,39(2):357-371.
[47]Neumann K,Karimi K,Meiners J,et al.A proinflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis[J].J Immunol,2017,198(1):128-137.
[48]Volarevic V,Mitrovic M,Milovanovic M,et al.Protective role of IL-33/ST2 axis in Con A-induced hepatitis[J].J Hepatol,2012,56(1):26-33.
[49]Liang Y,Jie Z,Hou L,et al.IL-33 induces nuocytes and modulates liver injury in viral hepatitis[J].J Immunol,2013,190(11):5666-5675.
[50]Pan H,Hong F,Radaeva S,et al.Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-,carbon tetrachloride-,and Fas ligand-induced injury via activation of STAT3[J].Cell Mol Immunol,2004,1(1):43-49.
[51]Zhao J,Zhang Z,Luan Y,et al.Pathological functions of interleukin-22 in chronic liver inflammation and fbrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment[J].Hepatology,2014,59(4):1331-1342.
[52]Li Z,Hodgkinson T,Gothard EJ,et al.Epidermal Notch1 recruits RORγ+group 3 innate lymphoid cells to orchestrate normal skin repair[J].Nat Commun,2016,7:11394.
[53]Rak GD,Osborne LC,Siracusa MC,et al.IL-33 Dependent group2 innate lymphoid cells promote cutaneous wound healing[J].JInvest Dermatol,2016,136(2):487-496.
[54]Salimi M,Barlow JL,Saunders SP,et al.A role for IL 25 and IL33 driven type 2 innate lymphoid cells in atopic dermatitis[J].JExp Med,2013,210(13):2939-2950.
[55]Salimi M,Xue L,Jolin H,et al.Group 2 innate lymphoid cells express functional NKp30 receptor inducing type 2 cytokine production[J].J Immunol,2016,196(1):45-54.
[56]Pantelyushin S,Haak S,Ingold B,et al.Rorγt+innate lymphocytes andγδT cells initiate psoriasiform plaque formation in mice[J].J Clin Invest,2012,122:2252-2256.
[57]Peng H,Tian Z.Natural killer cell memory:progress and implications[J].Front Immunol,2017,8:1143.
[58]Wang X,Peng H,Cong J,et al.Memory formation and long-term maintenance of IL-7Rα+ILC1s via a lymph node-liver axis[J].Nat Commun,2018,9(1):4854.
[59]Pantelyushin S,Haak S,Ingold B,et al.Rorγt+innate lymphocytes andγδT cells initiate psoriasiform plaque formation in mice[J].J Clin Invest,2012,122(6):2252-2256.