西帕依固龈液对头颈部肿瘤放疗期间口咽部黏膜的保护作用研究
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摘要
目的观察西帕依固龈液对于头颈部肿瘤患者放疗期间口咽部黏膜的保护作用。方法选择2015年1月1日—2017年6月30日在我院行单纯放疗的头颈部肿瘤120例,采用随机数字表法分成西帕依固龈液组40例、复方氯己定组43例和未用药组37例,在常规口腔清洁基础上分别给予西帕依固龈液、复方氯己定含漱液及不用药治疗放射性口咽部黏膜损伤。比较3组放疗期间口腔黏膜损伤、咽部疼痛和不良反应发生情况。结果放疗期间,轻度口腔黏膜损伤和咽部疼痛发生率西帕依固龈液组>复方氯己定组>未用药组,中重度口腔黏膜损伤和咽部疼痛发生率西帕依固龈液组<复方氯己定组<未用药组,差异均有统计学意义(P <0. 01)。西帕依固龈液组患者无用药相关不良反应发生,复方氯己定组患者均有不同程度的口腔、牙齿着色反应。结论西帕依固龈液可明显减轻头颈部肿瘤患者放疗期间中重度口腔黏膜损伤和咽部疼痛,对口咽部黏膜有一定的保护作用。
Objective To evaluate the protective effect of Xipayi gingiva protective solution on oropharyngeal mucosa during radiotherapy to head and neck tumors. Methods A total of 120 patients with head and neck tumors who underwent radiotherapy in our hospital from January 1,2015 to June 30,2017 were divided into Xipayi gingiva protective solution group( n = 40),Compound Gargle Solution Chlorhexidine Giuconatie group( n = 43) and untreatment group( n = 37) according to random number table. On the basis of regular oral cavity cleaning,Xipayi gingiva protective solution,Compound Gargle Solution Chlorhexidine Giuconatie and no medication were used to treat radiation-induced oropharyngeal mucosal injury in the three groups. Oral mucosal injury,pharynx pain and adverse reactions were compared during radiotherapy period between the three groups. Results During radiotherapy,incidence of mild oral mucosal injury and pharyngeal pain was as follows: Xipayi gingiva protective solution group > Compound Gargle Solution Chlorhexidine Giuconatie group > untreatment group( P < 0. 01); incidence of moderate to severe oral mucosal injury and pharyngeal pain was Xipayi gingiva protective solution group < Compound Gargle Solution Chlorhexidine Giuconatie group < untreatment group( P < 0. 01). No adverse drug reactions were found in Xipayi gingiva protective solution group,whereas there were some oral and tooth coloration reactions in Compound Gargle Solution Chlorhexidine Giuconatie group. Conclusion Xipayi gingiva protective solution can significantly alleviate moderate to severe oral mucosa injury and pharyngeal pain for patients with head and neck tumors during radiotherapy,and have a protective effect on oropharyngeal mucosa.
Objective To evaluate the protective effect of Xipayi gingiva protective solution on oropharyngeal mucosa during radiotherapy to head and neck tumors. Methods A total of 120 patients with head and neck tumors who underwent radiotherapy in our hospital from January 1,2015 to June 30,2017 were divided into Xipayi gingiva protective solution group( n = 40),Compound Gargle Solution Chlorhexidine Giuconatie group( n = 43) and untreatment group( n = 37) according to random number table. On the basis of regular oral cavity cleaning,Xipayi gingiva protective solution,Compound Gargle Solution Chlorhexidine Giuconatie and no medication were used to treat radiation-induced oropharyngeal mucosal injury in the three groups. Oral mucosal injury,pharynx pain and adverse reactions were compared during radiotherapy period between the three groups. Results During radiotherapy,incidence of mild oral mucosal injury and pharyngeal pain was as follows: Xipayi gingiva protective solution group > Compound Gargle Solution Chlorhexidine Giuconatie group > untreatment group( P < 0. 01); incidence of moderate to severe oral mucosal injury and pharyngeal pain was Xipayi gingiva protective solution group < Compound Gargle Solution Chlorhexidine Giuconatie group < untreatment group( P < 0. 01). No adverse drug reactions were found in Xipayi gingiva protective solution group,whereas there were some oral and tooth coloration reactions in Compound Gargle Solution Chlorhexidine Giuconatie group. Conclusion Xipayi gingiva protective solution can significantly alleviate moderate to severe oral mucosa injury and pharyngeal pain for patients with head and neck tumors during radiotherapy,and have a protective effect on oropharyngeal mucosa.
引文
[1]李凯新,陈媛媛,陈明,等.放射性口腔黏膜炎的研究进展[J].中华放射医学与防护杂志,2016,36(11):875-880.
[2]齐创,王荧,向东华.盐酸吗啡缓释片直肠给药治疗头颈部肿瘤放射性黏膜损伤所致口腔疼痛的临床观察[J].癌症进展,2016,14(3):259-261,265.
[3]武霞,杨清华,蒋丽华,等.维生素C与康复新防治头颈部肿瘤放疗引起口腔黏膜损伤的临床研究[J].实用肿瘤杂志,2014,29(5):466-469.
[4]刘罡.西帕依固龈液治疗复发性口腔溃疡疗效分析[J].中华全科医学,2013,11(6):889,954.
[5] Cox J D,Stetz J,Pajak T F. Toxicity criteria of the Radiation Therapy Oncology Group(RTOG)and the European Organization for Research and Treatment of Cancer(EORTC)[J]. Int J Radiat Oncol Biol Phys,1995,31(5):1341-1346.
[6] Feldt K S,Ryden M B,Miles S. Treatment of pain in cognitively impaired compared with cognitively intact older patients with hip-fracture[J]. J Am Geriatr Soc,1998,46(9):1079-1085.
[7]李婕.头颈部放射治疗中口腔并发症的研究进展[J].淮海医药,2017,35(5):628-630.
[8]鲁雷,卢冰,王捷.头颈部肿瘤放疗口腔不良反应的防治进展[J].肿瘤预防与治疗,2015,28(2):99-103.
[9]陈善联.放射治疗头颈部肿瘤致正常组织损伤的临床探讨[J].世界临床医学,2017,11(11):124,126.
[10]陈玉林,田静,吴黎霞,等.两种皮肤保护剂预防急性放射性皮肤损伤的对比研究[J].实用医院临床杂志,2013,10(2):96-97.
[11]邢华英,唐媛媛,李丹明,等.抗氧化食物联合中药防治放射性口咽黏膜炎[J].护理学杂志,2015,30(5):14-16.
[12]孙红艳,吕安坤.西帕依固龈液治疗单纯性牙龈炎临床疗效及口臭值的系统评价[J].世界科学技术(中医药现代化),2014,20(8):1850-1854.
[13]冯锦虹,米那瓦尔·阿不都热依木,买买提吐逊·吐尔地.西帕依固龈液治疗复发性口腔溃疡的疗效观察[J].新疆医科大学学报,2005,28(3):242-243.
[14]董滢,蒋柳宏,谢丽娜.西帕依固龈液治疗错颌畸形矫治过程中牙龈炎疗效观察[J].新中医,2013,45(12):119-120.
[15]哈木拉提·吾甫尔,艾比拜·玉素甫,钟良军.西帕依固龈液对内毒素诱导人牙龈成纤维细胞分泌IL-6的抑制作用[J].中南大学学报(医学版),2006,31(3):326-328,335.
[16]王庆兰,邱艳茹.不同漱口液治疗放射性口腔炎疗效观察[J].蚌埠医学院学报,2014,39(2):270-271.
[17]汪跃平,游云华,梁军,等.西帕依固龈液防治口腔黏膜急性放射损伤的疗效观察[J].中国实用医药,2010,5(7):34-35.
[18]史绍英.重组人表皮生长因子联合复方氯己定防治鼻咽癌放疗性口腔黏膜炎的临床效果[J].中国实用医刊,2016,43(14):88-90.
[2]齐创,王荧,向东华.盐酸吗啡缓释片直肠给药治疗头颈部肿瘤放射性黏膜损伤所致口腔疼痛的临床观察[J].癌症进展,2016,14(3):259-261,265.
[3]武霞,杨清华,蒋丽华,等.维生素C与康复新防治头颈部肿瘤放疗引起口腔黏膜损伤的临床研究[J].实用肿瘤杂志,2014,29(5):466-469.
[4]刘罡.西帕依固龈液治疗复发性口腔溃疡疗效分析[J].中华全科医学,2013,11(6):889,954.
[5] Cox J D,Stetz J,Pajak T F. Toxicity criteria of the Radiation Therapy Oncology Group(RTOG)and the European Organization for Research and Treatment of Cancer(EORTC)[J]. Int J Radiat Oncol Biol Phys,1995,31(5):1341-1346.
[6] Feldt K S,Ryden M B,Miles S. Treatment of pain in cognitively impaired compared with cognitively intact older patients with hip-fracture[J]. J Am Geriatr Soc,1998,46(9):1079-1085.
[7]李婕.头颈部放射治疗中口腔并发症的研究进展[J].淮海医药,2017,35(5):628-630.
[8]鲁雷,卢冰,王捷.头颈部肿瘤放疗口腔不良反应的防治进展[J].肿瘤预防与治疗,2015,28(2):99-103.
[9]陈善联.放射治疗头颈部肿瘤致正常组织损伤的临床探讨[J].世界临床医学,2017,11(11):124,126.
[10]陈玉林,田静,吴黎霞,等.两种皮肤保护剂预防急性放射性皮肤损伤的对比研究[J].实用医院临床杂志,2013,10(2):96-97.
[11]邢华英,唐媛媛,李丹明,等.抗氧化食物联合中药防治放射性口咽黏膜炎[J].护理学杂志,2015,30(5):14-16.
[12]孙红艳,吕安坤.西帕依固龈液治疗单纯性牙龈炎临床疗效及口臭值的系统评价[J].世界科学技术(中医药现代化),2014,20(8):1850-1854.
[13]冯锦虹,米那瓦尔·阿不都热依木,买买提吐逊·吐尔地.西帕依固龈液治疗复发性口腔溃疡的疗效观察[J].新疆医科大学学报,2005,28(3):242-243.
[14]董滢,蒋柳宏,谢丽娜.西帕依固龈液治疗错颌畸形矫治过程中牙龈炎疗效观察[J].新中医,2013,45(12):119-120.
[15]哈木拉提·吾甫尔,艾比拜·玉素甫,钟良军.西帕依固龈液对内毒素诱导人牙龈成纤维细胞分泌IL-6的抑制作用[J].中南大学学报(医学版),2006,31(3):326-328,335.
[16]王庆兰,邱艳茹.不同漱口液治疗放射性口腔炎疗效观察[J].蚌埠医学院学报,2014,39(2):270-271.
[17]汪跃平,游云华,梁军,等.西帕依固龈液防治口腔黏膜急性放射损伤的疗效观察[J].中国实用医药,2010,5(7):34-35.
[18]史绍英.重组人表皮生长因子联合复方氯己定防治鼻咽癌放疗性口腔黏膜炎的临床效果[J].中国实用医刊,2016,43(14):88-90.