IgA肾病合并高尿酸血症的临床研究
摘要
目的探讨血清尿酸对免疫球蛋白A(IgA)肾病临床病理及预后的影响,为临床治疗和预后评估提供依据。方法 109例经肾活检确诊为原发性IgA肾病患者,按照高尿酸血症的定义分为高尿酸血症组(85例)和正常血尿酸组(24例)。比较两组患者的临床指标及病理分级。结果两组患者性别、年龄、24 h尿蛋白定量、血清IgA、补体C3水平比较差异无统计学意义(χ~2/t=0.691、0.423、0.799、0.648、1.037, P>0.05);高尿酸血症组患者总胆固醇、甘油三酯、尿素氮、血肌酐水平均高于正常血尿酸组,差异具有统计学意义(t=2.776、3.527、3.111、18.544, P<0.05)。高尿酸血症组病理分级以Ⅳ～Ⅴ级为主(64.71%),正常尿酸组病理分级以Ⅰ～Ⅱ级为主(58.33%),两组患者IgA肾病的病理分级比较差异具有统计学意义(P<0.05)。结论 IgA肾病合并高尿酸血症病理改变程度较尿酸正常组更加严重。
引文
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[4]朱和同,李先维.非布司他联合别嘌醇治疗慢性肾脏病伴高尿酸血症的疗效与安全性.中国医院用药评价与分析,2017,17(7):892-894.
[5]Chen Y,Xu B,Sun W,et al.Impact of the serum uric acid level on subclinical atherosclerosis in middle-aged and elderly chinese.Journal of Atherosclerosis and Thrombosis,2015,22(8):823-832.
[6]Patetsios P,Song M,Shutze WP,et al.Identification of uric acid and xanthine oxidase in atherosclerotic plaque.American Journal of Cardiology,2001,88(2):188-191.
[7]Bakan A,Oral A,Elcioglu OC,et al.Hyperuricemia is associated with progression of IgA nephropathy.International Urology&Nephrology,2015,47(4):673-678.