摘要
目的:系统评价养阴生肌散(膜)局部治疗复发性口腔溃疡的疗效和安全性。方法:检索Cochrane图书馆(2017年第5期)、Pub Med、PMC、Medline、EMBASE、CNKI、CBM、VIP和万方数据资源系统等,收集养阴生肌散(膜)局部治疗复发性口腔溃疡的临床研究文献。参照Cochrane系统评价手册5. 1. 0版评价文献质量,采用Rev Man 5. 3软件对总有效率进行Meta分析,采用ITC软件对养阴生肌散与养阴生肌膜进行疗效间接比较。结果:纳入11篇临床研究文献,包括1 837例患者。Meta分析结果显示养阴生肌散(膜)治疗复发性口腔溃疡疗效优于常规治疗组(OR=5. 22,95%CI:3. 93~6. 93,P <0. 000 01),亚组分析显示养阴生肌散与养阴生肌膜改善复发性口腔溃疡疗效均优于常规治疗组(OR=5. 08,95%CI:3. 63~7. 10,P <0. 000 01与OR=6. 67,95%CI:3. 82~11. 66,P <0. 000 01),间接比较结果显示养阴生肌膜治疗ROU的总有效率优于养阴生肌散(P=0. 009)。未查及不良反应的报道。结论:养阴生肌散(膜)治疗复发性口腔溃疡疗效优于常规治疗。
Objective: To systematically evaluate the efficacy and safety of Yang Yin Sheng Ji pulvis( membranae) in the treatment of recurrent oral ulcers( ROU). Methods: All clinical studies of Yang Yin Sheng Ji pulvis( membranae) for the treatment of ROU were searched from Cochrane Library( Issue 5,2017),Pub Med,PMC,Medline,EMBASE,CNKI,CBM,VIP and WANFANG DATA.The quality of the included studies was evaluated referring to the Cochrane Reviewer's Handbook 5. 1. 0,Meta-analysis of the total effective rate was performed using Rev Man 5. 3. 5 software,ITC software was used to compare the efficacy of Yang Yin Sheng Ji pulvis and Yang Yin Sheng Ji membranae in Meta. Results: 11 studies including 1837 patients were included. The results of Meta-analysis showed that Yang Yin Sheng Ji pulvis( membranae) for the treatment of ROU is more effective than the roultine treatment( OR = 5. 22,95% CI:3. 93 ~ 6. 93,P < 0. 000 01),subgroup analysis showed that Yang Yin Sheng Ji pulvis and Yang Yin Sheng Ji membrane are superior to the routine treatment( OR = 5. 08,95% CI: 3. 63 ~ 7. 10,P < 0. 000 01 and OR = 6. 67 95% CI: 3. 82 ~ 11. 66,P < 0. 000 01),respectively. Indirect comparison results showed that the total efficiency of Yang Yin Sheng Ji membrane is higher than that of Yang Yin Sheng Ji Pulvis( P = 0. 009). No adverse reaction of Yang Yin Sheng Ji pulvis( membrane) was reported. Conclusion: Yang Yin Sheng Ji pulvis( membranae) is more effective in the treatment of ROU than the routine treatment.
引文
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