养阴生肌散(膜)局部治疗复发性口腔溃疡的系统评价
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摘要
目的:系统评价养阴生肌散(膜)局部治疗复发性口腔溃疡的疗效和安全性。方法:检索Cochrane图书馆(2017年第5期)、Pub Med、PMC、Medline、EMBASE、CNKI、CBM、VIP和万方数据资源系统等,收集养阴生肌散(膜)局部治疗复发性口腔溃疡的临床研究文献。参照Cochrane系统评价手册5. 1. 0版评价文献质量,采用Rev Man 5. 3软件对总有效率进行Meta分析,采用ITC软件对养阴生肌散与养阴生肌膜进行疗效间接比较。结果:纳入11篇临床研究文献,包括1 837例患者。Meta分析结果显示养阴生肌散(膜)治疗复发性口腔溃疡疗效优于常规治疗组(OR=5. 22,95%CI:3. 93～6. 93,P <0. 000 01),亚组分析显示养阴生肌散与养阴生肌膜改善复发性口腔溃疡疗效均优于常规治疗组(OR=5. 08,95%CI:3. 63～7. 10,P <0. 000 01与OR=6. 67,95%CI:3. 82～11. 66,P <0. 000 01),间接比较结果显示养阴生肌膜治疗ROU的总有效率优于养阴生肌散(P=0. 009)。未查及不良反应的报道。结论:养阴生肌散(膜)治疗复发性口腔溃疡疗效优于常规治疗。
Objective: To systematically evaluate the efficacy and safety of Yang Yin Sheng Ji pulvis( membranae) in the treatment of recurrent oral ulcers( ROU). Methods: All clinical studies of Yang Yin Sheng Ji pulvis( membranae) for the treatment of ROU were searched from Cochrane Library( Issue 5,2017),Pub Med,PMC,Medline,EMBASE,CNKI,CBM,VIP and WANFANG DATA.The quality of the included studies was evaluated referring to the Cochrane Reviewer's Handbook 5. 1. 0,Meta-analysis of the total effective rate was performed using Rev Man 5. 3. 5 software,ITC software was used to compare the efficacy of Yang Yin Sheng Ji pulvis and Yang Yin Sheng Ji membranae in Meta. Results: 11 studies including 1837 patients were included. The results of Meta-analysis showed that Yang Yin Sheng Ji pulvis( membranae) for the treatment of ROU is more effective than the roultine treatment( OR = 5. 22,95% CI:3. 93 ～ 6. 93,P < 0. 000 01),subgroup analysis showed that Yang Yin Sheng Ji pulvis and Yang Yin Sheng Ji membrane are superior to the routine treatment( OR = 5. 08,95% CI: 3. 63 ～ 7. 10,P < 0. 000 01 and OR = 6. 67 95% CI: 3. 82 ～ 11. 66,P < 0. 000 01),respectively. Indirect comparison results showed that the total efficiency of Yang Yin Sheng Ji membrane is higher than that of Yang Yin Sheng Ji Pulvis( P = 0. 009). No adverse reaction of Yang Yin Sheng Ji pulvis( membrane) was reported. Conclusion: Yang Yin Sheng Ji pulvis( membranae) is more effective in the treatment of ROU than the routine treatment.
Objective: To systematically evaluate the efficacy and safety of Yang Yin Sheng Ji pulvis( membranae) in the treatment of recurrent oral ulcers( ROU). Methods: All clinical studies of Yang Yin Sheng Ji pulvis( membranae) for the treatment of ROU were searched from Cochrane Library( Issue 5,2017),Pub Med,PMC,Medline,EMBASE,CNKI,CBM,VIP and WANFANG DATA.The quality of the included studies was evaluated referring to the Cochrane Reviewer's Handbook 5. 1. 0,Meta-analysis of the total effective rate was performed using Rev Man 5. 3. 5 software,ITC software was used to compare the efficacy of Yang Yin Sheng Ji pulvis and Yang Yin Sheng Ji membranae in Meta. Results: 11 studies including 1837 patients were included. The results of Meta-analysis showed that Yang Yin Sheng Ji pulvis( membranae) for the treatment of ROU is more effective than the roultine treatment( OR = 5. 22,95% CI:3. 93 ～ 6. 93,P < 0. 000 01),subgroup analysis showed that Yang Yin Sheng Ji pulvis and Yang Yin Sheng Ji membrane are superior to the routine treatment( OR = 5. 08,95% CI: 3. 63 ～ 7. 10,P < 0. 000 01 and OR = 6. 67 95% CI: 3. 82 ～ 11. 66,P < 0. 000 01),respectively. Indirect comparison results showed that the total efficiency of Yang Yin Sheng Ji membrane is higher than that of Yang Yin Sheng Ji Pulvis( P = 0. 009). No adverse reaction of Yang Yin Sheng Ji pulvis( membrane) was reported. Conclusion: Yang Yin Sheng Ji pulvis( membranae) is more effective in the treatment of ROU than the routine treatment.
引文
[1]Scully C,Porter S.Oral mucosal disease:Recurrent aphthous stomatitis[J].Br J Oral Maxillofac Surg,2008,46(3):198-206.
[2]LandováH,Daněk Z,Gajdziok J,et al.Oral mucosa and therapy of recurrent aphthous stomatitis[J].Ceska Slov Farm,2013,62(1):12-18.
[3]李亚朋,李军,杨永进.复发性口腔溃疡中医药临床研究进展[J].中国中医药信息杂志,2008,15(5):104-105.
[4]李胜,张超,原瑞霞,等.间接比较软件简介[J].中国循证医学杂志,2015,15(3):362-366.
[5]章瑜芳,柯细彤,李宝才,等.灯盏细辛注射液与灯盏花素注射液治疗缺血性中风急性期临床疗效间接比较的Meta分析[J].中国中药杂志,2017,42(6):1194-1201.
[6]吴婧伟.养阴生肌散加蜂蜜治疗复发性口腔溃疡55例[J].中医杂志,2009,(9):778.
[7]王淑英,郭秋桂,王丹青.养阴生肌散治疗口腔溃疡的疗效观察[J].西北药学杂志,2002,17(5):225-226.
[8]柯华,卫衍加,余澍,等.养阴生肌散治疗复发性口腔溃疡临床观察[J].时珍国医国药,2001,12(12):1105.
[9]黄华锋,徐轩,孟昭业,等.养阴生肌膜治疗复发性口腔溃疡[J].金陵医院学报,1996,9(2):173-174.
[10]李晋凤,李新翔,查成喜.养阴生肌膜治疗复发性口腔溃疡102例[J].西部中医药,2013,26(12):91-92.
[11]吴国英.“养阴生肌膜”治疗复发性口腔溃疡疗效观察[J].临床口腔医学杂志,2000,16(3):172-173.
[12]吴柳青,谢锦玲.养阴生肌散治疗复发性口疮210例疗效观察[J].黑龙江中医药,2000,(1):23.
[13]林景广.养阴生肌散治疗复发性阿弗他溃疡的疗效观察[J].辽宁中医杂志,2009,36(9):1520-1521.
[14]麦伟持.养阴生肌散治疗复发性阿弗它溃疡的疗效观察[J].海南医学,2009,20(2):75-76.
[15]张宪,赵曼.养阴生肌散治疗复发性口疮[J].中原医刊,1997,24(10):37.
[16]陈慧华.“养阴生肌散”治疗口腔溃疡疗效观察[J].口腔材料器械杂志,2001,10(4):187-188.
[17]张敬,沙晶晶,龚娟.IFN-γ+874A/T位点和IL-2-330T/G位点的单核苷酸多态性与复发性口腔溃疡易感性的关系[J].实用口腔医学杂志,2016,32(6):852-856.
[18]王栋,李言君,付爱丽,等.Treg与IL-17在复发性口腔溃疡中表达的相关性研究[J].实用口腔医学杂志,2012,28(4):466-469.
[19]Preeti L,Magesh K,Rajkumar K,et al.Recurrent aphthous stomatitis[J].J Oral Maxillofac Pathol,2011,15(3):252-256.
[20]Vaillant L,Samimi M.Aphthous ulcers and oral ulcerations[J].Presse Med,2016,45(2):215-226.
[21]南京中医药大学.中药大辞典[M].2版.上海:上海科学技术出版社,2006:565-567,788-793,825-827,869-872,1726-1729,2820-2825.
[22]刘洋,邵轩,向琴,等.青黛对白假丝酵母菌抗菌作用的研究[J].中医药导报,2015,21(1):48-49.
[23]孙森凤,张颖颖,褚万春.黄柏药理作用的研究进展[J].山东化工,2017,46(14):99-100.
[24]赵树进,吴红霞,曹永舒.甘草及其提取物对豚鼠β-肾上腺素受体耐受性的保护作用[J].中国中药杂志,1991,16(6):370-371.
[25]尤淑霞,吴德康,刘圣金,等.白矾的基原考证及药理作用[J].中国中医药信息杂志,2010,17(7):111-112.
[26]李喜平,张程亮,刘东.牛黄的现代研究(四):药理作用[J].医药导报,2017,36(4):355-360.
[27]宁愿,程玉鹏,马爱萍,等.龙胆药理作用的研究进展[J].化学工程师,2017,(6):47-49.
[28]魏楚蓉,伍赶球.冰片的药理作用及其机制研究进展[J].国际病理科学与临床杂志,2010,30(5):447-451.
[2]LandováH,Daněk Z,Gajdziok J,et al.Oral mucosa and therapy of recurrent aphthous stomatitis[J].Ceska Slov Farm,2013,62(1):12-18.
[3]李亚朋,李军,杨永进.复发性口腔溃疡中医药临床研究进展[J].中国中医药信息杂志,2008,15(5):104-105.
[4]李胜,张超,原瑞霞,等.间接比较软件简介[J].中国循证医学杂志,2015,15(3):362-366.
[5]章瑜芳,柯细彤,李宝才,等.灯盏细辛注射液与灯盏花素注射液治疗缺血性中风急性期临床疗效间接比较的Meta分析[J].中国中药杂志,2017,42(6):1194-1201.
[6]吴婧伟.养阴生肌散加蜂蜜治疗复发性口腔溃疡55例[J].中医杂志,2009,(9):778.
[7]王淑英,郭秋桂,王丹青.养阴生肌散治疗口腔溃疡的疗效观察[J].西北药学杂志,2002,17(5):225-226.
[8]柯华,卫衍加,余澍,等.养阴生肌散治疗复发性口腔溃疡临床观察[J].时珍国医国药,2001,12(12):1105.
[9]黄华锋,徐轩,孟昭业,等.养阴生肌膜治疗复发性口腔溃疡[J].金陵医院学报,1996,9(2):173-174.
[10]李晋凤,李新翔,查成喜.养阴生肌膜治疗复发性口腔溃疡102例[J].西部中医药,2013,26(12):91-92.
[11]吴国英.“养阴生肌膜”治疗复发性口腔溃疡疗效观察[J].临床口腔医学杂志,2000,16(3):172-173.
[12]吴柳青,谢锦玲.养阴生肌散治疗复发性口疮210例疗效观察[J].黑龙江中医药,2000,(1):23.
[13]林景广.养阴生肌散治疗复发性阿弗他溃疡的疗效观察[J].辽宁中医杂志,2009,36(9):1520-1521.
[14]麦伟持.养阴生肌散治疗复发性阿弗它溃疡的疗效观察[J].海南医学,2009,20(2):75-76.
[15]张宪,赵曼.养阴生肌散治疗复发性口疮[J].中原医刊,1997,24(10):37.
[16]陈慧华.“养阴生肌散”治疗口腔溃疡疗效观察[J].口腔材料器械杂志,2001,10(4):187-188.
[17]张敬,沙晶晶,龚娟.IFN-γ+874A/T位点和IL-2-330T/G位点的单核苷酸多态性与复发性口腔溃疡易感性的关系[J].实用口腔医学杂志,2016,32(6):852-856.
[18]王栋,李言君,付爱丽,等.Treg与IL-17在复发性口腔溃疡中表达的相关性研究[J].实用口腔医学杂志,2012,28(4):466-469.
[19]Preeti L,Magesh K,Rajkumar K,et al.Recurrent aphthous stomatitis[J].J Oral Maxillofac Pathol,2011,15(3):252-256.
[20]Vaillant L,Samimi M.Aphthous ulcers and oral ulcerations[J].Presse Med,2016,45(2):215-226.
[21]南京中医药大学.中药大辞典[M].2版.上海:上海科学技术出版社,2006:565-567,788-793,825-827,869-872,1726-1729,2820-2825.
[22]刘洋,邵轩,向琴,等.青黛对白假丝酵母菌抗菌作用的研究[J].中医药导报,2015,21(1):48-49.
[23]孙森凤,张颖颖,褚万春.黄柏药理作用的研究进展[J].山东化工,2017,46(14):99-100.
[24]赵树进,吴红霞,曹永舒.甘草及其提取物对豚鼠β-肾上腺素受体耐受性的保护作用[J].中国中药杂志,1991,16(6):370-371.
[25]尤淑霞,吴德康,刘圣金,等.白矾的基原考证及药理作用[J].中国中医药信息杂志,2010,17(7):111-112.
[26]李喜平,张程亮,刘东.牛黄的现代研究(四):药理作用[J].医药导报,2017,36(4):355-360.
[27]宁愿,程玉鹏,马爱萍,等.龙胆药理作用的研究进展[J].化学工程师,2017,(6):47-49.
[28]魏楚蓉,伍赶球.冰片的药理作用及其机制研究进展[J].国际病理科学与临床杂志,2010,30(5):447-451.