成纤维细胞生长因子18对骨和软骨发育
|
摘要
成纤维细胞生长因子18(FGF18)是调节骨和软骨形成的重要生长因子,它通过多种途径影响胚胎及出生后骨和软骨的发展。目前,大部分研究认为FGF18对骨和软骨的发育起正向调节的作用,但也有研究持相反的观点。由于软骨组织供血不足等原因,软骨损伤相关疾病(如骨关节炎)的治疗较为困难,且尚无有效的治疗药物。研究发现的FGF18对软骨细胞增殖和细胞外基质产生的促进作用为该类疾病的治疗提供了新的契机。本文将对FGF18的研究进展做简要综述。
引文
[1]KARUPPAIAH K,YU K,LIM J.FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth[J].Development,2016,143(10):1811-22.
[2]ORNITZ DM,MARIE PJ.Fibroblast growth factor signaling in skeletal development and disease[J].Genes Dev,2015,29(14):1463-86.
[3]CINQUE L,FORRESTER,BARTOLOMEO,et al.RFGF signalling regulates bone growth through autophagy[J].Nature,2015,528(7581):272-5.
[4]BRADLEY EW,CARPIO LR,NEWTON AC,et al.Deletion of the PH-domain and leucine-rich repeat protein phosphatase 1(Phlpp1)increases fibroblast growth factor(Fgf)18 expression and promotes chondrocyte proliferation[J].J Biol Chem,2015,290(26):16272-80.
[5]ROCKEL JS,YU C,WHETSTONE H,et al.Hedgehog inhibitsβ-catenin activity in synovial joint development and osteoarthritis[J].J Clin Invest,2016,126(5):1649-63.
[6]NAGAYAMA T,OKUHARA S,OTA MS,et al.FGF18accelerates osteoblast differentiation by upregulating Bmp2 expression[J].Congenit Anom,2013,52(2):82-3.
[7]MAHAPATRA C,SINGH RK,KIM JJ,et al.Osteopromoting reservoir of stem cells:bioactive mesoporous nanocarrier/collagen gel through slow-releasing FGF18 and the activated BMP signaling[J].ACS Appl Mater Interfaces,2016,8:27573-84.
[8]LIU Z,XU J,COLVIN JS,et al.Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18[J].Genes Dev,2002,16(7):859-69.
[9]JEON E,YUN YR,KANG W,et al.Investigating the role of FGF18 in the cultivation and osteogenic differentiation of mesenchymal stem cells[J].PLoS One,2017,7(8):e43982.
[10]ZHAI F,SONG N,MA J,et al.FGF18 inhibits MC3T3E1 cell osteogenic differentiation via the ERK signaling pathway[J].Mol Med Rep,2017,16(4):4127-32.
[11]MORI Y,SAITO T,CHANG SH,et al.Identification of fibroblast growth factor-18 as a molecule to protect adult articular cartilage by gene expression profiling[J].J Biol Chem,2014,289(14):10192-200.
[12]GIGOUT A,GUEHRING H,FROEMEL D,et al.Sprifermin(rhFGF18)enables proliferation of chondrocytes producing a hyaline cartilage matrix[J].Osteoarthritis and Cartilage,2017,25(11):1858-67.
[13]REKER D,KJELGAARD-PETERSEN CF,SIEBUHR AS,et al.Sprifermin(rh FGF18)modulates extracellular matrix turnover in cartilage explants ex vivo[J].J Transl Med,2017,15(1):250.
[14]DAHLBERG LE,AYDEMIR A,MUURAHAINEN N,et al.Afirst-in-human,double-blind,randomised,placebo-controlled,dose ascending study of intra-articular rhFGF18(sprifermin)in patients with advanced knee osteoarthritis[J].Clin Exp Rheumatol,2016,34(3):440-50.
[15]LOHMANDER LS,HELLOT S,DREHER D,et al.Intraarticular sprifermin(recombinant human fibroblast growth factor 18)in knee osteoarthritis[J].Arthritis Rheumatol,2014,66(7):1820-31.
[16]ECKSTEIN F,WIRTH W,GUERMAZI A,et al.Intraarticular sprifermin not only increases cartilage thickness,but also reduces cartilage loss:location-independent post hoc analysis using magnetic resonance imaging[J].Arthritis Rheumatol,2015,67(11):2916-22.
[17]POWER J,HERNANDEZ P,GUEHRING H,et al.Intra-articular injection of rhFGF-18 improves the healing in microfracture treated chondral defects in an ovine model[J].J Orthop Res,2014,32(5):669-76.
[18]HOWARD D,WARDALE J,GUEHRING H,et al.Delivering rhFGF-18 via a bilayer collagen membrane to enhance microfracture treatment of chondral defects in a large animal model[J].JOrthop Res,2015,33(8):1120-7.
[19]SENNETT ML,MELONI GR,FARRAN AJE,et al.Sprifermin treatment enhances cartilage integration in an in vitro repair model[J].J Orthop Res,2018,36(10):2648-56.
[20]Riegger J,Joos H,Palm HG,et al.Striking a new path in reducing cartilage breakdown:combination of antioxidative therapy and chondroanabolic stimulation after blunt cartilage trauma[J].J Cell Mol Med,2018,22(1):77-88.
[2]ORNITZ DM,MARIE PJ.Fibroblast growth factor signaling in skeletal development and disease[J].Genes Dev,2015,29(14):1463-86.
[3]CINQUE L,FORRESTER,BARTOLOMEO,et al.RFGF signalling regulates bone growth through autophagy[J].Nature,2015,528(7581):272-5.
[4]BRADLEY EW,CARPIO LR,NEWTON AC,et al.Deletion of the PH-domain and leucine-rich repeat protein phosphatase 1(Phlpp1)increases fibroblast growth factor(Fgf)18 expression and promotes chondrocyte proliferation[J].J Biol Chem,2015,290(26):16272-80.
[5]ROCKEL JS,YU C,WHETSTONE H,et al.Hedgehog inhibitsβ-catenin activity in synovial joint development and osteoarthritis[J].J Clin Invest,2016,126(5):1649-63.
[6]NAGAYAMA T,OKUHARA S,OTA MS,et al.FGF18accelerates osteoblast differentiation by upregulating Bmp2 expression[J].Congenit Anom,2013,52(2):82-3.
[7]MAHAPATRA C,SINGH RK,KIM JJ,et al.Osteopromoting reservoir of stem cells:bioactive mesoporous nanocarrier/collagen gel through slow-releasing FGF18 and the activated BMP signaling[J].ACS Appl Mater Interfaces,2016,8:27573-84.
[8]LIU Z,XU J,COLVIN JS,et al.Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18[J].Genes Dev,2002,16(7):859-69.
[9]JEON E,YUN YR,KANG W,et al.Investigating the role of FGF18 in the cultivation and osteogenic differentiation of mesenchymal stem cells[J].PLoS One,2017,7(8):e43982.
[10]ZHAI F,SONG N,MA J,et al.FGF18 inhibits MC3T3E1 cell osteogenic differentiation via the ERK signaling pathway[J].Mol Med Rep,2017,16(4):4127-32.
[11]MORI Y,SAITO T,CHANG SH,et al.Identification of fibroblast growth factor-18 as a molecule to protect adult articular cartilage by gene expression profiling[J].J Biol Chem,2014,289(14):10192-200.
[12]GIGOUT A,GUEHRING H,FROEMEL D,et al.Sprifermin(rhFGF18)enables proliferation of chondrocytes producing a hyaline cartilage matrix[J].Osteoarthritis and Cartilage,2017,25(11):1858-67.
[13]REKER D,KJELGAARD-PETERSEN CF,SIEBUHR AS,et al.Sprifermin(rh FGF18)modulates extracellular matrix turnover in cartilage explants ex vivo[J].J Transl Med,2017,15(1):250.
[14]DAHLBERG LE,AYDEMIR A,MUURAHAINEN N,et al.Afirst-in-human,double-blind,randomised,placebo-controlled,dose ascending study of intra-articular rhFGF18(sprifermin)in patients with advanced knee osteoarthritis[J].Clin Exp Rheumatol,2016,34(3):440-50.
[15]LOHMANDER LS,HELLOT S,DREHER D,et al.Intraarticular sprifermin(recombinant human fibroblast growth factor 18)in knee osteoarthritis[J].Arthritis Rheumatol,2014,66(7):1820-31.
[16]ECKSTEIN F,WIRTH W,GUERMAZI A,et al.Intraarticular sprifermin not only increases cartilage thickness,but also reduces cartilage loss:location-independent post hoc analysis using magnetic resonance imaging[J].Arthritis Rheumatol,2015,67(11):2916-22.
[17]POWER J,HERNANDEZ P,GUEHRING H,et al.Intra-articular injection of rhFGF-18 improves the healing in microfracture treated chondral defects in an ovine model[J].J Orthop Res,2014,32(5):669-76.
[18]HOWARD D,WARDALE J,GUEHRING H,et al.Delivering rhFGF-18 via a bilayer collagen membrane to enhance microfracture treatment of chondral defects in a large animal model[J].JOrthop Res,2015,33(8):1120-7.
[19]SENNETT ML,MELONI GR,FARRAN AJE,et al.Sprifermin treatment enhances cartilage integration in an in vitro repair model[J].J Orthop Res,2018,36(10):2648-56.
[20]Riegger J,Joos H,Palm HG,et al.Striking a new path in reducing cartilage breakdown:combination of antioxidative therapy and chondroanabolic stimulation after blunt cartilage trauma[J].J Cell Mol Med,2018,22(1):77-88.