基于数据挖掘探讨《四圣心源》治疗消渴病的组方用药规律
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摘要
目的:探讨黄元御《四圣心源》治疗消渴病的组方用药规律,为临床治疗消渴病提供参考依据。方法:将《四圣心源》方剂中涉及药物进行整理,建立Excel 2007四圣心源方药数据库,运用频数分析及聚类分析法对《四圣心源》的用药情况进行统计学分析。结果:筛选出140首方剂,涉及药物103味,用药频次达893次,消渴用药中药物使用频次位居前4为茯苓、泽泻、桂枝、附子,药物类别排列第1位为利水渗湿药,体现黄氏论治消渴以扶阳抑阴为大法,从肝脾肾论治,根本在于顾护脾土。结论:黄元御《四圣心源》治疗消渴病不离扶阳抑阴、崇尚脾土,基于数据挖掘其用药规律可为临床治疗提供参考。
Objective: To discuss the pattern of the treatment of diabetes from Si Sheng Xin Yuan, to provide a reference for the clinical treatment of diabetes. Methods: The drug prescriptions involved in Si Sheng Xin Yuan, were arranged to build EXCEL2007 database of Si Sheng Xin Yuan, and frequency analysis and cluster analysis were used for statistical analysis. Results: The results showed that there're 140 prescriptions and 103 drug, and the total usage rate is 893. The drugs with top four frequencies were Fuling(Poria cocos), Zexie(Alisma orientalis), Guizhi(Cinnamomum cassia twig) and Fuzi(Aconite root). Drug categories ranked first in the list is drugs for diuresis and dampness and it reflects HUANG Yuan-yu treats diabetes according to the main principle of reinforcing Yang and suppressing Yin, with treatment of liver, spleen and kidney, based on protecting spleen and soil. Conclusion: Not only encouraging Yang to suppress Yin, but also attaches great importance to the spleen soilis is the mainly therapy of diabetes from Si Sheng Xin Yuan of HUANG Yuan-yu, and it can provide a reference for clinical treatment based on data mining.
Objective: To discuss the pattern of the treatment of diabetes from Si Sheng Xin Yuan, to provide a reference for the clinical treatment of diabetes. Methods: The drug prescriptions involved in Si Sheng Xin Yuan, were arranged to build EXCEL2007 database of Si Sheng Xin Yuan, and frequency analysis and cluster analysis were used for statistical analysis. Results: The results showed that there're 140 prescriptions and 103 drug, and the total usage rate is 893. The drugs with top four frequencies were Fuling(Poria cocos), Zexie(Alisma orientalis), Guizhi(Cinnamomum cassia twig) and Fuzi(Aconite root). Drug categories ranked first in the list is drugs for diuresis and dampness and it reflects HUANG Yuan-yu treats diabetes according to the main principle of reinforcing Yang and suppressing Yin, with treatment of liver, spleen and kidney, based on protecting spleen and soil. Conclusion: Not only encouraging Yang to suppress Yin, but also attaches great importance to the spleen soilis is the mainly therapy of diabetes from Si Sheng Xin Yuan of HUANG Yuan-yu, and it can provide a reference for clinical treatment based on data mining.
引文
[1]黄元御.四圣心源[M].孙洽熙,校注.北京:中国中医药出版社,2009.
[2]黄兆胜.中药学[M].北京:人民卫生出版社,2002.
[3]南京中医药大学.中药大辞典[M].上海:上海科学技术出版社,2006.
[4]李俊慧,郭开元,周士慧,等.黄元御从肝脾肾论治消渴理论探析[J].江苏中医药,2017,49(5):13-14.
[5]俞跃,阮诗玮.基于黄元御“中气升降”理论探讨虚劳证治[J].中国中医药信息杂志,2017,24(6):114-116.
[6]尚蕊.以药统方依方用药——黄元御《长沙药解》特色[J].中国中医药现代远程教育,2017,15(8):62-63.
[7]李博文,王聪,杜娟,等.黄元御《四圣心源》代表方剂配伍分析[J].现代中医药,2015,35(5):99-102.
[8]赵凡,张春和,陈文慧.《四圣心源》治疗遗精学术思想探讨[J].辽宁中医药大学学报,2015,17(9):133-135.
[9]季青青,张国梁,刘雨香,等.数据挖掘技术在名老中医学术经验研究的应用[J].中医药临床杂志,2018,30(4):587-590.
[10]杨必安,黄作阵.黄元御学术思想探源[J].世界中医药,2015,10(11):1694-1696,1700.
[11]刘臻华.从《四圣心源》论消渴及其变证的辨治思路[J].山东中医杂志,2016,35(10):857-858.
[12]田列,石岩.《四圣心源》论治消渴[J].吉林中医药,2016,36(1):94-97.
[13]马玄静.黄元御中气升降理论探析[D].石家庄:河北医科大学,2015.
[14]戚徐斌.黄元御《四圣心源》论治泄利学说初探[J].亚太传统医药,2017,13(8):58-59.
[15]周博文.从黄元御“中气升降”理论探讨气血瘀滞证治[J].中国中医药信息杂志,2017,24(4):115-117.
[2]黄兆胜.中药学[M].北京:人民卫生出版社,2002.
[3]南京中医药大学.中药大辞典[M].上海:上海科学技术出版社,2006.
[4]李俊慧,郭开元,周士慧,等.黄元御从肝脾肾论治消渴理论探析[J].江苏中医药,2017,49(5):13-14.
[5]俞跃,阮诗玮.基于黄元御“中气升降”理论探讨虚劳证治[J].中国中医药信息杂志,2017,24(6):114-116.
[6]尚蕊.以药统方依方用药——黄元御《长沙药解》特色[J].中国中医药现代远程教育,2017,15(8):62-63.
[7]李博文,王聪,杜娟,等.黄元御《四圣心源》代表方剂配伍分析[J].现代中医药,2015,35(5):99-102.
[8]赵凡,张春和,陈文慧.《四圣心源》治疗遗精学术思想探讨[J].辽宁中医药大学学报,2015,17(9):133-135.
[9]季青青,张国梁,刘雨香,等.数据挖掘技术在名老中医学术经验研究的应用[J].中医药临床杂志,2018,30(4):587-590.
[10]杨必安,黄作阵.黄元御学术思想探源[J].世界中医药,2015,10(11):1694-1696,1700.
[11]刘臻华.从《四圣心源》论消渴及其变证的辨治思路[J].山东中医杂志,2016,35(10):857-858.
[12]田列,石岩.《四圣心源》论治消渴[J].吉林中医药,2016,36(1):94-97.
[13]马玄静.黄元御中气升降理论探析[D].石家庄:河北医科大学,2015.
[14]戚徐斌.黄元御《四圣心源》论治泄利学说初探[J].亚太传统医药,2017,13(8):58-59.
[15]周博文.从黄元御“中气升降”理论探讨气血瘀滞证治[J].中国中医药信息杂志,2017,24(4):115-117.