血清同型半胱氨酸与胱抑素C检测在妊娠期高血压疾病中的应用价值
|
摘要
目的探讨血清同型半胱氨酸(Hcy)及胱抑素C (Cys C)检测在妊娠期高血压疾病中的应用价值。方法选择2016年3月至2017年4月期间上海市宝山区罗店医院收治的102例疾病超进展(HDP)患者为研究对象,其中妊娠期高血压患者50例纳入高血压组、子痫前期轻度患者37例纳入轻度组、子痫前期重度患者15例纳入重度组,另随机选择同期60例健康妊娠产妇纳入对照组,比较不同组别受检者的血清Hcy及Cys-C水平。结果 HDP组患者的血清Hcy及Cys C分别为(21.12±6.43)μmol/L、(1.95±0.78) mg/L,明显高于对照组的(9.83±3.05)μmol/L、(0.82±0.39) mg/L,差异均有统计学意义(P<0.05);高血压组、轻度组和重度组患者的血清Hcy、Cys C水平分别为(16.95±4.23)μmol/L、(1.57±0.53) mg/L,(19.54±5.16)μmol/L、(1.86±0.71) mg/L和(24.42±7.03)μmol/L、(2.16±1.05) mg/L,Hcy、Cys C水平均随着病情的加重逐渐升高,差异均有统计学意义(P<0.05)。结论联合检测血清Hcy及Cys C水平对监测妊娠期高血压疾病的发生及病情严重程度具有重要的临床价值。
Objective To investigate the value of serum homocysteine(Hcy) and cystatin C(Cys-C) in hypertensive disorder of pregnancy(HDP). Methods A total of 102 cases of HDP patients, who admitted to Luodian Hospital of Shanghai Baoshan District from March 2016 to April 2017, were selected as the research subjects, of which 50 cases with gestational hypertension were chosen as the hypertension group, 37 cases with mild preeclampsia were included into the mild group, 15 cases with severe preeclampsia were enrolled into the severe group. At the same period, another 60 cases of healthy pregnant women were randomly selected as the control group. Serum Hcy and Cys-C Levels in different groups were compared. Results In the HDP patients, serum Hcy and Cys-C respectively were(21.12±6.43) μmol/L,(1.95±0.78) mg/L, which were significantly higher than corresponding(9.83±3.05) μmol/L and(0.82±0.39) mg/L in the control group(P<0.05). In the HDP patients, serum Hcy and Cys-C levels in the hypertension group, mild group and severe group were(16.95±4.23) μmol/L,(1.57±0.53) mg/L,(19.54±5.16) μmol/L and(1.86±0.71) mg/L,(24.42±7.03) μ mol/L,(2.16 ± 1.05) mg/L, which increased step by step, and the differences were statistically significant(P<0.05). Conclusion Combined detection of serum Hcy and Cys-C has important clinical significance in monitoring the occur and severity of hypertensive disorder of pregnancy.
Objective To investigate the value of serum homocysteine(Hcy) and cystatin C(Cys-C) in hypertensive disorder of pregnancy(HDP). Methods A total of 102 cases of HDP patients, who admitted to Luodian Hospital of Shanghai Baoshan District from March 2016 to April 2017, were selected as the research subjects, of which 50 cases with gestational hypertension were chosen as the hypertension group, 37 cases with mild preeclampsia were included into the mild group, 15 cases with severe preeclampsia were enrolled into the severe group. At the same period, another 60 cases of healthy pregnant women were randomly selected as the control group. Serum Hcy and Cys-C Levels in different groups were compared. Results In the HDP patients, serum Hcy and Cys-C respectively were(21.12±6.43) μmol/L,(1.95±0.78) mg/L, which were significantly higher than corresponding(9.83±3.05) μmol/L and(0.82±0.39) mg/L in the control group(P<0.05). In the HDP patients, serum Hcy and Cys-C levels in the hypertension group, mild group and severe group were(16.95±4.23) μmol/L,(1.57±0.53) mg/L,(19.54±5.16) μmol/L and(1.86±0.71) mg/L,(24.42±7.03) μ mol/L,(2.16 ± 1.05) mg/L, which increased step by step, and the differences were statistically significant(P<0.05). Conclusion Combined detection of serum Hcy and Cys-C has important clinical significance in monitoring the occur and severity of hypertensive disorder of pregnancy.
引文
[1]邓莉,方碧梅.妊娠期高血压疾病的临床流行病学分析[J].海南医学, 2015, 26(17):2602-2603.
[2]张琚芳,朱启英.血管内皮损伤机制在妊娠期高血压疾病中的研究进展[J].中国优生与遗传杂志, 2009, 17(1):13-15.
[3]乐杰.妇产科学[M]. 7版.北京:人民卫生出版社, 2008:94-100.
[4]蒋丽江,郭跃文,郑巍,等.妊娠期高血压疾病危险因素及对母婴预后的影响[J].中国现代医生, 2012, 50(35):24-26.
[5]郭含珠.妊娠期高血压疾病对母婴结局的影响[J].海南医学, 2012,23(8):68-70.
[6]温丽,郭珍,胡际东,等.汉族女性妊娠期高血压疾病的流行病学及发病机制研究[J].医学研究杂志, 2017, 46(5):128-131.
[7] HEIMRATH J, PAPROCKA M, CZEKANSKI A, et al. Pregnancy-induced hypertension is accompanied by decreased number of circulating endothelial cells and circulating endothelial progenitor cells[J]. Arch Immunol Ther Exp(Warsz), 2014, 62(4):353-356.
[8]王新格,张建军.不同类型妊娠期高血压疾病对高龄孕产妇妊娠结局的影响分析[J].中国性科学, 2017, 26(1):106-108.
[9]张婷,毛平安,章玲宾.妊娠期高血压疾病危险因素的logistic回归分析[J].实用预防医学, 2016, 23(4):457-458, 452.
[10]吴福杉,苏虹梅,陈婷丽.血清胱抑素C和同型半胱氨酸水平与早期糖尿病肾病的关系[J].海南医学, 2017, 28(2):214-216.
[11]邓远琼,张志娟,李宏翔,等.血管内皮功能及同型半胱氨酸对冠心病的预测价值研究[J].中国全科医学, 2013, 16(31):3672-3675.
[12]任明芬,魏旭明,张三强,等.急性冠脉综合征与血管内皮生长因子及同型半胱氨酸的相关分析[J].重庆医学, 2016, 45(8):1046-1048,1052.
[13]雷湘菊.血清同型半胱氨酸与妊娠期高血压的关系[J].湖南师范大学学报(医学版), 2010, 7(4):72-73.
[14]张玲,王鹓,陈祥云,等.血浆同型半胱氨酸水平与妊娠期高血压疾病的关系[J].山东医药, 2015, 55(25):33-34.
[15]樊秦娥,吴立兵,刘雪琴,等.妊娠高血压患者血清瘦素、Cys C及β-HCG水平检测的临床意义[J].现代生物医学进展, 2016, 16(5):910-912.
[16]周连华,范玉娟,姜文娟,等.血清胱抑素C在早期糖尿病肾病患者肾功能受损评价中的诊断价值[J].临床内科杂志, 2012, 29(2):108-109.
[17]张功和,吴节荣,周猛,同型半胱氨酸、胱抑素C和超敏C反应蛋白在动脉粥样硬化中的临床意义[J].国际检验医学杂志, 2016, 37(20):2818-2819, 2822.
[18]刘红红,沈小梅.高血压合并代谢综合征患者血清胱抑素C与血管内皮功能的相关性分析[J].中西医结合心脑血管病杂志, 2017, 15(14):1755-1758.
[2]张琚芳,朱启英.血管内皮损伤机制在妊娠期高血压疾病中的研究进展[J].中国优生与遗传杂志, 2009, 17(1):13-15.
[3]乐杰.妇产科学[M]. 7版.北京:人民卫生出版社, 2008:94-100.
[4]蒋丽江,郭跃文,郑巍,等.妊娠期高血压疾病危险因素及对母婴预后的影响[J].中国现代医生, 2012, 50(35):24-26.
[5]郭含珠.妊娠期高血压疾病对母婴结局的影响[J].海南医学, 2012,23(8):68-70.
[6]温丽,郭珍,胡际东,等.汉族女性妊娠期高血压疾病的流行病学及发病机制研究[J].医学研究杂志, 2017, 46(5):128-131.
[7] HEIMRATH J, PAPROCKA M, CZEKANSKI A, et al. Pregnancy-induced hypertension is accompanied by decreased number of circulating endothelial cells and circulating endothelial progenitor cells[J]. Arch Immunol Ther Exp(Warsz), 2014, 62(4):353-356.
[8]王新格,张建军.不同类型妊娠期高血压疾病对高龄孕产妇妊娠结局的影响分析[J].中国性科学, 2017, 26(1):106-108.
[9]张婷,毛平安,章玲宾.妊娠期高血压疾病危险因素的logistic回归分析[J].实用预防医学, 2016, 23(4):457-458, 452.
[10]吴福杉,苏虹梅,陈婷丽.血清胱抑素C和同型半胱氨酸水平与早期糖尿病肾病的关系[J].海南医学, 2017, 28(2):214-216.
[11]邓远琼,张志娟,李宏翔,等.血管内皮功能及同型半胱氨酸对冠心病的预测价值研究[J].中国全科医学, 2013, 16(31):3672-3675.
[12]任明芬,魏旭明,张三强,等.急性冠脉综合征与血管内皮生长因子及同型半胱氨酸的相关分析[J].重庆医学, 2016, 45(8):1046-1048,1052.
[13]雷湘菊.血清同型半胱氨酸与妊娠期高血压的关系[J].湖南师范大学学报(医学版), 2010, 7(4):72-73.
[14]张玲,王鹓,陈祥云,等.血浆同型半胱氨酸水平与妊娠期高血压疾病的关系[J].山东医药, 2015, 55(25):33-34.
[15]樊秦娥,吴立兵,刘雪琴,等.妊娠高血压患者血清瘦素、Cys C及β-HCG水平检测的临床意义[J].现代生物医学进展, 2016, 16(5):910-912.
[16]周连华,范玉娟,姜文娟,等.血清胱抑素C在早期糖尿病肾病患者肾功能受损评价中的诊断价值[J].临床内科杂志, 2012, 29(2):108-109.
[17]张功和,吴节荣,周猛,同型半胱氨酸、胱抑素C和超敏C反应蛋白在动脉粥样硬化中的临床意义[J].国际检验医学杂志, 2016, 37(20):2818-2819, 2822.
[18]刘红红,沈小梅.高血压合并代谢综合征患者血清胱抑素C与血管内皮功能的相关性分析[J].中西医结合心脑血管病杂志, 2017, 15(14):1755-1758.