石墨烯及其衍生物在肿瘤诊疗方面的应用
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摘要
功能化石墨烯及其衍生物具有独特的物理化学性质,在很多领域备受关注。其中,在生物医学领域已成为研究热点,尤其在恶性肿瘤的早期诊断与治疗方面具有独特的优越性。本研究就近几年来石墨烯及其衍生物在肿瘤诊断及其在抗肿瘤作用中的相关研究作一简要综述,为恶性肿瘤的诊断与治疗提供新的视角,为石墨烯临床应用提供一定的理论依据。
Functionalized graphee and its derivatives have raised much attention due to their unique physical and chemical properties. Among them, functionalized graphene has become a research hotspot in the field of biomedicine, especially in the early diagnosis and the treatment of malignant tumors. In this review, we discussed the recent research focusing on studying the roles of graphene and its derivatives in diagnosis of tumor and anti-tumor. This paper would suggest a new way for diagnosis and treatment of malignant tumor, and provide theoretical basis for the clinical application of graphene as well
Functionalized graphee and its derivatives have raised much attention due to their unique physical and chemical properties. Among them, functionalized graphene has become a research hotspot in the field of biomedicine, especially in the early diagnosis and the treatment of malignant tumors. In this review, we discussed the recent research focusing on studying the roles of graphene and its derivatives in diagnosis of tumor and anti-tumor. This paper would suggest a new way for diagnosis and treatment of malignant tumor, and provide theoretical basis for the clinical application of graphene as well
引文
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Egeblad M.,and Werb Z.,2002,New functions for the matrix metalloproteinases in cancer progression,Nat.Rev.Cancer,2(3):161-174
Geim A.K.,and Novoselov K.S.,2007,The rise of graphene,Nat Mater.,6(3):183-191
Guo H.,Zhou X.,Lu Y.,Xie L.,Chen Q.,Keller E.T.,and Zhang J.,2015,Translational progress on tumor biomarkers,Thoracic cancer,6(6):665-671
Guo H.L.,Wang X.F.,Qian Q.Y.,Wang F.B.,and Xia X.H.2009a,A green approach to the synthesis of graphene nanosheets,ACS Nano,3(9):2653-2659
Guo R.,Li R.,Li X.,Zhang L.,Jiang X.,and Liu B.,2009b,Dual-functional alginic acid hybrid nanospheres for cell imaging and drug delivery,Small,5(6):709-717
Kim S.H.,Kaplan J.A.,Sun Y.,Shieh A.,Sun H.L.,Croce C.M.Grinstaff M.W.,and Parquette J.R.,2015,The self-assembly of anticancer camptothecin-dipeptide nanotubes:a minimalistic and high drug loading approach to increased efficacy Chemistry,21(1):101-105
Li C.,2013,Functionalized graphene oxide for tumor markers detecting and anticancer drugs targeted delivery,Thesis for MS.,Southwest University,Supervisor:Yang S.,pp.1-45(李程,2013,基于功能化氧化石墨烯检测肿瘤标志物及抗肿瘤药向传递的研究,硕士学位论文,西南大学,导师:宋杨pp.1-45)
Li C.,Nie C.H.,Zhang L.J.,and Xu H.M.,2014,Advances in research on application of tumor markers and their screening technique,Yaoxue Jinzhan(Progress in Pharmaceutical Sciences),38(1):1-13(李策,聂彩辉,张力君,徐寒梅,2014肿瘤标志物的应用及其筛选技术研究进展,药学进展,38(1):1-13)
Li K.Y.,2014,The preparation of nano-graphene oxide and the application in gene delivery and stem cell differentiation Thesis for M.S.,Soochow University,Supervisor:Liu J.,pp1-55(李坤阳,2014,纳米氧化石墨烯基底材料的制备及其在基因转染和干细胞分化中的应用,硕士学位论文,苏州大学,导师:刘坚,pp.1-55)
Li P.,Gao Y.,Sun Z.,Chang D.,Gao G.,and Dong A.,2016Synthesis,characterization,and bactericidal evaluation of chitosan/guanidine functionalized graphene oxide composites,Molecules,22(1):12
Li X.,Zhang G.,Bai X.,Sun X.,Wang X.,Wang E.,and Dai H.2008,Highly conducting graphene sheets and langmuir-blodgett films,Nat.Nanotechnol.,3(9):538-542
Liu Z.,Robinson J.T.,Sun X.,and Dai H.,2008,PEGylated nano-graphene oxide for delivery of water insoluble cancer drugs,J.Am.Chem.Soc.,130(33):10876-10877
Lu J.,Wang J.C.,Zhao M.F.,and Huang Y.,2014,Preparation and electrochemical properties of graphene oxide,Cailiao Daobao(Materials Review),28(22):28-31(陆军,王建朝,赵美峰,黄严,2014,氧化石墨烯的制备及电化学性质研究,材料导报,28(22):28-31)
Markovic Z.M.,Harhaji-Trajkovic L.M.,Todorovic-Markovic B.M.,Kepic D.P.,Arsikin K.M.,Jovanovic S.P.,Pantovic A.C.,Dramicanin M.D,and Trajkovic V.S.,2011,In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes,Biomaterials,32(4):1121-1129
Mohammed A.A.,El-Tanni H.,El-Khatib H.M.,Mirza A.A.,Mirza A.A.,and Alturaifi T.H.,2016,Urinary bladder cancer:biomarkers and target therapy,new era for more attention,Oncol.Rev.,10(2):86-92
Niu G.L.,2012,The preparation of functionalized graphene oxide nano carrier and the effects on the proliferation of the carrier loading h TERTsi RNA on cervical cancer Hela cells,Thesis for M.S.,Liaoning Medical University,Supervisor:Wen Y.K.,pp.1-48(牛高丽,2012,功能化氧化石墨烯纳米载体的制备及载h TERTsi RNA对宫颈癌Hela细胞增殖的影响,硕士学位论文,辽宁医学院,导师:温玉库,pp.1-48)
Pan C.N,He J.,and Zhong C.L.,2016,Study on thermoelectric properties of graphene nanoribbons,Hunan Gongye Daxue Xuebao(Journal of Hunan University of Technology),30(2):68-71(潘长宁,何军,钟春良,2016,石墨烯纳米条带的热电性质研究,湖南工业大学学报,30(2):68-71)
Peng C.,Hu W.,Zhou Y.,Fan C.,and Huang Q.,2010,Intracellular imaging with a grapheme-based fluorescent probe,Small,6(15):1686-1692
Song Y.,Chen Y.,Feng L.,Ren J.,and Qu X.,2011,Selective and quantitative cancer cell detection using target-directed functionalized graphene and its synergetic peroxidase-like activity,Chem.Commun.(Camb),47(15):4436-4438
Wang H.X.,2013,Photoactive graphene-synthesis and photoelectric property study,Dissertation for Ph.D.,Lanzhou University,Supervisor:Zhang H.L.,pp.1-98(汪航行,2013,光活性石墨烯的制备及其光电性质研究,博士学位论文,兰州大学,导师:张浩力,pp.1-98))
Zhang J.,2013,Dual-polymer functionalized nanoscale graphene oxide as a highly effective gene transfection agent for insect cells with cell-type dependent cellular uptake mechanisms,Thesis for M.S.,Soochow University,Supervisor:Peng R.,pp.1-44(张静,2013,氧化石墨烯作为高效的基因转染的载体,硕士学位论文,苏州大学,导师:彭瑞,pp.1-44)
Zhang L.,Xia J.,Zhao Q.,Liu L.,and Zhang Z.,2010,Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs,Small,6(4):537-544
Cao X.F.,Feng F.L.,Yang X.Y.,and Zhou J.,2013,Preparation and characterization of functional graphene oxide as nanocarriers for genes and anti-tumor drugs,Tianjin Yike Daxue(Journal of Tianjin Medical University),19(3):178-181(曹秀芬,冯福立,杨晓英,周晶,2013,功能化氧化石墨烯作为基因和抗肿瘤药物纳米载体的制备及性能研究,天津医科大学学报,19(3):178-181)
Egeblad M.,and Werb Z.,2002,New functions for the matrix metalloproteinases in cancer progression,Nat.Rev.Cancer,2(3):161-174
Geim A.K.,and Novoselov K.S.,2007,The rise of graphene,Nat Mater.,6(3):183-191
Guo H.,Zhou X.,Lu Y.,Xie L.,Chen Q.,Keller E.T.,and Zhang J.,2015,Translational progress on tumor biomarkers,Thoracic cancer,6(6):665-671
Guo H.L.,Wang X.F.,Qian Q.Y.,Wang F.B.,and Xia X.H.2009a,A green approach to the synthesis of graphene nanosheets,ACS Nano,3(9):2653-2659
Guo R.,Li R.,Li X.,Zhang L.,Jiang X.,and Liu B.,2009b,Dual-functional alginic acid hybrid nanospheres for cell imaging and drug delivery,Small,5(6):709-717
Kim S.H.,Kaplan J.A.,Sun Y.,Shieh A.,Sun H.L.,Croce C.M.Grinstaff M.W.,and Parquette J.R.,2015,The self-assembly of anticancer camptothecin-dipeptide nanotubes:a minimalistic and high drug loading approach to increased efficacy Chemistry,21(1):101-105
Li C.,2013,Functionalized graphene oxide for tumor markers detecting and anticancer drugs targeted delivery,Thesis for MS.,Southwest University,Supervisor:Yang S.,pp.1-45(李程,2013,基于功能化氧化石墨烯检测肿瘤标志物及抗肿瘤药向传递的研究,硕士学位论文,西南大学,导师:宋杨pp.1-45)
Li C.,Nie C.H.,Zhang L.J.,and Xu H.M.,2014,Advances in research on application of tumor markers and their screening technique,Yaoxue Jinzhan(Progress in Pharmaceutical Sciences),38(1):1-13(李策,聂彩辉,张力君,徐寒梅,2014肿瘤标志物的应用及其筛选技术研究进展,药学进展,38(1):1-13)
Li K.Y.,2014,The preparation of nano-graphene oxide and the application in gene delivery and stem cell differentiation Thesis for M.S.,Soochow University,Supervisor:Liu J.,pp1-55(李坤阳,2014,纳米氧化石墨烯基底材料的制备及其在基因转染和干细胞分化中的应用,硕士学位论文,苏州大学,导师:刘坚,pp.1-55)
Li P.,Gao Y.,Sun Z.,Chang D.,Gao G.,and Dong A.,2016Synthesis,characterization,and bactericidal evaluation of chitosan/guanidine functionalized graphene oxide composites,Molecules,22(1):12
Li X.,Zhang G.,Bai X.,Sun X.,Wang X.,Wang E.,and Dai H.2008,Highly conducting graphene sheets and langmuir-blodgett films,Nat.Nanotechnol.,3(9):538-542
Liu Z.,Robinson J.T.,Sun X.,and Dai H.,2008,PEGylated nano-graphene oxide for delivery of water insoluble cancer drugs,J.Am.Chem.Soc.,130(33):10876-10877
Lu J.,Wang J.C.,Zhao M.F.,and Huang Y.,2014,Preparation and electrochemical properties of graphene oxide,Cailiao Daobao(Materials Review),28(22):28-31(陆军,王建朝,赵美峰,黄严,2014,氧化石墨烯的制备及电化学性质研究,材料导报,28(22):28-31)
Markovic Z.M.,Harhaji-Trajkovic L.M.,Todorovic-Markovic B.M.,Kepic D.P.,Arsikin K.M.,Jovanovic S.P.,Pantovic A.C.,Dramicanin M.D,and Trajkovic V.S.,2011,In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes,Biomaterials,32(4):1121-1129
Mohammed A.A.,El-Tanni H.,El-Khatib H.M.,Mirza A.A.,Mirza A.A.,and Alturaifi T.H.,2016,Urinary bladder cancer:biomarkers and target therapy,new era for more attention,Oncol.Rev.,10(2):86-92
Niu G.L.,2012,The preparation of functionalized graphene oxide nano carrier and the effects on the proliferation of the carrier loading h TERTsi RNA on cervical cancer Hela cells,Thesis for M.S.,Liaoning Medical University,Supervisor:Wen Y.K.,pp.1-48(牛高丽,2012,功能化氧化石墨烯纳米载体的制备及载h TERTsi RNA对宫颈癌Hela细胞增殖的影响,硕士学位论文,辽宁医学院,导师:温玉库,pp.1-48)
Pan C.N,He J.,and Zhong C.L.,2016,Study on thermoelectric properties of graphene nanoribbons,Hunan Gongye Daxue Xuebao(Journal of Hunan University of Technology),30(2):68-71(潘长宁,何军,钟春良,2016,石墨烯纳米条带的热电性质研究,湖南工业大学学报,30(2):68-71)
Peng C.,Hu W.,Zhou Y.,Fan C.,and Huang Q.,2010,Intracellular imaging with a grapheme-based fluorescent probe,Small,6(15):1686-1692
Song Y.,Chen Y.,Feng L.,Ren J.,and Qu X.,2011,Selective and quantitative cancer cell detection using target-directed functionalized graphene and its synergetic peroxidase-like activity,Chem.Commun.(Camb),47(15):4436-4438
Wang H.X.,2013,Photoactive graphene-synthesis and photoelectric property study,Dissertation for Ph.D.,Lanzhou University,Supervisor:Zhang H.L.,pp.1-98(汪航行,2013,光活性石墨烯的制备及其光电性质研究,博士学位论文,兰州大学,导师:张浩力,pp.1-98))
Zhang J.,2013,Dual-polymer functionalized nanoscale graphene oxide as a highly effective gene transfection agent for insect cells with cell-type dependent cellular uptake mechanisms,Thesis for M.S.,Soochow University,Supervisor:Peng R.,pp.1-44(张静,2013,氧化石墨烯作为高效的基因转染的载体,硕士学位论文,苏州大学,导师:彭瑞,pp.1-44)
Zhang L.,Xia J.,Zhao Q.,Liu L.,and Zhang Z.,2010,Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs,Small,6(4):537-544