噬血细胞性淋巴组织细胞增多症的研究进展
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摘要
<正>噬血细胞性淋巴组织细胞增多症(hemophagocytic lymphohistiocytosis,HLH)是由于细胞毒性T淋巴细胞(cytotoxic lymphocyte,CTL)和自然杀伤细胞(natural killer cell,NK)不能裂解靶细胞而遗传的(原发的)或获得的(继发性的)过度炎症反应[1-3],结果是所谓的细胞因子风暴与严重全身炎症反应综合征(systemic inflammatory response syndrome,SIRS),多器官功能障
引文
[1] George MR. Hemophagocytic lymphohistiocytosis: review of etiologies and management[J]. J Blood Med, 2014, 5:69-86
[2] Zhang L, Zhou J, Sokol L. Hereditary and acquired hemophagocytic lymphohistiocytosis[J]. Cancer Control, 2014, 21(4):301-312
[3] Ramos-Casals M, Brito-Zerón P, López-Guillermo A, et al. Adult haemophagocytic syndrome[J]. Lancet, 2014, 383(9927):1503-1516
[4] García-Montoya L, Sáenz-Tenorio CN, Janta I, et al. Hemophagocytic lymphohistiocytosis in a patient with Sj?gren’s syndrome: case report and review[J]. Rheumatol Int, 2016, 37(4):1-7
[5] Xie M, Li L, Zhu L, et al. An effective diagnostic index for lymphoma-associated hemophagocytic syndrome[J]. QJM, 2018[2018-10-14].http://europepmc.org/abstract/MED/29800321
[6] Raschke RA, Garcia-Orr R. Hemophagocytic lymphohistiocytosis: a potentially underrecognized association with systemic inflammatory response syndrome, severe sepsis, and septic shock in adults[J]. Chest, 2011, 140(4):933
[7] Henter JI,Horne A,Aricó M,et al. HLH-2004:Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiotosis[J].Pediatr Blood Cancer,2007,48(2):124-131
[8] Sepulveda FE, Maschalidi S, Vosshenrich CA, et al. A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice[J]. Blood, 2015, 125(9):1427-1434
[9] Devitt K, Cerny J, Switzer B, et al. Hemophagocytic lymphohistiocytosis secondary to T-cell/histiocyte-rich large B-cell lymphoma[J]. Leuk Res Rep, 2014, 3(2):42-45
[10] García-Montoya L, Sáenz-Tenorio CN, Janta I, et al. Hemophagocytic lymphohistiocytosis in a patient with Sj?gren’s syndrome: case report and review[J]. Rheumatol Int, 2016, 37(4):663-669
[11] Ouachée-Chardin M,Elie C,de Saint Basile G,et al.Hematopoietic stem cell transplantation in hemophagocytic lymphohistiocytosis: a single-center report of 48 patients[J].Pediatrics, 2006,117(4):e743-e750
[12] Marsh RA, Allen CE, McClain KL, et al. Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab[J]. Pediatr Blood Cancer, 2013, 60(1):101-109
[13] Erker C, Parker-Murray P, Talano JA. Usual and unusual manifestations of familial hemophagocytic lymphohistiocytosis and Langerhans cell histiocytosis[J]. Pediatr Clin North Am,2017,64(1):91-109
[14] Ueda I, Kurokawa Y, Koike K, et al. Late-onset cases of familial hemophagocytic lymphohistiocytosis with missense perforin gene mutations[J].Am J Hematol,2007,82(6):427-432
[15] Mehta RS, Smith RE. Hemophagocytic lymphohistiocytosis (HLH): a review of literature[J]. Med Oncol, 2013, 30(4):740
[16] Verbsky JW, Grossman WJ. Hemophagocytic lymphohistiocytosis: diagnosis, pathophysiology, treatment, and future perspectives.[J]. Ann Med, 2006, 38(1):20-31
[17] Kaplanski G. Interleukin-18: Biological properties and role in disease pathogenesis[J]. Immunol Rev, 2018, 281(1):138-153
[18] Esteban YM, de Jong JLO, Tesher MS. An overview of hemophagocytic lymphohistiocytosis[J]. Pediatric Annals, 2017, 46(8):309-313
[19] K?gi D , Vignaux F , Ledermann B , et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity[J]. Science, 1994, 265(5171):528-530
[20] Morimoto A, Nakazawa Y, Ishii E. Hemophagocytic lymphohistiocytosis: Pathogenesis, diagnosis, and management[J]. Pediatr Int, 2016, 58(9):817-825
[21] Moss DJ , Burrows SR , Khanna R , et al. Immune surveillance against Epstein-Barr virus.[J]. Semin Immunol, 1992, 4(2):97-104
[22] Kasahara Y,Yachie A. Cell type specific infection of Epstein-Barr virus (EBV) in EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection[J]. Crit Rev Oncol Hematol, 2002, 44(3):283-294
[23] Filippone EJ, Farber JL. Hemophagocytic lymphohistiocytosis: an update for nephrologists[J]. Int Urol Nephrol, 2016, 48(8):1291-1304
[24] Goel S, Polski JM, Imran H. Sensitivity and specificity of bone marrow hemophagocytosis in hemophagocytic lymphohistiocytosis.[J]. Ann Clin Lab Sci, 2012, 42(1):21-25
[25] Allen CE, Yu X, Kozinetz CA,et al.Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis[J].Pediatr Blood Cancer,2008,50(6):1227-1235
[26] Ishii E. Hemophagocytic Lymphohistiocytosis in Children: Pathogenesis and Treatment[J]. Front Pediatr, 2016, 4:47
[27] Trottestam H, Horne A, Aricò M, et al. Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol[J]. Blood, 2011, 118(17):4577-4584
[28] Marsh RA, Vaughn G, Kim MO,et al. Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation[J]. Blood, 2010, 116(26):5824-5831
[29] Kaplanski G. Interleukin-18: Biological properties and role in disease pathogenesis[J]. Immunol Rev, 2018, 281(1):138-153
[30] Kogawa K, Sato H, Asano T, et al.Prognostic factors of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children: report of the Japan histiocytosis study group.[J]. Pediatr Blood Cancer,2014,61(7):1257-1262
[2] Zhang L, Zhou J, Sokol L. Hereditary and acquired hemophagocytic lymphohistiocytosis[J]. Cancer Control, 2014, 21(4):301-312
[3] Ramos-Casals M, Brito-Zerón P, López-Guillermo A, et al. Adult haemophagocytic syndrome[J]. Lancet, 2014, 383(9927):1503-1516
[4] García-Montoya L, Sáenz-Tenorio CN, Janta I, et al. Hemophagocytic lymphohistiocytosis in a patient with Sj?gren’s syndrome: case report and review[J]. Rheumatol Int, 2016, 37(4):1-7
[5] Xie M, Li L, Zhu L, et al. An effective diagnostic index for lymphoma-associated hemophagocytic syndrome[J]. QJM, 2018[2018-10-14].http://europepmc.org/abstract/MED/29800321
[6] Raschke RA, Garcia-Orr R. Hemophagocytic lymphohistiocytosis: a potentially underrecognized association with systemic inflammatory response syndrome, severe sepsis, and septic shock in adults[J]. Chest, 2011, 140(4):933
[7] Henter JI,Horne A,Aricó M,et al. HLH-2004:Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiotosis[J].Pediatr Blood Cancer,2007,48(2):124-131
[8] Sepulveda FE, Maschalidi S, Vosshenrich CA, et al. A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice[J]. Blood, 2015, 125(9):1427-1434
[9] Devitt K, Cerny J, Switzer B, et al. Hemophagocytic lymphohistiocytosis secondary to T-cell/histiocyte-rich large B-cell lymphoma[J]. Leuk Res Rep, 2014, 3(2):42-45
[10] García-Montoya L, Sáenz-Tenorio CN, Janta I, et al. Hemophagocytic lymphohistiocytosis in a patient with Sj?gren’s syndrome: case report and review[J]. Rheumatol Int, 2016, 37(4):663-669
[11] Ouachée-Chardin M,Elie C,de Saint Basile G,et al.Hematopoietic stem cell transplantation in hemophagocytic lymphohistiocytosis: a single-center report of 48 patients[J].Pediatrics, 2006,117(4):e743-e750
[12] Marsh RA, Allen CE, McClain KL, et al. Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab[J]. Pediatr Blood Cancer, 2013, 60(1):101-109
[13] Erker C, Parker-Murray P, Talano JA. Usual and unusual manifestations of familial hemophagocytic lymphohistiocytosis and Langerhans cell histiocytosis[J]. Pediatr Clin North Am,2017,64(1):91-109
[14] Ueda I, Kurokawa Y, Koike K, et al. Late-onset cases of familial hemophagocytic lymphohistiocytosis with missense perforin gene mutations[J].Am J Hematol,2007,82(6):427-432
[15] Mehta RS, Smith RE. Hemophagocytic lymphohistiocytosis (HLH): a review of literature[J]. Med Oncol, 2013, 30(4):740
[16] Verbsky JW, Grossman WJ. Hemophagocytic lymphohistiocytosis: diagnosis, pathophysiology, treatment, and future perspectives.[J]. Ann Med, 2006, 38(1):20-31
[17] Kaplanski G. Interleukin-18: Biological properties and role in disease pathogenesis[J]. Immunol Rev, 2018, 281(1):138-153
[18] Esteban YM, de Jong JLO, Tesher MS. An overview of hemophagocytic lymphohistiocytosis[J]. Pediatric Annals, 2017, 46(8):309-313
[19] K?gi D , Vignaux F , Ledermann B , et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity[J]. Science, 1994, 265(5171):528-530
[20] Morimoto A, Nakazawa Y, Ishii E. Hemophagocytic lymphohistiocytosis: Pathogenesis, diagnosis, and management[J]. Pediatr Int, 2016, 58(9):817-825
[21] Moss DJ , Burrows SR , Khanna R , et al. Immune surveillance against Epstein-Barr virus.[J]. Semin Immunol, 1992, 4(2):97-104
[22] Kasahara Y,Yachie A. Cell type specific infection of Epstein-Barr virus (EBV) in EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection[J]. Crit Rev Oncol Hematol, 2002, 44(3):283-294
[23] Filippone EJ, Farber JL. Hemophagocytic lymphohistiocytosis: an update for nephrologists[J]. Int Urol Nephrol, 2016, 48(8):1291-1304
[24] Goel S, Polski JM, Imran H. Sensitivity and specificity of bone marrow hemophagocytosis in hemophagocytic lymphohistiocytosis.[J]. Ann Clin Lab Sci, 2012, 42(1):21-25
[25] Allen CE, Yu X, Kozinetz CA,et al.Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis[J].Pediatr Blood Cancer,2008,50(6):1227-1235
[26] Ishii E. Hemophagocytic Lymphohistiocytosis in Children: Pathogenesis and Treatment[J]. Front Pediatr, 2016, 4:47
[27] Trottestam H, Horne A, Aricò M, et al. Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol[J]. Blood, 2011, 118(17):4577-4584
[28] Marsh RA, Vaughn G, Kim MO,et al. Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation[J]. Blood, 2010, 116(26):5824-5831
[29] Kaplanski G. Interleukin-18: Biological properties and role in disease pathogenesis[J]. Immunol Rev, 2018, 281(1):138-153
[30] Kogawa K, Sato H, Asano T, et al.Prognostic factors of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children: report of the Japan histiocytosis study group.[J]. Pediatr Blood Cancer,2014,61(7):1257-1262