蒙药达日布-8丸对高脂血症大鼠调节血脂作用的实验研究
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摘要
目的观察蒙药达日布-8丸对高脂血症大鼠血脂的调节作用。方法取50只Wistar大鼠,随机分为5组,每组10只,设立正常对照组、高脂血症模型组、蒙药达日布-8高、低剂量组及血脂康组,基础饲料喂养1周后,每组每天给予相应饲料饲喂及药物灌胃给药,连续12周,末次给药后断头取血,分离血清,送检血脂。结果与正常对照组相比,高脂血症模型组明显升高大鼠血清总胆固醇,同时降低高密度脂蛋白(P<0.01),说明高脂血症模型大鼠制作成功。达日布-8高剂量组及低剂量组均可明显降低血清总胆固醇及甘油三酯,与高脂血症模型组相比有显著性差异(P<0.01)。达日布-8高剂量组与血脂康组相比可以明显降低血清总胆固醇及低密度脂蛋白(P<0.05)。但达日布-8丸高、低剂量组对高密度脂蛋白的影响与高脂血症模型组相比则无显著性差异。结论蒙药达日布-8丸对于高脂血症模型大鼠具有显著的调节血脂作用。
Objective To observe the regulating effect of Mongolian medicine Daribu-8 pill on hyperlipidemia rats. Methods Fifty Wistar rats were randomly divided into 5 groups,with 10 rats in each group,involving normal control group,hyperlipidemia model group,Mongolian Daribu-8 high and low dose group and Xuezhikang group. Each group was given the corresponding drug administered orally every day, totally for 12 weeks. When the last administration was finished,rats blood was decapitated for the blood, and the serum was separated for blood lipid test. Results Compared with the normal control group,hyper- lipidemia model group was significantly increased in rats and reduce serum total cholesterol,high density lipoprotein( P < 0. 01),the model of hyperlipidemia rats success. Daribu-8 high dose group and low dose group can significantly reduce the serum total cholesterol and triglyceride,there was significant difference compared with the hyperlipidemia model group( P < 0. 01). Compared Daribu-8 high dose group and Xu- ezhikang group can obviously reduce the serum total cholesterol and low density lipoprotein( P < 0. 05). But Daribu- 8 pill high and low dose group of high density lipoprotein compared with the hyperlipidemia model group showed no significant difference. Conclusion Mongolian medicine Daribu-8 pill has signifi- cant moderation effect for hyperlipidemia model rats.
Objective To observe the regulating effect of Mongolian medicine Daribu-8 pill on hyperlipidemia rats. Methods Fifty Wistar rats were randomly divided into 5 groups,with 10 rats in each group,involving normal control group,hyperlipidemia model group,Mongolian Daribu-8 high and low dose group and Xuezhikang group. Each group was given the corresponding drug administered orally every day, totally for 12 weeks. When the last administration was finished,rats blood was decapitated for the blood, and the serum was separated for blood lipid test. Results Compared with the normal control group,hyper- lipidemia model group was significantly increased in rats and reduce serum total cholesterol,high density lipoprotein( P < 0. 01),the model of hyperlipidemia rats success. Daribu-8 high dose group and low dose group can significantly reduce the serum total cholesterol and triglyceride,there was significant difference compared with the hyperlipidemia model group( P < 0. 01). Compared Daribu-8 high dose group and Xu- ezhikang group can obviously reduce the serum total cholesterol and low density lipoprotein( P < 0. 05). But Daribu- 8 pill high and low dose group of high density lipoprotein compared with the hyperlipidemia model group showed no significant difference. Conclusion Mongolian medicine Daribu-8 pill has signifi- cant moderation effect for hyperlipidemia model rats.
引文
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[10]麻春杰,博日吉汗·格日勒图,呼日乐巴根,等.荜茇宁对动脉粥样硬化家兔抗氧化酶活性的影响[J].中国药科大学学报,2008,39(1):68-71.
[11]麻春杰,哈斯阿古拉,张立全,等.荜茇宁对高脂血症大鼠血脂代谢及其相关基因表达的影响[J].中草药,2008,39(7):1039-1043.
[12]麻春杰,博日吉汗格日勒图,呼日乐巴根,等.荜茇宁对家兔实验性动脉粥样硬化的影响[J].中国中药杂志,2008,33(4):436-440.
[13]裴轶琨.沙棘油软胶囊辅助降血脂功能研究[J].中国油脂,2011,36(9):48-50.
[14]内蒙古自治区食品药品监督管理局.内蒙古蒙药制剂规范[M].呼和浩特:内蒙古人民出版社,2007:200-201.
[15]孟根杜希,徐凤芹.蒙药达日布-8丸治疗高脂血症46例疗效观察[J].中华中医药杂志,2012,27(3):761-763.
[2]孟根杜希,徐凤芹.蒙药达日布八味丸治疗高脂血症46例疗效观察[J].中华中医药杂志,2012,27(3):761-763.
[3]王德山,肖玉芳,董朝晖,等.枸杞抗实验性高血脂肝脂量效关系及毒性研究[J].辽宁中医杂志,1997(12):567-568.
[4]乔晓鸣,任延明,包天名,等.沙棘总黄铜TFH改善血管性痴呆血脂的试验研究[J],青海医学院学报,2010,31(3):193-202.
[5]张颖,张力木,李同德,等.沙棘对四氯化碳致小鼠肝损伤的保护作用[J].中国医院药学杂志,2010,30(6):464-466.
[6]李路平,岳海涛,李天舒.沙棘提取物对急性血瘀模型大鼠血液流变学及血栓形成的影响[J].中草药,2010,21(2):272-274.
[7]苑博,张放,程嘉艺,等.沙棘总黄铜对人脐静脉血管内皮损伤细胞增殖及细胞周期的影响[J].山东医药,2011,51(15):34-35.
[8]张颖,张立木,秦树存,等.泰山沙棘果提取物调血脂作用研究[J].中国药方,2011,22(7):586-588.
[9]麻春杰,阿拉坦高勒,娜日苏,等.荜茇宁对动脉粥样硬化家兔主动脉LOX-1和VCAM-1基因表达的影响[J].中国药学杂志,2008,43(19):1449-1453.
[10]麻春杰,博日吉汗·格日勒图,呼日乐巴根,等.荜茇宁对动脉粥样硬化家兔抗氧化酶活性的影响[J].中国药科大学学报,2008,39(1):68-71.
[11]麻春杰,哈斯阿古拉,张立全,等.荜茇宁对高脂血症大鼠血脂代谢及其相关基因表达的影响[J].中草药,2008,39(7):1039-1043.
[12]麻春杰,博日吉汗格日勒图,呼日乐巴根,等.荜茇宁对家兔实验性动脉粥样硬化的影响[J].中国中药杂志,2008,33(4):436-440.
[13]裴轶琨.沙棘油软胶囊辅助降血脂功能研究[J].中国油脂,2011,36(9):48-50.
[14]内蒙古自治区食品药品监督管理局.内蒙古蒙药制剂规范[M].呼和浩特:内蒙古人民出版社,2007:200-201.
[15]孟根杜希,徐凤芹.蒙药达日布-8丸治疗高脂血症46例疗效观察[J].中华中医药杂志,2012,27(3):761-763.