内皮祖细胞在动脉粥样硬化临床中的应用
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摘要
内皮祖细胞(EPCs)是一种成血管干细胞,通过刺激诱导能够增殖分化为成熟血管内皮细胞的前体细胞,参与血管内皮细胞的损伤和修复。动脉粥样硬化(AS)是血管内皮损伤和脂质聚集在动脉壁上形成的血管病变。机体可通过动员体内EPCs来修复血管内皮细胞从而达到缓解,治疗AS的目的。EPCs对血管内皮细胞修复的作用近年来被广泛研究,本文就内皮祖细胞对AS治疗中的应用以及其基础研究进行系统的综述。
Endothelial progenitor cells(EPCs) is an angiogenic stem cells can induce proliferation by stimulating precursor cells differentiate into mature endothelial cells involved in endothelial cell injury and repair. Atherosclerosis(AS) is a vascular endothelial injury and lipid accumulation in the artery walls forming blood vessels. Mobilization of EPCs in vivo by the body to repair the endothelial cells so as to achieve mitigation, treatment, AS purposes. EPCs repair of vascular endothelial cells has been extensively studied in recent years, in this paper, application of progenitor cells in the treatment of atherosclerosis and its basic researches were systematically reviewed.
Endothelial progenitor cells(EPCs) is an angiogenic stem cells can induce proliferation by stimulating precursor cells differentiate into mature endothelial cells involved in endothelial cell injury and repair. Atherosclerosis(AS) is a vascular endothelial injury and lipid accumulation in the artery walls forming blood vessels. Mobilization of EPCs in vivo by the body to repair the endothelial cells so as to achieve mitigation, treatment, AS purposes. EPCs repair of vascular endothelial cells has been extensively studied in recent years, in this paper, application of progenitor cells in the treatment of atherosclerosis and its basic researches were systematically reviewed.
引文
[1]Balaji S,King A,Crombleholme TM,et al.The role of endothelial progenitor cells in postnatal vasculogenesis:implications for therapeutic neovascularization and wound healing[J].Wound Healing Society,2012,6(2):283-295.
[2]Ross R.Atherosclerosis-an inflamrnatory disease[J].The New England Journal of Medicine,1999,2(340):115-126.
[3]李蓉,蔡辉.内皮细胞凋亡与动脉粥样硬化关系的研究进展[J].中国老年学杂志,2012,6(32):1649-1652.
[4]Wang X,Wang F,Li N,et al.The effects of endothelial progenitor cells on rat atherosclerosis[J].Biotechnology and Applied Biochemistry,2014,5(14):1-7.
[5]Rauscher FM,Goldchmidt-Clermont PJ,Davis BH,et al.Aging,progenitor cell exhau stion and atherosclerosis[J].Circulation,2003,108(4):457-463.
[6]Asahara T,Murohara T,Sullivan A,et al.Isolation of putative progenitor endothelial cells forangiogenesis[J].Science,1997,275(14):964-967.
[7]Jujio K,Ii M,Losordo DW.Endotheelial progenitor cells in neovascularization of infarcted myocardium[J].J Mol Cell Cardiol,2008,45(4):530-544.
[8]Leone AM,Valgimigli M,Giannico MB,et al.From bone marrow to the arterial wall:the ongoing tale of endothelial progenitor cells[J].Eur Heart J,2009,30(8):890-899.
[9]Takahashi T,Kalka C,Masuda H,et al.Ischemia and cytokine induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization[J].Nature Medicine,1999,5(4):434-438.
[10]Ii M,Nishimura H,Iwakura A,et al.Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via imported nitric oxide synthase activity[J].Circulation,2005,111(9):1114-1120.
[11]Fadini GP,Baesso I,Albiero M,et al.Technical notes on endothelial progenitor cells[J].Atherosclerosis,2008,197(2):496-503.
[12]Yoder MC.Defining human endothelial progenitor cells[J].J Thromb Haemost Suppl,2009,(1):49-52.
[13]Pearson JD.Endothelial progenitor cells-an evolving story[J].Microvasc Res,2010,79(3):162-168.
[14]Gehling UM,Ergun S,Schumacher U,et al.In vitro differentiation of endothelial cells from AC133-progenitor cells[J].Blood,2000,95(10):3106-3112.
[15]Urbich C,Dimmeler S.Endothelial progenitor cells:characterization and role in vascular biology[J].Circ Res,2004,95(4):343-353.
[16]Hur J,Yoon CH,Kim HS,et al.Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis[J].Arterioscler Thromb Vasc Biol,2004,24(2):288-293.
[17]Hill JM,Zalos G,Halcox JP,et al.Circulating endotherial progenitor cells,vascular function,and cardiovascular risk[J].N Engl J Med,2003,3(48):593-600.
[18]Nieda M,Nicol A,Denning-Kendall P,et al.Endotherial cell precursors are normal components of human umbilical cord blood[J].Br J Haematol,1997,98(3):775-777.
[19]Crisa L,Cirulli V,Smith KA,et al.Human cord blood progenitors sustain thymic T-cell development and a novel from of angiogenesis[J].Blood,1999,94(11):3928-3940.
[20]Naruse K,Hamada Y,Nakamura E,et al.Therapeutic neovascularization using co rd blood-derived endothelial progenitor cells for diabetic neuropathy[J].Diabetes,2005,54(6):1823-1828.
[21]Endtmann C,Ebrahimian T,Czech T,et a1.AngiotensinⅡimpairs endothelial progenitor cell number and function in vitro and in vivo:implications for vas cular regeneration[J].Hypertension,2011,58(3):394-403.
[22]Aziz MT,Nabi EA,Hamid M,et al.Endothelial progenitor cells regenerate infracted myocardium with neovascularisation development[J].Cairo University Journal of Advanced Research,2014,72(1):175-183..
[23]Tateishi-Yuyama E,Matsubara H,Murohara T,et al.Therapeuticangiogenesis for patients with limb ischaemia by autologoustransplantation of bone-marrow cells:a pilot study and arandomised controlled trial[J].Lancet,2002,360(9331):427-435.
[24]Rauscher FM,Goldchmidt-Clermont PJ,Davis BH,et al.Aging,progenitor cell exhaustion,and atherosclerosis[J].Circulation,2003,108(4):457-463.
[25]He T,Smith LA,Harrington S,et al.Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries[J].Stroke,2004,35(10):2378-2384.
[26]Liu P,Zhou B,Gu D,et a1.Endothelial progenitor cell therapy in atheroscleresis:a double.edged sword[J].Ageing Res Rev,2009,8(2):83-93.
[27]吴倩倩,方涛.内皮祖细胞与粥样斑块稳定性研究进展[J].心血管病学进展,2014,7(35):488-491.
[28]Leone AM,Valgimigli M,Giannico MB,et al.From bone marrow to the arterial wall:the ongoing tale of endothelial progenitor cells[J].Eur Heart J,2009,30(8):890-899.
[29]李海清,赵强,孙晓宁,等.生理性雌激素对骨髓源性内皮祖细胞迁移功能的影响[J].中国分子心脏病学杂志,2009,4(9):79-83.
[30]黄焕亮,吴沃栋,许耕红,等.中青年原发性高血压患者循环内皮祖细胞CD34+水平与颈动脉粥样硬化的相关性研究[J].中国危重病急救医学,2010,6(22):375-378.
[31]孔朝红,刘煜敏,朱江,等.高脂大鼠内皮祖细胞生物学特性的实验研究[J].中国神经免疫学和神经病杂志,2010,7(17):253-260.
[32]刘华伟,王丽莉,刘庆君,等.2型糖尿病患者外周血内皮祖细胞数量变化及机制探讨[J].天津医科大学学报,2013,7(19):323-325.
[33]张金盈,张力,厉菁,等.冠心病患者外周血内皮祖细胞数量与心血管危险因素的关系[J].郑州大学学报:医学版,2008,1(43):73-75.
[34]Mobarrez F,Antoniewicz L,Bosson JA,et al.The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers[J].Plots One,2014,9(2):314.
[35]Mac Eneaney,Kushner EJ,Van Guilder GP,et al.Endothelial progenitor cell number and colony-forming capacity in overweight and obese adults[J].Int J Obes(Lond),2009,33(2):219-225.
[36]尹扬光,黄岚,赵晓辉,等.SDF-1对内皮祖细胞增殖迁移的影响及AMD3100对其的干预[J].第三军医大学学报,2007,29(6):475-478.
[37]赵子粼,许顶立,郭志刚,等.内皮祖细胞对心梗后心衰患者心功能改变的影响[J].南方医科大学学报,2011,31(3):504-507.
[38]龚晓明,郑澜,翟树林,等.有氧运动对中老年大鼠外周血内皮祖细胞增殖及黏附能力的影响[J].现代预防医学,2014,41(3):527-530.
[39]De Biase C,De Rosa R,Luciano R,et al.Effects of physical activity on endothelial progenitor cells[J].Frontiers in Physiology,2014,3(4):414.
[40]周丽昉,康治臣,高长斌,等.辛伐他汀对兔外周血内皮祖细胞增殖、迁移、黏附能力的影响[J].中国老年学杂志,2011,31(8):1387-1389.
[41]Zhu JH,Tao QM,Chen JZ,et al.Statins contribute to enhancement of the number and the function of endothelial progenitor cells from peripheral blood[J].Sheng Li Xue Bao,2004,56(3):357-364.
[42]徐义喜,栾天竹,史平炜,等.匹伐他汀对体外培养人脐静脉血内皮祖细胞数量及功能的影响[J].现代生物医学进展,2014,6(14):1053-1056.
[43]张敏州,王磊,曹爱琴,等.内皮祖细胞与中医药研究进展[J].中西医结合心脑血管病杂志,2007,5(4):283-285.
[44]武丽萍,马华,杜海滨,等.中药芪红合剂含药血清对人外周血内皮祖细胞增殖的影响[J].中西医结合心脑血管病杂志,2009,7(3):304-306.
[45]沈艺,谢南姿.黄芪甲苷对人外周血内皮祖细胞体外血管生成能力的影响[J].中西医结合心脑血管病杂志,2012,10(10):1214-1216.
[46]季亢挺,唐疾飞,柴俊德,等.黄芪甲苷对内皮祖细胞氧化损伤的影响[J].中国中西医结合杂志,2011,31(6):807-809.
[47]万槐斌,周婉明,程锦,等.小檗碱联合阿托伐他汀治疗对急性冠脉综合征患者循环内皮祖细胞的影响[J].中西医结合心脑血管病杂志,2013,11(6):648-650.
[48]孟根杜希,徐凤芹.蒙药达日布八味丸治疗高脂血症46例疗效观察[J].中华中医药杂志,2012,27(3):761-763.
[49]李姹润,孟根杜希,孟根达来,等.蒙药达日布-8丸对高脂血症大鼠调节血脂作用的实验研究[J].环球中医药,2013,6(11):819-821.
[2]Ross R.Atherosclerosis-an inflamrnatory disease[J].The New England Journal of Medicine,1999,2(340):115-126.
[3]李蓉,蔡辉.内皮细胞凋亡与动脉粥样硬化关系的研究进展[J].中国老年学杂志,2012,6(32):1649-1652.
[4]Wang X,Wang F,Li N,et al.The effects of endothelial progenitor cells on rat atherosclerosis[J].Biotechnology and Applied Biochemistry,2014,5(14):1-7.
[5]Rauscher FM,Goldchmidt-Clermont PJ,Davis BH,et al.Aging,progenitor cell exhau stion and atherosclerosis[J].Circulation,2003,108(4):457-463.
[6]Asahara T,Murohara T,Sullivan A,et al.Isolation of putative progenitor endothelial cells forangiogenesis[J].Science,1997,275(14):964-967.
[7]Jujio K,Ii M,Losordo DW.Endotheelial progenitor cells in neovascularization of infarcted myocardium[J].J Mol Cell Cardiol,2008,45(4):530-544.
[8]Leone AM,Valgimigli M,Giannico MB,et al.From bone marrow to the arterial wall:the ongoing tale of endothelial progenitor cells[J].Eur Heart J,2009,30(8):890-899.
[9]Takahashi T,Kalka C,Masuda H,et al.Ischemia and cytokine induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization[J].Nature Medicine,1999,5(4):434-438.
[10]Ii M,Nishimura H,Iwakura A,et al.Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via imported nitric oxide synthase activity[J].Circulation,2005,111(9):1114-1120.
[11]Fadini GP,Baesso I,Albiero M,et al.Technical notes on endothelial progenitor cells[J].Atherosclerosis,2008,197(2):496-503.
[12]Yoder MC.Defining human endothelial progenitor cells[J].J Thromb Haemost Suppl,2009,(1):49-52.
[13]Pearson JD.Endothelial progenitor cells-an evolving story[J].Microvasc Res,2010,79(3):162-168.
[14]Gehling UM,Ergun S,Schumacher U,et al.In vitro differentiation of endothelial cells from AC133-progenitor cells[J].Blood,2000,95(10):3106-3112.
[15]Urbich C,Dimmeler S.Endothelial progenitor cells:characterization and role in vascular biology[J].Circ Res,2004,95(4):343-353.
[16]Hur J,Yoon CH,Kim HS,et al.Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis[J].Arterioscler Thromb Vasc Biol,2004,24(2):288-293.
[17]Hill JM,Zalos G,Halcox JP,et al.Circulating endotherial progenitor cells,vascular function,and cardiovascular risk[J].N Engl J Med,2003,3(48):593-600.
[18]Nieda M,Nicol A,Denning-Kendall P,et al.Endotherial cell precursors are normal components of human umbilical cord blood[J].Br J Haematol,1997,98(3):775-777.
[19]Crisa L,Cirulli V,Smith KA,et al.Human cord blood progenitors sustain thymic T-cell development and a novel from of angiogenesis[J].Blood,1999,94(11):3928-3940.
[20]Naruse K,Hamada Y,Nakamura E,et al.Therapeutic neovascularization using co rd blood-derived endothelial progenitor cells for diabetic neuropathy[J].Diabetes,2005,54(6):1823-1828.
[21]Endtmann C,Ebrahimian T,Czech T,et a1.AngiotensinⅡimpairs endothelial progenitor cell number and function in vitro and in vivo:implications for vas cular regeneration[J].Hypertension,2011,58(3):394-403.
[22]Aziz MT,Nabi EA,Hamid M,et al.Endothelial progenitor cells regenerate infracted myocardium with neovascularisation development[J].Cairo University Journal of Advanced Research,2014,72(1):175-183..
[23]Tateishi-Yuyama E,Matsubara H,Murohara T,et al.Therapeuticangiogenesis for patients with limb ischaemia by autologoustransplantation of bone-marrow cells:a pilot study and arandomised controlled trial[J].Lancet,2002,360(9331):427-435.
[24]Rauscher FM,Goldchmidt-Clermont PJ,Davis BH,et al.Aging,progenitor cell exhaustion,and atherosclerosis[J].Circulation,2003,108(4):457-463.
[25]He T,Smith LA,Harrington S,et al.Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries[J].Stroke,2004,35(10):2378-2384.
[26]Liu P,Zhou B,Gu D,et a1.Endothelial progenitor cell therapy in atheroscleresis:a double.edged sword[J].Ageing Res Rev,2009,8(2):83-93.
[27]吴倩倩,方涛.内皮祖细胞与粥样斑块稳定性研究进展[J].心血管病学进展,2014,7(35):488-491.
[28]Leone AM,Valgimigli M,Giannico MB,et al.From bone marrow to the arterial wall:the ongoing tale of endothelial progenitor cells[J].Eur Heart J,2009,30(8):890-899.
[29]李海清,赵强,孙晓宁,等.生理性雌激素对骨髓源性内皮祖细胞迁移功能的影响[J].中国分子心脏病学杂志,2009,4(9):79-83.
[30]黄焕亮,吴沃栋,许耕红,等.中青年原发性高血压患者循环内皮祖细胞CD34+水平与颈动脉粥样硬化的相关性研究[J].中国危重病急救医学,2010,6(22):375-378.
[31]孔朝红,刘煜敏,朱江,等.高脂大鼠内皮祖细胞生物学特性的实验研究[J].中国神经免疫学和神经病杂志,2010,7(17):253-260.
[32]刘华伟,王丽莉,刘庆君,等.2型糖尿病患者外周血内皮祖细胞数量变化及机制探讨[J].天津医科大学学报,2013,7(19):323-325.
[33]张金盈,张力,厉菁,等.冠心病患者外周血内皮祖细胞数量与心血管危险因素的关系[J].郑州大学学报:医学版,2008,1(43):73-75.
[34]Mobarrez F,Antoniewicz L,Bosson JA,et al.The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers[J].Plots One,2014,9(2):314.
[35]Mac Eneaney,Kushner EJ,Van Guilder GP,et al.Endothelial progenitor cell number and colony-forming capacity in overweight and obese adults[J].Int J Obes(Lond),2009,33(2):219-225.
[36]尹扬光,黄岚,赵晓辉,等.SDF-1对内皮祖细胞增殖迁移的影响及AMD3100对其的干预[J].第三军医大学学报,2007,29(6):475-478.
[37]赵子粼,许顶立,郭志刚,等.内皮祖细胞对心梗后心衰患者心功能改变的影响[J].南方医科大学学报,2011,31(3):504-507.
[38]龚晓明,郑澜,翟树林,等.有氧运动对中老年大鼠外周血内皮祖细胞增殖及黏附能力的影响[J].现代预防医学,2014,41(3):527-530.
[39]De Biase C,De Rosa R,Luciano R,et al.Effects of physical activity on endothelial progenitor cells[J].Frontiers in Physiology,2014,3(4):414.
[40]周丽昉,康治臣,高长斌,等.辛伐他汀对兔外周血内皮祖细胞增殖、迁移、黏附能力的影响[J].中国老年学杂志,2011,31(8):1387-1389.
[41]Zhu JH,Tao QM,Chen JZ,et al.Statins contribute to enhancement of the number and the function of endothelial progenitor cells from peripheral blood[J].Sheng Li Xue Bao,2004,56(3):357-364.
[42]徐义喜,栾天竹,史平炜,等.匹伐他汀对体外培养人脐静脉血内皮祖细胞数量及功能的影响[J].现代生物医学进展,2014,6(14):1053-1056.
[43]张敏州,王磊,曹爱琴,等.内皮祖细胞与中医药研究进展[J].中西医结合心脑血管病杂志,2007,5(4):283-285.
[44]武丽萍,马华,杜海滨,等.中药芪红合剂含药血清对人外周血内皮祖细胞增殖的影响[J].中西医结合心脑血管病杂志,2009,7(3):304-306.
[45]沈艺,谢南姿.黄芪甲苷对人外周血内皮祖细胞体外血管生成能力的影响[J].中西医结合心脑血管病杂志,2012,10(10):1214-1216.
[46]季亢挺,唐疾飞,柴俊德,等.黄芪甲苷对内皮祖细胞氧化损伤的影响[J].中国中西医结合杂志,2011,31(6):807-809.
[47]万槐斌,周婉明,程锦,等.小檗碱联合阿托伐他汀治疗对急性冠脉综合征患者循环内皮祖细胞的影响[J].中西医结合心脑血管病杂志,2013,11(6):648-650.
[48]孟根杜希,徐凤芹.蒙药达日布八味丸治疗高脂血症46例疗效观察[J].中华中医药杂志,2012,27(3):761-763.
[49]李姹润,孟根杜希,孟根达来,等.蒙药达日布-8丸对高脂血症大鼠调节血脂作用的实验研究[J].环球中医药,2013,6(11):819-821.