复方木尼孜其颗粒口服联合氨甲环酸溶液湿敷及激光照射治疗女性黄褐斑患者效果评价
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摘要
目的:探讨复方木尼孜其颗粒口服联合氨甲环酸溶液湿敷及激光照射在女性黄褐斑患者中应用效果。方法:选取我院收治的女性黄褐斑患者82例,按照随机数字表法分组,对照组41例给予维生素C+维生素E+氨甲环酸溶液湿敷+激光照射治疗,观察组41例给予复方木尼孜其颗粒+氨甲环酸溶液湿敷+激光照射治疗,观察比较两组治疗效果及治疗前、治疗8周后血清促黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)水平变化情况,并统计两组治疗前、治疗8周后生活质量(DLQI)评分变化情况。结果:观察组治疗总有效率为92.68%(38/41),高于对照组75.61%(31/41)(P<0.05);治疗8周后观察组血清LH、FSH、E2水平低于对照组(P<0.05);治疗8周后观察组DLQI评分低于对照组(P<0.05)。结论:复方木尼孜其颗粒口服联合氨甲环酸溶液湿敷、激光照射可显著改善女性黄褐斑患者雌激素水平,提高疗效,提高患者生活质量。
Objective: To investigate the application effect of compound Mu Niqiqi granules combined with tranexamic acid solution wet coating and laser irradiation in female patients with chloasma. Methods: A total of 82 female patients with chloasma were enrolled in our hospital. According to the random number table method, 41 patients in the control group were treated with vitamin C + vitamin E + tranexamic acid solution + laser irradiation, and 41 patients in the observation group were given compound granule + tranexamic acid solution wet compress + laser irradiation treatment. The therapeutic effects of the two groups and serum luteinizing hormone(LH), follicle stimulating hormone(FSH), estradiol(E2) before treatment and after 8 weeks of treatment Level changes, and the changes in quality of life(DLQI) scores before and after 8 weeks of treatment were observed. Results: The total effective rate of the observation group was 92.68%(38/41), which was higher than that of the control group 75.61%(31/41)(P<0.05). After 8 weeks of treatment, the serum LH, FSH and E2 levels in the observation group were lower than those in the control group.(P<0.05); the DLQI score of the observation group was lower than that of the control group after 8 weeks of treatment(P<0.05). Conclusion: The combination of compound Mu Niyi and its granules combined with tranexamic acid solution and laser irradiation can significantly improve the estrogen level in women with chloasma, improve the curative effect and improve the quality of life of patients.
Objective: To investigate the application effect of compound Mu Niqiqi granules combined with tranexamic acid solution wet coating and laser irradiation in female patients with chloasma. Methods: A total of 82 female patients with chloasma were enrolled in our hospital. According to the random number table method, 41 patients in the control group were treated with vitamin C + vitamin E + tranexamic acid solution + laser irradiation, and 41 patients in the observation group were given compound granule + tranexamic acid solution wet compress + laser irradiation treatment. The therapeutic effects of the two groups and serum luteinizing hormone(LH), follicle stimulating hormone(FSH), estradiol(E2) before treatment and after 8 weeks of treatment Level changes, and the changes in quality of life(DLQI) scores before and after 8 weeks of treatment were observed. Results: The total effective rate of the observation group was 92.68%(38/41), which was higher than that of the control group 75.61%(31/41)(P<0.05). After 8 weeks of treatment, the serum LH, FSH and E2 levels in the observation group were lower than those in the control group.(P<0.05); the DLQI score of the observation group was lower than that of the control group after 8 weeks of treatment(P<0.05). Conclusion: The combination of compound Mu Niyi and its granules combined with tranexamic acid solution and laser irradiation can significantly improve the estrogen level in women with chloasma, improve the curative effect and improve the quality of life of patients.
引文
[1]赵琴,刘丽,何翔.自拟消斑汤经验方与逍遥丸内服辨治肝气郁结型黄褐斑的临床效果随机对照研究[J].成都中医药大学学报,2017,40(1):22-25.
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[9]余慧,梁虹,鞠小玲,等.激光联合氨甲环酸、谷胱甘肽及维生素C治疗黄褐斑的临床观察[J].现代生物医学进展,2015,15(27):5295-5298.
[10]曾丽,胡晗菲,谢红矩,等.口服氨甲环酸片联合Q开关1064 nm Nd:YAG激光治疗黄褐斑临床疗效观察[J].中南医学科学杂志,2016,44(3):328-331.
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[12]朱荣艺,王宏伟.氨甲环酸联合非剥脱点阵激光治疗黄褐斑临床疗效评价[J].中国麻风皮肤病杂志,2017,33(12):723-725.
[2]吕作衡,李海波.308准分子激光联合复方木尼孜其颗粒治疗白癜风临床疗效[J].牡丹江医学院学报,2016,37(1):61-63.
[3]罗青锋,朱凌艳.针刺结合加味桃红四物汤治疗女性黄褐斑的疗效及其对患者雌激素和孕激素的影响[J].中国医学创新,2017,37(33):64-67.
[4]王丽英,马会妙,王燕,等.滋阴祛斑汤联合强脉冲光对黄褐斑患者生活质量和SOD MDA LPO的影响研究[J].四川中医,2016,34(2):103-104.
[5]梁伟,李怀军,阎新佳,等.七白颗粒对女性黄褐斑气滞血瘀证患者抗氧化作用及性激素水平的影响[J].中国实验方剂学杂志,2017,23(20):163-168.
[6]李璟蓉,张新斐,欧阳群,等.隔药壮灸神阙穴治疗女性黄褐斑临床疗效观察及其对血清性激素水平影响研究[J].广州医药,2015,46(4):26-28.
[7]凌丰,沈纳峰,叶岩.复方木尼孜其颗粒联合维A酸乳膏治疗黄褐斑的临床疗效及其机制分析[J].中国生化药物杂志,2015,35(9):118-120.
[8]杨晓东,陈敏,张媛,等.激光联合复方木尼孜其颗粒治疗女性黄褐斑的效果观察[J].宁夏医学杂志,2017,39(10):942-943.
[9]余慧,梁虹,鞠小玲,等.激光联合氨甲环酸、谷胱甘肽及维生素C治疗黄褐斑的临床观察[J].现代生物医学进展,2015,15(27):5295-5298.
[10]曾丽,胡晗菲,谢红矩,等.口服氨甲环酸片联合Q开关1064 nm Nd:YAG激光治疗黄褐斑临床疗效观察[J].中南医学科学杂志,2016,44(3):328-331.
[11]常树霞,万宇婷.调Q1064n m点阵激光联合氨甲环酸治疗黄褐斑的临床观察[J].皮肤性病诊疗学杂志,2016,23(5):307-309.
[12]朱荣艺,王宏伟.氨甲环酸联合非剥脱点阵激光治疗黄褐斑临床疗效评价[J].中国麻风皮肤病杂志,2017,33(12):723-725.