老鹳草-聚乙烯醇药用微胶囊的制备及研究
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摘要
应用微胶囊技术,以聚乙烯醇为壁材,老鹳草水提取物为芯材,戊二醛为交联剂,采用界面聚合法制备了老鹳草-聚乙烯醇微胶囊。采用扫描电镜(SEM)、热重分析仪等手段分别对微胶囊的表面形貌、热稳定性进行了分析表征。探讨了芯壁质量配合比、交联剂用量、反应时间等因素对微胶囊外观形貌的影响。结果表明,在一定范围内,随着壁材用量的减少,戊二醛用量的增加,反应时间的延长,微胶囊的分散性、成囊情况逐渐变好,在反应时间为60min,芯壁质量配合比为6∶5,戊二醛的用量为2mL条件下,制得的老鹳草-聚乙烯醇微胶囊的平均粒径为17.11μm,表面光滑,颗粒圆整,且热稳定性较好,可以应用于复合织物领域。
Using microcapsules technology,geranium-polyvinyl alcohol microcapsules were prepared by interfacial polymerization using polyvinyl alcohol as shell material,geranium extract as core,and glutaraldehyde as the crosslinking agent.The surface morphology and thermal stability of microcapsules were characterized by scanning electron microscopy and thermogravimetric analysis.The effects of core/shell mass ratio,dosage of crosslinking agent and reaction time on the microcapsule appearance were investigated.The results showed that,in a certain range,with decreasing the amount of wall material,increasing the amount of glutaraldehyde,and the prolonging of reaction time,the dispersion and coating situation of microcapsules were gradually improved,when the reaction time was 60 min,the core/wall mass ratio was 6∶5,and the dosages of glutaraldehyde was 2 mL,the microcapsules with the average particle size of 17.11μm can be prepared.And they had smooth surface,rounded particles and better thermal stability,which can be applied to the field of composite fabrics.
Using microcapsules technology,geranium-polyvinyl alcohol microcapsules were prepared by interfacial polymerization using polyvinyl alcohol as shell material,geranium extract as core,and glutaraldehyde as the crosslinking agent.The surface morphology and thermal stability of microcapsules were characterized by scanning electron microscopy and thermogravimetric analysis.The effects of core/shell mass ratio,dosage of crosslinking agent and reaction time on the microcapsule appearance were investigated.The results showed that,in a certain range,with decreasing the amount of wall material,increasing the amount of glutaraldehyde,and the prolonging of reaction time,the dispersion and coating situation of microcapsules were gradually improved,when the reaction time was 60 min,the core/wall mass ratio was 6∶5,and the dosages of glutaraldehyde was 2 mL,the microcapsules with the average particle size of 17.11μm can be prepared.And they had smooth surface,rounded particles and better thermal stability,which can be applied to the field of composite fabrics.
引文
[1]蒋玉清,金哲雄.老鹳草的药理作用研究进展.第一届全国中药商品学术大会论文集[C]青岛:中华中医药学会,2008.
[2]孙仁爽,金哲雄,张哲鹏,等.老鹳草中药材红外光谱的分析与鉴定[J].光谱学与光谱分析,2013,33(1):81-84.
[3]何文涛.老鹳草不同产地的红外光谱分析与鉴定[D].哈尔滨:哈尔滨商业大学,2012.
[4]李祎,张志杨,李超,等.老鹳草总鞣质的提取工艺优化[J].中医学报,2017,32(2):269-272.
[5]Bezerra F M,Carmona O G,Carmona C G,et al.Controlled release of microencapsulated citronella essential oil on cotton and polyestermatrices[J].Cellulose,2016,23(2):1459-1470.
[6]许时婴,张晓鸣,夏书芹,等.微胶囊技术:原理及应用[M].北京:化学工业出版社,2006:12-145.
[7]倪卓,杜学晓,邢锋,等.一种水溶性囊芯微胶囊的制备方法[J].化学与粘合,2009,31(1):7-9.
[8]冯喜庆,刘文波.纸张用水溶性香精微胶囊的制备[J].中国造纸,2015,34(4):33-38.
[9]王俊华,王峰,蔡再生.一种水性芯材微胶囊化新方法的探讨[J].印染助剂,2008,25(4):16-18.
[10]李孟轩.纺织品涂层用两种类型复合药物芯材微胶囊的制备及释放性能研究[D].天津:天津工业大学,2015.
[2]孙仁爽,金哲雄,张哲鹏,等.老鹳草中药材红外光谱的分析与鉴定[J].光谱学与光谱分析,2013,33(1):81-84.
[3]何文涛.老鹳草不同产地的红外光谱分析与鉴定[D].哈尔滨:哈尔滨商业大学,2012.
[4]李祎,张志杨,李超,等.老鹳草总鞣质的提取工艺优化[J].中医学报,2017,32(2):269-272.
[5]Bezerra F M,Carmona O G,Carmona C G,et al.Controlled release of microencapsulated citronella essential oil on cotton and polyestermatrices[J].Cellulose,2016,23(2):1459-1470.
[6]许时婴,张晓鸣,夏书芹,等.微胶囊技术:原理及应用[M].北京:化学工业出版社,2006:12-145.
[7]倪卓,杜学晓,邢锋,等.一种水溶性囊芯微胶囊的制备方法[J].化学与粘合,2009,31(1):7-9.
[8]冯喜庆,刘文波.纸张用水溶性香精微胶囊的制备[J].中国造纸,2015,34(4):33-38.
[9]王俊华,王峰,蔡再生.一种水性芯材微胶囊化新方法的探讨[J].印染助剂,2008,25(4):16-18.
[10]李孟轩.纺织品涂层用两种类型复合药物芯材微胶囊的制备及释放性能研究[D].天津:天津工业大学,2015.