精准光联合异维A酸治疗酒糟鼻的临床疗效观察
|
摘要
目的:观察精准光(DPL)联合异维A酸治疗酒糟鼻的临床疗效。方法:选取2015年10月至2018年3月于我院门诊就诊的90例酒糟鼻患者为对象,采用简单随机法将其均分为观察组(n=45)和对照组(n=45),对照组给予异维A酸治疗,观察组给予DPL联合异维A酸治疗,比较两组治疗后患者的临床疗效、皮损积分及不良反应发生率。结果:治疗后观察组的红斑积分、丘疹积分和脓疱积分均显著低于对照组(P<0.05);治疗后观察组总有效率为88.89%,显著高于对照组的66.67%(P<0.05);治疗后观察组总不良反应率为6.67%,显著低对照组的22.22%(P<0.05)。结论:DPL联合异维A酸治疗酒糟鼻的临床疗效显著,能够降低患者临床症状,且安全性较高,值得临床进一步推广。
Objective:To observe the clinical efficacy of precise light(DPL) combined with isotretinoin in the treatment of rosacea. Methods:90 patients with rosacea in the outpatient clinic from October 2015 to March 2018 were enrolled, They were divided into observation group(n=45) and control group(n=45) by simple random method.The control group was treated with isotretinoin, the observation group was treated with DPL combined with isotretinoin. The clinical efficacy, lesion score and adverse reaction rate of the two groups were compared. Results:After treatment, the erythema score, papule score and pustule score of the observation group were significantly lower than the control group(P<0.05). The total effective rate of the observation group after treatment was 88.89%, significantly higher than that of the control group(66.67%)(P<0.05). The total adverse reaction rate in the observation group after treatment was 6.67%, significantly lower than that in the control group(22.22%,(P<0.05). Conclusion:The clinical efficacy of DPL combined with isotretinoin in the treatment of rosacea is significant, which can reduce the clinical symptoms of patients, and it is safer and worthy of further clinical promotion.
Objective:To observe the clinical efficacy of precise light(DPL) combined with isotretinoin in the treatment of rosacea. Methods:90 patients with rosacea in the outpatient clinic from October 2015 to March 2018 were enrolled, They were divided into observation group(n=45) and control group(n=45) by simple random method.The control group was treated with isotretinoin, the observation group was treated with DPL combined with isotretinoin. The clinical efficacy, lesion score and adverse reaction rate of the two groups were compared. Results:After treatment, the erythema score, papule score and pustule score of the observation group were significantly lower than the control group(P<0.05). The total effective rate of the observation group after treatment was 88.89%, significantly higher than that of the control group(66.67%)(P<0.05). The total adverse reaction rate in the observation group after treatment was 6.67%, significantly lower than that in the control group(22.22%,(P<0.05). Conclusion:The clinical efficacy of DPL combined with isotretinoin in the treatment of rosacea is significant, which can reduce the clinical symptoms of patients, and it is safer and worthy of further clinical promotion.
引文
[1] Mm V D L,van Ratingen A R,van Rappard D C,et al.DOMINO,doxycycline 40mg vs minocycline 100mg in the treatment of rosacea:a randomised,single blinded,non-inferiority trial,comparing efficacy and safety[J].Br Dermatol,2017,176(6):1465.
[2] 张兵兵,余土根.余土根教授治疗酒渣鼻临床经验[J].浙江中医药大学学报,2016,40(4):286～287.
[3] 张丽,吴忠孝,沈燕娜,等.羟氯喹联合595nm染料激光治疗玫瑰痤疮临床疗效观察[J].临床皮肤科杂志,2017,25(6):413～417.
[4] Lei Y,Li S F,Yu Y L,et al.Clinical efficacy of utilizing Ultrapulse CO2 combined with fractional CO2 laser for the treatment of hypertrophic scars in Asians-A prospective clinical evaluation[J].Cosmet Dermatol,2017,16(2):210～216.
[5] 万远芳,柯丹,陶春蓉.凉血清肺散联合米诺环素治疗玫瑰痤疮的临床疗效[J].医学综述,2017,23(4):802～804.
[6] 胡彩霞,张国强,崔瑜,等.康复新液联合强脉冲光治疗玫瑰痤疮的临床观察[J].中国药房,2017,28(17):2399～2402.
[7] 赵辨.中国临床皮肤病学[M].江苏科学技术出版社,2010.
[8] 马仁燕,Juliandri,王小燕,等.2%夫西地酸乳膏联合小剂量盐酸米诺环素治疗玫瑰痤疮自身对照研究[J].中国麻风皮肤病杂志,2017,33(9):520～523.
[9] Bangsgaard N,Fischer L A N,Zachariae C.Sensitization to and allergic contact dermatitis caused by Mirvaso;(brimonidine tartrate) for treatment of rosacea - 2 cases[J].Contact Dermatitis,2016,74(6):378～379.
[10] 徐丽梅,毛俊涛,王智敏.595nm脉冲染料激光联合强脉冲光治疗酒渣鼻31例临床观察[J].中国皮肤性病学杂志,2016(4):419～421
[2] 张兵兵,余土根.余土根教授治疗酒渣鼻临床经验[J].浙江中医药大学学报,2016,40(4):286～287.
[3] 张丽,吴忠孝,沈燕娜,等.羟氯喹联合595nm染料激光治疗玫瑰痤疮临床疗效观察[J].临床皮肤科杂志,2017,25(6):413～417.
[4] Lei Y,Li S F,Yu Y L,et al.Clinical efficacy of utilizing Ultrapulse CO2 combined with fractional CO2 laser for the treatment of hypertrophic scars in Asians-A prospective clinical evaluation[J].Cosmet Dermatol,2017,16(2):210～216.
[5] 万远芳,柯丹,陶春蓉.凉血清肺散联合米诺环素治疗玫瑰痤疮的临床疗效[J].医学综述,2017,23(4):802～804.
[6] 胡彩霞,张国强,崔瑜,等.康复新液联合强脉冲光治疗玫瑰痤疮的临床观察[J].中国药房,2017,28(17):2399～2402.
[7] 赵辨.中国临床皮肤病学[M].江苏科学技术出版社,2010.
[8] 马仁燕,Juliandri,王小燕,等.2%夫西地酸乳膏联合小剂量盐酸米诺环素治疗玫瑰痤疮自身对照研究[J].中国麻风皮肤病杂志,2017,33(9):520～523.
[9] Bangsgaard N,Fischer L A N,Zachariae C.Sensitization to and allergic contact dermatitis caused by Mirvaso;(brimonidine tartrate) for treatment of rosacea - 2 cases[J].Contact Dermatitis,2016,74(6):378～379.
[10] 徐丽梅,毛俊涛,王智敏.595nm脉冲染料激光联合强脉冲光治疗酒渣鼻31例临床观察[J].中国皮肤性病学杂志,2016(4):419～421