高乌头的化学成分及药理作用研究进展
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摘要
目的总结高乌头的化学成分和药理作用,为高乌头的进一步开发和利用提供参考。方法通过查阅国内外相关文献并进行归纳、分析,对高乌头的化学成分和药理作用等进行综述。结果高乌头的主要成分为生物碱类,包括C_(18)-型二萜生物碱、C_(19)-型二萜生物碱和C_(20)-型二萜生物碱等。现代药理研究表明,高乌头具有镇痛、局部麻醉、抗心律失常、抗炎及抗肿瘤等多种生物活性。结论高乌头的现代研究取得了一定的进展,但研究深度仍不够,需要进一步探讨。
Objective To summary the chemical constituents and pharmacological effects of Aconitum sinomontanum Nakai,so as to provide references for the further exploration and utilization.Methods The domestic and overseas research literatures on chemical constituents and pharmacological effects of Aconitum sinomontanum Nakai were reviewed and analyzed.Results The main chemical constituents of Aconitum sinomontanum Nakai are alkaloids,including C_(18) diterpenoid alkaloids,C_(19) diterpenoid alkaloids,and C_(20) diterpenoid alkaloids.Modern pharmacological research has demonstrated that Aconitum sinomontanum Nakai have analgesia,local anesthesia,anti-arrhythmia,anti-inflammatory,anti-tumor and other biological activities.Conclusion Although much progress has been made in modern research of Aconitum sinomontanum Nakai, the research depth is still not enough and needs further discussion.
Objective To summary the chemical constituents and pharmacological effects of Aconitum sinomontanum Nakai,so as to provide references for the further exploration and utilization.Methods The domestic and overseas research literatures on chemical constituents and pharmacological effects of Aconitum sinomontanum Nakai were reviewed and analyzed.Results The main chemical constituents of Aconitum sinomontanum Nakai are alkaloids,including C_(18) diterpenoid alkaloids,C_(19) diterpenoid alkaloids,and C_(20) diterpenoid alkaloids.Modern pharmacological research has demonstrated that Aconitum sinomontanum Nakai have analgesia,local anesthesia,anti-arrhythmia,anti-inflammatory,anti-tumor and other biological activities.Conclusion Although much progress has been made in modern research of Aconitum sinomontanum Nakai, the research depth is still not enough and needs further discussion.
引文
[1] 李鸣,冯毓秀,高光跃.陕甘地区乌头类中草药的生药学研究[J].西北药学杂志,1993,8(3):106-112.
[2] 魏华波,张宝华,谭兵,等.氢溴酸高乌甲素的药理作用及临床应用研究进展[J].重庆医学,2014,43(20):2660-2662.
[3] 中国科学院中国植物志编辑委员会.中国植物志:27卷[M].北京:科学出版社,1979:168.
[4] 肖培根,王锋鹏,高峰,等.中国乌头属植物药用亲缘学研究[J].植物分类学报,2006,44(1):1-46.
[5] 韦璧瑜,孔宪武,赵志远,等.高乌头生物碱的研究(一)[J].西北师范大学学报:自然科学版,1980,(1):79-87.
[6] 陈泗英,刘玉青,杨崇仁.高乌头的化学成分[J].云南植物研究,1980,2(4):473-475.
[7] 彭崇胜,王建忠,简锡贤,等.高乌头和彭州岩乌头中生物碱成分的研究[J].天然产物研究与开发,2000,12(4):45-51.
[8] 彭崇胜,王锋鹏,王建忠,等.两个新的双去甲二萜生物碱高乌宁碱丁和高乌宁碱戊的结构研究[J].药学学报,2000,35(3):201-203.
[9] 彭崇胜,陈东林,陈巧鸿,等.高乌头根中新的二萜生物碱[J].有机化学,2005,25(10):1235-1239.
[10] Tan J J,Tan C H,Ruan B Q,et a1.Two new 18-carbon norditerpenoid alkaloids from Aconitum sinomontanum[J].J Asian Nat Prod Res,2006,8(6):535-539.
[11] Xu B,Xue J H,Tan J J,et al.Two new alkaloids from the roots of Aconitum sinomontanumNakai[J].Helv Chim Acta,2014,97(5):727-732.
[12] Zhang Q,Tan J J,Chen X Q,et al.Two novel C18-diterpenoid alkaloids,sinomontadine with an unprecedented seven-membered ring A and chloride-containing sinomontanine N from Aconitum sinomontanum[J].Tetrahedron Lett,2017,58(3):1717-1720.
[13] Wang F P,Peng C H,Jian X X,et al.Five new norditerpenoid alkaloids from Aconitum sinomontanum[J].J Asian Nat Prod Res,2001,3(1):15-22.
[14] Yuan C L,Wang X L.Isolation of active substances and bioactivity of Aconitum sinomontanumNakai[J].Nat Prod Res,2012,26(22):2099-2102.
[15] Tang H,Wen F L,Wang S H,et al.New C20-diterpenoid alkaloids from Aconitum sinomontanum[J].Chinese Chem Lett,2016,27(5):761-763.
[16] Ono M,Satoh T.Pharmacological studies of lappaconitine.A nalgesic activities[J].Arzneimittel Forsc,1988,38(7):892-895.
[17] 林密迦,杨锡馨,林财珠,等.高乌甲素对手术致痛大鼠一氧化氮合酶的影响[J].福建医科大学学报,2011,45(4):261-263.
[18] Ou S,Zhao Y D,Xiao Z,et al.Effect of lappaconitine on neuropathic pain mediated by P2X3 receptor in rat dorsal root ganglion[J].Neurochem Int,2011,58(5):564-573.
[19] 肖智,张福安,张兰英.高乌甲素在大鼠中脑导水管周围灰质的镇痛机制[J].基础医学与临床,2014,34(3):324-327.
[20] Bello-Ram1rez A M,Buend1a-Orozco J,Nava-Ocampo A A.A QSAR analysis to explain the analgesic properties of Aconitum alkaloids[J].Fun Clin Pharmacol,2003,17(5):575-580.
[21] Sun W X,Dong T G,Ding C M.Crystal structure analysis and antinociceptive property of lappaconitine hydrochloride[J].Adv Mater Res,2011,343/344(1/2):1049-1052.
[22] 辛蕊华,程富胜,胡振英,等.高乌甲素的研究概况[J].中兽医医药杂志,2009,28(2):74-76.
[23] 林密迦,杨锡馨.高乌甲素对手术致痛大鼠的镇痛及局麻作用的研究[J].海峡药学,2011,23(4):29-31.
[24] Wang J L,Shen X L,Chen Q H,et al.Structure-analgesic activity relationship studies on the C(18)-and C(19)-diterpenoid alkaloids[J].Chem Pharm Bull,2009,57(8):801-807.
[25] Yunusov M S.Antiarrhythmic agents based on diterpenoid alkaloids[J].Russ Chem Bull,2011,60(4):633-638.
[26] Bryzgalov A O,Romanov V E,Tolstikova T G,et al.Lappaconitine:influence of halogen substituent on the antiarrhythmic activity[J].Cardiovasc Hematol Agents Med Chem,2013,11(3):211-217.
[27] Vakhitova I V,Farafontova E I,Khisamutdinova R I,et al.To the mechanisms of antarrhythmic action of allapinine[J].Bioorg Khim,2013,39(1):105-116.
[28] 胡建楣,肖柳英,潘竞锵,等.高乌甲素抑制佐剂性关节炎大鼠模型的实验研究[J].中药材,2009,32(3):420-422.
[29] Wang Y Z,Xiao Y Q,Zhang C,et al.Study of analgesic and anti-inflammatory effects of lappaconitine gelata[J].J Traditl Chin Med,2009,29(2):141-145.
[30] 黄维艳,候明勇,欧珊.高乌甲素对脊髓损伤大鼠IL-1β、IL-10、TNF-α水平的影响[J].河南医学研究,2017,26(1):1729-1732.
[31] Solyanik G I,Fedorchuk A G,Pyaskovskaya O N,et al.Anticancer activity of aconitine-containing herbal extract BC1[J].Exp Oncol,2004,26(4):307-311.
[32] 盛良翮,徐萌,徐立群,等.高乌甲素对非小细胞肺癌体外杀伤作用及其分子机制[J].中药材,2014,37(5):840-843.
[33] 郑富霞.高乌甲素对人非小细胞肺癌A549细胞株的作用及机制[J].中国老年学杂志,2015,35(12):3231-3232.
[34] 林妮,肖柳英,林培英,等.氢溴酸高乌甲素抗肿瘤的实验研究[J].中医研究,2005,18(10):16-17.
[35] 马君义,韩小芬,陈香玲,等.硫酸高乌甲素对人肝癌Hep G2细胞增殖、凋亡与细胞周期的影响[J].中成药,2017,39(9):1940-1942.
[36] 宁异真,谭宇蕙,吴映雅,等.参附注射液和高乌甲素对小鼠肝癌细胞H22生长抑制及诱导凋亡作用[J].中国生化药物杂志,2007,28(6):375-377.
[37] 伍耀衡,宁异真,许建邦,等.参附注射液、高乌甲素注射液诱导白血病细胞株HL-60分化、凋亡的研究[J].广州中医药大学学报,2008,25(2):131-137.
[38] 杨文艳,冯国忠,梁承远,等.高乌甲素缩醛类化合物的合成及抗肿瘤活性研究[J].陕西科技大学学报,2017,35(2):135-141.
[39] Ahmad M,Ahmad W,Ahmad M,et al.Norditerpenoid alkaloids from the roots of Aconitum heterophyllum Wall with antibacterial activity[J].J Enzym Inhib Med Chem,2008,23(6):1018-1022.
[40] 高稚淇,谢红,陈玲.高乌头生物碱高乌甲素对大鼠心肌缺血/再灌注损伤的保护作用研究[J].江苏中医药,2015,47(6):79-81.
[41] 张应强.高乌甲素提取、抗氧化活性及提取残渣制备碳纳米纤维的研究[D].兰州:兰州理工大学,2017.
[42] 赵俊林.高乌甲素的临床应用概述[J].海峡药学,2012,24(8):7-9.
[43] Shaheen F,Ahmad M,Khan M T H,et al.Alkaloids of Aconitum laeve and their anti-inflammatory,antioxidant and tyrosinase inhibition activities[J].Phytochem Lett,2005,66(8):935-940.
[44] 原春兰,卫粉艳.辫根七杀虫活性研究[J].西北农业学报,2007,16(3):235-238.
[45] 原春兰,卫粉艳.高乌头水剂杀虫剂田间药效试验[J].现代农药,2011,10(3):39-41.
[46] 吴延吉.甘肃高乌头有效部位的研究[D].天津:天津大学,2007.
[47] Polyakov N E,Khan V K,Taraban M B,et al.Complexation of lappaconitine with glycyrrhizic acid:stability and reactivity studies[J].J Phys Chem B,2005,109(51):24526-24530.
[48] 李芸,胡昌江,候桃霞,等.正交实验优选高乌头解毒的炮制工艺研究[J].中成药,2015,37(4):905-909.
[2] 魏华波,张宝华,谭兵,等.氢溴酸高乌甲素的药理作用及临床应用研究进展[J].重庆医学,2014,43(20):2660-2662.
[3] 中国科学院中国植物志编辑委员会.中国植物志:27卷[M].北京:科学出版社,1979:168.
[4] 肖培根,王锋鹏,高峰,等.中国乌头属植物药用亲缘学研究[J].植物分类学报,2006,44(1):1-46.
[5] 韦璧瑜,孔宪武,赵志远,等.高乌头生物碱的研究(一)[J].西北师范大学学报:自然科学版,1980,(1):79-87.
[6] 陈泗英,刘玉青,杨崇仁.高乌头的化学成分[J].云南植物研究,1980,2(4):473-475.
[7] 彭崇胜,王建忠,简锡贤,等.高乌头和彭州岩乌头中生物碱成分的研究[J].天然产物研究与开发,2000,12(4):45-51.
[8] 彭崇胜,王锋鹏,王建忠,等.两个新的双去甲二萜生物碱高乌宁碱丁和高乌宁碱戊的结构研究[J].药学学报,2000,35(3):201-203.
[9] 彭崇胜,陈东林,陈巧鸿,等.高乌头根中新的二萜生物碱[J].有机化学,2005,25(10):1235-1239.
[10] Tan J J,Tan C H,Ruan B Q,et a1.Two new 18-carbon norditerpenoid alkaloids from Aconitum sinomontanum[J].J Asian Nat Prod Res,2006,8(6):535-539.
[11] Xu B,Xue J H,Tan J J,et al.Two new alkaloids from the roots of Aconitum sinomontanumNakai[J].Helv Chim Acta,2014,97(5):727-732.
[12] Zhang Q,Tan J J,Chen X Q,et al.Two novel C18-diterpenoid alkaloids,sinomontadine with an unprecedented seven-membered ring A and chloride-containing sinomontanine N from Aconitum sinomontanum[J].Tetrahedron Lett,2017,58(3):1717-1720.
[13] Wang F P,Peng C H,Jian X X,et al.Five new norditerpenoid alkaloids from Aconitum sinomontanum[J].J Asian Nat Prod Res,2001,3(1):15-22.
[14] Yuan C L,Wang X L.Isolation of active substances and bioactivity of Aconitum sinomontanumNakai[J].Nat Prod Res,2012,26(22):2099-2102.
[15] Tang H,Wen F L,Wang S H,et al.New C20-diterpenoid alkaloids from Aconitum sinomontanum[J].Chinese Chem Lett,2016,27(5):761-763.
[16] Ono M,Satoh T.Pharmacological studies of lappaconitine.A nalgesic activities[J].Arzneimittel Forsc,1988,38(7):892-895.
[17] 林密迦,杨锡馨,林财珠,等.高乌甲素对手术致痛大鼠一氧化氮合酶的影响[J].福建医科大学学报,2011,45(4):261-263.
[18] Ou S,Zhao Y D,Xiao Z,et al.Effect of lappaconitine on neuropathic pain mediated by P2X3 receptor in rat dorsal root ganglion[J].Neurochem Int,2011,58(5):564-573.
[19] 肖智,张福安,张兰英.高乌甲素在大鼠中脑导水管周围灰质的镇痛机制[J].基础医学与临床,2014,34(3):324-327.
[20] Bello-Ram1rez A M,Buend1a-Orozco J,Nava-Ocampo A A.A QSAR analysis to explain the analgesic properties of Aconitum alkaloids[J].Fun Clin Pharmacol,2003,17(5):575-580.
[21] Sun W X,Dong T G,Ding C M.Crystal structure analysis and antinociceptive property of lappaconitine hydrochloride[J].Adv Mater Res,2011,343/344(1/2):1049-1052.
[22] 辛蕊华,程富胜,胡振英,等.高乌甲素的研究概况[J].中兽医医药杂志,2009,28(2):74-76.
[23] 林密迦,杨锡馨.高乌甲素对手术致痛大鼠的镇痛及局麻作用的研究[J].海峡药学,2011,23(4):29-31.
[24] Wang J L,Shen X L,Chen Q H,et al.Structure-analgesic activity relationship studies on the C(18)-and C(19)-diterpenoid alkaloids[J].Chem Pharm Bull,2009,57(8):801-807.
[25] Yunusov M S.Antiarrhythmic agents based on diterpenoid alkaloids[J].Russ Chem Bull,2011,60(4):633-638.
[26] Bryzgalov A O,Romanov V E,Tolstikova T G,et al.Lappaconitine:influence of halogen substituent on the antiarrhythmic activity[J].Cardiovasc Hematol Agents Med Chem,2013,11(3):211-217.
[27] Vakhitova I V,Farafontova E I,Khisamutdinova R I,et al.To the mechanisms of antarrhythmic action of allapinine[J].Bioorg Khim,2013,39(1):105-116.
[28] 胡建楣,肖柳英,潘竞锵,等.高乌甲素抑制佐剂性关节炎大鼠模型的实验研究[J].中药材,2009,32(3):420-422.
[29] Wang Y Z,Xiao Y Q,Zhang C,et al.Study of analgesic and anti-inflammatory effects of lappaconitine gelata[J].J Traditl Chin Med,2009,29(2):141-145.
[30] 黄维艳,候明勇,欧珊.高乌甲素对脊髓损伤大鼠IL-1β、IL-10、TNF-α水平的影响[J].河南医学研究,2017,26(1):1729-1732.
[31] Solyanik G I,Fedorchuk A G,Pyaskovskaya O N,et al.Anticancer activity of aconitine-containing herbal extract BC1[J].Exp Oncol,2004,26(4):307-311.
[32] 盛良翮,徐萌,徐立群,等.高乌甲素对非小细胞肺癌体外杀伤作用及其分子机制[J].中药材,2014,37(5):840-843.
[33] 郑富霞.高乌甲素对人非小细胞肺癌A549细胞株的作用及机制[J].中国老年学杂志,2015,35(12):3231-3232.
[34] 林妮,肖柳英,林培英,等.氢溴酸高乌甲素抗肿瘤的实验研究[J].中医研究,2005,18(10):16-17.
[35] 马君义,韩小芬,陈香玲,等.硫酸高乌甲素对人肝癌Hep G2细胞增殖、凋亡与细胞周期的影响[J].中成药,2017,39(9):1940-1942.
[36] 宁异真,谭宇蕙,吴映雅,等.参附注射液和高乌甲素对小鼠肝癌细胞H22生长抑制及诱导凋亡作用[J].中国生化药物杂志,2007,28(6):375-377.
[37] 伍耀衡,宁异真,许建邦,等.参附注射液、高乌甲素注射液诱导白血病细胞株HL-60分化、凋亡的研究[J].广州中医药大学学报,2008,25(2):131-137.
[38] 杨文艳,冯国忠,梁承远,等.高乌甲素缩醛类化合物的合成及抗肿瘤活性研究[J].陕西科技大学学报,2017,35(2):135-141.
[39] Ahmad M,Ahmad W,Ahmad M,et al.Norditerpenoid alkaloids from the roots of Aconitum heterophyllum Wall with antibacterial activity[J].J Enzym Inhib Med Chem,2008,23(6):1018-1022.
[40] 高稚淇,谢红,陈玲.高乌头生物碱高乌甲素对大鼠心肌缺血/再灌注损伤的保护作用研究[J].江苏中医药,2015,47(6):79-81.
[41] 张应强.高乌甲素提取、抗氧化活性及提取残渣制备碳纳米纤维的研究[D].兰州:兰州理工大学,2017.
[42] 赵俊林.高乌甲素的临床应用概述[J].海峡药学,2012,24(8):7-9.
[43] Shaheen F,Ahmad M,Khan M T H,et al.Alkaloids of Aconitum laeve and their anti-inflammatory,antioxidant and tyrosinase inhibition activities[J].Phytochem Lett,2005,66(8):935-940.
[44] 原春兰,卫粉艳.辫根七杀虫活性研究[J].西北农业学报,2007,16(3):235-238.
[45] 原春兰,卫粉艳.高乌头水剂杀虫剂田间药效试验[J].现代农药,2011,10(3):39-41.
[46] 吴延吉.甘肃高乌头有效部位的研究[D].天津:天津大学,2007.
[47] Polyakov N E,Khan V K,Taraban M B,et al.Complexation of lappaconitine with glycyrrhizic acid:stability and reactivity studies[J].J Phys Chem B,2005,109(51):24526-24530.
[48] 李芸,胡昌江,候桃霞,等.正交实验优选高乌头解毒的炮制工艺研究[J].中成药,2015,37(4):905-909.