宁泌泰胶囊联合地红霉素肠溶片治疗解脲脲原体阳性精液不液化症临床研究
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摘要
目的观察宁泌泰胶囊联合地红霉素肠溶片治疗精液解脲脲原体(Uu)培养阳性精液不液化症的临床疗效。方法将精液Uu培养阳性的精液不液化症患者120例按2∶1比例随机分为治疗组80例,对照组40例,连续用药2周为1个疗程,观察2个疗程。治疗组口服宁泌泰胶囊4粒/次,3次/d,同时口服地红霉素肠溶片0.5 g/次,1次/d,均饭后服用,对照组仅口服地红霉素肠溶片。主要观察Uu转阴率、精液液化时间,并观察不良反应。结果治疗2周、4周后治疗组和对照组Uu转阴率分别为72.5%、95.0%和55.0%、92.5%,治疗2周后治疗组转阴率明显高于对照组(P<0.05),总的转阴率两组比较无统计学意义(P>0.05)。治疗组和对照组精液液化时间治疗前分别为(76.19±14.13)、(77.08±13.34)min,治疗2周后分别为(58.64±13.15)、(67.12±12.52)min,治疗4周后分别为(48.64±12.38)、(56.12±12.86)min,两组治疗前后精液液化时间比较差异显著(P<0.05),组间比较治疗组明显优于对照组(P<0.01)。结论宁泌泰胶囊联合地红霉素肠溶片能部分缩短Uu转阴的时间,明显缩短精液液化时间,对Uu阳性精液不液化症有明显的临床疗效。
Objective To investigate the clinical effect of Ningmitai Capsule combined with Dirithromycin Enteric Tablets in the treatment of positive semen nonliquefaction in the culture of Ureaplasma urealyticum(Uu). Methods A total of 120 cases of semen liquefaction patients with positive semen Uu culture were randomly divided into treatment group with 80 cases and control group with40 cases, which were continuous administrated for two weeks for a period of treatment and observated for two courses of treatment. In the treatment group, four Ningmitai Capsules were taken orally per time, three times per day, and 0.5 g Dirithromycin Enteric Tablets were taken orally per time, once per day, after meals, while the control group only took the Dirithromycin Enteric Tablets orally. Uu negative conversion rate and semen liquefaction time(min) were observed, and adverse reactions were also observed. Results The Uu negative conversion rate in the treatment group and control group after 2 weeks, 4 weeks was 72.5%, 95.0% and 55%, 92.5%,respectively, the negative conversion rate of treatment group was obviously higher than that of control group after 2 weeks treatment(P < 0.05), and there has no statistical significance in the total negative conversion rate of two groups(P > 0.05). The semen liquefaction time before treatment in the treatment group and control group respectively was(76.19 ± 14.13) min and(77.08 ± 13.34)min, which was(58.64 ± 13.15) min and(67.12 ± 12.52) min two weeks after treatment,(48.64 ± 12.38) min and(56.12 ± 12.86) min 4 weeks after treatment were, semen liquefaction time of the two groups before and after treatment was significant different(P < 0.05),and the treatment group was better than control group(P < 0.01). Conclusion Ningmitai Capsule combined with Dirithromycin Enteric Tablets can partly shorten the Uu negative conversion time, obviously shorten the semen liquefaction time, and has obvious clinical efficacy for Uu positive semen nonliquefaction disease.
Objective To investigate the clinical effect of Ningmitai Capsule combined with Dirithromycin Enteric Tablets in the treatment of positive semen nonliquefaction in the culture of Ureaplasma urealyticum(Uu). Methods A total of 120 cases of semen liquefaction patients with positive semen Uu culture were randomly divided into treatment group with 80 cases and control group with40 cases, which were continuous administrated for two weeks for a period of treatment and observated for two courses of treatment. In the treatment group, four Ningmitai Capsules were taken orally per time, three times per day, and 0.5 g Dirithromycin Enteric Tablets were taken orally per time, once per day, after meals, while the control group only took the Dirithromycin Enteric Tablets orally. Uu negative conversion rate and semen liquefaction time(min) were observed, and adverse reactions were also observed. Results The Uu negative conversion rate in the treatment group and control group after 2 weeks, 4 weeks was 72.5%, 95.0% and 55%, 92.5%,respectively, the negative conversion rate of treatment group was obviously higher than that of control group after 2 weeks treatment(P < 0.05), and there has no statistical significance in the total negative conversion rate of two groups(P > 0.05). The semen liquefaction time before treatment in the treatment group and control group respectively was(76.19 ± 14.13) min and(77.08 ± 13.34)min, which was(58.64 ± 13.15) min and(67.12 ± 12.52) min two weeks after treatment,(48.64 ± 12.38) min and(56.12 ± 12.86) min 4 weeks after treatment were, semen liquefaction time of the two groups before and after treatment was significant different(P < 0.05),and the treatment group was better than control group(P < 0.01). Conclusion Ningmitai Capsule combined with Dirithromycin Enteric Tablets can partly shorten the Uu negative conversion time, obviously shorten the semen liquefaction time, and has obvious clinical efficacy for Uu positive semen nonliquefaction disease.
引文
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[6]李莉华,黄勋彬,章慧平,等.宁泌泰胶囊联合盐酸多西环素治疗溶脲脲原体阳性慢性前列腺炎的临床研究[J].中华男科学杂志,2017,23(2):169-172.
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[15]刘薇,黄精俸,江振洲,等.宁泌泰胶囊对大鼠大肠杆菌感染性盆腔炎的改善作用研究[J].药物评价研究,2015,38(6):612-616.
[16]俞旭君,高庆和.宁泌泰胶囊在下尿路症状中临床应用中国专家共识[J].中华男科学杂志,2017,23(9):852-855.
[17]夏明康,胡珍真,杨素娜,等.宁泌泰胶囊联合抗生素治疗慢性前列腺炎的Meta分析[J].中草药,2015,46(11):1704-1709.
[18]蔡健,陈熙猛,汪广兵.宁泌泰胶囊治疗精囊炎所致血精症的疗效观察[J].中草药,2014,45(23):3440-3442.
[19]陈思达,刘步平,钱丽欢,等.宁泌泰治疗慢性前列腺炎Meta分析[J].现代医院,2015,15(12):8-12.
[20]韩伟,张喜庄,杨永军,等.单用宁泌泰胶囊治疗BPH疗效观察[J].临床泌尿外科杂志,2012,27(11):853-854.
[21]胡珍真,段燕康,杨素娜,等.宁泌泰胶囊临床应用新进展[J].中国中西医结合外科杂志,2014,20(6):672-674.
[2]郜亮,阮衍泰.精液液化异常与生殖道溶脲脲原体、沙眼衣原体感染相关性研究[J].中国妇幼保健,2011,26(35):5561-5563.
[3]李芃,赵星球,姚鹏,等.地红霉素治疗男性非淋菌性尿道炎疗效观察[J].中国药师,2005,8(8):662-663.
[4]谢毓芳,杨荣华,陈红.宁泌泰胶囊治疗慢性非细菌性前列腺炎及对患者血清炎症因子的影响[J].中国性科学,2015,24(11):13-16.
[5]杨世喜.宁泌泰联合生物反馈治疗IIIB型慢性前列腺炎合并不育症疗效观察[J].长江大学学报:自然科学版,2017,14(4):38-40.
[6]李莉华,黄勋彬,章慧平,等.宁泌泰胶囊联合盐酸多西环素治疗溶脲脲原体阳性慢性前列腺炎的临床研究[J].中华男科学杂志,2017,23(2):169-172.
[7]岳兴如,侯宗霞,刘萍,等.白茅根抗炎的药理作用[J].中国临床康复,2006,10(43):85-87.
[8]王培卿,张橡楠,刘瑜新,等.9种蓼科植物抗菌活性[J].中国实验方剂学杂志,2013,19(17):109-112.
[9]李晓燕.中药连翘抗菌活性的考察[J].山东医药工业,1997,16(2):46-47.
[10]徐婵,吴潇潇,万定荣,等.三颗针抗菌活性成分研究[J].华中科技大学学报:医学版,2015,44(5):556-562.
[11]林浩然,郑幼兰,陈仁通,等.木芙蓉治疗滴虫性阴道炎及霉菌性阴道炎的实验和临床研究[J].医学研究通讯,1990,19(10):22-25.
[12]陈文吟,余宙耀,李灼亮.肝毒清方单味药水提物的体外抗HBV作用[J].中药材,1999,22(9):463-465.
[13]龚纯贵,张国庆,王希营,等.仙鹤草提取物镇痛抗炎试验的实验研究[J].药学实践杂志,2006,24(6):339-341.
[14]张飞,窦圣姗,张杰.宁泌泰胶囊的抗炎作用研究[J].现代药物与临床,2015,30(11):1317-1319.
[15]刘薇,黄精俸,江振洲,等.宁泌泰胶囊对大鼠大肠杆菌感染性盆腔炎的改善作用研究[J].药物评价研究,2015,38(6):612-616.
[16]俞旭君,高庆和.宁泌泰胶囊在下尿路症状中临床应用中国专家共识[J].中华男科学杂志,2017,23(9):852-855.
[17]夏明康,胡珍真,杨素娜,等.宁泌泰胶囊联合抗生素治疗慢性前列腺炎的Meta分析[J].中草药,2015,46(11):1704-1709.
[18]蔡健,陈熙猛,汪广兵.宁泌泰胶囊治疗精囊炎所致血精症的疗效观察[J].中草药,2014,45(23):3440-3442.
[19]陈思达,刘步平,钱丽欢,等.宁泌泰治疗慢性前列腺炎Meta分析[J].现代医院,2015,15(12):8-12.
[20]韩伟,张喜庄,杨永军,等.单用宁泌泰胶囊治疗BPH疗效观察[J].临床泌尿外科杂志,2012,27(11):853-854.
[21]胡珍真,段燕康,杨素娜,等.宁泌泰胶囊临床应用新进展[J].中国中西医结合外科杂志,2014,20(6):672-674.