老年高血压患者左心室肥厚与血浆Klotho蛋白水平的相关性
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摘要
目的探讨老年高血压患者左心室肥厚(LVH)与血浆Klotho蛋白水平的相关性。方法合并LVH的老年高血压患者74例为LVH组,同期排除LVH的高血压患者80例为对照组,应用酶联免疫吸附试验(ELISA)检测血浆Klotho蛋白水平,对比两组一般临床指标,分析LVH的独立危险因素。结果 LVH组Klotho蛋白水平明显低于对照组(P<0.001),而体重指数(BMI)明显高于对照组(P<0.01)。Logistic多因素回归分析提示低血浆Klotho蛋白水平是老年高血压患者LVH的独立危险因素(P=0.000),同时2型糖尿病和高BMI也是高血压LVH的危险因素(均P<0.05)。结论血浆Klotho蛋白水平降低与LVH发生有相关性,血浆Klotho蛋白水平的监测在LVH的预防、诊断及预后判断中有重要临床意义。
Objective To explore the association of plasma Klotho level with left ventricular hypertrophy in elderly hypertension patients.Methods The level of Klotho protein was tested in 74 elderly hypertension patients( age≥60 years) with left ventricular hypertrophy,and 80 controls by ELISA. The correlation between plasma Klotho level with left ventricular hypertrophy in elderly hypertension patients was tested by statistical analysis.Results Compared with that of control group,Klotho protein level in hypertension group was significantly decreased( P<0.01),BMI was significantly higher than that of control group( P< 0.01). The low plasma Klotho level was identified as independent risk factors of left ventricular hypertrophy in elderly hypertension patients( OR 20.885,95% CI 7.964 ～ 54.770,P = 0.000). Diabetes and high BMI were the risk factors for left ventricular hypertrophy in hypertension patients.Conclusions Klotho protein level may be associated with left ventricular hypertrophy in elderly hypertension patients. There is important clinical significance of monitoring plasma Klotho protein level in the prevention,diagnosis and prognosis of left ventricular hypertrophy.
Objective To explore the association of plasma Klotho level with left ventricular hypertrophy in elderly hypertension patients.Methods The level of Klotho protein was tested in 74 elderly hypertension patients( age≥60 years) with left ventricular hypertrophy,and 80 controls by ELISA. The correlation between plasma Klotho level with left ventricular hypertrophy in elderly hypertension patients was tested by statistical analysis.Results Compared with that of control group,Klotho protein level in hypertension group was significantly decreased( P<0.01),BMI was significantly higher than that of control group( P< 0.01). The low plasma Klotho level was identified as independent risk factors of left ventricular hypertrophy in elderly hypertension patients( OR 20.885,95% CI 7.964 ～ 54.770,P = 0.000). Diabetes and high BMI were the risk factors for left ventricular hypertrophy in hypertension patients.Conclusions Klotho protein level may be associated with left ventricular hypertrophy in elderly hypertension patients. There is important clinical significance of monitoring plasma Klotho protein level in the prevention,diagnosis and prognosis of left ventricular hypertrophy.
引文
1 Kuro-o M,Matsumura Y,Aizawa H,et al.Mutation of the mouse klotho gene leads to a syndrome resembling ageing[J].Nature,1997;390(6655):45-51.
2刘晓林,马厚勋,田小春,等.Klotho基因3个SNP位点与老年高血压及脂代谢的相关性[J].中国老年学杂志,2010;30(23):3429-32.
3蒋宜,刘晓林,田晓春,等.老年高血压患者克老素基因单核苷酸多态性与其左心室肥厚的相关性研究[J].重庆医科大学学报,2013;38(8):891-5.
4李宝善,马厚勋,王艳娇,等.Klotho基因转导延缓自发性高血压大鼠高血压进程及改善其心脏损害的作用研究[J].中华医学遗传学杂志,2012;29(6):662-8.
5 Marwick TH,Gillebert TC,Aurigemma G,et al.Recommendations on the use of echocardiography in adult hypertension:a report from the European Association of Cardiovascular Imaging(EACVI)and the American Society of Echocardiography(ASE)[J].J Am Soc Echocardiog,2015;28(7):727-54.
6中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[J].中华心血管病杂志,2007;35(5):390-419.
7中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011;39(7):579-616.
8阎国辉,张玉东,孙志丹.遗传性高血压致左室肥厚机制的研究现状[J].中国综合临床,2004;6(6):573-4.
9 Rohini A,Agrawal N,Koyani CN,et al.Molecular targets and regulators of cardiac hypertrophy[J].Pharmacol Res,2010;61(4):269-80.
10李龙,李莉,崔天祥,等.Klotho基因多态性与高血压左室肥厚的关系[J].中国老年学杂志,2013;33(11):2501-3.
11 Yamazaki M,Ozono K,Okada T,et al.Both FGF23 and extracellular phosphate activate Raf/MEK/ERK pathway via FGF receptors in HEK293 cells[J].J Cell Biochem,2010;111(5):1210-21.
12 Xie J,Cha SK,An SW,et al.Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart[J].Nat Commun,2011;3:1238.
2刘晓林,马厚勋,田小春,等.Klotho基因3个SNP位点与老年高血压及脂代谢的相关性[J].中国老年学杂志,2010;30(23):3429-32.
3蒋宜,刘晓林,田晓春,等.老年高血压患者克老素基因单核苷酸多态性与其左心室肥厚的相关性研究[J].重庆医科大学学报,2013;38(8):891-5.
4李宝善,马厚勋,王艳娇,等.Klotho基因转导延缓自发性高血压大鼠高血压进程及改善其心脏损害的作用研究[J].中华医学遗传学杂志,2012;29(6):662-8.
5 Marwick TH,Gillebert TC,Aurigemma G,et al.Recommendations on the use of echocardiography in adult hypertension:a report from the European Association of Cardiovascular Imaging(EACVI)and the American Society of Echocardiography(ASE)[J].J Am Soc Echocardiog,2015;28(7):727-54.
6中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[J].中华心血管病杂志,2007;35(5):390-419.
7中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011;39(7):579-616.
8阎国辉,张玉东,孙志丹.遗传性高血压致左室肥厚机制的研究现状[J].中国综合临床,2004;6(6):573-4.
9 Rohini A,Agrawal N,Koyani CN,et al.Molecular targets and regulators of cardiac hypertrophy[J].Pharmacol Res,2010;61(4):269-80.
10李龙,李莉,崔天祥,等.Klotho基因多态性与高血压左室肥厚的关系[J].中国老年学杂志,2013;33(11):2501-3.
11 Yamazaki M,Ozono K,Okada T,et al.Both FGF23 and extracellular phosphate activate Raf/MEK/ERK pathway via FGF receptors in HEK293 cells[J].J Cell Biochem,2010;111(5):1210-21.
12 Xie J,Cha SK,An SW,et al.Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart[J].Nat Commun,2011;3:1238.