摘要
目的:探讨益智醒脑方联合西医治疗对阿尔茨海默病患者脑脊液炎性因子及神经递质的影响。方法:选择2014年10月~2016年10月收治的阿尔茨海默病患者124例为研究对象,采用随机数字表法分为观察组和对照组各62例。对照组给予多奈派齐片等西医常规治疗,观察组给予益智醒脑方联合西医治疗。治疗12周后,比较两组脑脊液炎性因子、神经递质、临床疗效等指标。结果:观察组有效率80.65%明显高于对照组64.52%(χ~2=4.052 9,P<0.05);脑脊液TNF-α、IL-6明显低于对照组,IL-4、IL-10含量明显高于对照组(t=10.911、8.739、5.000、4.046,P<0.05、P<0.01);多巴胺(DA)、5-羟色胺(5-HT)、去甲肾上腺素(NE)含量明显高于对照组(t=9.435、7.916、5.985,P<0.05、P<0.01)。结论:益智醒脑方联合西医治疗有助于缓解阿尔茨海默病临床症状,提高治疗效果,可能与抑制患者炎症症状、调节神经递质表达水平有关。
Objective: To study the effect of inflammatory factor and neurotransmitter of Yizhi Xingnao Fang combined with western medicine for patients with alzheimer' s disease. Methods: 124 cases alzheimer' s patients from October 2014 to October 2016 were divided into observation group and control group,the control group given donepezil etc conventional western medicine therapy,observation group given Yizhi Xingnao Fang combinde with western medicine therapy. 12 weeks after treatment,cerebrospinal fluid inflammatory factors,neurotransmitter and clinical efficacy were compared between two groups. Results: Observation group effective rate80. 65% was significantly higher than control group 64. 52%( χ~2= 4. 052 9,P < 0. 05); cerebrospinal fluid TNF-α,IL-6 were significantly lower than control group,IL-4,IL-10 were significantly higher than control group( t = 10. 911,8. 739,5. 000,4. 046,P<0. 05,P<0. 01); DA,5-HT,NE were significantly higher than control group( t = 9. 435,7. 916,5. 985,P < 0. 05,P < 0. 01). Conclusion: Yizhi Xingnao Fang combined with western medicine therapy help to improve the clinical symptoms and therapeutic effect,which may be related to the suppression of inflammatory symptoms,regulation of neurotransmitter expression level.
引文
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