卡培他滨节拍化疗联合复方苦参注射液治疗晚期结直肠癌的临床疗效观察
|
摘要
目的观察卡培他滨节拍化疗联合复方苦参注射液治疗多程化疗后进展的晚期结直肠癌患者的临床疗效,以及对患者免疫功能和生活质量的影响。方法选取2014年1月—2016年1月在该院住院治疗的60例多程化疗后再进展的晚期结直肠癌患者,随机分为对照组和观察组,每组各30例;对照组采用卡培他滨节拍化疗方案治疗;观察组在对照组基础上加用复方苦参注射液进行治疗。比较二组的临床疗效、免疫功能和生活质量等指标变化。结果观察组和对照组患者治疗有效率分别为53.3%和36.7%,差异无统计学意义(P>0.05);但在改善患者生活质量方面观察组优于对照组,差异有统计学意义(P<0.05);化疗后二组免疫功能均能得到改善,观察组NK细胞数量、CD3~+、CD4~+T淋巴细胞数量,及CD4~+/CD8~+均高于对照组,CD8~+T淋巴细胞水平低于化疗前;观察组化疗后免疫球蛋白水平和生活质量均高于化疗前和对照组(P<0.05)。结论卡培他滨节拍化疗联合复方苦参注射液方案治疗多程化疗后再进展的晚期结直肠癌效果良好,并可改善患者免疫功能和生活质量,值得临床应用推广。
Objective To observe the clinical efficacy of capecitabine metronomic chemotherapy combined with compound matrine injection in the treatment of advanced colorectal cancer patients after multicourse chemotherapy,as well as the influence on immune function and quality of life of patients.Methods Seventy patients with advanced colorectal cancer treated in Tangshan People′s Hospital from January 2014 to January 2016 in were involved in this survey and were randomly divided into the control group and the observation group,30 cases in each group.The control group was treated with capecitabine metronomic chemotherapy,while the observation group was treated with compound matrine injection with chemotherapy.The curative effect,life quality and immune function in the two groups were compared.Results The effective rates of treatment in the observation group and the control group were 53.3% and 36.7%,respectively,with no significant difference(P>0.05); but the observation group was better than the control group in improving the quality of life(P<0.05); the immune function of the two groups was improved after chemotherapy.The number of NK cells,CD3~+,CD4~+T lymphocyte and CD4~+/CD8~+ in the observation group were higher than those in the control group.The level of CD8~+ T lymphocyte in the control group was lower than that before chemotherapy,and the level of immunoglobulin and quality of life in the observation group were higher than those before chemotherapy and in the control group(P<0.05).Conclusion Capecitabine metronomic chemotherapy combined with compound matrine Injection is effective in the treatment of advanced colorectal cancer which progresses after multi-course chemotherapy,and can improve the immune function and quality of life of patients.It is worthy of clinical application and promotion.
Objective To observe the clinical efficacy of capecitabine metronomic chemotherapy combined with compound matrine injection in the treatment of advanced colorectal cancer patients after multicourse chemotherapy,as well as the influence on immune function and quality of life of patients.Methods Seventy patients with advanced colorectal cancer treated in Tangshan People′s Hospital from January 2014 to January 2016 in were involved in this survey and were randomly divided into the control group and the observation group,30 cases in each group.The control group was treated with capecitabine metronomic chemotherapy,while the observation group was treated with compound matrine injection with chemotherapy.The curative effect,life quality and immune function in the two groups were compared.Results The effective rates of treatment in the observation group and the control group were 53.3% and 36.7%,respectively,with no significant difference(P>0.05); but the observation group was better than the control group in improving the quality of life(P<0.05); the immune function of the two groups was improved after chemotherapy.The number of NK cells,CD3~+,CD4~+T lymphocyte and CD4~+/CD8~+ in the observation group were higher than those in the control group.The level of CD8~+ T lymphocyte in the control group was lower than that before chemotherapy,and the level of immunoglobulin and quality of life in the observation group were higher than those before chemotherapy and in the control group(P<0.05).Conclusion Capecitabine metronomic chemotherapy combined with compound matrine Injection is effective in the treatment of advanced colorectal cancer which progresses after multi-course chemotherapy,and can improve the immune function and quality of life of patients.It is worthy of clinical application and promotion.
引文
[1] A de Gramont,A Figer,M Seymour,et al.Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer[J].Journal of Clinical Oncology,2000,18(16):2938
[2] Ono T,Ishida H,Kumamoto K,et al.Outcome in disappearing colorectal cancer liver metastases during oxaliplatin-based chemotherapy[J].Oncol Lett,2012,9(4):905-909
[3] Kerbel R S.Tumor angiogenesis:past,present and the near future[J].Carcinogenesis,2000,21( 3):505-515
[4] Folkman J.Metronomic chemotherapy:an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance[J].Cancer Lett,2014,12(39):780-797
[5] Blum JL,Jones SE,Buzdar AU,et al.Multicenter phase Ⅱ study of capecitabine in paclitaxel-refractory metastatic breast cancer[J].J Clin Oncol,1999,17(2):485-493
[6] Browder T,Butterfield C E,Kraling B M,et al.Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer[J].Cancer Research,2000,60(7):1878
[7] 方凤奇,张洁,张春霞.沙利度胺联合卡培他滨节拍化疗治疗转移性乳腺癌的临床研究[J].山东医药,2012,52(24):63-65
[8] 徐丽叶,宋晨,吴涛,等.卡培他滨节拍式化疗治疗晚期胃癌疗效观察[J].中国医药导报,2012,9(15):188-192
[9] 翟臻.复方苦参注射液治疗Ⅲ-Ⅳ期癌症患者癌性疼痛的临床效果[J].中国医药,2017,12(11):1729-1731
[10] 黄晓智,王建功,王晓红,等.复方苦参注射液联合放化疗治疗晚期头颈部鳞癌76例[J].中国煤炭工业医学杂志,2012,(15)12:1873-1875
[11] 闫卿,刘全华,尹宜发.复方苦参注射液联合奥沙利铂治疗直肠癌疗效观察[J].现代中西医结合杂志,2015,24(31):3488-3489
[12] 刘武,程晓磊,董凡,等.复方苦参注射液联合同步放化疗治疗局部晚期直肠癌的临床研究[J].天津药学,2014,26(3):33-35
[13] 黄思夏,范文斌,刘鹏,等.复方苦参注射液联合铂类化疗药物治疗中晚期胃癌的Meta分析[J].中国中药杂志,2011,36(22):3198
[14] 袁斌.中西医结合在胃肠道恶性肿瘤治疗中的临床应用价值[J].实用临床医药杂志,2013,17(17):132-133;136
[15] 崔忠,赵清涛,孙建斌,等.复方苦参注射液对胆胰结合部恶性肿瘤术后化疗患者免疫功能的影响[J].解放军医药杂志,2017,29(4):20-23
[2] Ono T,Ishida H,Kumamoto K,et al.Outcome in disappearing colorectal cancer liver metastases during oxaliplatin-based chemotherapy[J].Oncol Lett,2012,9(4):905-909
[3] Kerbel R S.Tumor angiogenesis:past,present and the near future[J].Carcinogenesis,2000,21( 3):505-515
[4] Folkman J.Metronomic chemotherapy:an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance[J].Cancer Lett,2014,12(39):780-797
[5] Blum JL,Jones SE,Buzdar AU,et al.Multicenter phase Ⅱ study of capecitabine in paclitaxel-refractory metastatic breast cancer[J].J Clin Oncol,1999,17(2):485-493
[6] Browder T,Butterfield C E,Kraling B M,et al.Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer[J].Cancer Research,2000,60(7):1878
[7] 方凤奇,张洁,张春霞.沙利度胺联合卡培他滨节拍化疗治疗转移性乳腺癌的临床研究[J].山东医药,2012,52(24):63-65
[8] 徐丽叶,宋晨,吴涛,等.卡培他滨节拍式化疗治疗晚期胃癌疗效观察[J].中国医药导报,2012,9(15):188-192
[9] 翟臻.复方苦参注射液治疗Ⅲ-Ⅳ期癌症患者癌性疼痛的临床效果[J].中国医药,2017,12(11):1729-1731
[10] 黄晓智,王建功,王晓红,等.复方苦参注射液联合放化疗治疗晚期头颈部鳞癌76例[J].中国煤炭工业医学杂志,2012,(15)12:1873-1875
[11] 闫卿,刘全华,尹宜发.复方苦参注射液联合奥沙利铂治疗直肠癌疗效观察[J].现代中西医结合杂志,2015,24(31):3488-3489
[12] 刘武,程晓磊,董凡,等.复方苦参注射液联合同步放化疗治疗局部晚期直肠癌的临床研究[J].天津药学,2014,26(3):33-35
[13] 黄思夏,范文斌,刘鹏,等.复方苦参注射液联合铂类化疗药物治疗中晚期胃癌的Meta分析[J].中国中药杂志,2011,36(22):3198
[14] 袁斌.中西医结合在胃肠道恶性肿瘤治疗中的临床应用价值[J].实用临床医药杂志,2013,17(17):132-133;136
[15] 崔忠,赵清涛,孙建斌,等.复方苦参注射液对胆胰结合部恶性肿瘤术后化疗患者免疫功能的影响[J].解放军医药杂志,2017,29(4):20-23