玉米醒酒肽构效关系及机理研究进展
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摘要
玉米醒酒肽是玉米黄粉蛋白水解后得到的一种低聚寡肽。在大量的体外、动物和人体试验中,玉米醒酒肽可以有效调节参与酒精代谢的相关酶活性以及改善机体摄入酒精后的各类生理反应,发挥显著的醒酒活性。具有醒酒活性的玉米肽在一级结构上体现明显的共性,具有相似的氨基酸组成序列,其醒酒机理也已经被广泛研究和证实。本文对玉米醒酒肽的活性验证试验、结构特征及醒酒机理进行综述,旨在为进一步开展玉米及其他来源醒酒肽的研究提供借鉴。
Corn sobering peptides are oligopeptides obtained after the hydrolysis of corn gluten meal protein. According to a large number of experiments in vitro, animals and human, corn sobering peptides was proven capable of regulating the activity of enzymes involved in alcohol metabolism effectively and improve various physiological responses of bodies after alcohol intake, playing a remarkable role in sobering. Corn sobering peptides show obvious commonality in primary structure with similar composition of amino acids and their sobering mechanisms have been widely studied and confirmed. In this paper, the activity verification tests, structural characteristics and sobering mechanisms of corn sobering peptides were reviewed, aiming to provide references for further research on sobering peptides of corn and other sources.
Corn sobering peptides are oligopeptides obtained after the hydrolysis of corn gluten meal protein. According to a large number of experiments in vitro, animals and human, corn sobering peptides was proven capable of regulating the activity of enzymes involved in alcohol metabolism effectively and improve various physiological responses of bodies after alcohol intake, playing a remarkable role in sobering. Corn sobering peptides show obvious commonality in primary structure with similar composition of amino acids and their sobering mechanisms have been widely studied and confirmed. In this paper, the activity verification tests, structural characteristics and sobering mechanisms of corn sobering peptides were reviewed, aiming to provide references for further research on sobering peptides of corn and other sources.
引文
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[2]左利梅. 浅析过量饮酒对健康的严重危害[J]. 大家健康(学术版), 2014,8(3):19 ZUO L M. An analysis of the serious harm to health by excessive drinking[J]. For all Health, 2014, 8(3):19
[3]MCKILLOP I H, SCHRUM L W. Alcohol and liver cancer[J]. Alcohol, 2005, 35(3):195-203
[4]NANJI A A, JOKELAINEN K, TIPOE G L, et al. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-κB-dependent genes[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2003, 284(2):G321-G327
[5]CHENG D Y, KONG H. The effect of Lycium barbarum polysaccharide on alcohol-induced oxidative stress in rats[J]. Molecules, 2011,16(3):2542-2550
[6]DEVI S L, VISWANATHAN P, ANURADHA C V. Taurine enhances the metabolism and detoxification of ethanol and prevents hepatic fibrosis in rats treated with iron and alcohol[J]. Environmental Toxicology and Pharmacology, 2009, 27(1):120-126
[7]SARI Y. Activity-dependent neuroprotective protein–derived peptide, NAP, preventing alcohol-induced apoptosis in fetal brain of C57BL/6 mouse[J]. Neuroscience, 2009, 158(4):1426-1435
[8]宁庆鹏, 王常青, 方甜, 等. 酶法制备花生粕醒酒多肽[J]. 食品科学, 2016,37(13):173-177NING Q P, WANG C Q, FANG T, et al. Preparation of polypeptides with sobering effect from peanut meal by enzymatic hydrolysis[J]. Food Science, 2016, 37(13):173-177
[9]LI Y G, JI D F, LIN T B, et al. Protective effect of sericin peptide against alcohol-induced gastric injury in mice[J]. Chinese Medical Journal, 2008, 20(121):2083-2087
[10]周勇, 陈烨, 王权, 等. 大豆肽的解酒作用及其机制研究[J]. 中药材, 2014,37(6):1033-1036ZHOU Y, CHEN Y, WANG Q, et al. Study on anti-alcohol mechanism of soybean peptide[J]. Journal of Chinese Medicinal Materials, 2014, 37(6):1033-1036
[11]何慧, 石燕玲, 徐淑芬, 等. 灵芝肽对乙醇诱导肝损伤小鼠的保护作用[J]. 食品科学, 2010, 31(3):213-216HE H,SHI Y L, XU S F, et al. Hepatoprotective effect of Ganoderma lucidum peptides against alcohol-induced liver injury in mice[J].Food Science, 2010, 31(3):213-216
[12]刘晶晶, 张杰, 王雪锋, 等. 蛋白酶酶解河蚬肉制备醒酒肽的工艺优化[J]. 食品工业, 2014, 35(6):51-55LIU J J, ZHANG J, WNAG X F, et al.Optimization of enzymolysis technology of anti-alcoholis peptide from corbicula fluminea[J].The Food Industry, 2014, 35(6):51-55
[13]ZHUANG H, TANG N, DONG S T, et al. Optimisation of antioxidant peptide preparation from corn gluten meal[J]. Journal of the Science of Food and Agriculture, 2013, 93(13):3264-3270
[14]PEREIRA T G, OLIVA-TELES A. Evaluation of corn gluten meal as a protein source in diets for gilthead sea bream (Sparus aurata L.) juveniles[J]. Aquaculture Research, 2003, 34(13):1111-1117
[15]WANG L Y, DING L, WANG Y, et al. Isolation and characterisation of in vitro and cellular free radical scavenging peptides from corn peptide fractions[J]. Molecules, 2015, 20(2):3221-3237
[16]JELSKI W, ZALEWSKI B, SZMITKOWSKI M. The activity of class Ⅰ,Ⅱ, Ⅲ, and IV alcohol dehydrogenase(ADH) isoenzymes and aldehyde dehydrogenase (ALDH)in liver cancer[J]. Digestive Diseases and Sciences, 2008,9(53):2550-2555
[17]吴晖, 李丽丽, 李晓凤, 等. 非水相中固定化酶水解制备玉米肽的体外醒酒活性研究[J]. 食品与发酵工业, 2010, 36(12):37-41WU H, LI L L, LI X F, et al. Study on sobering activity in vitro of corn peptide prepared by immobilized enzyme in non-aqueous phase[J]. Food and fermentation industries, 2010, 36(12):37-41
[18]YU G C, LI J T, HE H, et al. Ultrafiltration preparation of potent bioactive corn peptide as alcohol metabolism stimulator in vivo and study on its mechanism of action[J]. Journal of Food Biochemistry, 2013, 37(2):161-167
[19]AMIRTHARAJ G J, NATARAJAN S K, PULIMOOD A, et al. Role of oxygen free radicals, nitric oxide and mitochondria in mediating cardiac alterations during liver cirrhosis induced by thioacetamide[J]. Cardiovascular Toxicology, 2017, 17(2):175-184
[20]张守文, 王佳音. 双酶复合水解对玉米肽醒酒活性的影响[J]. 中国食品添加剂, 2014(2):87-93ZHANG S W, WANG J Y. The effect of double composite enzyme hydrolysis on the activty of corn sober peptide[J].China Food Additives, 2014(2):87-93
[21]隋玉杰.玉米肽的制备条件及其醒酒护肝机理研究[D]. 武汉:华中农业大学, 2006SUI Y J. Study on preparation, antialcoholism and hepatic-protection mechanism of corn peptides[D].Wuhan: Huazhong Agricultural University,2006
[22]于国才.新型高活性玉米醒酒保肝肽的制备、活性与结构[D]. 武汉:华中农业大学, 2010YU G C. Preparation, activities and structuers of noetype potent bioactive corn peptides as alcohol metabolism[D].Wuhan:Huazhong Agricultural University,2010
[23]郭辉.双酶法制备玉米肽及其醒酒保肝机理研究[D]. 武汉:华中农业大学, 2009GUO H. Study on preparation,antialcoholism and hepatorpotection mechanisms of corn peptides by two kinds of enzymes[D]. Wuhan: Huazhong Agricultural University,2009
[24]LI H, GUO P, HU X, et al. Preparation of corn (Zea mays) peptides and their protective effect against alcohol-induced acute hepatic injury in NH mice[J]. Biotechnology and Applied Biochemistry, 2007, 47(3):169-174
[25]于国才, 何慧, 靳桢, 等. 纳滤技术浓缩纯化玉米肽及对其醒酒活性的影响[J]. 食品科学, 2011, 32(8):10-14 YU G C, HE H, JIN Z, et al. Nanofiltration for concentration and purification of corn peptides and their effects on antialcoholism activity[J].Food Science, 2011, 32(8):10-14
[26]刘鹏.低分子量促乙醇代谢玉米肽制备与蛋白成分对活性贡献关系研究[D].广州:华南理工大学, 2015LIU P. Preparation of corn originated low-molecular-weight peptides with anti-alcoholism activity and the contribution of different protein components to activity[D].Guangzhou: South China University of Technology,2015
[27]WANG X J, ZHENG X Q, KOPPARAPU N K, et al. Purification and evaluation of a novel antioxidant peptide from corn protein hydrolysate[J]. Process Biochemistry, 2014, 49(9):1562-1569
[28]LI H M, HU X, GUO P, et al. Antioxidant properties and possible mode of action of corn protein peptides and zein peptides[J]. Journal of Food Biochemistry, 2010, 34(s1):44-60
[29]潘兴昌, 曾瑜, 刘文颖, 等. 玉米低聚肽和姜黄素对小鼠的醒酒功能研究[J]. 食品与发酵工业, 2016, 42(11):25-34PAN X C, ZENG Y, LIU W Y, et al. Study on the sobering effect of corn oligopeptide and curcumin on mice[J]. Food and Fermentation Industries, 2016, 42(11):25-34
[30]YAMAGUCHI M, TAKADA M, NOZAKI O, et al. Preparation of corn peptide from corn gluten meal and its administration effect on alcohol metabolism in stroke-prone spontaneously hypertensive rats[J]. Journal of Nutritional Science and Vitaminology, 1996, 42(3):219-231
[31]郭辉, 何慧, 韩樱, 等. 玉米肽对小鼠酒后肝脏乙醇脱氢酶活力的影响及醒酒机理[J]. 食品科学, 2011, 32(11):265-269GUO H, HE H, HAN Y, et al. Effect of corn peptides on alcohold ehydrogenase activity in live of mice after drinking and its anti-alcohol mechanism[J].Food Science, 2011, 32(11):265-269 2011, 32(11):265-269
[32]YAMAGUCHI M, NISHIKIORI F, NOZAKI O, et al. Effect of long-term ‘corn peptide’ ingestion on alcohol metabolism in stroke-prone spontaneously hypertensive rats with alcohol loading[J]. Journal of Nutritional Science and Vitaminology, 1996, 42(6):567-580
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