六君子汤加减治疗慢性萎缩性胃炎(脾胃虚弱证)对患者症状改善、胃肠功能及疗效影响分析
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摘要
目的:探讨慢性萎缩性胃炎(脾胃虚弱证)经六君子汤治疗的临床疗效。方法:纳入2015年3月-2017年3月期间在我院门诊就诊的103例慢性萎缩性胃炎(脾胃虚弱证)患者为本次研究对象,采用随机数字表法将其分为治疗组(53例)与对照组(50例)。对照组给予常规西药治疗,治疗组在对照组的基础上给予六君子汤加减治疗。观察两组患者治疗后的临床疗效,治疗前后临床症状积分及胃肠功能相关指标水平变化情况。结果:治疗组临床总有效率(94.34%)显著高于对照组的76.00%,(P<0.05);治疗前,两组患者胃脘痞满、胃脘疼痛、乏力、食少积分及胃泌素(Gastrin,GAS)、胃动素(Motilin,MOT)水平比较差异均无统计学意义(P> 0.05),治疗后,治疗组胃脘痞满、胃脘疼痛、乏力、食少积分显著低于对照组(P <0.05);治疗组GAS、MOT水平显著高于对照组(P <0.05)。结论:采用六君子汤加减治疗慢性萎缩性胃炎(脾胃虚弱证)的临床疗效显著,可有效改善患者临床症状及胃肠功能。
Objective: To investigate the clinical efficacy of the Liujunzi decoction( 六君子汤) on chronic atrophic gastritis of the Piwei Xuruo type( 脾胃虚弱证). Methods: 103 patients were randomly divided into the treatment groups(53 cases) and the control group(50 cases). The control group was given conventional western medicine; the treatment group was given the Liujunzi decoction more. The efficacy, clinical symptom scores and gastrointestinal function were observed. Results: The total efficiency(94.34%) in the treatment group was significantly higher than 76.00% in the control group(P<0.05). After treatment, the scores of gastric fistula, stomach cramps, fatigue,and food less in the treatment group were significantly lower than the control group(P<0.05). GAS and MOT levels in the treatment group were significantly higher than the control group(P<0.05). Conclusion: The Liujunzi decoction on chronic atrophic gastritis of the Piwei Xuruo type shows a significant effect, can effectively improve the clinical symptoms and gastrointestinal function.
Objective: To investigate the clinical efficacy of the Liujunzi decoction( 六君子汤) on chronic atrophic gastritis of the Piwei Xuruo type( 脾胃虚弱证). Methods: 103 patients were randomly divided into the treatment groups(53 cases) and the control group(50 cases). The control group was given conventional western medicine; the treatment group was given the Liujunzi decoction more. The efficacy, clinical symptom scores and gastrointestinal function were observed. Results: The total efficiency(94.34%) in the treatment group was significantly higher than 76.00% in the control group(P<0.05). After treatment, the scores of gastric fistula, stomach cramps, fatigue,and food less in the treatment group were significantly lower than the control group(P<0.05). GAS and MOT levels in the treatment group were significantly higher than the control group(P<0.05). Conclusion: The Liujunzi decoction on chronic atrophic gastritis of the Piwei Xuruo type shows a significant effect, can effectively improve the clinical symptoms and gastrointestinal function.
引文
[1]郑君.甘草总黄酮对慢性萎缩性胃炎大鼠胃黏膜保护作用及药理机制研究[D].广州:广州南方医科大学,2014.
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[5]写国斌,张军.慢性萎缩性胃炎发病的相关危险因素分析[J].中国保健营养,2017,27(24):68.
[6]王秀娟.慢性萎缩性胃炎的中医药治疗进展[A].中华中医药学会·中华中医学会第十二届全国脾胃病学术交流会论文集[C].北京:中华中医药学会.2010.
[7]谷春雨,刘建军,刘西斌,等.益气活血方对慢性萎缩性胃炎胃液p H值及血清胃蛋白酶原的影响[J].中国中西医结合消化杂志,2012,20(01):1-3.
[8]闵琛,许春娣,奚容平,等.獐乳对大鼠小肠推进及胃酸、胃蛋白酶分泌影响的实验研究[J].中国儿童保健杂志,2005,13(05):419-421.
[9]荣源.慢性萎缩性胃炎的中医治疗[J].中华中西医杂志,2008,9(11):972-975.
[10]燕东,王少丽,白宇宁,等.基于络病理论探析慢性萎缩性胃炎的中医病机[J].中医杂志,2015,56(15):1282-1285.
[11]周继胜.中医辨证治疗胃脘痛642例分析[J].中华现代中西医杂志,2004,1(07):633.
[12]董凤彩.白术不同化学成分的药理作用[J].中医临床研究,2015,7(14):28-29.
[13]徐硕,姜文清,邝咏梅,等.茯苓的化学成分及生物活性研究进展[J].西北药学杂志,2016,31(03):327-330.
[2]叶海潇.林上助胃黏膜微观辨证治疗慢性萎缩性胃炎[J].实用中医内科杂志,2015,29(03):9-10.
[3]中华人民共和国卫生部.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:124-129.
[4]中华医学会消化病分会.中国慢性胃炎共识意见[J].现代消化及介入诊疗,2013,18(02):119-128.
[5]写国斌,张军.慢性萎缩性胃炎发病的相关危险因素分析[J].中国保健营养,2017,27(24):68.
[6]王秀娟.慢性萎缩性胃炎的中医药治疗进展[A].中华中医药学会·中华中医学会第十二届全国脾胃病学术交流会论文集[C].北京:中华中医药学会.2010.
[7]谷春雨,刘建军,刘西斌,等.益气活血方对慢性萎缩性胃炎胃液p H值及血清胃蛋白酶原的影响[J].中国中西医结合消化杂志,2012,20(01):1-3.
[8]闵琛,许春娣,奚容平,等.獐乳对大鼠小肠推进及胃酸、胃蛋白酶分泌影响的实验研究[J].中国儿童保健杂志,2005,13(05):419-421.
[9]荣源.慢性萎缩性胃炎的中医治疗[J].中华中西医杂志,2008,9(11):972-975.
[10]燕东,王少丽,白宇宁,等.基于络病理论探析慢性萎缩性胃炎的中医病机[J].中医杂志,2015,56(15):1282-1285.
[11]周继胜.中医辨证治疗胃脘痛642例分析[J].中华现代中西医杂志,2004,1(07):633.
[12]董凤彩.白术不同化学成分的药理作用[J].中医临床研究,2015,7(14):28-29.
[13]徐硕,姜文清,邝咏梅,等.茯苓的化学成分及生物活性研究进展[J].西北药学杂志,2016,31(03):327-330.