羟脯氨酸导致草酸钙结石形成的研究进展
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摘要
羟脯氨酸是近些年来发现的一种草酸钙结石形成过程中的草酸前体。在尿路结石形成过程中,草酸钙结石占大部分,而羟脯氨酸作为草酸前体在人的肉类饮食过程中占了绝大部分,并最终可能诱发草酸钙结石形成。本文综述羟脯氨酸诱发草酸钙结石形成的代谢过程,并初步探讨羟脯氨酸在动物模型上的应用。
Hydroxyproline is an oxalic acid precursor discovered in the formation of calcium oxalate stones in recent years. In the formation of urinary stones, calcium oxalate stones accounted for most, and hydroxyproline as a precursor of oxalate in the course of human meat diet accounted for the majority, and might eventually induce the formation of calcium oxalate stones. This paper summarized hydroxyproline inducing metabolic process of calcium oxalate stone formation and hydroxyproline in the application of animal models.
Hydroxyproline is an oxalic acid precursor discovered in the formation of calcium oxalate stones in recent years. In the formation of urinary stones, calcium oxalate stones accounted for most, and hydroxyproline as a precursor of oxalate in the course of human meat diet accounted for the majority, and might eventually induce the formation of calcium oxalate stones. This paper summarized hydroxyproline inducing metabolic process of calcium oxalate stone formation and hydroxyproline in the application of animal models.
引文
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[14]Bushinsky DA,Asplin JR,Grynpas MD,et al.Calcium oxalate stone formation in genetic hypercalciuric stone-forming rats[J].Kidney Int,2002,61(3):975-987..
[15]Bushinsky DA,Asplin JR.Thiazides reduce brushite,but not calcium oxalate,supersaturation,and stone formation in genetic hypercalciuric stone-forming rats[J].J Am Soc Nephrol,2005,16(2):417-424.
[16]Ogawa Y,Hossain RZ,Ogawa T,et al.Vitamin B6 deficiency augments endogenous oxalogenesis after intravenous L-hydroxyproline loading in rats[J].Urol Res,2007,35(1):15-21.
[17]Wiessner JH,Garrett MR,Roman RJ,et al.Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome sub stitu tion strains[J].Am J Physiol Renal Physiol,2009,297(2):F301-F306.
[18]Wiessner JH,Garrett MR,Roman RJ,et al.Improved methodology to induce hyperoxaluria without treatment using hydroxyproline[J].Urol Res,2011,39(5):373-377.
[19]叶章群,邓耀良,董诚,等.泌尿系结石[M].北京:人民卫生出版社,2010:149-155.
[20]Kaplon DM,Penniston KL,Darriet C,et al.Hydroxyproline-induced hyperoxaluria using acidified and traditional diets in the porcine model[J].J Endourol,2010,24(3):355-359.
[21]Patel SR,Penniston KL,Iwicki L,et al.Dietary induction of long-term hyperoxaluria in the porcine model[J].J Endourol,2012,26(5):433-438.
[22]叶章群,邓耀良,董诚,等.泌尿系结石[M].北京:人民卫生出版社,2010:590-591.
[23]Knight J,Holmes RP,Cramer SD,et al.Hydroxyproline metabolism in mouse models of primary hyperoxaluria[J].Am J Physiol Renal Physi ol,2012,302(6):F688-F693.
[2]傅龙龙,王共先,傅斌.泌尿系结石病因学的研究进展[J].天津医药,2012,40(9):968-970.
[3]正井基之,刘杨,李范.尿路结石的成因及用饮食疗法预防复发[J].日本医学介绍,2004,25(12):561-564.
[4]蒋礼,徐光辉.尿石症危险因素研究进展[J].广东医学,2007,28(8):1354-1356.
[5]蒋雷鸣,康彩艳,曾宪华,等.348例尿石成分分析[J].广西医学,2006,28(7):984-987.
[6]叶章群,邓耀良,董诚,等.泌尿系结石[M].北京:人民卫生出版社,2010:31.
[7]郑少雄,黄趟萍,李彦增.血、尿羟脯氨酸测定的临床意义[J].天津医药,1987,(1):11-15.
[8]Evan AP,Bledsoe SB,Smith SB,et al.Calcium oxalate crystal localization and osteopontin immunostaining in genetic hyperca-l ciuric stone-forming rats[J].Kidney Int,2004,65(1):154-161.
[9]曾勇庆,王慧.猪肉中羟脯氨酸的分光光度法测定[J].山东农业大学学报,2000,31(1):79-81.
[10]Riedel TJ,Johnson LC,Knight J,et al.Structural and biochem ical studies of human 4-hydroxy-2-oxoglutarate aldolase:implications for hydroxyproline metabolism in primary hyperoxaluria[J].PLoS One,2011,6(10):e26021.
[11]叶章群,邓耀良,董诚,等.泌尿系结石[M].北京:人民卫生出版社,2010:50-52.
[12]卢锋,张士青.内生性草酸代谢及影响因素研究进展[J].医学综述,2012,18(1):40-43.
[13]Knight J,Jiang J,Assimos DG,et al.Hydroxyproline ingestion and urinary oxalate and glycolate excretion[J].Kidney Int,2006,70(11):1929-34.
[14]Bushinsky DA,Asplin JR,Grynpas MD,et al.Calcium oxalate stone formation in genetic hypercalciuric stone-forming rats[J].Kidney Int,2002,61(3):975-987..
[15]Bushinsky DA,Asplin JR.Thiazides reduce brushite,but not calcium oxalate,supersaturation,and stone formation in genetic hypercalciuric stone-forming rats[J].J Am Soc Nephrol,2005,16(2):417-424.
[16]Ogawa Y,Hossain RZ,Ogawa T,et al.Vitamin B6 deficiency augments endogenous oxalogenesis after intravenous L-hydroxyproline loading in rats[J].Urol Res,2007,35(1):15-21.
[17]Wiessner JH,Garrett MR,Roman RJ,et al.Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome sub stitu tion strains[J].Am J Physiol Renal Physiol,2009,297(2):F301-F306.
[18]Wiessner JH,Garrett MR,Roman RJ,et al.Improved methodology to induce hyperoxaluria without treatment using hydroxyproline[J].Urol Res,2011,39(5):373-377.
[19]叶章群,邓耀良,董诚,等.泌尿系结石[M].北京:人民卫生出版社,2010:149-155.
[20]Kaplon DM,Penniston KL,Darriet C,et al.Hydroxyproline-induced hyperoxaluria using acidified and traditional diets in the porcine model[J].J Endourol,2010,24(3):355-359.
[21]Patel SR,Penniston KL,Iwicki L,et al.Dietary induction of long-term hyperoxaluria in the porcine model[J].J Endourol,2012,26(5):433-438.
[22]叶章群,邓耀良,董诚,等.泌尿系结石[M].北京:人民卫生出版社,2010:590-591.
[23]Knight J,Holmes RP,Cramer SD,et al.Hydroxyproline metabolism in mouse models of primary hyperoxaluria[J].Am J Physiol Renal Physi ol,2012,302(6):F688-F693.